GREAT POINT PARTNERS LLC Quant / Systematic

CIK: 0001281446 · Show all filings

Period: Q2 2018 (← Previous) (Next →)

Filing Date: Aug 14, 2018

Total Value ($000): $721,561 (100.0% shares, 0.0% debt)

Holdings (38)

PTCT PTC THERAPEUTICS INC 7.3%

Value ($000) $52,906 Shares 1,568,500 Est. Cost $16.50 Unrealized +89.0%

KURA KURA ONCOLOGY INC 6.6%

Value ($000) $47,813 Shares 2,627,110 Est. Cost $11.71 Unrealized +44.7%

IOVA IOVANCE BIOTHERAPEUTICS INC 6.2%

Value ($000) $44,618 Shares 3,485,745 Est. Cost $10.06 Unrealized +45.3%

BCRX BIOCRYST PHARMACEUTICALS 5.9%

Value ($000) $42,851 Shares 7,478,275 Est. Cost $5.01 Unrealized +9.8%

— SPARK THERAPEUTICS INC 5.7%

Value ($000) $41,380 Shares 500,000 Est. Cost $16879.86 Unrealized —

— ACCELERON PHARMA INC 5.1%

Value ($000) $36,778 Shares 758,000 Est. Cost $14939.33 Unrealized —

— ZAFGEN INC 5.0%

Value ($000) $35,805 Shares 3,500,000 Est. Cost $10.23 Unrealized —

— GLOBAL BLOOD THERAPEUTICS INC 4.8%

Value ($000) $34,822 Shares 770,400 Est. Cost $29.02 Unrealized —

ACAD ACADIA PHARMACEUTICALS INC 4.2%

Value ($000) $30,540 Shares 2,000,000 Est. Cost $17.83 Unrealized 0.0%

EXEL EXELIXIS INC 4.0%

Value ($000) $28,725 Shares 1,334,793 Est. Cost $25.37 Unrealized -18.5%

— GLOBAL BLOOD THERAPEUTICS INC 3.8%

Value ($000) $27,219 Shares 602,200 Est. Cost $29.02 Unrealized —

— ACCELERON PHARMA INC 3.7%

Value ($000) $26,798 Shares 552,300 Est. Cost $14939.33 Unrealized —

ALNY ALNYLAM PHARMACEUTICALS INC 3.6%

Value ($000) $25,617 Shares 260,100 Est. Cost $99.19 Unrealized 0.0%

— FOAMIX PHARMACEUTICALS LTD 3.3%

Value ($000) $23,956 Shares 4,781,708 Est. Cost $7.50 Unrealized —

NVCR NOVOCURE LTD 3.1%

Value ($000) $22,348 Shares 713,998 Est. Cost $19.34 Unrealized +43.9%

— FIVE PRIME THERAPEUTICS INC 2.8%

Value ($000) $19,921 Shares 1,260,000 Est. Cost $11841.43 Unrealized —

UTHR UNITED THERAPEUTICS CORP DEL 2.7%

Value ($000) $19,195 Shares 169,639 Est. Cost $109.92 Unrealized 0.0%

VYGR VOYAGER THERAPEUTICS INC 2.0%

Value ($000) $14,264 Shares 730,010 Est. Cost $19.54 Unrealized —

— ALEXION PHARMACEUTICALS INC 1.9%

Value ($000) $13,719 Shares 110,506 Est. Cost $124.15 Unrealized —

SVRA SAVARA INC 1.8%

Value ($000) $13,296 Shares 1,174,541 Est. Cost $11.09 Unrealized -9.5%

— ARENA PHARMACEUTICALS INC 1.8%

Value ($000) $13,167 Shares 302,000 Est. Cost $3910.17 Unrealized —

CYTK CYTOKINETICS INC 1.7%

Value ($000) $11,989 Shares 1,444,481 Est. Cost $8.32 Unrealized 0.0%

— CORSICANTO II DESIGNATED ACT 1.5%

Value ($000) $10,900 Shares 10,000,000 Est. Cost $1102.50 Unrealized —

EXEL EXELIXIS INC 1.5%

Value ($000) $10,760 Shares 500,000 Est. Cost $25.37 Unrealized -18.5%

PTGX PROTAGONIST THERAPEUTICS INC 1.4%

Value ($000) $9,903 Shares 1,473,609 Est. Cost $7.68 Unrealized 0.0%

— RIGEL PHARMACEUTICALS INC 1.3%

Value ($000) $9,644 Shares 3,407,840 Est. Cost $288.10 Unrealized —

— GLOBAL BLOOD THERAPEUTICS INC 1.3%

Value ($000) $9,040 Shares 200,000 Est. Cost $29.02 Unrealized —

— ACHILLION PHARMACEUTICALS INC 1.2%

Value ($000) $8,458 Shares 2,988,716 Est. Cost $3710.00 Unrealized —

— CTI BIOPHARMA CORP 1.1%

Value ($000) $7,654 Shares 1,537,020 Est. Cost $3899.78 Unrealized —

— SIERRA ONCOLOGY INC 0.9%

Value ($000) $6,752 Shares 2,280,921 Est. Cost $2070.00 Unrealized —

— ACCELERON PHARMA INC 0.7%

Value ($000) $5,235 Shares 107,900 Est. Cost $14939.33 Unrealized —

— AMARIN CORP PLC 0.7%

Value ($000) $4,932 Shares 1,596,200 Est. Cost $4.03 Unrealized —

— ACORDA THERAPEUTICS INC 0.6%

Value ($000) $4,187 Shares 145,900 Est. Cost — Unrealized —

— AMARIN CORP PLC 0.5%

Value ($000) $3,266 Shares 1,056,825 Est. Cost $4.03 Unrealized —

CGEN COMPUGEN LTD 0.3%

Value ($000) $2,506 Shares 759,494 Est. Cost $3.76 Unrealized 0.0%

— CELLDEX THERAPEUTICS INC NEW 0.1%

Value ($000) $405 Shares 804,483 Est. Cost $0.50 Unrealized —

— STREAMLINE HEALTH SOLUTIONS 0.0%

Value ($000) $183 Shares 130,137 Est. Cost $6.45 Unrealized —

— NOVELION THERAPEUTICS INC 0.0%

Value ($000) $9 Shares 2,500 Est. Cost $3.60 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
PTCT	PTC THERAPEUTICS INC	1,568,500	$52,906	7.3%	$16.50	+89.0%	COM	69366J200
KURA	KURA ONCOLOGY INC	2,627,110	$47,813	6.6%	$11.71	+44.7%	COM	50127T109
IOVA	IOVANCE BIOTHERAPEUTICS INC	3,485,745	$44,618	6.2%	$10.06	+45.3%	COM	462260100
BCRX	BIOCRYST PHARMACEUTICALS	7,478,275	$42,851	5.9%	$5.01	+9.8%	COM	09058V103
—	SPARK THERAPEUTICS INC	500,000	$41,380	5.7%	$16879.86	—	COM	84652J103
—	ACCELERON PHARMA INC	758,000	$36,778	5.1%	$14939.33	—	COM	00434H108
—	ZAFGEN INC	3,500,000	$35,805	5.0%	$10.23	—	COM	98885E103
—	GLOBAL BLOOD THERAPEUTICS INC	770,400	$34,822	4.8%	$29.02	—	COM	37890U108
ACAD	ACADIA PHARMACEUTICALS INC	2,000,000	$30,540	4.2%	$17.83	0.0%	COM	004225108
EXEL	EXELIXIS INC	1,334,793	$28,725	4.0%	$25.37	-18.5%	COM	30161Q104
—	GLOBAL BLOOD THERAPEUTICS INC	602,200	$27,219	3.8%	$29.02	—	Call	37890U108
—	ACCELERON PHARMA INC	552,300	$26,798	3.7%	$14939.33	—	Put	00434H108
ALNY	ALNYLAM PHARMACEUTICALS INC	260,100	$25,617	3.6%	$99.19	0.0%	COM	02043Q107
—	FOAMIX PHARMACEUTICALS LTD	4,781,708	$23,956	3.3%	$7.50	—	SHS	M46135105
NVCR	NOVOCURE LTD	713,998	$22,348	3.1%	$19.34	+43.9%	ORD SHS	G6674U108
—	FIVE PRIME THERAPEUTICS INC	1,260,000	$19,921	2.8%	$11841.43	—	COM	33830X104
UTHR	UNITED THERAPEUTICS CORP DEL	169,639	$19,195	2.7%	$109.92	0.0%	COM	91307C102
VYGR	VOYAGER THERAPEUTICS INC	730,010	$14,264	2.0%	$19.54	—	COM	92915B106
—	ALEXION PHARMACEUTICALS INC	110,506	$13,719	1.9%	$124.15	—	COM	015351109
SVRA	SAVARA INC	1,174,541	$13,296	1.8%	$11.09	-9.5%	COM	805111101
—	ARENA PHARMACEUTICALS INC	302,000	$13,167	1.8%	$3910.17	—	COM NEW	040047607
CYTK	CYTOKINETICS INC	1,444,481	$11,989	1.7%	$8.32	0.0%	COM NEW	23282W605
—	CORSICANTO II DESIGNATED ACT	10,000,000	$10,900	1.5%	$1102.50	—	NOTE	220485AB2
EXEL	EXELIXIS INC	500,000	$10,760	1.5%	$25.37	-18.5%	Call	30161Q104
PTGX	PROTAGONIST THERAPEUTICS INC	1,473,609	$9,903	1.4%	$7.68	0.0%	COM	74366E102
—	RIGEL PHARMACEUTICALS INC	3,407,840	$9,644	1.3%	$288.10	—	COM NEW	766559603
—	GLOBAL BLOOD THERAPEUTICS INC	200,000	$9,040	1.3%	$29.02	—	Put	37890U108
—	ACHILLION PHARMACEUTICALS INC	2,988,716	$8,458	1.2%	$3710.00	—	COM	00448Q201
—	CTI BIOPHARMA CORP	1,537,020	$7,654	1.1%	$3899.78	—	COM NEW	12648L601
—	SIERRA ONCOLOGY INC	2,280,921	$6,752	0.9%	$2070.00	—	COM	82640U107
—	ACCELERON PHARMA INC	107,900	$5,235	0.7%	$14939.33	—	Call	00434H108
—	AMARIN CORP PLC	1,596,200	$4,932	0.7%	$4.03	—	Call	023111206
—	ACORDA THERAPEUTICS INC	145,900	$4,187	0.6%	—	—	Call	00484M106
—	AMARIN CORP PLC	1,056,825	$3,266	0.5%	$4.03	—	SPONS ADR NEW	023111206
CGEN	COMPUGEN LTD	759,494	$2,506	0.3%	$3.76	0.0%	ORD	M25722105
—	CELLDEX THERAPEUTICS INC NEW	804,483	$405	0.1%	$0.50	—	COM	15117B103
—	STREAMLINE HEALTH SOLUTIONS	130,137	$183	0.0%	$6.45	—	COM	86323X106
—	NOVELION THERAPEUTICS INC	2,500	$9	0.0%	$3.60	—	COM NEW	67001K202