GREAT POINT PARTNERS LLC Quant / Systematic

Location: Greenwich, CT

CIK: 0001281446 · Show all filings

Period: Q4 2018 (← Previous) (Next →)

Filing Date: Feb 15, 2019

Total Value: $791M (100.0% shares, 0.0% debt)

Holdings (40)

BCRX BIOCRYST PHARMACEUTICALS 7.8%

Value $61.51M Shares 7,622,256 Est. Cost $5.12 Unrealized +51.9%

IOVA IOVANCE BIOTHERAPEUTICS INC 6.2%

Value $49.27M Shares 5,567,348 Est. Cost $9.91 Unrealized -2.7%

— GLOBAL BLOOD THERAPEUTICS INC 6.1%

Value $48.44M Shares 1,180,000 Est. Cost $41.05 Unrealized —

— ACCELERON PHARMA INC 5.7%

Value $45.14M Shares 1,036,575 Est. Cost $10938.26 Unrealized —

ACAD ACADIA PHARMACEUTICALS INC 5.6%

Value $44.5M Shares 2,752,256 Est. Cost $18.73 Unrealized +3.7%

PTCT PTC THERAPEUTICS INC 5.3%

Value $42.04M Shares 1,225,000 Est. Cost $24.56 Unrealized +46.4%

KURA KURA ONCOLOGY INC 4.9%

Value $38.88M Shares 2,769,527 Est. Cost $12.07 Unrealized +9.8%

UTHR UNITED THERAPEUTICS CORP DEL 4.8%

Value $38.2M Shares 350,800 Est. Cost $115.91 Unrealized +0.0%

— ZOGENIX INC 4.6%

Value $36.46M Shares 1,000,000 Est. Cost $36.46 Unrealized —

— AUDENTES THERAPEUTICS INC 4.5%

Value $35.35M Shares 1,657,873 Est. Cost $21.32 Unrealized —

VRTX VERTEX PHARMACEUTICALS INC 4.2%

Value $33.14M Shares 200,000 Est. Cost — Unrealized —

PBYI PUMA BIOTECHNOLOGY INC 3.5%

Value $28.08M Shares 1,379,700 Est. Cost $30.01 Unrealized 0.0%

— ARRAY BIOPHARMA INC 3.3%

Value $26.36M Shares 1,850,000 Est. Cost $14.25 Unrealized —

— SPARK THERAPEUTICS INC 3.1%

Value $24.68M Shares 630,600 Est. Cost $10538.47 Unrealized —

— FIVE PRIME THERAPEUTICS INC 2.8%

Value $22.3M Shares 2,398,409 Est. Cost $6226.03 Unrealized —

— INTERCEPT PHARMACEUTICALS INC 2.5%

Value $20.16M Shares 200,000 Est. Cost — Unrealized —

CYTK CYTOKINETICS INC 2.5%

Value $20.05M Shares 3,173,288 Est. Cost $7.94 Unrealized -7.7%

— ZAFGEN INC 2.3%

Value $17.81M Shares 3,598,392 Est. Cost $9.93 Unrealized —

— FOAMIX PHARMACEUTICALS LTD 1.8%

Value $14.53M Shares 4,047,561 Est. Cost $7.50 Unrealized —

SVRA SAVARA INC CMN 1.7%

Value $13.77M Shares 1,819,195 Est. Cost $11.29 Unrealized -20.3%

TGTX TG THERAPEUTICS INC 1.6%

Value $12.3M Shares 3,000,000 Est. Cost $9.17 Unrealized -45.8%

RVLPQ OSMOTICA PHARMACEUTICALS PLC 1.5%

Value $11.63M Shares 1,500,000 Est. Cost $8.00 Unrealized 0.0%

— CYMABAY THERAPEUTICS INC 1.4%

Value $11.16M Shares 1,418,489 Est. Cost $7.87 Unrealized —

— MILLENDO THERAPEUTICS INC 1.3%

Value $10.24M Shares 1,288,093 Est. Cost $7.95 Unrealized —

KRYS KRYSTAL BIOTECH INC 1.3%

Value $10.23M Shares 492,100 Est. Cost $20.94 Unrealized 0.0%

ENTA ENANTA PHARMACEUTICALS INC 1.3%

Value $10.16M Shares 143,481 Est. Cost $100.17 Unrealized -23.5%

— AMAG PHARMACEUTICALS INC 1.3%

Value $10.1M Shares 664,681 Est. Cost $15.19 Unrealized —

— PROTEOSTASIS THERAPEUTICS INC 1.2%

Value $9.867M Shares 3,045,423 Est. Cost $3.24 Unrealized —

— MENLO THERAPEUTICS INC 1.1%

Value $9.082M Shares 2,204,407 Est. Cost $7.51 Unrealized —

— NOVAVAX INC 1.0%

Value $8.28M Shares 4,500,000 Est. Cost — Unrealized —

PTGX PROTAGONIST THERAPEUTICS INC 0.8%

Value $6.431M Shares 955,618 Est. Cost $7.68 Unrealized +3.3%

— INTRA CELLULAR THERAPIES INC 0.6%

Value $4.556M Shares 400,000 Est. Cost — Unrealized —

VYGR VOYAGER THERAPEUTICS INC 0.4%

Value $3.432M Shares 365,132 Est. Cost $19.24 Unrealized —

MDGL MADRIGAL PHARMACEUTICALS INC 0.4%

Value $3.1M Shares 27,500 Est. Cost $250.94 Unrealized -38.3%

ALNY ALNYLAM PHARMACEUTICALS INC 0.4%

Value $2.931M Shares 40,197 Est. Cost $99.37 Unrealized -22.6%

— SAGE THERAPEUTICS INC 0.3%

Value $2.491M Shares 26,000 Est. Cost — Unrealized —

— SAGE THERAPEUTICS INC 0.3%

Value $2.491M Shares 26,000 Est. Cost — Unrealized —

ARGX ARGENX SE 0.2%

Value $1.777M Shares 18,500 Est. Cost $75.84 Unrealized —

— SUNESIS PHARMACEUTICALS INC 0.0%

Value $132K Shares 317,962 Est. Cost $2.00 Unrealized —

— STREAMLINE HEALTH SOLUTIONS 0.0%

Value $105K Shares 130,137 Est. Cost $6.45 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
BCRX	BIOCRYST PHARMACEUTICALS	7,622,256	$61.51M	7.8%	$5.12	+51.9%	COM	09058V103
IOVA	IOVANCE BIOTHERAPEUTICS INC	5,567,348	$49.27M	6.2%	$9.91	-2.7%	COM	462260100
—	GLOBAL BLOOD THERAPEUTICS INC	1,180,000	$48.44M	6.1%	$41.05	—	COM	37890U108
—	ACCELERON PHARMA INC	1,036,575	$45.14M	5.7%	$10938.26	—	COM	00434H108
ACAD	ACADIA PHARMACEUTICALS INC	2,752,256	$44.5M	5.6%	$18.73	+3.7%	COM	004225108
PTCT	PTC THERAPEUTICS INC	1,225,000	$42.04M	5.3%	$24.56	+46.4%	COM	69366J200
KURA	KURA ONCOLOGY INC	2,769,527	$38.88M	4.9%	$12.07	+9.8%	COM	50127T109
UTHR	UNITED THERAPEUTICS CORP DEL	350,800	$38.2M	4.8%	$115.91	+0.0%	COM	91307C102
—	ZOGENIX INC	1,000,000	$36.46M	4.6%	$36.46	—	COM	98978L204
—	AUDENTES THERAPEUTICS INC	1,657,873	$35.35M	4.5%	$21.32	—	COM	05070R104
VRTX	VERTEX PHARMACEUTICALS INC	200,000	$33.14M	4.2%	—	—	Put	92532F100
PBYI	PUMA BIOTECHNOLOGY INC	1,379,700	$28.08M	3.5%	$30.01	0.0%	COM	74587V107
—	ARRAY BIOPHARMA INC	1,850,000	$26.36M	3.3%	$14.25	—	COM	04269X105
—	SPARK THERAPEUTICS INC	630,600	$24.68M	3.1%	$10538.47	—	COM	84652J103
—	FIVE PRIME THERAPEUTICS INC	2,398,409	$22.3M	2.8%	$6226.03	—	COM	33830X104
—	INTERCEPT PHARMACEUTICALS INC	200,000	$20.16M	2.5%	—	—	Put	45845P108
CYTK	CYTOKINETICS INC	3,173,288	$20.05M	2.5%	$7.94	-7.7%	COM	23282W605
—	ZAFGEN INC	3,598,392	$17.81M	2.3%	$9.93	—	COM	98885E103
—	FOAMIX PHARMACEUTICALS LTD	4,047,561	$14.53M	1.8%	$7.50	—	SHS	M46135105
SVRA	SAVARA INC CMN	1,819,195	$13.77M	1.7%	$11.29	-20.3%	COM	805111101
TGTX	TG THERAPEUTICS INC	3,000,000	$12.3M	1.6%	$9.17	-45.8%	COM	88322Q108
RVLPQ	OSMOTICA PHARMACEUTICALS PLC	1,500,000	$11.63M	1.5%	$8.00	0.0%	SHS	G6S41R101
—	CYMABAY THERAPEUTICS INC	1,418,489	$11.16M	1.4%	$7.87	—	COM	23257D103
—	MILLENDO THERAPEUTICS INC	1,288,093	$10.24M	1.3%	$7.95	—	COM	60040X103
KRYS	KRYSTAL BIOTECH INC	492,100	$10.23M	1.3%	$20.94	0.0%	COM	501147102
ENTA	ENANTA PHARMACEUTICALS INC	143,481	$10.16M	1.3%	$100.17	-23.5%	COM	29251M106
—	AMAG PHARMACEUTICALS INC	664,681	$10.1M	1.3%	$15.19	—	COM	00163U106
—	PROTEOSTASIS THERAPEUTICS INC	3,045,423	$9.867M	1.2%	$3.24	—	COM	74373B109
—	MENLO THERAPEUTICS INC	2,204,407	$9.082M	1.1%	$7.51	—	COM	586858102
—	NOVAVAX INC	4,500,000	$8.28M	1.0%	—	—	Call	670002104
PTGX	PROTAGONIST THERAPEUTICS INC	955,618	$6.431M	0.8%	$7.68	+3.3%	COM	74366E102
—	INTRA CELLULAR THERAPIES INC	400,000	$4.556M	0.6%	—	—	Put	46116X101
VYGR	VOYAGER THERAPEUTICS INC	365,132	$3.432M	0.4%	$19.24	—	COM	92915B106
MDGL	MADRIGAL PHARMACEUTICALS INC	27,500	$3.1M	0.4%	$250.94	-38.3%	COM	558868105
ALNY	ALNYLAM PHARMACEUTICALS INC	40,197	$2.931M	0.4%	$99.37	-22.6%	COM	02043Q107
—	SAGE THERAPEUTICS INC	26,000	$2.491M	0.3%	—	—	Put	78667J108
—	SAGE THERAPEUTICS INC	26,000	$2.491M	0.3%	—	—	Call	78667J108
ARGX	ARGENX SE	18,500	$1.777M	0.2%	$75.84	—	SPONSORED ADR	04016X101
—	SUNESIS PHARMACEUTICALS INC	317,962	$132K	0.0%	$2.00	—	COM	867328700
—	STREAMLINE HEALTH SOLUTIONS	130,137	$105K	0.0%	$6.45	—	COM	86323X106