GREAT POINT PARTNERS LLC Quant / Systematic

CIK: 0001281446 · Show all filings

Period: Q4 2019 (← Previous) (Next →)

Filing Date: Feb 14, 2020

Total Value ($000): $1,148,462 (100.0% shares, 0.0% debt)

Holdings (37)

IOVA IOVANCE BIOTHERAPEUTICS INC 12.1%

Value ($000) $138,820 Shares 5,015,175 Est. Cost $9.91 Unrealized +129.6%

— ZYMEWORKS INC 8.8%

Value ($000) $101,093 Shares 2,223,789 Est. Cost $9373.73 Unrealized —

PTCT PTC THERAPEUTICS INC 7.3%

Value ($000) $84,053 Shares 1,750,000 Est. Cost $28.65 Unrealized +48.3%

AXSM AXSOME THERAPEUTICS INC 6.5%

Value ($000) $75,163 Shares 727,200 Est. Cost $40.39 Unrealized 0.0%

— NEXTCURE INC 5.6%

Value ($000) $63,911 Shares 1,134,584 Est. Cost $56.33 Unrealized —

TGTX TG THERAPEUTICS INC 5.3%

Value ($000) $60,326 Shares 5,434,783 Est. Cost $7.60 Unrealized 0.0%

— SAGE THERAPEUTICS INC 5.0%

Value ($000) $57,467 Shares 796,057 Est. Cost $72.19 Unrealized —

— MOMENTA PHARMACEUTICALS INC 4.8%

Value ($000) $55,055 Shares 2,790,400 Est. Cost $162.34 Unrealized —

— CONSTELLATION PHARMCETICLS I 4.7%

Value ($000) $53,476 Shares 1,135,122 Est. Cost $47.11 Unrealized —

ACAD ACADIA PHARMACEUTICALS INC 4.7%

Value ($000) $53,475 Shares 1,250,000 Est. Cost $22.38 Unrealized +94.4%

— ACCELERON PHARMA INC 4.6%

Value ($000) $53,020 Shares 1,000,000 Est. Cost $18289.17 Unrealized —

UTHR UNITED THERAPEUTICS CORP DEL 4.2%

Value ($000) $47,667 Shares 541,179 Est. Cost $81.51 Unrealized +7.9%

— DERMIRA INC 3.5%

Value ($000) $39,739 Shares 2,621,333 Est. Cost $203.29 Unrealized —

PRTA PROTHENA CORP PLC 2.9%

Value ($000) $33,258 Shares 2,100,941 Est. Cost $10.02 Unrealized +7.0%

— ABEONA THERAPEUTICS INC 2.1%

Value ($000) $23,587 Shares 7,213,012 Est. Cost $2.82 Unrealized —

ARVN ARVINAS INC 2.0%

Value ($000) $22,600 Shares 550,000 Est. Cost $29.28 Unrealized 0.0%

— ZOGENIX INC 1.9%

Value ($000) $21,895 Shares 420,000 Est. Cost $9440.90 Unrealized —

AUPH AURINIA PHARMACEUTICALS INC 1.8%

Value ($000) $20,260 Shares 1,000,000 Est. Cost — Unrealized —

TNDM TANDEM DIABETES CARE INC 1.3%

Value ($000) $14,903 Shares 250,000 Est. Cost $63.83 Unrealized -3.4%

— GW PHARMACEUTICALS PLC 1.3%

Value ($000) $14,814 Shares 141,683 Est. Cost $104.56 Unrealized —

— ZOGENIX INC 1.1%

Value ($000) $13,033 Shares 250,000 Est. Cost $9440.90 Unrealized —

— AXONICS MODULATION TECH INC 1.1%

Value ($000) $12,927 Shares 466,507 Est. Cost $27.71 Unrealized —

KURA KURA ONCOLOGY INC 1.0%

Value ($000) $11,739 Shares 853,777 Est. Cost $12.73 Unrealized +16.4%

— MILLENDO THERAPEUTICS INC 1.0%

Value ($000) $11,659 Shares 1,729,759 Est. Cost $7.64 Unrealized —

— MOLECULAR TEMPLATES INC 1.0%

Value ($000) $11,538 Shares 825,000 Est. Cost $13.99 Unrealized —

— OPTINOSE INC 0.9%

Value ($000) $10,897 Shares 1,181,834 Est. Cost $9.22 Unrealized —

— MENLO THERAPEUTICS INC 0.7%

Value ($000) $7,665 Shares 1,652,013 Est. Cost $7.51 Unrealized —

VRAYQ VIEWRAY INC 0.6%

Value ($000) $7,238 Shares 1,715,153 Est. Cost $3.23 Unrealized 0.0%

DXCM DEXCOM INC 0.5%

Value ($000) $5,709 Shares 26,100 Est. Cost $38.85 Unrealized +22.1%

LQDA LIQUIDIA TECHNOLOGIES INC 0.5%

Value ($000) $5,463 Shares 1,277,955 Est. Cost $4.01 Unrealized 0.0%

GNFTY GENFIT S A 0.4%

Value ($000) $4,135 Shares 207,766 Est. Cost $24.00 Unrealized —

IONS IONIS PHARMACEUTICALS INC 0.3%

Value ($000) $3,927 Shares 65,000 Est. Cost $65.17 Unrealized -8.6%

BBIO BRIDGEBIO PHARMA INC 0.2%

Value ($000) $2,748 Shares 78,400 Est. Cost $27.72 Unrealized 0.0%

INSM INSMED INC 0.2%

Value ($000) $2,325 Shares 97,359 Est. Cost $20.34 Unrealized 0.0%

CYTK CYTOKINETICS INC 0.1%

Value ($000) $1,698 Shares 160,073 Est. Cost $10.27 Unrealized 0.0%

— ATARA BIOTHERAPEUTICS INC 0.1%

Value ($000) $1,153 Shares 70,000 Est. Cost $14.12 Unrealized —

AXSM AXSOME THERAPEUTICS INC 0.0%

Value ($000) $26 Shares 254 Est. Cost $40.39 Unrealized 0.0%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
IOVA	IOVANCE BIOTHERAPEUTICS INC	5,015,175	$138,820	12.1%	$9.91	+129.6%	COM	462260100
—	ZYMEWORKS INC	2,223,789	$101,093	8.8%	$9373.73	—	COM	98985W102
PTCT	PTC THERAPEUTICS INC	1,750,000	$84,053	7.3%	$28.65	+48.3%	COM	69366J200
AXSM	AXSOME THERAPEUTICS INC	727,200	$75,163	6.5%	$40.39	0.0%	Call	05464T104
—	NEXTCURE INC	1,134,584	$63,911	5.6%	$56.33	—	COM	65343E108
TGTX	TG THERAPEUTICS INC	5,434,783	$60,326	5.3%	$7.60	0.0%	COM	88322Q108
—	SAGE THERAPEUTICS INC	796,057	$57,467	5.0%	$72.19	—	COM	78667J108
—	MOMENTA PHARMACEUTICALS INC	2,790,400	$55,055	4.8%	$162.34	—	COM	60877T100
—	CONSTELLATION PHARMCETICLS I	1,135,122	$53,476	4.7%	$47.11	—	COM	210373106
ACAD	ACADIA PHARMACEUTICALS INC	1,250,000	$53,475	4.7%	$22.38	+94.4%	COM	004225108
—	ACCELERON PHARMA INC	1,000,000	$53,020	4.6%	$18289.17	—	COM	00434H108
UTHR	UNITED THERAPEUTICS CORP DEL	541,179	$47,667	4.2%	$81.51	+7.9%	COM	91307C102
—	DERMIRA INC	2,621,333	$39,739	3.5%	$203.29	—	COM	24983L104
PRTA	PROTHENA CORP PLC	2,100,941	$33,258	2.9%	$10.02	+7.0%	SHS	G72800108
—	ABEONA THERAPEUTICS INC	7,213,012	$23,587	2.1%	$2.82	—	COM	00289Y107
ARVN	ARVINAS INC	550,000	$22,600	2.0%	$29.28	0.0%	COM	04335A105
—	ZOGENIX INC	420,000	$21,895	1.9%	$9440.90	—	COM NEW	98978L204
AUPH	AURINIA PHARMACEUTICALS INC	1,000,000	$20,260	1.8%	—	—	Call	05156V102
TNDM	TANDEM DIABETES CARE INC	250,000	$14,903	1.3%	$63.83	-3.4%	COM NEW	875372203
—	GW PHARMACEUTICALS PLC	141,683	$14,814	1.3%	$104.56	—	ADS	36197T103
—	ZOGENIX INC	250,000	$13,033	1.1%	$9440.90	—	Call	98978L204
—	AXONICS MODULATION TECH INC	466,507	$12,927	1.1%	$27.71	—	COM	05465P101
KURA	KURA ONCOLOGY INC	853,777	$11,739	1.0%	$12.73	+16.4%	COM	50127T109
—	MILLENDO THERAPEUTICS INC	1,729,759	$11,659	1.0%	$7.64	—	COM	60040X103
—	MOLECULAR TEMPLATES INC	825,000	$11,538	1.0%	$13.99	—	COM	608550109
—	OPTINOSE INC	1,181,834	$10,897	0.9%	$9.22	—	COM	68404V100
—	MENLO THERAPEUTICS INC	1,652,013	$7,665	0.7%	$7.51	—	COM	586858102
VRAYQ	VIEWRAY INC	1,715,153	$7,238	0.6%	$3.23	0.0%	COM	92672L107
DXCM	DEXCOM INC	26,100	$5,709	0.5%	$38.85	+22.1%	COM	252131107
LQDA	LIQUIDIA TECHNOLOGIES INC	1,277,955	$5,463	0.5%	$4.01	0.0%	COM	53635D202
GNFTY	GENFIT S A	207,766	$4,135	0.4%	$24.00	—	ADS	372279109
IONS	IONIS PHARMACEUTICALS INC	65,000	$3,927	0.3%	$65.17	-8.6%	COM	462222100
BBIO	BRIDGEBIO PHARMA INC	78,400	$2,748	0.2%	$27.72	0.0%	COM	10806X102
INSM	INSMED INC	97,359	$2,325	0.2%	$20.34	0.0%	COM PAR $.01	457669307
CYTK	CYTOKINETICS INC	160,073	$1,698	0.1%	$10.27	0.0%	COM NEW	23282W605
—	ATARA BIOTHERAPEUTICS INC	70,000	$1,153	0.1%	$14.12	—	COM	046513107
AXSM	AXSOME THERAPEUTICS INC	254	$26	0.0%	$40.39	0.0%	COM	05464T104