Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q1 2025 (← Previous) (Next →)
Filing Date: Aug 6, 2025
Total Value: $2.831B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| — | VERONA PHARMA PLC | 6,563,340 | $417M | 14.7% | $63.49 | $23.99 | — | SPONSORED ADS | 925050106 |
| ACLX | ARCELLX INC | 2,926,478 | $192M | 6.8% | $65.60 * | $24.76 | +173.6% | COMMON STOCK | 03940C100 |
| FOLD | AMICUS THERAPEUTICS INC | 21,464,527 | $175M | 6.2% | $8.16 * | $7.36 | +25.7% | COM | 03152W109 |
| EWTX | EDGEWISE THERAPEUTICS INC | 6,547,328 | $144M | 5.1% | $22.00 * | $22.55 | +16.4% | COM | 28036F105 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 2,548,445 | $135M | 4.8% | $52.97 * | $35.98 | +54.2% | COM | 76243J105 |
| NUVL | NUVALENT INC | 1,633,968 | $116M | 4.1% | $70.92 * | $38.37 | +103.8% | COM | 670703107 |
| SLNO | SOLENO THERAPEUTICS INC | 1,506,602 | $108M | 3.8% | $71.45 * | $6.32 | +670.0% | COM | 834203309 |
| — | INTRA-CELLULAR THERAPIES INC | 786,358 | $104M | 3.7% | $131.92 | $69.08 | — | COM | 46116X101 |
| MGTX | MEIRAGTX HLDGS PLC | 12,581,103 | $85.25M | 3.0% | $6.78 | $10.52 | -36.2% | COM | G59665102 |
| AORT | ARTIVION INC | 2,793,703 | $68.67M | 2.4% | $24.58 * | $19.16 | +45.0% | COM | 228903100 |
| ALDX | ALDEYRA THERAPEUTICS INC | 9,275,851 | $53.34M | 1.9% | $5.75 * | $7.81 | -24.3% | COM | 01438T106 |
| PTGX | PROTAGONIST THERAPEUTICS INC | 1,091,271 | $52.77M | 1.9% | $48.36 * | $26.52 | +58.0% | COM | 74366E102 |
| EOLS | EVOLUS INC | 4,129,142 | $49.67M | 1.8% | $12.03 * | $10.21 | +28.1% | COM | 30052C107 |
| IMVT | IMMUNOVANT INC | 2,844,072 | $48.61M | 1.7% | $17.09 * | $23.44 | -10.7% | COM | 45258J102 |
| SLDB | SOLID BIOSCIENCES INC | 11,906,646 | $44.05M | 1.6% | $3.70 * | $6.40 | -33.1% | COM NEW | 83422E204 |
| CNTA | CENTESSA PHARMACEUTICALS PLC | 3,040,395 | $43.72M | 1.5% | $14.38 | $12.79 | — | SPONSORED ADS | 152309100 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 12,711,788 | $42.33M | 1.5% | $3.33 * | $11.89 | -56.6% | COM | 462260100 |
| IMTX | IMMATICS N.V | 9,383,456 | $42.32M | 1.5% | $4.51 * | $10.65 | -51.0% | SHS | N44445109 |
| APGE | APOGEE THERAPEUTICS INC | 1,122,767 | $41.95M | 1.5% | $37.36 * | $25.91 | +49.2% | COM | 03770N101 |
| AXSM | AXSOME THERAPEUTICS INC | 355,107 | $41.42M | 1.5% | $116.63 * | $77.79 | +46.4% | COM | 05464T104 |
| INSM | INSMED INC | 509,300 | $38.85M | 1.4% | $76.29 | $65.83 | +16.2% | COM PAR $.01 | 457669307 |
| SYRE | SPYRE THERAPEUTICS INC | 2,313,272 | $37.32M | 1.3% | $16.14 * | $16.88 | +23.2% | COM NEW | 00773J202 |
| PRAX | PRAXIS PRECISION MEDICINES I | 980,894 | $37.15M | 1.3% | $37.87 * | $51.14 | +22.1% | COM NEW | 74006W207 |
| ARGX | ARGENX SE | 59,510 | $35.22M | 1.2% | $591.86 | $527.37 | — | SPONSORED ADR | 04016X101 |
| — | ASTRIA THERAPEUTICS INC | 6,485,420 | $34.63M | 1.2% | $5.34 | $11.36 | — | COM | 04635X102 |
| — | AKERO THERAPEUTICS INC | 792,960 | $32.1M | 1.1% | $40.48 | $35.95 | — | COM | 00973Y108 |
| — | MERUS N V | 690,485 | $29.06M | 1.0% | $42.09 | $49.51 | — | COM | N5749R100 |
| AMLX | AMYLYX PHARMACEUTICALS INC | 7,874,348 | $27.88M | 1.0% | $3.54 | $3.88 | -8.3% | COM | 03237H101 |
| ADMA | ADMA BIOLOGICS INC | 1,373,233 | $27.24M | 1.0% | $19.84 * | $8.62 | +100.5% | COM | 000899104 |
| PCVX | VAXCYTE INC | 706,567 | $26.68M | 0.9% | $37.76 * | $56.58 | +41.3% | COM | 92243G108 |
| JANX | JANUX THERAPEUTICS INC | 970,412 | $26.2M | 0.9% | $27.00 * | $50.50 | -25.4% | COM | 47103J105 |
| DYN | DYNE THERAPEUTICS INC | 2,313,403 | $24.2M | 0.9% | $10.46 * | $20.29 | -29.5% | COM | 26818M108 |
| CELC | CELCUITY INC | 2,362,279 | $23.88M | 0.8% | $10.11 * | $13.53 | -16.4% | COM | 15102K100 |
| ZYME | ZYMEWORKS INC | 1,864,672 | $22.21M | 0.8% | $11.91 * | $8.44 | +61.5% | COM | 98985Y108 |
| ISRG | INTUITIVE SURGICAL INC | 40,619 | $20.12M | 0.7% | $495.27 * | $349.51 | +58.2% | COM NEW | 46120E602 |
| OBIO | ORCHESTRA BIOMED HLDGS INC | 4,592,556 | $19.66M | 0.7% | $4.28 * | $8.81 | -43.6% | COM | 68572M106 |
| BBNX | BETA BIONICS INC | 1,593,608 | $19.51M | 0.7% | $12.24 * | $18.64 | 0.0% | COM | 08659B102 |
| PODD | INSULET CORP | 71,597 | $18.8M | 0.7% | $262.61 * | $223.36 | +21.2% | COM | 45784P101 |
| RGEN | REPLIGEN CORP | 129,801 | $16.52M | 0.6% | $127.24 * | $153.93 | 0.0% | COM | 759916109 |
| DRUG | BRIGHT MINDS BIOSCIENCES INC | 444,649 | $16.04M | 0.6% | $36.07 | $35.32 | +3.6% | COM NEW | 10919W405 |
| MDGL | MADRIGAL PHARMACEUTICALS INC | 46,500 | $15.4M | 0.5% | $331.23 | $328.59 | 0.0% | COM | 558868105 |
| INBX | INHIBRX BIOSCIENCES INC | 1,064,026 | $14.89M | 0.5% | $13.99 * | $15.62 | -13.1% | COM | 45720N103 |
| BSX | BOSTON SCIENTIFIC CORP | 130,000 | $13.11M | 0.5% | $100.88 | $100.70 | 0.0% | COM | 101137107 |
| SION | SIONNA THERAPEUTICS INC | 1,251,101 | $13.09M | 0.5% | $10.46 * | $16.34 | 0.0% | COM | 829401108 |
| IKT | INHIBIKASE THERAPEUTICS INC | 5,925,000 | $12.98M | 0.5% | $2.19 * | $2.49 | +0.7% | COM NEW | 45719W205 |
| VKTX | VIKING THERAPEUTICS INC | 509,005 | $12.29M | 0.4% | $24.15 * | $52.65 | -40.0% | COM | 92686J106 |
| DXCM | DEXCOM INC | 178,000 | $12.16M | 0.4% | $68.29 * | $81.60 | 0.0% | COM | 252131107 |
| NBIX | NEUROCRINE BIOSCIENCES | 100,050 | $11.07M | 0.4% | $110.60 * | $120.49 | +5.1% | COM | 64125C109 |
| EWTX | EDGEWISE THERAPEUTICS INC | 500,000 | $11M | 0.4% | $22.00 * | $22.55 | +16.4% | Call | 28036F105 |
| XENE | XENON PHARMACEUTICALS INC | 325,324 | $10.91M | 0.4% | $33.55 * | $26.63 | +42.6% | COM | 98420N105 |
| ACRV | ACRIVON THERAPEUTICS INC | 5,360,858 | $10.88M | 0.4% | $2.03 * | $10.66 | -49.5% | COMMON STOCK | 004890109 |
| NAUT | NAUTILUS BIOTECHNOLOGY INC | 12,594,211 | $10.84M | 0.4% | $0.86 * | $8.54 | -82.6% | COM | 63909J108 |
| AQST | AQUESTIVE THERAPEUTICS INC | 3,727,208 | $10.81M | 0.4% | $2.90 * | $3.03 | 0.0% | COM | 03843E104 |
| CTNM | CONTINEUM THERAPEUTICS INC | 1,441,249 | $10.06M | 0.4% | $6.98 * | $16.10 | -43.5% | CL A | 21217B100 |
| — | CARGO THERAPEUTICS INC | 2,431,085 | $9.895M | 0.3% | $4.07 | $22.72 | — | COM | 14179K101 |
| OM | OUTSET MED INC | 833,333 | $9.217M | 0.3% | $11.06 * | $11.92 | 0.0% | COM NEW | 690145206 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 659,662 | $8.892M | 0.3% | $13.48 * | $17.99 | -5.3% | COM | 92790C104 |
| EYPT | EYEPOINT PHARMACEUTICALS INC | 1,537,274 | $8.332M | 0.3% | $5.42 * | $10.04 | -30.3% | COM NEW | 30233G209 |
| ADGM | ADAGIO MED HLDGS INC | 9,812,419 | $7.899M | 0.3% | $0.80 * | $4.76 | -77.7% | COM | 00534B100 |
| AVR | ANTERIS TECHNOLOGIES GLOBAL | 2,140,000 | $7.79M | 0.3% | $3.64 * | $5.59 | +15.0% | COM | 03675P102 |
| IRON | DISC MEDICINE INC | 150,000 | $7.446M | 0.3% | $49.64 * | $55.60 | 0.0% | COM | 254604101 |
| ADPT | ADAPTIVE BIOTECHNOLOGIES COR | 930,972 | $6.917M | 0.2% | $7.43 * | $7.69 | 0.0% | COM | 00650F109 |
| OCUL | OCULAR THERAPEUTIX INC | 915,775 | $6.713M | 0.2% | $7.33 * | $7.10 | +8.3% | COM | 67576A100 |
| DCTH | DELCATH SYS INC | 462,422 | $5.887M | 0.2% | $12.73 * | $13.80 | +2.9% | COM NEW | 24661P807 |
| — | RAPT THERAPEUTICS INC | 4,418,947 | $5.391M | 0.2% | $1.22 | $1.58 | — | COM | 75382E109 |
| KMTS | KESTRA MED TECHNOLOGIES LTD | 200,000 | $4.984M | 0.2% | $24.92 * | $22.98 | 0.0% | SHS | G52441105 |
| BBOT | HELIX ACQUISITION CORP II | 398,000 | $4.497M | 0.2% | $11.30 * | $10.35 | +3.8% | CL A ORD SHS | G4444H101 |
| OKUR | ONKURE THERAPEUTICS INC | 1,004,439 | $4.319M | 0.2% | $4.30 * | $15.14 | -62.9% | COM CL A | 68277Q105 |
| IRD | OPUS GENETICS INC | 4,325,000 | $4.246M | 0.2% | $0.98 * | $1.12 | 0.0% | COM | 67577R102 |
| AVTX | AVALO THERAPEUTICS INC | 520,000 | $4.165M | 0.1% | $8.01 * | $7.58 | 0.0% | COM NEW | 05338F306 |
| NRIX | NURIX THERAPEUTICS INC | 297,553 | $3.535M | 0.1% | $11.88 * | $22.92 | -27.0% | COM | 67080M103 |
| MREO | MEREO BIOPHARMA GROUP PLC | 876,961 | $1.973M | 0.1% | $2.25 | $3.58 | — | SPON ADS | 589492107 |
| — | LYRA THERAPEUTICS INC | 12,757,562 | $1.607M | 0.1% | $0.13 | $6.65 | — | COM | 55234L105 |
| KALA | KALA BIO INC | 277,610 | $1.591M | 0.1% | $5.73 * | $7.57 | 0.0% | COM NEW | 483119202 |
| — | ATHIRA PHARMA INC | 5,402,964 | $1.539M | 0.1% | $0.28 | $12.75 | — | COM | 04746L104 |
| — | BIODESIX INC | 2,173,880 | $1.359M | 0.0% | $0.63 | $1.53 | — | COM | 09075X108 |
| — | SCPHARMACEUTICALS INC | 500,000 | $1.315M | 0.0% | $2.63 | $3.54 | — | COM | 810648105 |
| TRAW | TRAWS PHARMA INC | 421,781 | $970K | 0.0% | $2.30 * | $5.34 | -2.7% | COM NEW | 68232V884 |
| RCKT | ROCKET PHARMACEUTICALS INC | 140,726 | $939K | 0.0% | $6.67 * | $20.82 | -52.5% | COM | 77313F106 |
| CGEM | CULLINAN THERAPEUTICS INC | 80,100 | $606K | 0.0% | $7.57 * | $9.60 | 0.0% | COM | 230031106 |
| LXEO | LEXEO THERAPEUTICS INC | 139,835 | $485K | 0.0% | $3.47 * | $11.93 | -62.9% | COM | 52886X107 |
| — | APPLIED THERAPEUTICS INC | 860,000 | $420K | 0.0% | $0.49 | $5.04 | — | COM | 03828A101 |
| NBTX | NANOBIOTIX | 105,053 | $376K | 0.0% | $3.58 | $16.50 | — | SPONSORED ADS | 63009J107 |
| ENSC | ENSYSCE BIOSCIENCES INC | 86,666 | $222K | 0.0% | $2.56 * | $6.89 | -16.0% | COM NEW | 293602504 |
| APYX | APYX MEDICAL CORPORATION | 150,000 | $206K | 0.0% | $1.37 | $1.40 | -1.5% | COM | 03837C106 |
| RVMDW | REVOLUTION MEDICINES INC | 250,000 | $9,500 | 0.0% | $0.04 | $0.33 | — | *W EXP 12/17/202 | 76155X118 |
| SRZNW | SURROZEN INC | 166,666 | $5,000 | 0.0% | $0.03 | $1.14 | — | *W EXP 08/01/203 | 86889P117 |