Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q2 2025 (← Previous) (Next →)
Filing Date: Aug 14, 2025
Total Value: $2.697B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| — | VERONA PHARMA PLC | 5,507,591 | $521M | 19.3% | $94.58 | $23.99 | — | SPONSORED ADS | 925050106 |
| ASND | ASCENDIS PHARMA A/S | 963,886 | $166M | 6.2% | $172.60 | $172.60 | — | SPONSORED ADR | 04351P101 |
| ACLX | ARCELLX INC | 2,478,000 | $163M | 6.0% | $65.85 * | $24.76 | +151.5% | COMMON STOCK | 03940C100 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 2,418,299 | $153M | 5.7% | $63.19 * | $35.98 | +70.2% | COM | 76243J105 |
| NUVL | NUVALENT INC | 1,375,180 | $105M | 3.9% | $76.30 * | $38.37 | +90.7% | COM | 670703107 |
| AORT | ARTIVION INC | 2,793,703 | $86.88M | 3.2% | $31.10 * | $19.16 | +41.3% | COM | 228903100 |
| MGTX | MEIRAGTX HLDGS PLC | 12,626,103 | $82.23M | 3.0% | $6.51 * | $10.52 | -43.9% | COM | G59665102 |
| INSM | INSMED INC | 650,252 | $65.44M | 2.4% | $100.64 * | $68.14 | +12.2% | COM PAR $.01 | 457669307 |
| EWTX | EDGEWISE THERAPEUTICS INC | 4,639,949 | $60.83M | 2.3% | $13.11 * | $22.55 | -36.0% | COM | 28036F105 |
| PTGX | PROTAGONIST THERAPEUTICS INC | 1,074,448 | $59.38M | 2.2% | $55.27 * | $26.52 | +80.9% | COM | 74366E102 |
| SLDB | SOLID BIOSCIENCES INC | 11,906,646 | $57.99M | 2.1% | $4.87 * | $6.40 | -44.8% | COM NEW | 83422E204 |
| APGE | APOGEE THERAPEUTICS INC | 1,182,148 | $51.34M | 1.9% | $43.43 * | $26.52 | +43.5% | COM | 03770N101 |
| AMLX | AMYLYX PHARMACEUTICALS INC | 7,902,365 | $50.65M | 1.9% | $6.41 * | $3.88 | +25.3% | COM | 03237H101 |
| IMTX | IMMATICS N.V | 9,383,456 | $50.48M | 1.9% | $5.38 * | $10.65 | -53.4% | SHS | N44445109 |
| — | AKERO THERAPEUTICS INC | 915,887 | $48.87M | 1.8% | $53.36 | $38.29 | — | COM | 00973Y108 |
| OMDA | OMADA HEALTH INC | 2,426,330 | $44.4M | 1.6% | $18.30 * | $17.31 | 0.0% | COM | 68170A108 |
| FOLD | AMICUS THERAPEUTICS INC | 7,412,830 | $42.48M | 1.6% | $5.73 * | $7.36 | -12.4% | COM | 03152W109 |
| ROIV | ROIVANT SCIENCES LTD | 3,331,465 | $37.55M | 1.4% | $11.27 * | $10.84 | 0.0% | SHS | G76279101 |
| — | MERUS N V | 708,176 | $37.25M | 1.4% | $52.60 | $49.59 | — | COM | N5749R100 |
| SLNO | SOLENO THERAPEUTICS INC | 430,439 | $36.06M | 1.3% | $83.78 * | $6.32 | +1083.6% | COM | 834203309 |
| — | ASTRIA THERAPEUTICS INC | 6,485,420 | $34.76M | 1.3% | $5.36 | $11.36 | — | COM | 04635X102 |
| IMVT | IMMUNOVANT INC | 2,137,890 | $34.21M | 1.3% | $16.00 * | $23.44 | -35.5% | COM | 45258J102 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 255,050 | $32.06M | 1.2% | $125.69 * | $116.96 | -1.9% | COM | 64125C109 |
| PRAX | PRAXIS PRECISION MEDICINES I | 752,921 | $31.66M | 1.2% | $42.05 * | $51.14 | -25.5% | COM NEW | 74006W207 |
| BSX | BOSTON SCIENTIFIC CORP | 280,000 | $30.07M | 1.1% | $107.41 * | $100.96 | +0.2% | COM | 101137107 |
| CAI | CARIS LIFE SCIENCES INC | 1,098,163 | $29.34M | 1.1% | $26.72 | $26.95 | 0.0% | COM | 142152107 |
| XBI | SPDR SERIES TRUST | 300,000 | $24.88M | 0.9% | $82.93 | — | — | Put | 78464A870 |
| ISRG | INTUITIVE SURGICAL INC | 45,119 | $24.52M | 0.9% | $543.41 * | $366.80 | +42.6% | COM NEW | 46120E602 |
| ADMA | ADMA BIOLOGICS INC | 1,303,468 | $23.74M | 0.9% | $18.21 * | $8.62 | +136.4% | COM | 000899104 |
| BBNX | BETA BIONICS INC | 1,593,608 | $23.2M | 0.9% | $14.56 * | $18.64 | -24.1% | COM NEW | 08659B102 |
| SYRE | SPYRE THERAPEUTICS INC | 1,529,445 | $22.9M | 0.8% | $14.97 | $16.88 | -12.4% | COM NEW | 00773J202 |
| EOLS | EVOLUS INC | 2,474,843 | $22.79M | 0.8% | $9.21 * | $10.21 | +0.2% | COM | 30052C107 |
| CELC | CELCUITY INC | 1,633,208 | $21.8M | 0.8% | $13.35 * | $13.53 | -19.5% | COM | 15102K100 |
| DYN | DYNE THERAPEUTICS INC | 2,247,390 | $21.4M | 0.8% | $9.52 * | $20.29 | -45.7% | COM | 26818M108 |
| SION | SIONNA THERAPEUTICS INC | 1,216,045 | $21.1M | 0.8% | $17.35 * | $16.34 | -19.8% | COM | 829401108 |
| AXSM | AXSOME THERAPEUTICS INC | 198,534 | $20.72M | 0.8% | $104.39 | $77.79 | +36.1% | COM | 05464T104 |
| RGEN | REPLIGEN CORP | 166,000 | $20.65M | 0.8% | $124.38 * | $148.11 | -14.1% | COM | 759916109 |
| PODD | INSULET CORP | 60,387 | $18.97M | 0.7% | $314.18 * | $223.36 | +29.2% | COM | 45784P101 |
| OM | OUTSET MED INC | 833,333 | $16.01M | 0.6% | $19.21 * | $11.92 | +30.9% | COM | 690145206 |
| ZYME | ZYMEWORKS INC | 1,275,274 | $16M | 0.6% | $12.55 * | $8.44 | +41.1% | COM | 98985Y108 |
| CTMX | CYTOMX THERAPEUTICS INC | 6,993,646 | $15.88M | 0.6% | $2.27 * | $1.61 | 0.0% | COM | 23284F105 |
| ALDX | ALDEYRA THERAPEUTICS INC | 4,051,631 | $15.52M | 0.6% | $3.83 * | $7.81 | -66.9% | COM | 01438T106 |
| CRL | CHARLES RIV LABS INTL INC | 100,000 | $15.17M | 0.6% | $151.73 * | $133.35 | 0.0% | COM | 159864107 |
| CNTA | CENTESSA PHARMACEUTICALS PLC | 1,146,935 | $15.07M | 0.6% | $13.14 | $12.79 | — | SPONSORED ADS | 152309100 |
| INBX | INHIBRX BIOSCIENCES INC | 977,892 | $13.95M | 0.5% | $14.27 * | $15.62 | -17.2% | COM | 45720N103 |
| ADGM | ADAGIO MED HLDGS INC | 9,876,576 | $12.84M | 0.5% | $1.30 * | $4.76 | -76.1% | COM | 00534B100 |
| NRIX | NURIX THERAPEUTICS INC | 1,096,985 | $12.49M | 0.5% | $11.39 * | $14.09 | -23.3% | COM | 67080M103 |
| TVTX | TRAVERE THERAPEUTICS INC | 834,252 | $12.35M | 0.5% | $14.80 * | $16.57 | 0.0% | COM | 89422G107 |
| OBIO | ORCHESTRA BIOMED HLDGS INC | 4,592,556 | $12.31M | 0.5% | $2.68 * | $8.81 | -66.9% | COM | 68572M106 |
| DRUG | BRIGHT MINDS BIOSCIENCES INC | 420,690 | $10.98M | 0.4% | $26.11 * | $35.32 | -15.1% | COM NEW | 10919W405 |
| IKT | INHIBIKASE THERAPEUTICS INC | 5,432,293 | $10.59M | 0.4% | $1.95 | $2.49 | -21.5% | COM NEW | 45719W205 |
| VKTX | VIKING THERAPEUTICS INC | 380,700 | $10.09M | 0.4% | $26.50 | $52.65 | -50.0% | COM | 92686J106 |
| RARE | ULTRAGENYX PHARMACEUTICAL IN | 270,000 | $9.817M | 0.4% | $36.36 | $36.05 | 0.0% | COM | 90400D108 |
| KYMR | KYMERA THERAPEUTICS INC | 210,106 | $9.169M | 0.3% | $43.64 * | $34.43 | 0.0% | COM | 501575104 |
| NAUT | NAUTILUS BIOTECHNOLOGY INC | 12,594,211 | $9.131M | 0.3% | $0.72 | $8.54 | -91.2% | COM | 63909J108 |
| PEN | PENUMBRA INC | 32,797 | $8.417M | 0.3% | $256.63 * | $272.19 | 0.0% | COM | 70975L107 |
| CBIO | CRESCENT BIOPHARMA INC. | 453,686 | $7.322M | 0.3% | $16.14 * | $21.15 | 0.0% | COM | G2545C104 |
| AQST | AQUESTIVE THERAPEUTICS INC | 2,190,420 | $7.25M | 0.3% | $3.31 * | $3.03 | -5.2% | COM | 03843E104 |
| JANX | JANUX THERAPEUTICS INC | 292,686 | $6.761M | 0.3% | $23.10 * | $50.50 | -47.8% | COM | 47103J105 |
| AVR | ANTERIS TECHNOLOGIES GLOBAL | 1,705,130 | $6.462M | 0.2% | $3.79 * | $5.59 | -27.3% | COM | 03675P102 |
| CAPR | CAPRICOR THERAPEUTICS INC | 650,000 | $6.455M | 0.2% | $9.93 | — | — | Put | 14070B309 |
| XENE | XENON PHARMACEUTICALS INC | 200,791 | $6.285M | 0.2% | $31.30 * | $26.63 | +22.5% | COM | 98420N105 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 447,507 | $6.256M | 0.2% | $13.98 * | $17.99 | -24.6% | COM | 92790C104 |
| CRVS | CORVUS PHARMACEUTICALS INC | 1,438,595 | $5.754M | 0.2% | $4.00 * | $3.64 | 0.0% | COM | 221015100 |
| SEPN | SEPTERNA INC | 541,450 | $5.723M | 0.2% | $10.57 * | $8.24 | 0.0% | COM | 81734D104 |
| GMED | GLOBUS MED INC | 88,500 | $5.223M | 0.2% | $59.02 * | $64.61 | 0.0% | CL A | 379577208 |
| — | ENVVENO MEDICAL CORPORATION | 1,284,966 | $5.127M | 0.2% | $3.99 | $3.99 | — | COM | 29415J106 |
| BBOT | HELIX ACQUISITION CORP II | 398,000 | $4.227M | 0.2% | $10.62 | $10.35 | +4.5% | CL A ORD SHS | G4444H101 |
| IRD | OPUS GENETICS INC | 4,325,000 | $4.075M | 0.2% | $0.94 | $1.12 | -17.1% | COM | 67577R102 |
| CTNM | CONTINEUM THERAPEUTICS INC | 699,486 | $2.777M | 0.1% | $3.97 * | $16.10 | -73.0% | CL A | 21217B100 |
| LYRA | LYRA THERAPEUTICS INC | 255,150 | $2.286M | 0.1% | $8.96 * | $8.30 | 0.0% | COM NEW | 55234L204 |
| — | SCPHARMACEUTICALS INC | 500,000 | $1.905M | 0.1% | $3.81 | $3.54 | — | COM | 810648105 |
| — | ATHIRA PHARMA INC | 5,402,964 | $1.632M | 0.1% | $0.30 | $12.75 | — | COM | 04746L104 |
| RAPT | RAPT THERAPEUTICS INC | 183,890 | $1.471M | 0.1% | $8.00 * | $7.63 | 0.0% | COM NEW | 75382E208 |
| TRIB | TRINITY BIOTECH PLC | 1,790,000 | $1.163M | 0.0% | $0.65 | $0.65 | — | SPONS ADR NEW | 896438504 |
| CAPR | CAPRICOR THERAPEUTICS INC | 100,000 | $993K | 0.0% | $9.93 | — | — | Call | 14070B309 |
| FBRX | FORTE BIOSCIENCES INC | 68,192 | $882K | 0.0% | $12.93 * | $8.61 | 0.0% | COM NEW | 34962G208 |
| AVTX | AVALO THERAPEUTICS INC | 139,667 | $697K | 0.0% | $4.99 * | $7.58 | -38.4% | COM NEW | 05338F306 |
| — | BIODESIX INC | 2,173,880 | $613K | 0.0% | $0.28 | $1.53 | — | COM | 09075X108 |
| LXEO | LEXEO THERAPEUTICS INC | 139,835 | $562K | 0.0% | $4.02 * | $11.93 | -72.4% | COM | 52886X107 |
| APYX | APYX MEDICAL CORPORATION | 150,000 | $338K | 0.0% | $2.25 * | $1.40 | +0.7% | COM | 03837C106 |
| KALA | KALA BIO INC | 55,227 | $263K | 0.0% | $4.76 * | $7.57 | -48.5% | COM NEW | 483119202 |
| ENSC | ENSYSCE BIOSCIENCES INC | 86,666 | $193K | 0.0% | $2.23 * | $6.89 | -66.8% | COM NEW | 293602504 |
| RVMDW | REVOLUTION MEDICINES INC | 250,000 | $65,675 | 0.0% | $0.26 | $0.33 | — | *W EXP 12/17/202 | 76155X118 |
| SRZNW | SURROZEN INC | 166,666 | $3,017 | 0.0% | $0.02 | $1.14 | — | *W EXP 08/01/203 | 86889P117 |