Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q4 2024 (← Previous) (Next →)
Filing Date: Feb 14, 2025
Total Value: $3.629B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| — | VERONA PHARMA PLC | 6,392,106 | $297M | 8.2% | $46.44 | $22.94 | — | SPONSORED ADS | 925050106 |
| ACLX | ARCELLX INC | 3,478,888 | $267M | 7.4% | $76.69 * | $24.76 | +248.9% | COMMON STOCK | 03940C100 |
| FOLD | AMICUS THERAPEUTICS INC | 24,245,952 | $228M | 6.3% | $9.42 * | $7.36 | +41.1% | COM | 03152W109 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 3,680,473 | $206M | 5.7% | $55.98 | $35.98 | +53.5% | COM | 76243J105 |
| NUVL | NUVALENT INC | 2,619,977 | $205M | 5.7% | $78.28 * | $38.37 | +143.4% | COM | 670703107 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 22,112,266 | $164M | 4.5% | $7.40 * | $11.89 | -22.0% | COM | 462260100 |
| PCVX | VAXCYTE INC | 1,718,417 | $141M | 3.9% | $81.86 * | $56.58 | +75.5% | COM | 92243G108 |
| — | INTRA-CELLULAR THERAPIES INC | 1,288,328 | $108M | 3.0% | $83.52 | $69.08 | — | COM | 46116X101 |
| CNTA | CENTESSA PHARMACEUTICALS PLC | 6,349,220 | $106M | 2.9% | $16.75 | $12.79 | — | SPONSORED ADS | 152309100 |
| PRAX | PRAXIS PRECISION MEDICINES I | 1,329,735 | $102M | 2.8% | $76.96 * | $51.14 | +41.5% | COM NEW | 74006W207 |
| AORT | ARTIVION INC | 2,793,703 | $79.87M | 2.2% | $28.59 * | $19.16 | +44.8% | COM | 228903100 |
| MGTX | MEIRAGTX HLDGS PLC | 12,581,103 | $76.58M | 2.1% | $6.09 * | $10.52 | -44.3% | COM | G59665102 |
| EWTX | EDGEWISE THERAPEUTICS INC | 2,685,537 | $71.7M | 2.0% | $26.70 * | $17.24 | +84.7% | COM | 28036F105 |
| SLNO | SOLENO THERAPEUTICS INC | 1,501,040 | $67.47M | 1.9% | $44.95 * | $6.32 | +719.4% | COM | 834203309 |
| IMTX | IMMATICS N.V | 9,383,456 | $66.72M | 1.8% | $7.11 * | $10.65 | -19.3% | SHS | N44445109 |
| PODD | INSULET CORP | 232,269 | $60.64M | 1.7% | $261.07 * | $223.36 | +12.8% | COM | 45784P101 |
| SYRE | SPYRE THERAPEUTICS INC | 2,574,723 | $59.94M | 1.7% | $23.28 * | $16.88 | +73.7% | COM NEW | 00773J202 |
| — | ASTRIA THERAPEUTICS INC | 6,485,420 | $57.98M | 1.6% | $8.94 | $11.36 | — | COM | 04635X102 |
| EOLS | EVOLUS INC | 5,145,846 | $56.81M | 1.6% | $11.04 * | $10.21 | +37.7% | COM | 30052C107 |
| AXSM | AXSOME THERAPEUTICS INC | 664,074 | $56.19M | 1.5% | $84.61 * | $77.79 | +18.2% | COM | 05464T104 |
| — | CARGO THERAPEUTICS INC | 3,683,004 | $53.11M | 1.5% | $14.42 | $22.72 | — | COM | 14179K101 |
| IMVT | IMMUNOVANT INC | 2,139,199 | $52.99M | 1.5% | $24.77 * | $24.27 | +16.9% | COM | 45258J102 |
| PTGX | PROTAGONIST THERAPEUTICS INC | 1,271,662 | $49.09M | 1.4% | $38.60 * | $26.52 | +64.4% | COM | 74366E102 |
| APGE | APOGEE THERAPEUTICS INC | 1,047,232 | $47.44M | 1.3% | $45.30 * | $24.99 | +104.1% | COM | 03770N101 |
| ALDX | ALDEYRA THERAPEUTICS INC | 9,275,851 | $46.29M | 1.3% | $4.99 * | $7.81 | -34.3% | COM | 01438T106 |
| JANX | JANUX THERAPEUTICS INC | 817,895 | $43.79M | 1.2% | $53.54 | $52.89 | 0.0% | COM | 47103J105 |
| ARGX | ARGENX SE | 67,471 | $41.49M | 1.1% | $615.00 | $527.37 | — | SPONSORED ADR | 04016X101 |
| VKTX | VIKING THERAPEUTICS INC | 995,894 | $40.07M | 1.1% | $40.24 * | $52.65 | +8.3% | COM | 92686J106 |
| PRAX | PRAXIS PRECISION MEDICINES I | 500,000 | $38.48M | 1.1% | $76.96 * | $51.14 | +41.5% | Call | 74006W207 |
| — | AKERO THERAPEUTICS INC | 1,185,592 | $32.98M | 0.9% | $27.82 | $35.95 | — | COM | 00973Y108 |
| ISRG | INTUITIVE SURGICAL INC | 63,119 | $32.95M | 0.9% | $521.96 | $349.51 | +49.0% | COM NEW | 46120E602 |
| ACRV | ACRIVON THERAPEUTICS INC | 5,360,858 | $32.27M | 0.9% | $6.02 * | $10.66 | -31.8% | COMMON STOCK | 004890109 |
| ZYME | ZYMEWORKS INC | 2,130,020 | $31.18M | 0.9% | $14.64 * | $8.44 | +65.6% | COM | 98985Y108 |
| CELC | CELCUITY INC | 2,362,279 | $30.92M | 0.9% | $13.09 * | $13.53 | +4.3% | COM | 15102K100 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 1,486,508 | $28.5M | 0.8% | $19.17 * | $17.99 | +20.9% | COM | 92790C104 |
| SLDB | SOLID BIOSCIENCES INC | 6,906,646 | $27.63M | 0.8% | $4.00 * | $7.94 | -30.8% | COM NEW | 83422E204 |
| AMLX | AMYLYX PHARMACEUTICALS INC | 6,774,348 | $25.61M | 0.7% | $3.78 * | $3.93 | +19.6% | COM | 03237H101 |
| PRCT | PROCEPT BIOROBOTICS CORP | 290,659 | $23.4M | 0.6% | $80.52 * | $55.40 | +54.2% | COM | 74276L105 |
| NAUT | NAUTILUS BIOTECHNOLOGY INC | 12,594,211 | $21.16M | 0.6% | $1.68 * | $8.54 | -72.0% | COM | 63909J108 |
| CTNM | CONTINEUM THERAPEUTICS INC | 1,441,249 | $21.11M | 0.6% | $14.65 * | $16.10 | -1.7% | CL A | 21217B100 |
| NTRA | NATERA INC | 125,000 | $19.79M | 0.5% | $158.30 * | $49.41 | +194.8% | COM | 632307104 |
| IKT | INHIBIKASE THERAPEUTICS INC | 5,925,000 | $19.26M | 0.5% | $3.25 * | $2.49 | 0.0% | COM NEW | 45719W205 |
| OBIO | ORCHESTRA BIOMED HLDGS INC | 4,592,556 | $18.37M | 0.5% | $4.00 * | $8.81 | -39.0% | COM | 68572M106 |
| PEN | PENUMBRA INC | 73,338 | $17.42M | 0.5% | $237.48 * | $227.37 | 0.0% | COM | 70975L107 |
| SEPN | SEPTERNA INC | 750,000 | $17.18M | 0.5% | $22.90 * | $23.65 | 0.0% | COM | 81734D104 |
| ORKA | ORUKA THERAPEUTICS INC | 845,567 | $16.4M | 0.5% | $19.39 * | $34.79 | -29.9% | COM | 687604108 |
| INBX | INHIBRX BIOSCIENCES INC | 1,064,026 | $16.39M | 0.5% | $15.40 | $15.62 | -2.5% | COM | 45720N103 |
| ADMA | ADMA BIOLOGICS INC | 890,280 | $15.27M | 0.4% | $17.15 * | $3.92 | +379.7% | COM | 000899104 |
| DRUG | BRIGHT MINDS BIOSCIENCES INC | 403,649 | $14.54M | 0.4% | $36.02 * | $35.19 | 0.0% | COM NEW | 10919W405 |
| ARVN | ARVINAS INC | 740,749 | $14.2M | 0.4% | $19.17 * | $37.87 | -35.9% | COM | 04335A105 |
| NBIX | NEUROCRINE BIOSCIENCES | 100,050 | $13.66M | 0.4% | $136.50 * | $120.49 | +2.7% | COM | 64125C109 |
| DYN | DYNE THERAPEUTICS INC | 543,277 | $12.8M | 0.4% | $23.56 * | $39.80 | -25.7% | COM | 26818M108 |
| XENE | XENON PHARMACEUTICALS INC | 325,324 | $12.75M | 0.4% | $39.20 * | $26.63 | +55.3% | COM | 98420N105 |
| — | MERUS N V | 300,000 | $12.62M | 0.3% | $42.05 | $59.17 | — | COM | N5749R100 |
| CGON | CG ONCOLOGY INC | 419,450 | $12.03M | 0.3% | $28.68 * | $40.84 | -16.2% | COM | 156944100 |
| AVR | ANTERIS TECHNOLOGIES GLOBAL | 2,140,000 | $11.94M | 0.3% | $5.58 | $5.59 | 0.0% | COM | 03675P102 |
| EYPT | EYEPOINT PHARMACEUTICALS INC | 1,537,274 | $11.45M | 0.3% | $7.45 * | $10.04 | -7.3% | COM NEW | 30233G209 |
| EW | EDWARDS LIFESCIENCES CORP | 145,000 | $10.73M | 0.3% | $74.03 * | $69.99 | 0.0% | COM | 28176E108 |
| TARS | TARSUS PHARMACEUTICALS INC | 186,662 | $10.34M | 0.3% | $55.37 * | $28.48 | +59.4% | COM | 87650L103 |
| ADGM | ADAGIO MED HLDGS INC | 9,812,419 | $10.3M | 0.3% | $1.05 * | $4.76 | -49.3% | COM | 00534B100 |
| INSM | INSMED INC | 144,000 | $9.942M | 0.3% | $69.04 * | $38.78 | +85.7% | COM PAR $.01 | 457669307 |
| CRNX | CRINETICS PHARMACEUTICALS IN | 184,525 | $9.435M | 0.3% | $51.13 * | $27.14 | +106.2% | COM | 22663K107 |
| — | RAPT THERAPEUTICS INC | 5,880,000 | $9.29M | 0.3% | $1.58 | $1.58 | — | COM | 75382E109 |
| OCUL | OCULAR THERAPEUTIX INC | 1,078,495 | $9.21M | 0.3% | $8.54 * | $7.10 | +37.5% | COM | 67576A100 |
| — | INARI MED INC | 178,797 | $9.128M | 0.3% | $51.05 | $51.05 | — | COM | 45332Y109 |
| OKUR | ONKURE THERAPEUTICS INC | 1,004,439 | $8.638M | 0.2% | $8.60 * | $15.14 | 0.0% | COM CL A | 68277Q105 |
| NRIX | NURIX THERAPEUTICS INC | 330,614 | $6.229M | 0.2% | $18.84 * | $22.92 | 0.0% | COM | 67080M103 |
| ZBIO | ZENAS BIOPHARMA INC | 744,035 | $6.094M | 0.2% | $8.19 * | $17.98 | -13.2% | COM | 98937L105 |
| IRTC | IRHYTHM TECHNOLOGIES INC | 65,153 | $5.875M | 0.2% | $90.17 * | $90.31 | -13.0% | COM | 450056106 |
| RAPP | RAPPORT THERAPEUTICS INC | 311,551 | $5.527M | 0.2% | $17.74 * | $23.15 | -4.3% | COM | 75383L102 |
| BBOT | HELIX ACQUISITION CORP II | 500,000 | $5.25M | 0.1% | $10.50 | $10.35 | +1.5% | CL A ORD SHS | G4444H101 |
| RCKT | ROCKET PHARMACEUTICALS INC | 378,584 | $4.759M | 0.1% | $12.57 * | $20.82 | -27.7% | COM | 77313F106 |
| CBLL | CERIBELL INC | 180,546 | $4.673M | 0.1% | $25.88 * | $27.25 | 0.0% | COM | 15678C102 |
| — | VERU INC | 6,483,157 | $4.217M | 0.1% | $0.65 | $0.81 | — | COM | 92536C103 |
| MREO | MEREO BIOPHARMA GROUP PLC | 1,085,512 | $3.799M | 0.1% | $3.50 | $3.58 | — | SPON ADS | 589492107 |
| CATX | PERSPECTIVE THERAPEUTICS INC | 1,190,263 | $3.797M | 0.1% | $3.19 * | $8.16 | 0.0% | COM NEW | 46489V302 |
| LCTX | LINEAGE CELL THERAPEUTICS IN | 7,236,843 | $3.637M | 0.1% | $0.50 * | $0.73 | 0.0% | COM | 53566P109 |
| — | BIODESIX INC | 2,173,880 | $3.326M | 0.1% | $1.53 | $1.53 | — | COM | 09075X108 |
| — | ATHIRA PHARMA INC | 5,402,964 | $3.17M | 0.1% | $0.59 | $12.75 | — | COM | 04746L104 |
| PEPG | PEPGEN INC | 829,536 | $3.144M | 0.1% | $3.79 * | $11.81 | -47.2% | COM | 713317105 |
| IBRX | IMMUNITYBIO INC | 1,221,734 | $3.128M | 0.1% | $2.56 * | $4.17 | 0.0% | COM | 45256X103 |
| BCYC | BICYCLE THERAPEUTICS PLC | 197,108 | $2.76M | 0.1% | $14.00 | $20.24 | — | SPONSORED ADS | 088786108 |
| — | LYRA THERAPEUTICS INC | 12,757,562 | $2.628M | 0.1% | $0.21 | $6.65 | — | COM | 55234L105 |
| — | VERRICA PHARMACEUTICALS INC | 3,249,669 | $2.275M | 0.1% | $0.70 | $12.42 | — | COM | 92511W108 |
| FBRX | FORTE BIOSCIENCES INC | 95,742 | $2.174M | 0.1% | $22.71 * | $10.28 | +15.7% | COM NEW | 34962G208 |
| — | SCPHARMACEUTICALS INC | 500,000 | $1.77M | 0.0% | $3.54 | $3.54 | — | COM | 810648105 |
| TRIB | TRINITY BIOTECH PLC | 1,790,000 | $1.575M | 0.0% | $0.88 | $2.04 | — | SPON ADR NEW | 896438504 |
| TRAW | TRAWS PHARMA INC | 164,157 | $1.458M | 0.0% | $8.88 * | $5.57 | 0.0% | COM NEW | 68232V884 |
| FULC | FULCRUM THERAPEUTICS INC | 238,000 | $1.119M | 0.0% | $4.70 * | $3.69 | 0.0% | COM | 359616109 |
| LXEO | LEXEO THERAPEUTICS INC | 139,835 | $920K | 0.0% | $6.58 * | $11.93 | -34.0% | COM | 52886X107 |
| NVAX | NOVAVAX INC | 100,000 | $804K | 0.0% | $8.04 | — | — | Put | 670002401 |
| NBTX | NANOBIOTIX | 266,093 | $764K | 0.0% | $2.87 | $16.50 | — | SPONSORED ADS | 63009J107 |
| — | APPLIED THERAPEUTICS INC | 860,000 | $736K | 0.0% | $0.86 | $5.04 | — | COM | 03828A101 |
| ENSC | ENSYSCE BIOSCIENCES INC | 86,666 | $705K | 0.0% | $8.14 * | $6.89 | 0.0% | COM NEW | 293602504 |
| DCTH | DELCATH SYS INC | 50,000 | $602K | 0.0% | $12.04 * | $10.55 | 0.0% | COM NEW | 24661P807 |
| PYXS | PYXIS ONCOLOGY INC | 188,462 | $294K | 0.0% | $1.56 * | $3.50 | -17.6% | COMMON STOCK | 747324101 |
| APYX | APYX MEDICAL CORPORATION | 150,000 | $237K | 0.0% | $1.58 * | $1.40 | 0.0% | COM | 03837C106 |
| RVMDW | REVOLUTION MEDICINES INC | 250,000 | $45,000 | 0.0% | $0.18 | $0.33 | — | *W EXP 12/17/202 | 76155X118 |
| SRZNW | SURROZEN INC | 166,666 | $3,567 | 0.0% | $0.02 | $1.14 | — | *W EXP 08/01/203 | 86889P117 |