Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q4 2015 (← Previous) (Next →)
Filing Date: Feb 16, 2016
Total Value: $1.352B (99.4% shares, 0.6% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| FOLD | AMICUS THERAPEUTICS INC | 15,239,444 | $148M | 10.9% | $9.70 * | $3.33 | +170.7% | COM | 03152W109 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 2,496,167 | $141M | 10.4% | $56.57 * | $13.82 | +267.7% | COM | 64125C109 |
| SRPT | SAREPTA THERAPEUTICS INC | 2,240,928 | $86.45M | 6.4% | $38.58 * | $30.34 | +6.9% | COM | 803607100 |
| — | DYAX CORP | 1,819,215 | $68.44M | 5.1% | $37.62 | $10.70 | — | COM | 26746E103 |
| — | TESARO INC | 968,659 | $50.68M | 3.7% | $52.32 | $37.49 | — | COM | 881569107 |
| — | RETROPHIN INC | 2,579,380 | $49.76M | 3.7% | $19.29 | $13.90 | — | COM | 761299106 |
| — | ALLERGAN PLC | 145,000 | $45.31M | 3.4% | $312.50 | $312.50 | — | SHS | G0177J108 |
| — | GLOBAL BLOOD THERAPEUTICS IN | 1,186,630 | $38.36M | 2.8% | $32.33 | $39.97 | — | COM | 37890U108 |
| — | NEVRO CORP | 484,279 | $32.69M | 2.4% | $67.51 | $47.65 | — | COM | 64157F103 |
| TEVA | TEVA PHARMACEUTICAL INDS LTD | 481,000 | $31.57M | 2.3% | $65.64 | $62.59 | — | ADR | 881624209 |
| — | VERSARTIS INC | 2,299,454 | $28.49M | 2.1% | $12.39 | $16.67 | — | COM | 92529L102 |
| — | GW PHARMACEUTICALS -ADR | 400,000 | $27.78M | 2.1% | $69.44 | — | — | Put | 36197T103 |
| XNCR | XENCOR INC | 1,854,784 | $27.12M | 2.0% | $14.62 * | $9.22 | +45.8% | COM | 98401F105 |
| — | IGNYTA INC | 1,812,060 | $24.28M | 1.8% | $13.40 | $15.09 | — | COM | 451731103 |
| — | LION BIOTECHNOLOGIES INC | 3,000,161 | $23.16M | 1.7% | $7.72 | $9.04 | — | COM | 53619R102 |
| — | ACELRX PHARMACEUTICALS INC | 5,995,760 | $23.08M | 1.7% | $3.85 | $9.69 | — | COM | 00444T100 |
| SRPT | Sarepta Therapeutics Inc | 500,000 | $19.29M | 1.4% | $38.58 * | $30.34 | +6.9% | Call | 803607100 |
| — | BAXTER INTL INC | 485,000 | $18.5M | 1.4% | $38.15 | $37.49 | — | COM | 71813109 |
| — | FIVE PRIME THERAPEUTICS INC | 434,129 | $18.02M | 1.3% | $41.50 | $26.34 | — | COM | 33830X104 |
| — | APPLIED GENETIC TECHNOL CORP | 861,513 | $17.57M | 1.3% | $20.40 | $11.72 | — | COM | 03820J100 |
| — | LA JOLLA PHARMACEUTICAL CO | 649,515 | $17.54M | 1.3% | $27.00 | $21.23 | — | COM PAR $.0001 2 | 503459604 |
| — | DERMIRA INC | 502,000 | $17.37M | 1.3% | $34.61 | $22.43 | — | COM | 24983L104 |
| QURE | UNIQURE NV | 967,093 | $16M | 1.2% | $16.54 * | $19.85 | -6.7% | SHS | N90064101 |
| — | QUOTIENT LTD | 893,540 | $14.3M | 1.1% | $16.00 | $13.88 | — | SHS | G73268107 |
| VRTX | VERTEX PHARMACEUTICALS INC | 110,000 | $13.84M | 1.0% | $125.83 * | $120.72 | 0.0% | COM | 92532F100 |
| — | ACCELERON PHARMA INC | 276,036 | $13.46M | 1.0% | $48.76 | $33.05 | — | COM | 00434H108 |
| CTMX | CYTOMX THERAPEUTICS INC | 642,047 | $13.4M | 1.0% | $20.87 * | $15.82 | 0.0% | COM | 23284F105 |
| RGNX | REGENXBIO INC | 779,213 | $12.93M | 1.0% | $16.60 * | $25.52 | -22.2% | COM | 75901B107 |
| — | CIDARA THERAPEUTICS INC | 742,858 | $12.75M | 0.9% | $17.16 | $13.24 | — | COM | 171757107 |
| — | PFENEX INC | 960,877 | $11.9M | 0.9% | $12.38 | $13.00 | — | COM | 717071104 |
| EGRX | EAGLE PHARMACEUTICALS INC | 133,145 | $11.81M | 0.9% | $88.67 * | $64.42 | +22.6% | COM | 269796108 |
| — | DBV TECHNOLOGIES S A | 306,715 | $11.14M | 0.8% | $36.31 | $35.53 | — | SPONSORED ADR | 23306J101 |
| — | BLUEPRINT MEDICINES CORP | 404,404 | $10.65M | 0.8% | $26.34 | $26.49 | — | COM | 09627Y109 |
| — | CAPITAL SR LIVING CORP | 483,700 | $10.09M | 0.7% | $20.86 | $25.46 | — | COM | 140475104 |
| — | AXOVANT SCIENCES LTD | 535,000 | $9.646M | 0.7% | $18.03 | $16.76 | — | COM | G0750W104 |
| — | DEPOMED INC | 500,000 | $9.065M | 0.7% | $18.13 | $18.13 | — | COM | 249908104 |
| — | ACADIA PHARMACEUTICALS INC | 245,240 | $8.743M | 0.6% | $35.65 | $41.88 | — | COM | 4225108 |
| — | BELLICUM PHARMACEUTICALS | 421,188 | $8.537M | 0.6% | $20.27 | $21.27 | — | COM | 79481107 |
| ALDX | ALDEYRA THERAPEUTICS INC | 1,240,458 | $8.41M | 0.6% | $6.78 | $8.59 | -21.8% | COM | 01438T106 |
| — | AMGEN INC | 50,000 | $8.117M | 0.6% | $162.34 | $161.72 | — | COM | 31162100 |
| — | VBI VACCINES | 3,260,356 | $7.955M | 0.6% | $2.44 | $2.61 | — | COM | 91790E102 |
| — | ONCOTHYREON INC | 3,414,121 | $7.579M | 0.6% | $2.22 | $3.04 | — | COM | 682324108 |
| — | ANI PHARMACEUTICALS INC | 7,500,000 | $7.461M | 0.6% | $0.99 | $1.05 | — | NOTE 3.000%12/0 | 00182CAA1 |
| — | MYOKARDIA INC | 502,903 | $7.372M | 0.5% | $14.66 | $14.66 | — | COM | 62857M105 |
| — | NEPTUNE TECHNOLOGIES BIORESO | 6,700,444 | $7.169M | 0.5% | $1.07 | $3.13 | — | COM | 64077P108 |
| — | ALCOBRA LTD | 1,028,272 | $6.458M | 0.5% | $6.28 | $6.28 | — | SHS | M2239P109 |
| — | AFFIMED N V | 868,820 | $6.186M | 0.5% | $7.12 | $52.46 | — | COM | N01045108 |
| — | ASSEMBLY BIOSCIENCES INC | 795,000 | $5.97M | 0.4% | $7.51 | $19.14 | — | COM | 45396108 |
| — | ABEONA THERAPEUTICS INC | 1,762,881 | $5.923M | 0.4% | $3.36 | $4.32 | — | COM | 00289Y107 |
| — | ARDELYX INC | 315,955 | $5.725M | 0.4% | $18.12 | $15.97 | — | COM | 39697107 |
| — | OTONOMY INC | 205,986 | $5.716M | 0.4% | $27.75 | $24.93 | — | COM | 68906L105 |
| — | ZYNERBA PHARMACEUTICALS INC | 558,446 | $5.623M | 0.4% | $10.07 | $14.31 | — | COM | 98986X109 |
| — | MINERVA NEUROSCIENCES | 810,537 | $4.919M | 0.4% | $6.07 | $5.00 | — | COM | 603380106 |
| — | NEURODERM LTD | 270,000 | $4.604M | 0.3% | $17.05 | $15.76 | — | ORD SHS | M74231107 |
| — | ANTHERA PHARMACEUTICALS INC | 992,156 | $4.604M | 0.3% | $4.64 | $3.66 | — | COM NEW | 03674U201 |
| — | PROTEON THERAPEUTICS INC | 275,000 | $4.265M | 0.3% | $15.51 | $10.40 | — | COM | 74371L109 |
| — | TRANSENTERIX INC | 1,715,941 | $4.256M | 0.3% | $2.48 | $3.81 | — | COM NEW | 89366M201 |
| — | TOKAI PHARMACEUTICALS INC | 485,338 | $4.232M | 0.3% | $8.72 | $14.80 | — | COM | 88907J107 |
| — | ALLIQUA BIOMEDICAL INC | 1,921,951 | $4.112M | 0.3% | $2.14 | $5.29 | — | COM NEW | 19621200 |
| — | SPECTRANETICS CORP | 269,570 | $4.06M | 0.3% | $15.06 | $15.06 | — | COM | 84760C107 |
| SRPT | Sarepta Therapeutics Inc | 100,000 | $3.858M | 0.3% | $38.58 * | $30.34 | +6.9% | Put | 803607100 |
| — | BAXTER INTERNATIONAL INC | 100,000 | $3.815M | 0.3% | $38.15 | $37.49 | — | Call | 71813109 |
| — | VITAE PHARMACEUTICALS INC | 200,000 | $3.62M | 0.3% | $18.10 | $13.55 | — | COM | 92847N103 |
| AKBA | AKEBIA THERAPEUTICS INC | 260,000 | $3.359M | 0.2% | $12.92 * | $9.18 | +11.2% | COM | 00972D105 |
| — | WALGREENS BOOTS ALLIANCE INC | 35,292 | $3.005M | 0.2% | $85.15 | $79.69 | — | COM | 931427108 |
| — | ENDOLOGIX INC | 300,000 | $2.97M | 0.2% | $9.90 | $10.02 | — | COM | 29266S106 |
| — | CIGNA CORPORATION | 20,000 | $2.927M | 0.2% | $146.35 | $156.41 | — | COM | 125509109 |
| — | MEDICINES CO | 75,000 | $2.801M | 0.2% | $37.35 | $37.35 | — | COM | 584688105 |
| — | ISHARES TR | 100,000 | $2.437M | 0.2% | $24.37 | $26.17 | — | HDG MSCI GERMN | 46434V704 |
| — | TITAN PHARMACEUTICALS INC DE | 522,728 | $2.321M | 0.2% | $4.44 | $4.44 | — | COM NEW A | 888314309 |
| — | MGC DIAGNOSTICS CORP | 336,287 | $2.213M | 0.2% | $6.58 | $8.55 | — | COM | 552768103 |
| CPRX | CATALYST PHARMACEUTICALS INC | 851,200 | $2.085M | 0.2% | $2.45 * | $3.60 | -20.5% | COM | 14888U101 |
| — | CORBUS PHARMACEUTICALS INC | 1,250,000 | $2.062M | 0.2% | $1.65 | $2.62 | — | COM | 21833P103 |
| — | NEOS THERAPEUTICS INC | 142,603 | $2.042M | 0.2% | $14.32 | $21.01 | — | COM | 64052L106 |
| — | PSIVIDA CORP | 415,000 | $2M | 0.1% | $4.82 | $4.28 | — | COM | 74440J101 |
| — | DERMA SCIENCES INC | 402,884 | $1.841M | 0.1% | $4.57 | $11.27 | — | COM PAR $.01 | 249827502 |
| EVH | EVOLENT HEALTH INC | 147,600 | $1.787M | 0.1% | $12.11 * | $18.37 | -19.8% | CL A | 30050B101 |
| — | ABEONA THERAPEUTICS INC | 1,259,636 | $1.656M | 0.1% | $1.31 | $1.80 | — | *W EXP 12/19/201 | 00289Y115 |
| XENE | XENON PHARMACEUTICALS INC | 205,800 | $1.655M | 0.1% | $8.04 * | $14.68 | -41.6% | COM | 98420N105 |
| — | INTEC PHARMA LTD JERUSALEM | 275,000 | $1.474M | 0.1% | $5.36 | $5.60 | — | SHS | M53644106 |
| CSBR | CHAMPIONS ONCOLOGY INC | 372,597 | $1.33M | 0.1% | $3.57 * | $6.08 | -23.3% | COM NEW | 15870P307 |
| — | ARNO THERAPEUTICS INC | 3,463,292 | $1.194M | 0.1% | $0.34 | $0.48 | — | COM | 42564203 |
| — | INVITAE CORP | 143,366 | $1.177M | 0.1% | $8.21 | $10.86 | — | COM | 46185L103 |
| — | SAGE THERAPEUTICS INC | 20,000 | $1.166M | 0.1% | $58.30 | $31.50 | — | COM | 78667J108 |
| — | BRAINSTORM CELL THERAPEUTICS | 400,000 | $1.144M | 0.1% | $2.86 | $2.86 | — | COM | 10501E102 |
| — | GENVEC INC | 615,844 | $1.133M | 0.1% | $1.84 | $2.54 | — | COM NEW | 37246C307 |
| — | SCYNEXIS INC | 175,000 | $1.087M | 0.1% | $6.21 | $8.79 | — | COM | 811292101 |
| — | NIVALIS THERAPEUTICS INC | 125,000 | $968K | 0.1% | $7.74 | $12.97 | — | COM | 65481J109 |
| — | COGENTIX MED INC | 673,257 | $869K | 0.1% | $1.29 | $1.62 | — | COM | 19243A104 |
| — | FIAT CHRYSLER AUTOMOBILES N | 62,000 | $867K | 0.1% | $13.98 | $14.53 | — | SHS | N31738102 |
| VCEL | VERICEL CORP | 305,662 | $789K | 0.1% | $2.58 * | $2.85 | -21.5% | COM | 92346J108 |
| — | AQUINOX PHARMACEUTICALS INC | 59,600 | $744K | 0.1% | $12.48 | $12.73 | — | COM | 03842B101 |
| VNDA | VANDA PHARMACEUTICALS INC | 71,849 | $669K | 0.0% | $9.31 * | $9.98 | 0.0% | COM | 921659108 |
| — | CREDIT SUISSE NASSAU BRH | 25,000 | $645K | 0.0% | $25.80 | $25.73 | — | INVRS VIX STERM | 22542D795 |
| — | IMMUNOMEDICS INC | 200,000 | $614K | 0.0% | $3.07 | $3.07 | — | COM | 452907108 |
| — | ACASTI PHARMA INC | 236,559 | $594K | 0.0% | $2.51 | $2.51 | — | CL A NEW | 00430K402 |
| — | DICERNA PHARMACEUTICALS INC | 50,000 | $594K | 0.0% | $11.88 | $13.96 | — | COM | 253031108 |
| ANIP | ANI PHARMACEUTICALS INC | 12,800 | $578K | 0.0% | $45.16 * | $45.00 | -4.4% | COM | 00182C103 |
| — | GALMED PHARMACEUTICALS LTD | 75,000 | $571K | 0.0% | $7.61 | $11.47 | — | SHS | M47238106 |
| NVO | NOVO-NORDISK A S | 9,540 | $554K | 0.0% | $58.07 | $56.06 | — | ADR | 670100205 |
| — | STEMLINE THERAPEUTICS INC | 78,603 | $496K | 0.0% | $6.31 | $14.47 | — | COM | 85858C107 |
| — | AVINGER INC | 19,566 | $444K | 0.0% | $22.69 | $12.91 | — | COM | 53734109 |
| — | MERRIMACK PHARMACEUTICALS IN | 50,000 | $395K | 0.0% | $7.90 | $7.90 | — | COM | 590328100 |
| — | TRILLIUM THERAPEUTICS INC | 30,000 | $378K | 0.0% | $12.60 | $21.83 | — | COM NEW | 89620X506 |
| — | ACHAOGEN INC | 60,000 | $344K | 0.0% | $5.73 | $6.03 | — | COM | 4449104 |
| — | BOVIE MEDICAL CORP | 162,700 | $342K | 0.0% | $2.10 | $2.39 | — | COM | 10211F100 |
| — | ARIAD PHARMACEUTICALS INC | 50,000 | $313K | 0.0% | $6.26 | $6.87 | — | COM | 04033A100 |
| — | AMPLIPHI BIOSCIENCES CORP | 74,800 | $298K | 0.0% | $3.98 | $3.95 | — | COM NEW | 03211P202 |
| — | TANDEM DIABETES CARE INC | 25,000 | $295K | 0.0% | $11.80 | $11.80 | — | COM | 875372104 |
| — | CURIS INC | 100,000 | $291K | 0.0% | $2.91 | $2.02 | — | COM | 231269101 |
| CRL | CHARLES RIV LABS INTL INC | 3,410 | $274K | 0.0% | $80.35 * | $72.12 | 0.0% | COM | 159864107 |
| — | HEALTH NET INC | 3,831 | $262K | 0.0% | $68.39 | $53.53 | — | COM | 42222G108 |
| — | TRIPLE-S MGMT CORP | 10,605 | $254K | 0.0% | $23.95 | $20.57 | — | CL B | 896749108 |
| GILD | GILEAD SCIENCES INC | 2,457 | $249K | 0.0% | $101.34 * | $70.55 | +3.3% | COM | 375558103 |
| — | PHARMERICA CORP | 6,800 | $238K | 0.0% | $35.00 | $33.24 | — | COM | 71714F104 |
| MCK | MCKESSON CORP | 1,179 | $233K | 0.0% | $197.63 * | $174.49 | 0.0% | COM | 58155Q103 |
| — | TARO PHARMACEUTICAL INDS LTD | 1,493 | $231K | 0.0% | $154.72 | $130.22 | — | SHS | M8737E108 |
| — | GREATBATCH INC | 4,391 | $231K | 0.0% | $52.61 | $57.85 | — | COM | 39153L106 |
| CRVL | CORVEL CORP | 5,115 | $225K | 0.0% | $43.99 * | $12.29 | 0.0% | COM | 221006109 |
| — | CAMBREX CORP | 4,692 | $221K | 0.0% | $47.10 | $21.59 | — | COM | 132011107 |
| COR | AMERISOURCEBERGEN CORP | 2,030 | $211K | 0.0% | $103.94 * | $72.76 | 0.0% | COM | 03073E105 |
| THC | TENET HEALTHCARE CORP | 6,927 | $210K | 0.0% | $30.32 * | $32.80 | 0.0% | COM NEW | 88033G407 |
| — | LIFEPOINT HEALTH INC | 2,862 | $210K | 0.0% | $73.38 | $71.26 | — | COM | 53219L109 |
| — | MAGELLAN HEALTH INC | 3,351 | $207K | 0.0% | $61.77 | $68.41 | — | COM NEW | 559079207 |
| — | VCA INC | 3,731 | $205K | 0.0% | $54.95 | $54.95 | — | COM | 918194101 |
| — | SURGICAL CARE AFFILIATES INC | 5,133 | $204K | 0.0% | $39.74 | $39.74 | — | COM | 86881L106 |
| BIIB | BIOGEN INC | 648 | $199K | 0.0% | $307.10 * | $287.35 | 0.0% | COM | 09062X103 |
| ENSG | ENSIGN GROUP INC | 8,744 | $198K | 0.0% | $22.64 * | $20.17 | 0.0% | COM | 29358P101 |
| — | EXACTECH INC | 10,734 | $195K | 0.0% | $18.17 | $18.17 | — | COM | 30064E109 |
| UNH | UNITEDHEALTH GROUP INC | 1,640 | $193K | 0.0% | $117.68 * | $99.29 | 0.0% | COM | 91324P102 |
| — | ALMOST FAMILY INC | 4,889 | $187K | 0.0% | $38.25 | $38.25 | — | COM | 20409108 |
| — | QUINTILES TRANSNATIO HLDGS I | 2,698 | $185K | 0.0% | $68.57 | $68.57 | — | COM | 74876Y101 |
| — | AMEDISYS INC | 4,648 | $183K | 0.0% | $39.37 | $39.37 | — | COM | 23436108 |
| CYH | COMMUNITY HEALTH SYS INC NEW | 6,724 | $178K | 0.0% | $26.47 * | $25.83 | 0.0% | COM | 203668108 |
| — | NANTKWEST INC | 10,000 | $173K | 0.0% | $17.30 | $17.30 | — | COM | 63016Q102 |
| ICLR | ICON PLC | 2,213 | $172K | 0.0% | $77.72 * | $62.71 | +13.9% | SHS | G4705A100 |
| CNC | CENTENE CORP DEL | 2,593 | $171K | 0.0% | $65.95 * | $29.62 | 0.0% | COM | 15135B101 |
| — | AMSURG CORP | 2,243 | $170K | 0.0% | $75.79 | $75.79 | — | COM | 03232P405 |
| — | LHC GROUP INC | 3,705 | $168K | 0.0% | $45.34 | $31.17 | — | COM | 50187A107 |
| — | LANNET INC | 4,182 | $168K | 0.0% | $40.17 | $41.46 | — | COM | 516012101 |
| MOH | MOLINA HEALTHCARE INC | 2,800 | $168K | 0.0% | $60.00 * | $66.88 | -5.8% | COM | 60855R100 |
| INFIQ | INFINITY PHARMACEUTICALS INC | 20,000 | $157K | 0.0% | $7.85 * | $15.11 | -43.0% | COM | 45665G303 |
| FONR | FONAR CORP | 8,473 | $146K | 0.0% | $17.23 * | $16.53 | 0.0% | COM NEW | 344437405 |
| — | DIGIRAD CORP | 24,988 | $145K | 0.0% | $5.80 | $5.80 | — | COM | 253827109 |
| LNTH | LANTHEUS HLDGS INC | 38,784 | $131K | 0.0% | $3.38 * | $3.60 | 0.0% | COM | 516544103 |
| MYGN | MYRIAD GENETICS INC | 2,500 | $108K | 0.0% | $43.20 * | $34.00 | +24.2% | COM | 62855J104 |
| UTMD | UTAH MED PRODS INC | 1,828 | $107K | 0.0% | $58.53 * | $56.70 | 0.0% | COM | 917488108 |
| CLLS | CELLECTIS S A | 2,996 | $93,000 | 0.0% | $31.04 | $34.42 | — | SPONSORED ADS | 15117K103 |
| — | NANOSPHERE INC | 35,379 | $22,000 | 0.0% | $0.62 | $3.25 | — | COM NEW | 63009F204 |
| — | ACCELERATE DIAGNOSTICS INC | 750 | $16,000 | 0.0% | $21.33 | $21.33 | — | COM | 00430H102 |
| — | IDERA PHARMACEUTICALS INC | 4,578 | $14,000 | 0.0% | $3.06 | $3.12 | — | COM NEW | 45168K306 |
| — | SUCAMPO PHARMACEUTICALS INC | 759 | $13,000 | 0.0% | $17.13 | $19.86 | — | CL A | 864909106 |
| — | CAPRICOR THERAPEUTICS INC | 4,000 | $12,000 | 0.0% | $3.00 | $8.75 | — | COM | 14070B101 |
| INGN | INOGEN INC | 125 | $5,000 | 0.0% | $40.00 * | $42.28 | 0.0% | COM | 45780L104 |
| — | FLEX PHARMA INC | 237 | $3,000 | 0.0% | $12.66 | $12.66 | — | COM | 33938A105 |