Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q3 2015 (← Previous) (Next →)
Filing Date: Nov 17, 2015
Total Value: $1.251B
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| FOLD | AMICUS THERAPEUTICS INC | 14,439,444 | $176M | 14.0% | $12.16 * | $3.01 | +420.3% | COM | 03152W109 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 2,942,967 | $117M | 9.4% | $39.79 * | $13.82 | +249.7% | COM | 64125C109 |
| SRPT | SAREPTA THERAPEUTICS INC | 2,784,928 | $89.42M | 7.1% | $32.11 * | $30.34 | +11.8% | COM | 803607100 |
| — | RETROPHIN INC | 2,647,080 | $53.63M | 4.3% | $20.26 | $13.90 | — | COM | 761299106 |
| — | TESARO INC | 981,759 | $39.37M | 3.1% | $40.10 | $37.49 | — | COM | 881569107 |
| — | GLOBAL BLOOD THERAPEUTICS IN | 921,800 | $38.86M | 3.1% | $42.16 | $42.16 | — | COM | 37890U108 |
| — | DYAX CORP | 1,646,315 | $31.43M | 2.5% | $19.09 | $7.87 | — | COM | 26746E103 |
| — | NEVRO CORP | 606,811 | $28.15M | 2.3% | $46.39 | $47.65 | — | COM | 64157F103 |
| — | GW PHARMACEUTICALS -ADR | 300,000 | $27.41M | 2.2% | $91.37 | — | — | PUT | 36197T103 |
| PTCT | PTC THERAPEUTICS INC | 1,005,000 | $26.83M | 2.1% | $26.70 | — | — | PUT | 69366J200 |
| — | VERSARTIS INC | 2,317,954 | $26.73M | 2.1% | $11.53 | $16.67 | — | COM | 92529L102 |
| IWM | ISHARES RUSSELL 2000 | 200,000 | $21.84M | 1.7% | $109.20 | — | — | PUT | 464287655 |
| XNCR | XENCOR INC | 1,754,784 | $21.46M | 1.7% | $12.23 * | $8.98 | +117.9% | COM | 98401F105 |
| — | ACELRX PHARMACEUTICALS INC | 6,264,060 | $19.11M | 1.5% | $3.05 | $9.69 | — | COM | 00444T100 |
| — | RELYPSA INC | 987,942 | $18.29M | 1.5% | $18.51 | $27.90 | — | COM | 759531106 |
| — | LA JOLLA PHARMACEUTICAL CO | 654,515 | $18.19M | 1.5% | $27.79 | $21.23 | — | COM PAR $.0001 2 | 503459604 |
| RGNX | REGENXBIO INC | 779,213 | $17.17M | 1.4% | $22.03 * | $25.52 | 0.0% | COM | 75901B107 |
| XBI | STREETTRACKS SPDR BIOTEC ETF | 275,000 | $17.12M | 1.4% | $62.25 | — | — | PUT | 78464A870 |
| — | LION BIOTECHNOLOGIES INC | 2,955,456 | $17.02M | 1.4% | $5.76 | $9.06 | — | COM | 53619R102 |
| — | IGNYTA INC | 1,931,600 | $16.96M | 1.4% | $8.78 | $15.09 | — | COM | 451731103 |
| — | CEMPRA INC | 582,500 | $16.22M | 1.3% | $27.84 | $29.61 | — | COM | 15130J109 |
| — | PFENEX INC | 971,043 | $14.57M | 1.2% | $15.01 | $13.00 | — | COM | 717071104 |
| QURE | UNIQURE NV | 690,269 | $14.12M | 1.1% | $20.45 * | $20.37 | +29.3% | SHS | N90064101 |
| SSO | PROSHARES ULTRA S & P500 | 200,000 | $11.12M | 0.9% | $55.60 | $64.53 | — | PUT | 74347R107 |
| — | CAPITAL SR LIVING CORP | 553,600 | $11.1M | 0.9% | $20.05 | $25.46 | — | COM | 140475104 |
| — | DERMIRA INC | 472,000 | $11.02M | 0.9% | $23.34 | $21.66 | — | COM | 24983L104 |
| — | DBV TECHNOLOGIES S A | 306,715 | $10.92M | 0.9% | $35.59 | $35.53 | — | SPONSORED ADR | 23306J101 |
| NVO | NOVO-NORDISK A/S-SPONS ADR | 200,000 | $10.85M | 0.9% | $54.24 | $54.48 | — | PUT | 670100205 |
| — | QUOTIENT LTD | 776,803 | $10.35M | 0.8% | $13.32 | $13.56 | — | SHS | G73268107 |
| GILD | GILEAD SCIENCES INC | 100,000 | $9.819M | 0.8% | $98.19 * | $70.55 | +9.9% | PUT | 375558103 |
| — | ACADIA PHARMACEUTICALS INC | 295,240 | $9.764M | 0.8% | $33.07 | $41.88 | — | COM | 4225108 |
| SRPT | Sarepta Therapeutics Inc | 300,000 | $9.634M | 0.8% | $32.11 * | $30.34 | +11.8% | CALL | 803607100 |
| — | CIDARA THERAPEUTICS INC | 742,858 | $9.449M | 0.8% | $12.72 | $13.24 | — | COM | 171757107 |
| EGRX | EAGLE PHARMACEUTICALS INC | 123,044 | $9.109M | 0.7% | $74.03 * | $63.23 | +31.6% | COM | 269796108 |
| TEVA | TEVA PHARMACEUTICAL INDS LTD | 160,000 | $9.034M | 0.7% | $56.46 | $56.46 | — | ADR | 881624209 |
| — | BLUEPRINT MEDICINES CORP | 404,404 | $8.629M | 0.7% | $21.34 | $26.49 | — | COM | 09627Y109 |
| — | VBI VACCINES INC | 3,260,356 | $8.607M | 0.7% | $2.64 | $2.61 | — | COM | 91790E102 |
| — | SHIRE PLC | 41,000 | $8.415M | 0.7% | $205.24 | $232.47 | — | SPONSORED ADR | 82481R106 |
| — | ZYNERBA PHARMACEUTICALS INC | 579,350 | $8.29M | 0.7% | $14.31 | $14.31 | — | COM | 98986X109 |
| — | NEOS THERAPEUTICS INC | 371,066 | $7.796M | 0.6% | $21.01 | $21.01 | — | COM | 64052L106 |
| — | ASSEMBLY BIOSCIENCES INC | 795,000 | $7.6M | 0.6% | $9.56 | $19.14 | — | COM | 45396108 |
| — | BELLICUM PHARMACEUTICALS INC | 521,188 | $7.572M | 0.6% | $14.53 | $21.27 | — | COM | 79481107 |
| — | NEPTUNE TECHNOLOGIES BIORESO | 6,700,444 | $7.37M | 0.6% | $1.10 | $3.13 | — | COM | 64077P108 |
| — | ABEONA THERAPEUTICS INC | 1,762,881 | $7.14M | 0.6% | $4.05 | $4.32 | — | COM | 00289Y107 |
| — | ANI PHARMACEUTICALS INC | 7,500,000 | $6.923M | 0.6% | $0.92 | $1.05 | — | NOTE 3.000%12/0 | 00182CAA1 |
| — | ACCELERON PHARMA INC | 276,036 | $6.873M | 0.5% | $24.90 | $33.05 | — | COM | 00434H108 |
| — | THORATEC CORP | 100,000 | $6.327M | 0.5% | $63.27 | $30.31 | — | CALL | 885175307 |
| — | ALLIQUA BIOMEDICAL INC | 1,921,951 | $6.092M | 0.5% | $3.17 | $5.29 | — | COM NEW | 19621200 |
| CLLS | CELLECTIS S A | 218,679 | $5.764M | 0.5% | $26.36 | $34.42 | — | SPONSORED ADS | 15117K103 |
| — | APPLIED GENETIC TECHNOL CORP | 850,992 | $5.591M | 0.4% | $6.57 | $11.61 | — | COM | 03820J100 |
| — | NEURODERM LTD | 270,000 | $5.581M | 0.4% | $20.67 | $15.76 | — | ORD SHS | M74231107 |
| ALDX | ALDEYRA THERAPEUTICS INC | 957,193 | $5.58M | 0.4% | $5.83 * | $9.14 | -14.5% | COM | 01438T106 |
| — | RELYPSA INC | 300,000 | $5.553M | 0.4% | $18.51 | $27.90 | — | CALL | 759531106 |
| — | ARDELYX INC | 315,955 | $5.46M | 0.4% | $17.28 | $15.97 | — | COM | 39697107 |
| — | THORATEC CORP | 86,000 | $5.44M | 0.4% | $63.26 | $30.31 | — | COM NEW | 885175307 |
| — | AFFIMED N V | 868,620 | $5.361M | 0.4% | $6.17 | $52.46 | — | COM | N01045108 |
| — | AXOVANT SCIENCES LTD | 410,000 | $5.297M | 0.4% | $12.92 | $16.38 | — | COM | G0750W104 |
| — | ANTHERA PHARMACEUTICALS INC | 992,156 | $5.206M | 0.4% | $5.25 | $3.66 | — | COM NEW | 03674U201 |
| — | TOKAI PHARMACEUTICALS INC | 485,338 | $5.024M | 0.4% | $10.35 | $14.80 | — | COM | 88907J107 |
| — | RELYPSA INC | 250,000 | $4.628M | 0.4% | $18.51 | $27.90 | — | PUT | 759531106 |
| — | FIVE PRIME THERAPEUTICS INC | 284,129 | $4.373M | 0.3% | $15.39 | $18.33 | — | COM | 33830X104 |
| — | MINVERA NEUROSCIENCES | 810,537 | $4.255M | 0.3% | $5.25 | $5.00 | — | COM | 603380106 |
| — | TRANSENTERIX INC | 1,826,432 | $4.127M | 0.3% | $2.26 | $3.81 | — | COM NEW | 89366M201 |
| — | PROTEON THERAPEUTICS INC | 275,000 | $3.825M | 0.3% | $13.91 | $10.40 | — | COM | 74371L109 |
| — | ISHARES TR | 145,000 | $3.29M | 0.3% | $22.69 | $26.17 | — | HDG MSCI GERMN | 46434V704 |
| — | ST JUDE MED INC | 51,520 | $3.251M | 0.3% | $63.10 | $63.10 | — | COM | 790849103 |
| — | CELYAD SA | 75,000 | $3.139M | 0.3% | $41.85 | $52.03 | — | ADR | 151205200 |
| — | WALGREENS BOOTS ALLIANCE INC | 35,292 | $2.933M | 0.2% | $83.11 | $79.69 | — | COM | 931427108 |
| RGEN | REPLIGEN CORP | 100,000 | $2.785M | 0.2% | $27.85 | — | — | PUT | 759916109 |
| PTCT | PTC THERAPEUTICS INC | 100,000 | $2.67M | 0.2% | $26.70 | — | — | CALL | 69366J200 |
| — | CIGNA CORPORATION | 19,470 | $2.629M | 0.2% | $135.03 | $156.68 | — | COM | 125509109 |
| — | ARIAD PHARMACEUTICALS INC | 450,000 | $2.628M | 0.2% | $5.84 | $6.87 | — | COM | 04033A100 |
| CPRX | CATALYST PHARMACEUTICALS INC | 851,200 | $2.554M | 0.2% | $3.00 * | $3.60 | +19.7% | COM | 14888U101 |
| AKBA | AKEBIA THERAPEUTICS INC | 260,000 | $2.512M | 0.2% | $9.66 * | $9.18 | 0.0% | COM | 00972D105 |
| — | MGC DIAGNOSTICS CORP | 336,287 | $2.219M | 0.2% | $6.60 | $8.55 | — | COM | 552768103 |
| — | VITAE PHARMACEUTICALS INC | 200,000 | $2.202M | 0.2% | $11.01 | $13.55 | — | COM | 92847N103 |
| EVH | EVOLENT HEALTH INC | 137,289 | $2.191M | 0.2% | $15.96 * | $18.64 | +4.6% | CL A | 30050B101 |
| — | ABEONA THERAPEUTICS INC | 1,259,636 | $2.173M | 0.2% | $1.73 | $1.80 | — | *W EXP 12/19/201 | 00289Y115 |
| CSBR | CHAMPIONS ONCOLOGY INC | 372,597 | $1.993M | 0.2% | $5.35 * | $6.08 | 0.0% | COM NEW | 15870P307 |
| — | BAXTER INTL INC | 60,000 | $1.971M | 0.2% | $32.85 | $32.85 | — | COM | 71813109 |
| — | CORBUS PHARMACEUTICALS INC | 1,250,000 | $1.962M | 0.2% | $1.57 | $2.62 | — | COM | 21833P103 |
| — | INTEC PHARMA LTD JERUSALEM | 350,000 | $1.96M | 0.2% | $5.60 | $5.60 | — | SHS | M53644106 |
| XENE | XENON PHARMACEUTICALS INC | 205,800 | $1.699M | 0.1% | $8.26 * | $14.68 | -32.4% | COM | 98420N105 |
| — | DERMA SCIENCES INC | 360,584 | $1.698M | 0.1% | $4.71 | $12.06 | — | COM PAR $.01 | 249827502 |
| — | REPROS THERAPEUTICS INC | 220,000 | $1.635M | 0.1% | $7.43 | $7.43 | — | COM NEW | 76028H209 |
| — | NIVALIS THERAPEUTICS INC | 125,000 | $1.621M | 0.1% | $12.97 | $12.97 | — | COM | 65481J109 |
| — | AVINGER INC | 97,500 | $1.434M | 0.1% | $14.71 | $12.91 | — | COM | 53734109 |
| — | GENVEC INC | 615,844 | $1.423M | 0.1% | $2.31 | $2.54 | — | COM NEW | 37246C307 |
| BCRX | BIOCRYST PHARMACEUTICALS | 123,745 | $1.411M | 0.1% | $11.40 * | $11.37 | +17.4% | COM | 09058V103 |
| — | POWERSHS DB US DOLLAR INDEX | 55,000 | $1.381M | 0.1% | $25.11 | $25.03 | — | DOLL INDX BULL | 73936D107 |
| — | ONCOTHYREON INC | 3,546,897 | $1.38M | 0.1% | $0.39 | $3.04 | — | COM | 682324108 |
| — | SCYNEXIS INC | 175,000 | $1.274M | 0.1% | $7.28 | $8.79 | — | COM | 811292101 |
| — | SYNERGY PHARMACEUTICALS DEL | 226,000 | $1.198M | 0.1% | $5.30 | $5.30 | — | COM NEW | 871639308 |
| — | CREDIT SUISSE NASSAU BRH | 46,500 | $1.132M | 0.1% | $24.34 | $25.73 | — | INVRS VIX STERM | 22542D795 |
| VCEL | VERICEL CORP | 351,162 | $952K | 0.1% | $2.71 * | $2.85 | +15.4% | COM | 92346J108 |
| — | BRAINSTORM CELL THERAPEUTICS | 400,000 | $916K | 0.1% | $2.29 | $4.45 | — | COM | 10501E201 |
| IRWD | IRONWOOD PHARMACEUTICALS INC | 86,229 | $899K | 0.1% | $10.43 * | $11.62 | -19.7% | COM CL A | 46333X108 |
| — | SAGE THERAPEUTICS INC | 20,000 | $847K | 0.1% | $42.35 | $31.50 | — | COM | 78667J108 |
| — | AQUINOX PHARMACEUTICALS INC | 59,600 | $839K | 0.1% | $14.08 | $12.73 | — | COM | 03842B101 |
| — | COGENTIX MED INC | 673,257 | $835K | 0.1% | $1.24 | $1.62 | — | COM | 19243A104 |
| — | FIAT CHRYSLER AUTOMOBILES N | 62,000 | $819K | 0.1% | $13.21 | $14.53 | — | SHS | N31738102 |
| ANIP | ANI PHARMACEUTICALS INC | 19,256 | $761K | 0.1% | $39.52 * | $45.00 | +26.4% | COM | 00182C103 |
| — | ARNO THERAPEUTICS INC | 2,034,721 | $712K | 0.1% | $0.35 | $0.58 | — | COM | 42564203 |
| — | STEMLINE THERAPEUTICS INC | 78,603 | $694K | 0.1% | $8.83 | $14.47 | — | COM | 85858C107 |
| — | ACASTI PHARMA INC | 2,365,600 | $626K | 0.1% | $0.26 | $1.23 | — | CL A SHS | 00430K105 |
| — | INVITAE CORP | 85,000 | $614K | 0.0% | $7.22 | $12.69 | — | COM | 46185L103 |
| XNCR | XENCOR INC | 50,000 | $612K | 0.0% | $12.24 * | $8.98 | +117.9% | PUT | 98401F105 |
| — | SUNESIS PHARMACEUTICALS INC | 700,000 | $567K | 0.0% | $0.81 | $2.52 | — | COM NEW | 867328601 |
| — | GALMED PHARMACEUTICALS LTD | 75,000 | $557K | 0.0% | $7.43 | $11.47 | — | SHS | M47238106 |
| TBT | PROSHARES TR | 12,000 | $520K | 0.0% | $43.33 | $43.33 | — | PSHS ULTSH 20YRS | 74347B201 |
| — | QUOTIENT LTD | 131,251 | $475K | 0.0% | $3.62 | $3.62 | — | *W EXP 10/30/201 | G73268123 |
| — | DICERNA PHARMACEUTICALS INC | 50,000 | $411K | 0.0% | $8.22 | $13.96 | — | COM | 253031108 |
| — | TRILLIUM THERAPEUTICS INC | 30,000 | $391K | 0.0% | $13.03 | $21.83 | — | COM NEW | 89620X506 |
| — | OTONOMY INC | 185,368 | $364K | 0.0% | $1.96 | $24.62 | — | COM | 68906L105 |
| — | ACHAOGEN INC | 60,000 | $346K | 0.0% | $5.77 | $6.03 | — | COM | 4449104 |
| — | BOVIE MEDICAL CORP | 162,700 | $322K | 0.0% | $1.98 | $2.39 | — | COM | 10211F100 |
| — | AMPLIPHI BIOSCIENCES | 80,000 | $316K | 0.0% | $3.95 | $3.95 | — | COM | 03211P202 |
| NVO | NOVO-NORDISK A S | 5,340 | $290K | 0.0% | $54.31 | $54.48 | — | ADR | 670100205 |
| — | INC RESH HLDGS INC | 7,261 | $290K | 0.0% | $39.94 | $40.08 | — | CL A | 45329R109 |
| — | AETNA INC NEW | 2,586 | $283K | 0.0% | $109.44 | $116.60 | — | COM | 00817Y108 |
| — | LHC GROUP INC | 5,917 | $265K | 0.0% | $44.79 | $31.17 | — | COM | 50187A107 |
| — | PSIVIDA CORP | 315,000 | $257K | 0.0% | $0.82 | $4.11 | — | COM | 74440J101 |
| — | GREATBATCH INC | 4,391 | $248K | 0.0% | $56.48 | $57.85 | — | COM | 39153L106 |
| GILD | GILEAD SCIENCES INC | 2,457 | $241K | 0.0% | $98.09 * | $70.55 | +9.9% | COM | 375558103 |
| — | ADDUS HOMECARE CORP | 7,601 | $237K | 0.0% | $31.18 | $31.18 | — | COM | 6739106 |
| — | HEALTH NET INC | 3,831 | $231K | 0.0% | $60.30 | $53.53 | — | COM | 42222G108 |
| — | TARO PHARMACEUTICAL INDS LTD | 1,493 | $213K | 0.0% | $142.67 | $130.22 | — | SHS | M8737E108 |
| EW | EDWARDS LIFESCIENCES CORP | 1,500 | $213K | 0.0% | $142.00 * | $24.14 | 0.0% | COM | 28176E108 |
| — | CURIS INC | 100,000 | $202K | 0.0% | $2.02 | $2.02 | — | COM | 231269101 |
| — | ANTHEM INC | 1,436 | $201K | 0.0% | $139.97 | $164.35 | — | COM | 36752103 |
| MOH | MOLINA HEALTHCARE INC | 2,888 | $199K | 0.0% | $68.91 * | $66.88 | +10.9% | COM | 60855R100 |
| HCA | HCA HOLDINGS INC | 2,563 | $198K | 0.0% | $77.25 * | $49.74 | +65.5% | COM | 40412C101 |
| CAH | CARDINAL HEALTH INC | 2,574 | $198K | 0.0% | $76.92 * | $63.64 | -2.1% | COM | 14149Y108 |
| — | CONCERT PHARMACEUTICALS INC | 10,379 | $195K | 0.0% | $18.79 | $18.79 | — | COM | 206022105 |
| — | PHARMERICA CORP | 6,800 | $194K | 0.0% | $28.53 | $33.24 | — | COM | 71714F104 |
| — | TRIPLE-S MGMT CORP | 10,605 | $189K | 0.0% | $17.82 | $20.57 | — | CL B | 896749108 |
| — | MAGELLAN HEALTH INC | 3,410 | $189K | 0.0% | $55.43 | $68.41 | — | COM NEW | 559079207 |
| — | WELLCARE HEALTH PLANS INC | 2,189 | $189K | 0.0% | $86.34 | $86.34 | — | COM | 94946T106 |
| ICLR | ICON PLC | 2,631 | $187K | 0.0% | $71.08 * | $62.71 | +20.0% | SHS | G4705A100 |
| — | CAMBREX CORP | 4,692 | $186K | 0.0% | $39.64 | $21.59 | — | COM | 132011107 |
| — | LIFEPOINT HEALTH INC | 2,522 | $179K | 0.0% | $70.98 | $70.98 | — | COM | 53219L109 |
| — | AMGEN INC | 1,280 | $177K | 0.0% | $138.28 | $138.28 | — | COM | 31162100 |
| INFIQ | INFINITY PHARMACEUTICALS INC | 20,000 | $169K | 0.0% | $8.45 * | $15.11 | -38.9% | COM | 45665G303 |
| — | LANNET INC | 4,048 | $168K | 0.0% | $41.50 | $41.50 | — | COM | 516012101 |
| — | SUCAMPO PHARMACEUTICALS INC | 7,905 | $157K | 0.0% | $19.86 | $19.86 | — | CL A | 864909106 |
| — | RECRO PHARMA INC | 12,063 | $145K | 0.0% | $12.02 | $12.02 | — | COM | 75629F109 |
| — | DIVERSICARE HEALTHCARE SVCS | 12,337 | $127K | 0.0% | $10.29 | $12.91 | — | COM | 255104101 |
| — | AMAG PHARMACEUTICALS INC | 2,904 | $115K | 0.0% | $39.60 | $39.60 | — | COM | 00163U106 |
| MYGN | MYRIAD GENETICS INC | 2,500 | $94,000 | 0.0% | $37.60 * | $34.00 | +4.4% | COM | 62855J104 |
| — | ENDOLOGIX INC | 5,755 | $71,000 | 0.0% | $12.34 | $16.41 | — | COM | 29266S106 |
| — | NANOSPHERE INC | 35,379 | $58,000 | 0.0% | $1.64 | $3.25 | — | COM NEW | 63009F204 |
| — | JUNIPER PHARMACEUTICALS INC | 1,736 | $20,000 | 0.0% | $11.52 | $9.15 | — | COM | 48203L107 |
| — | VALEANT PHARMACEUTICALS INTERNATIONAL IN | 100 | $18,000 | 0.0% | $180.00 | — | — | CALL | 91911K102 |
| — | CAPRICOR THERAPEUTICS INC | 4,000 | $16,000 | 0.0% | $4.00 | $8.75 | — | COM | 14070B101 |
| — | NUVASIVE INC | 252 | $12,000 | 0.0% | $47.62 | $47.62 | — | COM | 670704105 |
| XBI | STREETTRACKS SPDR BIOTEC ETF | 100 | $6,000 | 0.0% | $60.00 | — | — | CALL | 78464A870 |
| — | IDERA PHARMACEUTICALS INC | 1,537 | $5,000 | 0.0% | $3.25 | $3.25 | — | COM NEW | 45168K306 |
| — | CONATUS PHARMACEUTICALS INC | 425 | $2,000 | 0.0% | $4.71 | $5.15 | — | COM | 20600T108 |