Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q3 2015 (← Previous) (Next →)
Filing Date: Nov 17, 2015
Total Value: $1.251B
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| FOLD | AMICUS THERAPEUTICS INC | 14,439,444 | $176M | 14.0% | $3.01 | +420.3% | — | 03152W109 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 2,942,967 | $117M | 9.4% | $13.82 | +249.7% | — | 64125C109 |
| SRPT | SAREPTA THERAPEUTICS INC | 2,784,928 | $89.42M | 7.1% | $30.34 | +11.8% | — | 803607100 |
| — | RETROPHIN INC | 2,647,080 | $53.63M | 4.3% | $13.90 | — | — | 761299106 |
| — | TESARO INC | 981,759 | $39.37M | 3.1% | $37.49 | — | — | 881569107 |
| — | GLOBAL BLOOD THERAPEUTICS IN | 921,800 | $38.86M | 3.1% | $42.16 | — | — | 37890U108 |
| — | DYAX CORP | 1,646,315 | $31.43M | 2.5% | $7.87 | — | — | 26746E103 |
| — | NEVRO CORP | 606,811 | $28.15M | 2.3% | $47.65 | — | — | 64157F103 |
| — | GW PHARMACEUTICALS -ADR | 300,000 | $27.41M | 2.2% | — | — | PUT | 36197T103 |
| PTCT | PTC THERAPEUTICS INC | 1,005,000 | $26.83M | 2.1% | — | — | PUT | 69366J200 |
| — | VERSARTIS INC | 2,317,954 | $26.73M | 2.1% | $16.67 | — | — | 92529L102 |
| IWM | ISHARES RUSSELL 2000 | 200,000 | $21.84M | 1.7% | — | — | PUT | 464287655 |
| XNCR | XENCOR INC | 1,754,784 | $21.46M | 1.7% | $8.98 | +117.9% | — | 98401F105 |
| — | ACELRX PHARMACEUTICALS INC | 6,264,060 | $19.11M | 1.5% | $9.69 | — | — | 00444T100 |
| — | RELYPSA INC | 987,942 | $18.29M | 1.5% | $27.90 | — | — | 759531106 |
| — | LA JOLLA PHARMACEUTICAL CO | 654,515 | $18.19M | 1.5% | $21.23 | — | — | 503459604 |
| RGNX | REGENXBIO INC | 779,213 | $17.17M | 1.4% | $25.52 | 0.0% | — | 75901B107 |
| XBI | STREETTRACKS SPDR BIOTEC ETF | 275,000 | $17.12M | 1.4% | — | — | PUT | 78464A870 |
| — | LION BIOTECHNOLOGIES INC | 2,955,456 | $17.02M | 1.4% | $9.06 | — | — | 53619R102 |
| — | IGNYTA INC | 1,931,600 | $16.96M | 1.4% | $15.09 | — | — | 451731103 |
| — | CEMPRA INC | 582,500 | $16.22M | 1.3% | $29.61 | — | — | 15130J109 |
| — | PFENEX INC | 971,043 | $14.57M | 1.2% | $13.00 | — | — | 717071104 |
| QURE | UNIQURE NV | 690,269 | $14.12M | 1.1% | $20.37 | +29.3% | — | N90064101 |
| SSO | PROSHARES ULTRA S & P500 | 200,000 | $11.12M | 0.9% | $64.53 | — | PUT | 74347R107 |
| — | CAPITAL SR LIVING CORP | 553,600 | $11.1M | 0.9% | $25.46 | — | — | 140475104 |
| — | DERMIRA INC | 472,000 | $11.02M | 0.9% | $21.66 | — | — | 24983L104 |
| — | DBV TECHNOLOGIES S A | 306,715 | $10.92M | 0.9% | $35.53 | — | — | 23306J101 |
| NVO | NOVO-NORDISK A/S-SPONS ADR | 200,000 | $10.85M | 0.9% | $54.48 | — | PUT | 670100205 |
| — | QUOTIENT LTD | 776,803 | $10.35M | 0.8% | $13.56 | — | — | G73268107 |
| GILD | GILEAD SCIENCES INC | 100,000 | $9.819M | 0.8% | $70.55 | +9.9% | PUT | 375558103 |
| — | ACADIA PHARMACEUTICALS INC | 295,240 | $9.764M | 0.8% | $41.88 | — | — | 4225108 |
| SRPT | Sarepta Therapeutics Inc | 300,000 | $9.634M | 0.8% | $30.34 | +11.8% | CALL | 803607100 |
| — | CIDARA THERAPEUTICS INC | 742,858 | $9.449M | 0.8% | $13.24 | — | — | 171757107 |
| EGRX | EAGLE PHARMACEUTICALS INC | 123,044 | $9.109M | 0.7% | $63.23 | +31.6% | — | 269796108 |
| TEVA | TEVA PHARMACEUTICAL INDS LTD | 160,000 | $9.034M | 0.7% | $56.46 | — | — | 881624209 |
| — | BLUEPRINT MEDICINES CORP | 404,404 | $8.629M | 0.7% | $26.49 | — | — | 09627Y109 |
| — | VBI VACCINES INC | 3,260,356 | $8.607M | 0.7% | $2.61 | — | — | 91790E102 |
| — | SHIRE PLC | 41,000 | $8.415M | 0.7% | $232.47 | — | — | 82481R106 |
| — | ZYNERBA PHARMACEUTICALS INC | 579,350 | $8.29M | 0.7% | $14.31 | — | — | 98986X109 |
| — | NEOS THERAPEUTICS INC | 371,066 | $7.796M | 0.6% | $21.01 | — | — | 64052L106 |
| — | ASSEMBLY BIOSCIENCES INC | 795,000 | $7.6M | 0.6% | $19.14 | — | — | 45396108 |
| — | BELLICUM PHARMACEUTICALS INC | 521,188 | $7.572M | 0.6% | $21.27 | — | — | 79481107 |
| — | NEPTUNE TECHNOLOGIES BIORESO | 6,700,444 | $7.37M | 0.6% | $3.13 | — | — | 64077P108 |
| — | ABEONA THERAPEUTICS INC | 1,762,881 | $7.14M | 0.6% | $4.32 | — | — | 00289Y107 |
| — | ANI PHARMACEUTICALS INC | 7,500,000 | $6.923M | 0.6% | $1.05 | — | — | 00182CAA1 |
| — | ACCELERON PHARMA INC | 276,036 | $6.873M | 0.5% | $33.05 | — | — | 00434H108 |
| — | THORATEC CORP | 100,000 | $6.327M | 0.5% | $30.31 | — | CALL | 885175307 |
| — | ALLIQUA BIOMEDICAL INC | 1,921,951 | $6.092M | 0.5% | $5.29 | — | — | 19621200 |
| CLLS | CELLECTIS S A | 218,679 | $5.764M | 0.5% | $34.42 | — | — | 15117K103 |
| — | APPLIED GENETIC TECHNOL CORP | 850,992 | $5.591M | 0.4% | $11.61 | — | — | 03820J100 |
| — | NEURODERM LTD | 270,000 | $5.581M | 0.4% | $15.76 | — | — | M74231107 |
| ALDX | ALDEYRA THERAPEUTICS INC | 957,193 | $5.58M | 0.4% | $9.14 | -14.5% | — | 01438T106 |
| — | RELYPSA INC | 300,000 | $5.553M | 0.4% | $27.90 | — | CALL | 759531106 |
| — | ARDELYX INC | 315,955 | $5.46M | 0.4% | $15.97 | — | — | 39697107 |
| — | THORATEC CORP | 86,000 | $5.44M | 0.4% | $30.31 | — | — | 885175307 |
| — | AFFIMED N V | 868,620 | $5.361M | 0.4% | $52.46 | — | — | N01045108 |
| — | AXOVANT SCIENCES LTD | 410,000 | $5.297M | 0.4% | $16.38 | — | — | G0750W104 |
| — | ANTHERA PHARMACEUTICALS INC | 992,156 | $5.206M | 0.4% | $3.66 | — | — | 03674U201 |
| — | TOKAI PHARMACEUTICALS INC | 485,338 | $5.024M | 0.4% | $14.80 | — | — | 88907J107 |
| — | RELYPSA INC | 250,000 | $4.628M | 0.4% | $27.90 | — | PUT | 759531106 |
| — | FIVE PRIME THERAPEUTICS INC | 284,129 | $4.373M | 0.3% | $18.33 | — | — | 33830X104 |
| — | MINVERA NEUROSCIENCES | 810,537 | $4.255M | 0.3% | $5.00 | — | — | 603380106 |
| — | TRANSENTERIX INC | 1,826,432 | $4.127M | 0.3% | $3.81 | — | — | 89366M201 |
| — | PROTEON THERAPEUTICS INC | 275,000 | $3.825M | 0.3% | $10.40 | — | — | 74371L109 |
| — | ISHARES TR | 145,000 | $3.29M | 0.3% | $26.17 | — | — | 46434V704 |
| — | ST JUDE MED INC | 51,520 | $3.251M | 0.3% | $63.10 | — | — | 790849103 |
| — | CELYAD SA | 75,000 | $3.139M | 0.3% | $52.03 | — | — | 151205200 |
| — | WALGREENS BOOTS ALLIANCE INC | 35,292 | $2.933M | 0.2% | $79.69 | — | — | 931427108 |
| RGEN | REPLIGEN CORP | 100,000 | $2.785M | 0.2% | — | — | PUT | 759916109 |
| PTCT | PTC THERAPEUTICS INC | 100,000 | $2.67M | 0.2% | — | — | CALL | 69366J200 |
| — | CIGNA CORPORATION | 19,470 | $2.629M | 0.2% | $156.68 | — | — | 125509109 |
| — | ARIAD PHARMACEUTICALS INC | 450,000 | $2.628M | 0.2% | $6.87 | — | — | 04033A100 |
| CPRX | CATALYST PHARMACEUTICALS INC | 851,200 | $2.554M | 0.2% | $3.60 | +19.7% | — | 14888U101 |
| AKBA | AKEBIA THERAPEUTICS INC | 260,000 | $2.512M | 0.2% | $9.18 | 0.0% | — | 00972D105 |
| — | MGC DIAGNOSTICS CORP | 336,287 | $2.219M | 0.2% | $8.55 | — | — | 552768103 |
| — | VITAE PHARMACEUTICALS INC | 200,000 | $2.202M | 0.2% | $13.55 | — | — | 92847N103 |
| EVH | EVOLENT HEALTH INC | 137,289 | $2.191M | 0.2% | $18.64 | +4.6% | — | 30050B101 |
| — | ABEONA THERAPEUTICS INC | 1,259,636 | $2.173M | 0.2% | $1.80 | — | — | 00289Y115 |
| CSBR | CHAMPIONS ONCOLOGY INC | 372,597 | $1.993M | 0.2% | $6.08 | 0.0% | — | 15870P307 |
| — | BAXTER INTL INC | 60,000 | $1.971M | 0.2% | $32.85 | — | — | 71813109 |
| — | CORBUS PHARMACEUTICALS INC | 1,250,000 | $1.962M | 0.2% | $2.62 | — | — | 21833P103 |
| — | INTEC PHARMA LTD JERUSALEM | 350,000 | $1.96M | 0.2% | $5.60 | — | — | M53644106 |
| XENE | XENON PHARMACEUTICALS INC | 205,800 | $1.699M | 0.1% | $14.68 | -32.4% | — | 98420N105 |
| — | DERMA SCIENCES INC | 360,584 | $1.698M | 0.1% | $12.06 | — | — | 249827502 |
| — | REPROS THERAPEUTICS INC | 220,000 | $1.635M | 0.1% | $7.43 | — | — | 76028H209 |
| — | NIVALIS THERAPEUTICS INC | 125,000 | $1.621M | 0.1% | $12.97 | — | — | 65481J109 |
| — | AVINGER INC | 97,500 | $1.434M | 0.1% | $12.91 | — | — | 53734109 |
| — | GENVEC INC | 615,844 | $1.423M | 0.1% | $2.54 | — | — | 37246C307 |
| BCRX | BIOCRYST PHARMACEUTICALS | 123,745 | $1.411M | 0.1% | $11.37 | +17.4% | — | 09058V103 |
| — | POWERSHS DB US DOLLAR INDEX | 55,000 | $1.381M | 0.1% | $25.03 | — | — | 73936D107 |
| — | ONCOTHYREON INC | 3,546,897 | $1.38M | 0.1% | $3.04 | — | — | 682324108 |
| — | SCYNEXIS INC | 175,000 | $1.274M | 0.1% | $8.79 | — | — | 811292101 |
| — | SYNERGY PHARMACEUTICALS DEL | 226,000 | $1.198M | 0.1% | $5.30 | — | — | 871639308 |
| — | CREDIT SUISSE NASSAU BRH | 46,500 | $1.132M | 0.1% | $25.73 | — | — | 22542D795 |
| VCEL | VERICEL CORP | 351,162 | $952K | 0.1% | $2.85 | +15.4% | — | 92346J108 |
| — | BRAINSTORM CELL THERAPEUTICS | 400,000 | $916K | 0.1% | $4.45 | — | — | 10501E201 |
| IRWD | IRONWOOD PHARMACEUTICALS INC | 86,229 | $899K | 0.1% | $11.62 | -19.7% | — | 46333X108 |
| — | SAGE THERAPEUTICS INC | 20,000 | $847K | 0.1% | $31.50 | — | — | 78667J108 |
| — | AQUINOX PHARMACEUTICALS INC | 59,600 | $839K | 0.1% | $12.73 | — | — | 03842B101 |
| — | COGENTIX MED INC | 673,257 | $835K | 0.1% | $1.62 | — | — | 19243A104 |
| — | FIAT CHRYSLER AUTOMOBILES N | 62,000 | $819K | 0.1% | $14.53 | — | — | N31738102 |
| ANIP | ANI PHARMACEUTICALS INC | 19,256 | $761K | 0.1% | $45.00 | +26.4% | — | 00182C103 |
| — | ARNO THERAPEUTICS INC | 2,034,721 | $712K | 0.1% | $0.58 | — | — | 42564203 |
| — | STEMLINE THERAPEUTICS INC | 78,603 | $694K | 0.1% | $14.47 | — | — | 85858C107 |
| — | ACASTI PHARMA INC | 2,365,600 | $626K | 0.1% | $1.23 | — | — | 00430K105 |
| — | INVITAE CORP | 85,000 | $614K | 0.0% | $12.69 | — | — | 46185L103 |
| XNCR | XENCOR INC | 50,000 | $612K | 0.0% | $8.98 | +117.9% | PUT | 98401F105 |
| — | SUNESIS PHARMACEUTICALS INC | 700,000 | $567K | 0.0% | $2.52 | — | — | 867328601 |
| — | GALMED PHARMACEUTICALS LTD | 75,000 | $557K | 0.0% | $11.47 | — | — | M47238106 |
| TBT | PROSHARES TR | 12,000 | $520K | 0.0% | $43.33 | — | — | 74347B201 |
| — | QUOTIENT LTD | 131,251 | $475K | 0.0% | $3.62 | — | — | G73268123 |
| — | DICERNA PHARMACEUTICALS INC | 50,000 | $411K | 0.0% | $13.96 | — | — | 253031108 |
| — | TRILLIUM THERAPEUTICS INC | 30,000 | $391K | 0.0% | $21.83 | — | — | 89620X506 |
| — | OTONOMY INC | 185,368 | $364K | 0.0% | $24.62 | — | — | 68906L105 |
| — | ACHAOGEN INC | 60,000 | $346K | 0.0% | $6.03 | — | — | 4449104 |
| — | BOVIE MEDICAL CORP | 162,700 | $322K | 0.0% | $2.39 | — | — | 10211F100 |
| — | AMPLIPHI BIOSCIENCES | 80,000 | $316K | 0.0% | $3.95 | — | — | 03211P202 |
| NVO | NOVO-NORDISK A S | 5,340 | $290K | 0.0% | $54.48 | — | — | 670100205 |
| — | INC RESH HLDGS INC | 7,261 | $290K | 0.0% | $40.08 | — | — | 45329R109 |
| — | AETNA INC NEW | 2,586 | $283K | 0.0% | $116.60 | — | — | 00817Y108 |
| — | LHC GROUP INC | 5,917 | $265K | 0.0% | $31.17 | — | — | 50187A107 |
| — | PSIVIDA CORP | 315,000 | $257K | 0.0% | $4.11 | — | — | 74440J101 |
| — | GREATBATCH INC | 4,391 | $248K | 0.0% | $57.85 | — | — | 39153L106 |
| GILD | GILEAD SCIENCES INC | 2,457 | $241K | 0.0% | $70.55 | +9.9% | — | 375558103 |
| — | ADDUS HOMECARE CORP | 7,601 | $237K | 0.0% | $31.18 | — | — | 6739106 |
| — | HEALTH NET INC | 3,831 | $231K | 0.0% | $53.53 | — | — | 42222G108 |
| EW | EDWARDS LIFESCIENCES CORP | 1,500 | $213K | 0.0% | $24.14 | 0.0% | — | 28176E108 |
| — | TARO PHARMACEUTICAL INDS LTD | 1,493 | $213K | 0.0% | $130.22 | — | — | M8737E108 |
| — | CURIS INC | 100,000 | $202K | 0.0% | $2.02 | — | — | 231269101 |
| — | ANTHEM INC | 1,436 | $201K | 0.0% | $164.35 | — | — | 36752103 |
| MOH | MOLINA HEALTHCARE INC | 2,888 | $199K | 0.0% | $66.88 | +10.9% | — | 60855R100 |
| HCA | HCA HOLDINGS INC | 2,563 | $198K | 0.0% | $49.74 | +65.5% | — | 40412C101 |
| CAH | CARDINAL HEALTH INC | 2,574 | $198K | 0.0% | $63.64 | -2.1% | — | 14149Y108 |
| — | CONCERT PHARMACEUTICALS INC | 10,379 | $195K | 0.0% | $18.79 | — | — | 206022105 |
| — | PHARMERICA CORP | 6,800 | $194K | 0.0% | $33.24 | — | — | 71714F104 |
| — | TRIPLE-S MGMT CORP | 10,605 | $189K | 0.0% | $20.57 | — | — | 896749108 |
| — | MAGELLAN HEALTH INC | 3,410 | $189K | 0.0% | $68.41 | — | — | 559079207 |
| — | WELLCARE HEALTH PLANS INC | 2,189 | $189K | 0.0% | $86.34 | — | — | 94946T106 |
| ICLR | ICON PLC | 2,631 | $187K | 0.0% | $62.71 | +20.0% | — | G4705A100 |
| — | CAMBREX CORP | 4,692 | $186K | 0.0% | $21.59 | — | — | 132011107 |
| — | LIFEPOINT HEALTH INC | 2,522 | $179K | 0.0% | $70.98 | — | — | 53219L109 |
| — | AMGEN INC | 1,280 | $177K | 0.0% | $138.28 | — | — | 31162100 |
| INFIQ | INFINITY PHARMACEUTICALS INC | 20,000 | $169K | 0.0% | $15.11 | -38.9% | — | 45665G303 |
| — | LANNET INC | 4,048 | $168K | 0.0% | $41.50 | — | — | 516012101 |
| — | SUCAMPO PHARMACEUTICALS INC | 7,905 | $157K | 0.0% | $19.86 | — | — | 864909106 |
| — | RECRO PHARMA INC | 12,063 | $145K | 0.0% | $12.02 | — | — | 75629F109 |
| — | DIVERSICARE HEALTHCARE SVCS | 12,337 | $127K | 0.0% | $12.91 | — | — | 255104101 |
| — | AMAG PHARMACEUTICALS INC | 2,904 | $115K | 0.0% | $39.60 | — | — | 00163U106 |
| MYGN | MYRIAD GENETICS INC | 2,500 | $94,000 | 0.0% | $34.00 | +4.4% | — | 62855J104 |
| — | ENDOLOGIX INC | 5,755 | $71,000 | 0.0% | $16.41 | — | — | 29266S106 |
| — | NANOSPHERE INC | 35,379 | $58,000 | 0.0% | $3.25 | — | — | 63009F204 |
| — | JUNIPER PHARMACEUTICALS INC | 1,736 | $20,000 | 0.0% | $9.15 | — | — | 48203L107 |
| — | VALEANT PHARMACEUTICALS INTERNATIONAL IN | 100 | $18,000 | 0.0% | — | — | CALL | 91911K102 |
| — | CAPRICOR THERAPEUTICS INC | 4,000 | $16,000 | 0.0% | $8.75 | — | — | 14070B101 |
| — | NUVASIVE INC | 252 | $12,000 | 0.0% | $47.62 | — | — | 670704105 |
| XBI | STREETTRACKS SPDR BIOTEC ETF | 100 | $6,000 | 0.0% | — | — | CALL | 78464A870 |
| — | IDERA PHARMACEUTICALS INC | 1,537 | $5,000 | 0.0% | $3.25 | — | — | 45168K306 |
| — | CONATUS PHARMACEUTICALS INC | 425 | $2,000 | 0.0% | $5.15 | — | — | 20600T108 |