Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q2 2016 (← Previous) (Next →)
Filing Date: Aug 11, 2016
Total Value: $1.442B (99.4% shares, 0.6% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| SRPT | Sarepta Therapeutics Inc | 7,619,300 | $145M | 10.1% | $24.99 | -26.1% | Put | 803607100 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 2,797,967 | $127M | 8.8% | $16.79 | +174.3% | COM | 64125C109 |
| — | TESARO INC | 1,143,615 | $96.12M | 6.7% | $40.07 | — | COM | 881569107 |
| FOLD | AMICUS | 15,239,444 | $83.21M | 5.8% | $3.33 | +110.1% | COM | 03152W109 |
| SRPT | SAREPTA THERAPEUTICS INC | 3,767,316 | $71.84M | 5.0% | $24.99 | -26.1% | COM | 803607100 |
| — | Retrophin Inc | 3,279,380 | $58.41M | 4.0% | $14.21 | — | COM | 761299106 |
| — | MEDIVATION INC | 760,000 | $45.83M | 3.2% | $53.89 | — | COM | 58501N101 |
| — | GLOBAL BLOOD THERAPEUTICS IN | 2,207,668 | $36.63M | 2.5% | $29.12 | — | COM | 37890U108 |
| — | VERSARTIS INC | 2,835,754 | $31.36M | 2.2% | $15.03 | — | COM | 92529L102 |
| — | NXSTAGE MEDICAL INC | 1,382,410 | $29.97M | 2.1% | $21.68 | — | COM | 67072V103 |
| — | LION BIOTECHNOLOGIES INC | 3,611,976 | $29.26M | 2.0% | $8.82 | — | COM | 53619R102 |
| XNCR | XENCOR INC | 1,529,574 | $29.05M | 2.0% | $9.22 | +48.7% | COM | 98401F105 |
| XBI | STREETTRACKS SPDR BIOTEC ETF | 500,000 | $27.05M | 1.9% | — | — | Put | 78464A870 |
| — | NEVRO CORP | 365,229 | $26.94M | 1.9% | $48.84 | — | COM | 64157F103 |
| — | CELATOR PHARMACEUTICALS INC | 838,400 | $25.3M | 1.8% | $11.03 | — | COM | 15089R102 |
| — | LA JOLLA PHARMACEUTICAL CO | 1,332,815 | $21.32M | 1.5% | $18.73 | — | COM PAR $.0001 2 | 503459604 |
| — | ACCELERON | 603,036 | $20.49M | 1.4% | $28.68 | — | COM | 00434H108 |
| SRPT | Sarepta Therapeutics Inc | 979,200 | $18.67M | 1.3% | $24.99 | -26.1% | Call | 803607100 |
| — | ST JUDE MEDICAL | 233,000 | $18.17M | 1.3% | $78.00 | — | COM | 790849103 |
| — | DBV TECHNOLOGIES S A | 546,696 | $17.83M | 1.2% | $34.24 | — | SPONSORED ADR | 23306J101 |
| — | QUOTIENT LTD | 2,249,067 | $17.43M | 1.2% | $10.76 | — | SHS | G73268107 |
| EVH | EVOLENT HEALTH INC | 873,064 | $16.76M | 1.2% | $12.68 | +8.3% | CL A | 30050B101 |
| — | ACELRX PHARMA | 5,995,760 | $16.13M | 1.1% | $9.69 | — | COM | 00444T100 |
| — | DERMIRA INC | 462,000 | $13.51M | 0.9% | $22.40 | — | COM | 24983L104 |
| — | VBI VACCINES INC | 3,058,433 | $12.08M | 0.8% | $2.61 | — | COM | 91790E102 |
| — | DEPOMED INC | 600,000 | $11.73M | 0.8% | $17.16 | — | COM | 249908104 |
| EGRX | EAGLE PHARMACEUTICALS INC | 300,000 | $11.64M | 0.8% | $55.68 | -25.2% | COM | 269796108 |
| VRTX | VERTEX PHARMACEUTICALS INC | 130,000 | $11.18M | 0.8% | $111.26 | -22.3% | COM | 92532F100 |
| ALDX | ALDEYRA | 1,940,458 | $11.04M | 0.8% | $7.50 | -25.6% | COM | 01438T106 |
| WVE | WAVE LIFE SCIENCES LTD | 522,595 | $10.81M | 0.7% | $15.04 | +3.6% | SHS | Y95308105 |
| — | CAPITAL SR LIVING CORP | 586,136 | $10.36M | 0.7% | $24.19 | — | COM | 140475104 |
| HEDJ | WISDOMTREE EUROPE HEDGED EQU | 200,000 | $10.11M | 0.7% | — | — | Put | 97717X701 |
| — | ALDER BIOPHARMACEUTICALS INC | 400,000 | $9.988M | 0.7% | $24.52 | — | COM | 14339105 |
| DXCM | DEXCOM INC | 125,174 | $9.93M | 0.7% | $16.96 | +0.4% | COM | 252131107 |
| QURE | UNIQURE NV | 1,342,093 | $9.891M | 0.7% | $18.17 | -34.2% | SHS | N90064101 |
| TEVA | TEVA PHARMACEUTICAL INDS LTD | 196,000 | $9.845M | 0.7% | $62.59 | — | ADR | 881624209 |
| — | CORBUS PHARMACEUTICALS HLDGS | 3,200,000 | $9.568M | 0.7% | $2.85 | — | COM | 21833P103 |
| — | BLUEPRINT MEDICINES CORP | 464,404 | $9.404M | 0.7% | $25.68 | — | COM | 09627Y109 |
| — | APPLIED GENETIC TECHNOL CORP | 658,851 | $9.309M | 0.6% | $11.75 | — | COM | 03820J100 |
| RGNX | REGENXBIO INC | 1,099,213 | $8.793M | 0.6% | $21.40 | -48.1% | COM | 75901B107 |
| — | MINERVA NEUROSCIENCES INC | 810,537 | $8.275M | 0.6% | $5.00 | — | COM | 603380106 |
| — | CIDARA THERAPEUTICS INC | 792,857 | $8.174M | 0.6% | $13.06 | — | COM | 171757107 |
| — | ANI PHARMACEUTICALS INC | 7,500,000 | $8.121M | 0.6% | $1.05 | — | NOTE 3.000%12/ | 00182CAA1 |
| — | PFENEX INC | 960,877 | $8.043M | 0.6% | $13.00 | — | COM | 717071104 |
| CTMX | CYTOMX THERAPEUTICS INC | 742,021 | $7.579M | 0.5% | $15.56 | -26.7% | COM | 23284F105 |
| — | pSivida Corp | 2,665,000 | $7.542M | 0.5% | $2.93 | — | COM | 74440J101 |
| — | FIVE PRIME THERAPEUTICS INC | 169,439 | $7.006M | 0.5% | $26.96 | — | COM | 33830X104 |
| — | NEPTUNE TECHNOLOGIES BIORESO | 6,750,444 | $6.885M | 0.5% | $3.13 | — | COM | 64077P108 |
| AKBA | AKEBIA THERAPEUTICS INC | 893,600 | $6.684M | 0.5% | $8.44 | +3.4% | COM | 00972D105 |
| — | SELECTA BIOSCIENCES INC | 450,000 | $6.296M | 0.4% | $13.99 | — | COM | 816212104 |
| — | MYOKARDIA INC | 502,894 | $6.235M | 0.4% | $14.66 | — | COM | 62857M105 |
| — | AXOVANT SCIENCES LTD | 485,000 | $6.227M | 0.4% | $16.76 | — | COM | G0750W104 |
| — | ZYNERBA PHARMACEUTICALS INC | 849,350 | $5.818M | 0.4% | $12.64 | — | COM | 98986X109 |
| — | FORWARD PHARMA A/S | 311,400 | $5.658M | 0.4% | $17.47 | — | SPONSORED ADR | 34986J105 |
| — | ACADIA PHARMACEUTICALS INC | 165,240 | $5.364M | 0.4% | $32.46 | — | COM | 4225108 |
| SUPN | SUPERNUS PHARMACEUTICALS INC | 250,000 | $5.093M | 0.4% | $13.99 | +26.8% | COM | 868459108 |
| — | FOAMIX PHARMACEUTICALS LTD | 795,000 | $5.048M | 0.3% | $6.35 | — | SHS | M46135105 |
| CLLS | CELLECTIS S A | 183,507 | $4.879M | 0.3% | $26.72 | — | SPONSORED ADS | 15117K103 |
| — | ALCOBRA LTD | 1,028,272 | $4.617M | 0.3% | $6.28 | — | SHS | M2239P109 |
| — | ANTHERA PHARMACEUTICALS INC | 1,492,156 | $4.611M | 0.3% | $3.65 | — | COM NEW | 03674U201 |
| — | NEOS THERAPEUTICS INC | 626,876 | $4.611M | 0.3% | $9.53 | — | COM | 64052L106 |
| — | ONCOBIOLOGICS INC | 1,312,763 | $4.463M | 0.3% | $3.40 | — | COM | 68235M105 |
| — | CLEARSIDE BIOMEDICAL INC | 634,808 | $4.45M | 0.3% | $7.01 | — | COM | 185063104 |
| — | ASSEMBLY BIOSCIENCES INC | 795,000 | $4.412M | 0.3% | $19.14 | — | COM | 45396108 |
| — | NEURODERM LTD | 270,000 | $4.388M | 0.3% | $15.76 | — | ORD SHS | M74231107 |
| — | TESARO INC | 50,000 | $4.203M | 0.3% | $40.07 | — | Put | 881569107 |
| — | Abeona Therapeutics Inc | 1,762,881 | $4.159M | 0.3% | $4.32 | — | COM | 00289Y107 |
| — | AGILE THERAPEUTICS INC | 514,288 | $3.914M | 0.3% | $7.13 | — | COM | 00847L100 |
| ANIP | ANI PHARMACEUTICALS INC | 67,161 | $3.749M | 0.3% | $35.16 | +38.2% | COM | 00182C103 |
| — | TOKAI PHARMACEUTICALS INC | 661,041 | $3.642M | 0.3% | $12.33 | — | COM | 88907J107 |
| — | GENVEC INC | 606,644 | $3.447M | 0.2% | $2.54 | — | COM NEW | 37246C307 |
| — | Cascadian Therapeutics Inc | 3,414,121 | $3.22M | 0.2% | $0.94 | — | COM | 14740B101 |
| — | PROTEOSTASIS THERAPEUTICS IN | 250,000 | $3.033M | 0.2% | $9.64 | — | COM | 74373B109 |
| — | AVEO PHARMACEUTICALS INC | 3,108,808 | $2.987M | 0.2% | $0.96 | — | COM | 053588109 |
| — | INNOCOLL HLDGS PLC | 560,000 | $2.808M | 0.2% | $5.01 | — | SHS | G4783X105 |
| — | CEMPRA INC | 170,000 | $2.803M | 0.2% | $17.40 | — | COM | 15130J109 |
| — | ARDELYX INC | 315,955 | $2.758M | 0.2% | $15.97 | — | COM | 39697107 |
| XENE | XENON PHARMACEUTICALS INC | 432,800 | $2.553M | 0.2% | $10.58 | -35.2% | COM | 98420N105 |
| — | ADMA BIOLOGICS INC | 398,394 | $2.371M | 0.2% | $5.95 | — | COM | 899104 |
| — | IGNYTA INC | 435,260 | $2.359M | 0.2% | $15.09 | — | COM | 451731103 |
| IONS | Ionis Pharmaceuticals Ord Shs | 100,000 | $2.329M | 0.2% | — | — | Put | 462222100 |
| — | PROTEON THERAPEUTICS INC | 275,000 | $2.208M | 0.2% | $10.40 | — | COM | 74371L109 |
| — | MGC DIAGNOSTICS CORP | 336,287 | $2.193M | 0.2% | $8.55 | — | COM | 552768103 |
| — | ALLIQUA BIOMEDICAL INC | 1,921,951 | $2.152M | 0.1% | $5.29 | — | COM NEW | 19621200 |
| — | PROGENICS PHARMACEUTICALS | 500,000 | $2.11M | 0.1% | — | — | Put | 743187106 |
| — | EIGER BIOPHARMACEUTICALS INC | 104,920 | $2.079M | 0.1% | $16.77 | — | COM | 28249U105 |
| — | RELYPSA INC | 100,000 | $1.85M | 0.1% | — | — | Put | 759531106 |
| — | AFFIMED N V | 734,301 | $1.821M | 0.1% | $2.48 | — | COM | N01045108 |
| — | DERMA SCIENCES INC | 432,884 | $1.706M | 0.1% | $10.71 | — | COM PAR $.01 | 249827502 |
| — | MEDGENICS INC | 300,000 | $1.665M | 0.1% | $5.55 | — | COM NEW | 58436Q203 |
| — | ARATANA THERAPEUTICS INC | 256,500 | $1.621M | 0.1% | $5.52 | — | COM | 03874P101 |
| — | ABIOMED INC | 14,700 | $1.607M | 0.1% | $109.32 | — | COM | 3654100 |
| — | CHINA BIOLOGIC PRODS INC | 14,000 | $1.488M | 0.1% | $114.50 | — | COM | 16938C106 |
| VCEL | VERICEL CORP | 557,342 | $1.254M | 0.1% | $2.81 | +2.4% | COM | 92346J108 |
| GMED | GLOBUS MED INC | 50,000 | $1.192M | 0.1% | $23.98 | 0.0% | CL A | 379577208 |
| — | ARNO THERAPEUTIC INC | 3,463,292 | $1.08M | 0.1% | $0.48 | — | COM | 42564203 |
| — | ABEONA THERAPEUTICS INC | 1,259,636 | $1.071M | 0.1% | $1.80 | — | *W EXP 12/19/201 | 00289Y115 |
| — | BRAINSTROM CELL THERAPEUTICS | 400,000 | $964K | 0.1% | $2.67 | — | COM | 10501E201 |
| — | LIPOCINE INC | 300,000 | $912K | 0.1% | — | — | Call | 53630X104 |
| — | LIPOCINE INC | 284,400 | $865K | 0.1% | — | — | Put | 53630X104 |
| PZRXQ | PHASERX INC | 200,000 | $852K | 0.1% | $4.94 | 0.0% | COM | 71723F103 |
| CSBR | CHAMPIONS ONCOLOGY INC | 372,597 | $801K | 0.1% | $6.08 | -45.7% | COM NEW | 15870P307 |
| LXRX | Lexicon Pharmaceuticals Inc | 50,000 | $718K | 0.0% | $13.56 | 0.0% | COM | 528872302 |
| — | LANNET INC | 26,670 | $634K | 0.0% | $23.77 | — | COM | 516012101 |
| — | MAGELLAN HEALTH INC | 8,772 | $577K | 0.0% | $68.12 | — | COM NEW | 559079207 |
| — | NIVALIS THERAPEUTICS INC | 125,000 | $575K | 0.0% | $12.97 | — | COM | 65481J109 |
| MCK | MCKESSON CORP | 2,979 | $556K | 0.0% | $158.79 | +2.4% | COM | 58155Q103 |
| — | AETNA INC NEW | 4,454 | $544K | 0.0% | $122.14 | — | COM | 00817Y108 |
| — | WELLCARE HEALTH PLANS INC | 5,056 | $542K | 0.0% | $92.69 | — | COM | 94946T106 |
| — | VWR CORP | 18,657 | $539K | 0.0% | $27.07 | — | COM | 91843L103 |
| — | AMN HEALTHCARE SERVICES INC | 13,445 | $537K | 0.0% | $39.94 | — | COM | 1744101 |
| — | VCA INC | 7,940 | $537K | 0.0% | $67.63 | — | COM | 918194101 |
| UHS | UNIVERSAL HLTH SVCS INC | 3,989 | $535K | 0.0% | $107.84 | +17.4% | CL B | 913903100 |
| — | STEMLINE THERAPEUTICS INC | 78,603 | $532K | 0.0% | $14.47 | — | COM | 85858C107 |
| — | LABORATORY CORP AMER HLDGS | 3,990 | $520K | 0.0% | $130.33 | — | COM NEW | 50540R409 |
| COR | AMERISOURCEBERGEN CORP | 6,500 | $516K | 0.0% | $59.88 | 0.0% | COM | 03073E105 |
| — | AEGLEA BIOTHERAPEUTICS INC | 105,893 | $515K | 0.0% | $4.86 | — | COM | 00773J103 |
| — | IMMUNOMEDICS INC | 221,700 | $514K | 0.0% | $2.58 | — | COM | 452907108 |
| — | ALMOST FAMILY INC | 11,942 | $509K | 0.0% | $37.62 | — | COM | 20409108 |
| UTHR | UNITED THERAPEUTICS CORP DEL | 4,753 | $503K | 0.0% | $126.54 | -11.8% | COM | 91307C102 |
| CAH | CARDINAL HEALTH INC | 6,398 | $499K | 0.0% | $61.11 | -1.4% | COM | 14149Y108 |
| — | COGENTIX MED INC | 517,760 | $498K | 0.0% | $1.62 | — | COM | 19243A104 |
| HCA | HCA HOLDINGS INC | 6,202 | $478K | 0.0% | $64.91 | +13.0% | COM | 40412C101 |
| — | KINDRED HEALTHCARE INC | 42,301 | $478K | 0.0% | $11.30 | — | COM | 494580103 |
| MOH | MOLINA HEALTHCARE INC | 9,200 | $459K | 0.0% | $60.92 | -12.3% | COM | 60855R100 |
| UNH | UNITEDHEALTH GROUP INC | 3,231 | $456K | 0.0% | $100.29 | +13.8% | COM | 91324P102 |
| PAHC | PHIBRO ANIMAL HEALTH CORP | 24,300 | $453K | 0.0% | $20.86 | 0.0% | CL A COM | 71742Q106 |
| CRL | CHARLES RIV LABS INTL INC | 5,482 | $452K | 0.0% | $72.99 | +12.9% | COM | 159864107 |
| — | SUCAMPO PHARMACEUTICALS INC | 41,096 | $451K | 0.0% | $11.14 | — | CL A | 864909106 |
| THC | TENET HEALTHCARE CORP | 16,200 | $448K | 0.0% | $29.55 | 0.0% | COM NEW | 88033G407 |
| — | ANTHEM INC | 3,400 | $447K | 0.0% | $139.04 | — | COM | 36752103 |
| — | OPHTHOTECH CORP | 8,145 | $416K | 0.0% | $51.07 | — | COM | 683745103 |
| — | ENZO BIOCHEM INC | 67,113 | $401K | 0.0% | $5.97 | — | COM | 294100102 |
| — | SCYNEXIS INC | 175,000 | $380K | 0.0% | $8.79 | — | COM | 811292101 |
| — | FIAT CHRYSLER AUTOMOBILES N | 62,000 | $379K | 0.0% | $14.53 | — | SHS | N31738102 |
| CNC | CENTENE CORP DEL | 4,948 | $353K | 0.0% | $29.73 | +5.6% | COM | 15135B101 |
| — | ACASTI PHARMA INC | 236,559 | $336K | 0.0% | $2.51 | — | CL A NEW | 00430K402 |
| NTLA | INTELLIA THERAPEUTICS INC | 15,000 | $320K | 0.0% | $26.61 | 0.0% | COM | 45826J105 |
| — | CELLDEX THERAPEUTICS INC NEW | 71,124 | $312K | 0.0% | $4.39 | — | COM | 15117B103 |
| — | MERRIMACK PHARMACEUTICALS IN | 50,000 | $270K | 0.0% | $7.90 | — | COM | 590328100 |
| RACE | FERRARI N V | 6,200 | $254K | 0.0% | $40.37 | +5.2% | COM | N3167Y103 |
| — | NOVAVAX INC | 32,000 | $233K | 0.0% | $7.28 | — | COM | 670002104 |
| — | MYLAN N V | 5,000 | $216K | 0.0% | $43.20 | — | SHS EURO | N59465109 |
| — | ONCOBIOLOGICS INC | 462,500 | $212K | 0.0% | $0.46 | — | *W EXP 02/18/201 | 68235M113 |
| — | ONCOBIOLOGICS INC | 462,500 | $202K | 0.0% | $0.44 | — | *W EXP 05/18/201 | 68235M121 |
| — | PERNIX THERAPEUTICS HLDGS IN | 1,000,000 | $200K | 0.0% | $0.20 | — | DBCV 4.250% 4/0 | 71426VAK4 |
| — | DIGIRAD CORP | 24,988 | $129K | 0.0% | $5.80 | — | COM | 253827109 |
| — | ABBOTT LABS | 3,040 | $120K | 0.0% | $39.47 | — | COM | 2824100 |
| — | PEREGRINE PHARMACEUTICALS IN | 224,332 | $81,000 | 0.0% | $0.37 | — | COM NEW | 713661304 |
| — | IMMUNOGEN INC | 25,745 | $79,000 | 0.0% | $3.07 | — | COM | 45253H101 |
| ABBV | ABBVIE INC | 1,250 | $77,000 | 0.0% | $40.97 | 0.0% | COM | 00287Y109 |
| — | DIPLOMAT PHARMACY INC | 2,175 | $76,000 | 0.0% | $34.94 | — | COM | 25456K101 |
| HLF | HERBALIFE LTD | 1,250 | $73,000 | 0.0% | $25.81 | +16.0% | COM USD SHS | G4412G101 |
| — | ZELTIQ AESTHETICS INC | 2,638 | $72,000 | 0.0% | $27.16 | — | COM | 98933Q108 |
| — | GENOCEA BIOSCIENCES INC | 17,313 | $71,000 | 0.0% | $7.74 | — | COM | 372427104 |
| — | AIMMUNE THERAPEUTICS INC | 6,448 | $70,000 | 0.0% | $10.86 | — | COM | 00900T107 |
| CORT | CORCEPT THERAPEUTICS INC | 11,000 | $60,000 | 0.0% | $5.20 | 0.0% | COM | 218352102 |
| — | AVEXIS INC | 1,515 | $58,000 | 0.0% | $27.24 | — | COM | 05366U100 |
| — | ATARA BIOTHERAPEUTICS INC | 2,500 | $56,000 | 0.0% | $22.40 | — | COM | 46513107 |
| — | SERES THERAPEUTICS INC | 1,540 | $45,000 | 0.0% | $29.22 | — | COM | 81750R102 |
| — | JUNO THERAPEUTICS INC | 1,113 | $43,000 | 0.0% | $38.63 | — | COM | 48205A109 |
| — | DYNAVAX TECHNOLOGIES CORP | 2,499 | $36,000 | 0.0% | $14.41 | — | COM NEW | 268158201 |
| — | BIOTIME INC | 13,740 | $36,000 | 0.0% | $2.62 | — | COM | 09066L105 |
| — | CAPRICOR THERAPEUTICS INC | 4,000 | $16,000 | 0.0% | $8.75 | — | COM | 14070B101 |
| — | AVINGER INC | 1,062 | $13,000 | 0.0% | $12.24 | — | COM | 53734109 |
| — | SEVION THERAPEUTICS | 59,220 | $12,000 | 0.0% | $0.20 | — | COM | 81834Q104 |
| GKOS | GLAUKOS CORP | 300 | $9,000 | 0.0% | $23.15 | 0.0% | COM | 377322102 |
| VYGR | VOYAGER THERAPEUTICS INC | 650 | $7,000 | 0.0% | $10.77 | — | COM | 92915B106 |
| INGN | INOGEN INC | 125 | $6,000 | 0.0% | $42.28 | +12.8% | COM | 45780L104 |
| — | ZIOPHARM ONCOLOGY INC | 1,000 | $5,000 | 0.0% | $5.00 | — | COM | 98973P101 |
| — | FLEX PHARMA INC | 237 | $2,000 | 0.0% | $12.66 | — | COM | 33938A105 |
| TNGNQ | TENGION INC | 1,826,399 | $1,000 | 0.0% | $0.00 | 0.0% | COM | 88034G208 |
| NPCUF | ALLON THERAPEUTICS | 751,124 | $0 | 0.0% | $0.00 | 0.0% | COM | 019774108 |