Sofinnova Investments, Inc. Quant / Systematic

Location: Menlo Park, CA

CIK: 0001631134 · Show all filings

Period: Q4 2025 (← Previous) (Next →)

Filing Date: Feb 13, 2026

Total Value: $2.319B (100.0% shares, 0.0% debt)

Holdings (60)

NTRA NATERA INC 15.3%
Value $355M Shares 1,550,280 Share Price $229.09 * Est. Cost/Share $9.81 Unrealized @ Report Date +2026.5%
JAZZ JAZZ PHARMACEUTICALS PLC 7.0%
Value $163M Shares 959,860 Share Price $170.00 * Est. Cost/Share $128.75 Unrealized @ Report Date +19.1%
AZN ASTRAZENECA PLC 6.5%
Value $150M Shares 1,632,334 Share Price $91.93 Est. Cost/Share $83.02 Unrealized @ Report Date —
VERA VERA THERAPEUTICS INC 6.1%
Value $141M Shares 2,793,987 Share Price $50.64 * Est. Cost/Share $15.35 Unrealized @ Report Date +131.3%
BMY BRISTOL-MYERS SQUIBB CO 3.5%
Value $81.61M Shares 1,512,994 Share Price $53.94 * Est. Cost/Share $47.53 Unrealized @ Report Date 0.0%
UTHR UNITED THERAPEUTICS CORP 3.3%
Value $76.81M Shares 157,641 Share Price $487.25 * Est. Cost/Share $313.03 Unrealized @ Report Date +48.8%
VRTX VERTEX PHARMACEUTICALS INC 3.2%
Value $74.62M Shares 164,594 Share Price $453.36 * Est. Cost/Share $421.64 Unrealized @ Report Date +2.2%
ABBV ABBVIE INC 3.1%
Value $72.61M Shares 317,783 Share Price $228.49 Est. Cost/Share $206.22 Unrealized @ Report Date +10.3%
ISRG INTUITIVE SURGICAL INC 3.1%
Value $71.91M Shares 126,968 Share Price $566.36 * Est. Cost/Share $510.25 Unrealized @ Report Date +4.3%
COGT COGENT BIOSCIENCES INC 3.0%
Value $70.1M Shares 1,973,625 Share Price $35.52 * Est. Cost/Share $7.16 Unrealized @ Report Date +292.8%
LLY ELI LILLY & CO 2.9%
Value $66.26M Shares 61,652 Share Price $1074.68 * Est. Cost/Share $955.55 Unrealized @ Report Date 0.0%
RAPP RAPPORT THERAPEUTICS INC 2.5%
Value $57.78M Shares 1,904,408 Share Price $30.34 * Est. Cost/Share $23.12 Unrealized @ Report Date +19.7%
BBIO BRIDGEBIO PHARMA INC 2.4%
Value $55.11M Shares 720,448 Share Price $76.49 * Est. Cost/Share $34.41 Unrealized @ Report Date +90.8%
RNAM AVIDITY BIOSCIENCES INC 2.3%
Value $53.75M Shares 745,116 Share Price $72.13 * Est. Cost/Share $33.95 Unrealized @ Report Date +90.3%
DYN DYNE THERAPEUTICS INC 1.9%
Value $44.09M Shares 2,254,161 Share Price $19.56 * Est. Cost/Share $18.03 Unrealized @ Report Date +5.1%
BMRN BIOMARIN PHARMACEUTICAL INC 1.8%
Value $41.43M Shares 697,133 Share Price $59.43 * Est. Cost/Share $54.44 Unrealized @ Report Date 0.0%
APGE APOGEE THERAPEUTICS INC 1.7%
Value $40.37M Shares 534,845 Share Price $75.48 * Est. Cost/Share $38.16 Unrealized @ Report Date +65.0%
— CIDARA THERAPEUTICS INC 1.7%
Value $39.82M Shares 180,265 Share Price $220.89 Est. Cost/Share $169.12 Unrealized @ Report Date —
PRAX PRAXIS PRECISION MEDICINES INC 1.6%
Value $37.06M Shares 125,722 Share Price $294.74 * Est. Cost/Share $49.76 Unrealized @ Report Date +274.3%
IMTX IMMATICS N.V 1.6%
Value $36.07M Shares 3,435,542 Share Price $10.50 * Est. Cost/Share $7.34 Unrealized @ Report Date +37.5%
INBX INHIBRX BIOSCIENCES INC 1.5%
Value $35.92M Shares 454,657 Share Price $79.00 * Est. Cost/Share $16.63 Unrealized @ Report Date +309.6%
IMNM IMMUNOME INC 1.5%
Value $34.76M Shares 1,618,477 Share Price $21.48 * Est. Cost/Share $17.80 Unrealized @ Report Date -1.4%
AVBP ARRIVENT BIOPHARMA INC 1.5%
Value $34.14M Shares 1,696,752 Share Price $20.12 * Est. Cost/Share $20.17 Unrealized @ Report Date +3.2%
GKOS GLAUKOS CORP 1.4%
Value $32.53M Shares 288,128 Share Price $112.91 * Est. Cost/Share $91.83 Unrealized @ Report Date +4.0%
IDYA IDEAYA BIOSCIENCES INC 1.3%
Value $30.6M Shares 885,121 Share Price $34.57 * Est. Cost/Share $25.35 Unrealized @ Report Date +25.8%
BIOA BIOAGE LABS INC 1.3%
Value $30.35M Shares 2,293,788 Share Price $13.23 * Est. Cost/Share $20.04 Unrealized @ Report Date -55.8%
CELC CELCUITY INC 1.3%
Value $29.86M Shares 299,417 Share Price $99.74 * Est. Cost/Share $46.51 Unrealized @ Report Date +76.7%
RYTM RHYTHM PHARMACEUTICALS INC 1.3%
Value $29.05M Shares 271,394 Share Price $107.04 Est. Cost/Share $57.98 Unrealized @ Report Date +82.9%
CNTA CENTESSA PHARMACEUTICALS PLC 1.2%
Value $27.62M Shares 1,104,274 Share Price $25.01 Est. Cost/Share $25.01 Unrealized @ Report Date —
SUPN SUPERNUS PHARMACEUTICALS INC 1.2%
Value $27.49M Shares 553,095 Share Price $49.70 * Est. Cost/Share $38.83 Unrealized @ Report Date +25.2%
INSM INSMED INC 1.2%
Value $27.29M Shares 156,801 Share Price $174.04 * Est. Cost/Share $95.36 Unrealized @ Report Date +91.4%
ALC ALCON AG 1.1%
Value $26.21M Shares 332,520 Share Price $78.81 * Est. Cost/Share $77.00 Unrealized @ Report Date 0.0%
RCUS ARCUS BIOSCIENCES INC 1.1%
Value $26.13M Shares 1,096,705 Share Price $23.83 * Est. Cost/Share $11.15 Unrealized @ Report Date +83.0%
DXCM DEXCOM INC 1.1%
Value $25.1M Shares 378,219 Share Price $66.37 * Est. Cost/Share $77.45 Unrealized @ Report Date -16.5%
PHVS PHARVARIS N V 0.9%
Value $20.68M Shares 745,169 Share Price $27.75 * Est. Cost/Share $21.08 Unrealized @ Report Date +14.3%
NKTR NEKTAR THERAPEUTICS 0.8%
Value $18.55M Shares 438,630 Share Price $42.28 * Est. Cost/Share $49.79 Unrealized @ Report Date +12.4%
CMPX COMPASS THERAPEUTICS INC 0.8%
Value $18.07M Shares 3,365,446 Share Price $5.37 * Est. Cost/Share $3.74 Unrealized @ Report Date +23.5%
ROIV ROIVANT SCIENCES LTD 0.7%
Value $15.94M Shares 734,582 Share Price $21.70 * Est. Cost/Share $10.86 Unrealized @ Report Date +81.7%
ANAB ANAPTYSBIO INC 0.6%
Value $13.95M Shares 287,690 Share Price $48.48 * Est. Cost/Share $20.04 Unrealized @ Report Date +94.6%
GEHC GE HEALTHCARE TECHNOLOGIES I 0.6%
Value $13.2M Shares 160,876 Share Price $82.02 * Est. Cost/Share $74.75 Unrealized @ Report Date +4.2%
EWTX EDGEWISE THERAPEUTICS INC 0.5%
Value $10.86M Shares 437,819 Share Price $24.81 * Est. Cost/Share $16.17 Unrealized @ Report Date +24.1%
EXAS EXACT SCIENCES CORP 0.4%
Value $10.3M Shares 101,443 Share Price $101.56 * Est. Cost/Share $50.44 Unrealized @ Report Date +59.2%
IRON DISC MEDICINE INC 0.4%
Value $8.815M Shares 111,010 Share Price $79.41 * Est. Cost/Share $80.32 Unrealized @ Report Date +5.2%
AMLX AMYLYX PHARMACEUTICALS INC 0.3%
Value $6.367M Shares 527,099 Share Price $12.08 * Est. Cost/Share $13.58 Unrealized @ Report Date 0.0%
MASI MASIMO CORP 0.3%
Value $6.009M Shares 46,201 Share Price $130.06 * Est. Cost/Share $143.19 Unrealized @ Report Date 0.0%
QURE UNIQURE NV 0.2%
Value $4.224M Shares 176,513 Share Price $23.93 * Est. Cost/Share $19.25 Unrealized @ Report Date +100.4%
NXTC NEXTCURE INC 0.1%
Value $3.159M Shares 222,654 Share Price $14.19 * Est. Cost/Share $5.23 Unrealized @ Report Date +98.0%
WVE WAVE LIFE SCIENCES LTD 0.1%
Value $2.689M Shares 158,182 Share Price $17.00 * Est. Cost/Share $7.07 Unrealized @ Report Date +43.8%
XENE XENON PHARMACEUTICALS INC 0.1%
Value $2.685M Shares 59,900 Share Price $44.82 * Est. Cost/Share $42.00 Unrealized @ Report Date 0.0%
EVMN EVOMMUNE INC 0.1%
Value $2.625M Shares 153,320 Share Price $17.12 * Est. Cost/Share $18.78 Unrealized @ Report Date 0.0%
AXSM AXSOME THERAPEUTICS INC 0.1%
Value $2.24M Shares 12,266 Share Price $182.64 * Est. Cost/Share $104.88 Unrealized @ Report Date +33.1%
ESTA ESTABLISHMENT LABS HLDGS INC 0.1%
Value $2.067M Shares 28,366 Share Price $72.88 * Est. Cost/Share $55.36 Unrealized @ Report Date +9.1%
RARE ULTRAGENYX PHARMACEUTICAL INC 0.1%
Value $1.916M Shares 83,300 Share Price $23.00 * Est. Cost/Share $32.88 Unrealized @ Report Date 0.0%
SVRA SAVARA INC 0.1%
Value $1.838M Shares 304,770 Share Price $6.03 * Est. Cost/Share $4.16 Unrealized @ Report Date +17.6%
MIRM MIRUM PHARMACEUTICALS INC 0.1%
Value $1.825M Shares 23,100 Share Price $78.99 * Est. Cost/Share $71.78 Unrealized @ Report Date 0.0%
ACAD ACADIA PHARMACEUTICALS INC 0.1%
Value $1.751M Shares 65,567 Share Price $26.71 * Est. Cost/Share $23.80 Unrealized @ Report Date +0.4%
JBIO JADE BIOSCIENCES INC 0.1%
Value $1.657M Shares 107,391 Share Price $15.43 * Est. Cost/Share $33.31 Unrealized @ Report Date -64.8%
BOLT BOLT BIOTHERAPEUTICS INC 0.0%
Value $753K Shares 137,721 Share Price $5.47 Est. Cost/Share $6.62 Unrealized @ Report Date -18.9%
SLNO SOLENO THERAPEUTICS INC 0.0%
Value $575K Shares 12,414 Share Price $46.30 * Est. Cost/Share $45.28 Unrealized @ Report Date +21.1%
IMA IMAGENEBIO INC 0.0%
Value $220K Shares 31,884 Share Price $6.90 * Est. Cost/Share $13.25 Unrealized @ Report Date -44.1%