Location: Miami Beach, FL
CIK: 0001535610 · Show all filings
Period: Q1 2015 (← Previous) (Next →)
Filing Date: May 15, 2015
Total Value: $2.402B (98.8% shares, 1.2% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| — | ISHARES RUSSELL 2000 ETF | 18,250 | $227M | 9.4% | $12435.01 | — | — | Put | 464287955 |
| — | SPDR S&P 500 ETF TRUST | 7,441 | $154M | 6.4% | $20643.06 | — | — | Put | 78462F953 |
| — | BIOGEN IDEC INC | 3,102 | $131M | 5.5% | $42224.05 | — | — | Call | 09062X903 |
| — | MERCK & CO INC | 17,188 | $98.8M | 4.1% | $5748.02 | — | — | Call | 58933Y905 |
| — | GILEAD SCIENCES INC | 9,967 | $97.81M | 4.1% | $9812.98 | — | — | Call | 375558903 |
| — | SALIX PHARMACEUTICALS LTD | 4,554 | $78.7M | 3.3% | $17281.07 | — | — | Call | 795435906 |
| — | ELI LILLY & CO | 9,961 | $72.37M | 3.0% | $7265.03 | — | — | Call | 532457908 |
| — | TEVA PHARMACEUTICAL INDUSTRIES LTD | 10,338 | $64.41M | 2.7% | $6230.03 | — | — | Call | 881624909 |
| — | PFIZER INC | 18,331 | $63.77M | 2.7% | $3479.02 | — | — | Call | 717081903 |
| — | BRISTOL MYERS SQUIBB CO. | 9,473 | $61.1M | 2.5% | $6450.02 | — | — | Call | 110122908 |
| — | ABBVIE INC | 10,307 | $60.34M | 2.5% | $5853.98 | — | — | Call | 00287Y909 |
| — | REGENERON PHARMACEUTICALS INC | 1,106 | $49.93M | 2.1% | $45148.28 | — | — | Call | 75886F907 |
| — | BLUEBIRD BIO INC | 2,996 | $36.18M | 1.5% | $12077.10 | — | — | Call | 09609G900 |
| — | ACTAVIS PLC | 1,205 | $35.86M | 1.5% | $29761.83 | — | — | Call | G0083B908 |
| — | MERCK & CO INC | 5,959 | $34.25M | 1.4% | $5747.94 | — | — | Put | 58933Y955 |
| — | ALNYLAM PHARMACEUTICALS INC | 3,249 | $33.93M | 1.4% | $10441.98 | — | — | Call | 02043Q907 |
| — | ACTAVIS PLC | 113,566 | $33.8M | 1.4% | $297.62 | $260.35 | — | SHS | G0083B108 |
| — | TENET HEALTHCARE CORP | 5,752 | $28.48M | 1.2% | $4950.97 | — | — | Put | 88033G957 |
| — | BIOMARIN PHARMACEUTICAL INC | 2,161 | $26.93M | 1.1% | $12461.82 | — | — | Call | 09061G901 |
| — | REGENERON PHARMACEUTICALS INC | 579 | $26.14M | 1.1% | $45148.53 | — | — | Put | 75886F957 |
| IWM | ISHARES RUSSELL 2000 ETF | 198,690 | $24.71M | 1.0% | $124.35 | $124.35 | — | ETF | 464287655 |
| — | INTERCEPT PHARMACEUTICALS INC | 843 | $23.77M | 1.0% | $28201.66 | — | — | Call | 45845P908 |
| — | MOBILEYE N.V. | 5,636 | $23.69M | 1.0% | $4202.98 | — | — | Put | N51488957 |
| — | NOVO NORDISK A/S | 4,222 | $22.54M | 0.9% | $5338.94 | — | — | Call | 670100905 |
| — | SPDR S&P BIOTECH ETF | 987 | $22.26M | 0.9% | $22550.15 | — | — | Put | 78464A950 |
| — | NEWLINK GENETICS CORP | 4,039 | $22.1M | 0.9% | $5470.91 | — | — | Call | 651511907 |
| — | BIOGEN IDEC INC | 514 | $21.7M | 0.9% | $42223.74 | — | — | Put | 09062X953 |
| — | REGULUS THERAPEUTIC INC | 11,798 | $19.99M | 0.8% | $1694.02 | — | — | Call | 75915K901 |
| — | GILEAD SCIENCES INC | 1,832 | $17.98M | 0.7% | $9812.77 | — | — | Put | 375558953 |
| — | MYLAN N.V. | 3,000 | $17.8M | 0.7% | $5935.00 | — | — | Put | N59465959 |
| — | GW PHARMACEUTICALS PLC | 1,923 | $17.52M | 0.7% | $9112.84 | — | — | Put | 36197T953 |
| — | MEDICINES CO 1.375% | 14,213,000 | $16.85M | 0.7% | $1.19 | $1.19 | — | DBCV | 584688AC9 |
| — | PUMA BIOTECHNOLOGY INC | 648 | $15.3M | 0.6% | $23611.11 | — | — | Put | 74587V957 |
| — | ACTAVIS PLC | 505 | $15.03M | 0.6% | $29762.38 | — | — | Put | G0083B958 |
| — | TESARO INC | 2,618 | $15.03M | 0.6% | $5739.88 | — | — | Call | 881569907 |
| — | SANGAMO BIOSCIENCES INC | 9,384 | $14.71M | 0.6% | $1567.99 | — | — | Call | 800677906 |
| — | ISHARES 20+ YR TR | 1,095 | $14.31M | 0.6% | $13069.41 | — | — | Put | 464287952 |
| — | INTEROIL CORP | 3,058 | $14.11M | 0.6% | $4614.13 | — | — | Put | 460951956 |
| — | COMMUNITY HEALTH SYSTEMS INC | 2,683 | $14.03M | 0.6% | $5228.10 | — | — | Put | 203668958 |
| — | MANNKIND CORP | 23,051 | $11.99M | 0.5% | $520.02 | — | — | Put | 56400P951 |
| — | ZOGENIX INC | 8,418,811 | $11.53M | 0.5% | $1.37 | $1.37 | — | COM | 98978L105 |
| — | ISIS PHARMACEUTICALS INC | 1,797 | $11.44M | 0.5% | $6366.72 | — | — | Call | 464330909 |
| — | CELLDEX THERAPEUTICS INC | 4,078 | $11.37M | 0.5% | $2786.91 | — | — | Call | 15117B903 |
| — | ABBVIE INC | 1,884 | $11.03M | 0.5% | $5854.03 | — | — | Put | 00287Y959 |
| — | THORATEC CORP | 2,439 | $10.22M | 0.4% | $4189.01 | — | — | Call | 885175907 |
| — | SAREPTA THERAPEUTICS INC | 7,267 | $9.651M | 0.4% | $1328.06 | — | — | Call | 803607900 |
| — | MOBILEYE N.V. | 226,080 | $9.502M | 0.4% | $42.03 | $42.03 | — | ORD SHS | N51488117 |
| — | TEVA PHARMACEUTICAL INDUSTRIES LTD | 1,515 | $9.438M | 0.4% | $6229.70 | — | — | Put | 881624959 |
| — | INTEROIL CORP | 202,932 | $9.363M | 0.4% | $46.14 | $58.17 | — | COM | 460951106 |
| — | PFIZER INC | 2,670 | $9.289M | 0.4% | $3479.03 | — | — | Put | 717081953 |
| MRK | MERCK & CO INC | 160,704 | $9.237M | 0.4% | $57.48 * | $39.35 | +2.4% | COM | 58933Y105 |
| — | TENAX THERAPEUTICS INC | 2,816,621 | $9.182M | 0.4% | $3.26 | $3.82 | — | COM | 88032L100 |
| — | DANAHER CORP | 1,000 | $8.49M | 0.4% | $8490.00 | — | — | Call | 235851902 |
| — | DANAHER CORP | 1,000 | $8.49M | 0.4% | $8490.00 | — | — | Put | 235851952 |
| — | GREAT BASIN SCIENTIFIC INC | 624,900 | $8.374M | 0.3% | $13.40 | $13.40 | — | UNIT | 39013L205 |
| — | NEWLINK GENETICS CORP | 1,495 | $8.179M | 0.3% | $5470.90 | — | — | Put | 651511957 |
| — | RECEPTOS INC | 480 | $7.915M | 0.3% | $16489.58 | — | — | Call | 756207906 |
| — | BIOMARIN PHARMACEUTICAL 0.75% | 5,000,000 | $7.441M | 0.3% | $1.49 | $1.49 | — | NOTE | 09061GAE1 |
| — | MANNKIND CORP | 14,005 | $7.283M | 0.3% | $520.03 | — | — | Call | 56400P901 |
| TLT | ISHARES 20+ YR TR | 55,320 | $7.23M | 0.3% | $130.69 | $130.69 | — | ETF | 464287432 |
| — | HCA HOLDINGS INC | 937 | $7.049M | 0.3% | $7522.95 | — | — | Call | 40412C901 |
| — | TENET HEALTHCARE CORP | 1,415 | $7.006M | 0.3% | $4951.24 | — | — | Call | 88033G907 |
| — | CEMPRA INC | 200,400 | $6.876M | 0.3% | $34.31 | $34.31 | — | COM | 15130J109 |
| — | DERMIRA INC | 385,185 | $6.773M | 0.3% | $17.58 | $18.06 | — | COM | 24983L104 |
| — | MANNKIND CORP | 1,263,452 | $6.57M | 0.3% | $5.20 | $5.53 | — | COM | 56400P201 |
| — | PERRIGO CO PLC | 390 | $6.456M | 0.3% | $16553.85 | — | — | Call | G97822903 |
| — | BIOMARIN PHARMACEUTICAL INC | 509 | $6.343M | 0.3% | $12461.69 | — | — | Put | 09061G951 |
| — | HORIZON PHARMA PLC | 2,429 | $6.308M | 0.3% | $2596.95 | — | — | Call | G4617B905 |
| — | BRAINSTORM CELL THERAPEUTICS INC | 1,409,537 | $6.272M | 0.3% | $4.45 | $4.45 | — | COM | 10501E201 |
| — | CELGENE CORP | 478 | $5.51M | 0.2% | $11527.20 | — | — | Put | 151020954 |
| — | ENDO INTERNATIONAL PLC | 601 | $5.391M | 0.2% | $8970.05 | — | — | Call | G30401906 |
| — | BELLICUM PHARMACEUTICALS INC | 231,515 | $5.364M | 0.2% | $23.17 | $23.04 | — | COM | 079481107 |
| — | ACHILLION PHARMACEUTICALS INC | 5,439 | $5.363M | 0.2% | $986.03 | — | — | Call | 00448Q901 |
| DHR | DANAHER CORP | 62,453 | $5.302M | 0.2% | $84.90 * | $33.15 | +5.2% | COM | 235851102 |
| — | NOVAVAX INC | 6,224 | $5.147M | 0.2% | $826.96 | — | — | Put | 670002954 |
| — | NEUROCRINE BIOSCIENCES INC | 1,288 | $5.115M | 0.2% | $3971.27 | — | — | Call | 64125C909 |
| — | LEXICON PHARMACEUTICALS INC. | 5,371,800 | $5.073M | 0.2% | $0.94 | $0.94 | — | COM | 528872104 |
| — | HALOZYME THERAPEUTICS INC | 3,502 | $5.001M | 0.2% | $1428.04 | — | — | Call | 40637H909 |
| — | BLUEBIRD BIO INC | 407 | $4.915M | 0.2% | $12076.17 | — | — | Put | 09609G950 |
| — | HERON THERAPEUTICS INC | 3,360 | $4.889M | 0.2% | $1455.06 | — | — | Call | 427746902 |
| — | GW PHARMACEUTICALS PLC | 52,776 | $4.809M | 0.2% | $91.12 | $91.12 | — | ADS | 36197T103 |
| — | GALENA BIOPHARMA INC | 3,436,456 | $4.777M | 0.2% | $1.39 | $1.43 | — | COM | 363256108 |
| — | PHARMACYCLICS INC | 186 | $4.761M | 0.2% | $25596.77 | — | — | Call | 716933906 |
| — | STEMCELLS INC | 4,660,000 | $4.753M | 0.2% | $1.02 | $1.21 | — | COM | 85857R204 |
| — | OVASCIENCE INC | 2,074,736 | $4.693M | 0.2% | $2.26 | $2.26 | — | COM | 69014Q101 |
| — | LION BIOTECHNOLOGIES INC | 375,234 | $4.544M | 0.2% | $12.11 | $12.11 | — | COM | 53619R102 |
| — | CELLADON CORP | 2,387 | $4.521M | 0.2% | $1894.01 | — | — | Call | 15117E907 |
| — | OMEROS CORP | 2,028 | $4.468M | 0.2% | $2203.16 | — | — | Call | 682143902 |
| — | COMMUNITY HEALTH SYSTEMS INC | 849 | $4.439M | 0.2% | $5228.50 | — | — | Call | 203668908 |
| — | REGULUS THERAPEUTIC INC | 260,930 | $4.42M | 0.2% | $16.94 | $16.04 | — | COM | 75915K101 |
| — | INCYTE CORP | 478 | $4.381M | 0.2% | $9165.27 | — | — | Put | 45337C952 |
| — | CELLDEX THERAPEUTICS INC | 1,547 | $4.311M | 0.2% | $2786.68 | — | — | Put | 15117B953 |
| — | MALLINCKRODT PUB LTD | 322 | $4.078M | 0.2% | $12664.60 | — | — | Put | G5785G957 |
| SGMO | SANGAMO BIOSCIENCES INC | 259,741 | $4.073M | 0.2% | $15.68 | $16.34 | -5.3% | COM | 800677106 |
| THC | TENET HEALTHCARE CORP | 80,481 | $3.985M | 0.2% | $49.51 * | $46.74 | 0.0% | COM | 88033G407 |
| — | CERNER CORP | 536 | $3.927M | 0.2% | $7326.49 | — | — | Call | 156782904 |
| — | DYAX CORP | 2,338 | $3.917M | 0.2% | $1675.36 | — | — | Call | 26746E903 |
| — | NOVAVAX INC | 4,698 | $3.885M | 0.2% | $826.95 | — | — | Call | 670002904 |
| — | QUEST RESOURCE HOLDING INC | 3,018,450 | $3.803M | 0.2% | $1.26 | $1.66 | — | COM | 74836W104 |
| — | PROGENICS PHARMACEUTICALS INC | 619,400 | $3.704M | 0.2% | $5.98 | $6.14 | — | COM | 743187106 |
| — | INFINITY PHARMACEUTICALS INC | 2,649 | $3.703M | 0.2% | $1397.89 | — | — | Call | 45665G903 |
| — | CERNER CORP | 499 | $3.656M | 0.2% | $7326.65 | — | — | Put | 156782954 |
| — | CESCA THERAPEUTICS INC | 3,992,662 | $3.593M | 0.1% | $0.90 | $1.37 | — | COM | 157131103 |
| — | OPKO HEALTH INC | 2,500 | $3.543M | 0.1% | $1417.20 | — | — | Put | 68375N953 |
| — | OVASCIENCE INC | 1,000 | $3.473M | 0.1% | $3473.00 | — | — | Call | 69014Q901 |
| — | EXELIXIS INC 4.25% | 4,500,000 | $3.426M | 0.1% | $0.76 | $0.76 | — | NOTE | 30161QAC8 |
| — | MYLAN N.V. | 56,800 | $3.371M | 0.1% | $59.35 | $59.35 | — | SHS | N59465109 |
| ASND | ASCENDIS PHARMA A S | 194,023 | $3.366M | 0.1% | $17.35 | $17.35 | — | ADR | 04351P101 |
| — | BIODELIVERY SCIENCES INTERNATIONAL INC | 3,152 | $3.31M | 0.1% | $1050.13 | — | — | Call | 09060J906 |
| — | RICEBRAN TECHNOLOGIES | 771,299 | $3.07M | 0.1% | $3.98 | $4.16 | — | COM | 762831204 |
| — | XTL BIOPHARMACEUTICALS LTD | 1,311,453 | $3.016M | 0.1% | $2.30 | $2.30 | — | ADR | 98386D208 |
| — | APPLIED GENETIC TECHNOLOGIES CORP | 150,000 | $2.999M | 0.1% | $19.99 | $19.99 | — | COM | 03820J100 |
| — | TEKMIRA PHARMACEUTICALS CORP. | 170,821 | $2.983M | 0.1% | $17.46 | $17.46 | — | COM | 87911B209 |
| — | ALKERMES PLC | 485 | $2.957M | 0.1% | $6096.91 | — | — | Put | G01767955 |
| — | NXSTAGE MEDICAL INC | 1,703 | $2.946M | 0.1% | $1729.89 | — | — | Call | 67072V903 |
| — | IMMUNOCELLULAR THERAPEUTICS INC | 5,889,021 | $2.856M | 0.1% | $0.48 | $0.48 | — | COM | 452536105 |
| — | ZOGENIX INC | 20,249 | $2.774M | 0.1% | $136.99 | — | — | Call | 98978L905 |
| — | RAPTOR PHARMACEUTICAL CORP | 2,543 | $2.764M | 0.1% | $1086.91 | — | — | Call | 75382F906 |
| — | VERTEX PHARMACEUTICALS INC | 234 | $2.76M | 0.1% | $11794.87 | — | — | Call | 92532F900 |
| HALO | HALOZYME THERAPEUTICS INC | 191,621 | $2.736M | 0.1% | $14.28 | $14.42 | 0.0% | COM | 40637H109 |
| PRQR | PROQR THERAPEUTICS N.V. | 124,380 | $2.721M | 0.1% | $21.88 * | $16.02 | +28.9% | SHS | N71542109 |
| — | NORTHWEST BIOTHERAPEUTICS INC | 3,552 | $2.616M | 0.1% | $736.49 | — | — | Put | 66737P950 |
| — | IGNYTA ORD SHS | 259,032 | $2.577M | 0.1% | $9.95 | $7.78 | — | COM | 451731103 |
| — | CELGENE CORP | 22,225 | $2.562M | 0.1% | $115.28 | $115.28 | — | COM | 151020104 |
| — | FORWARD PHARMA A/S | 90,060 | $2.55M | 0.1% | $28.31 | $28.31 | — | ADR | 34986J105 |
| OPK | OPKO HEALTH INC | 177,551 | $2.516M | 0.1% | $14.17 * | $13.01 | 0.0% | COM | 68375N103 |
| — | T2 BIOSYSTEMS INC | 161,650 | $2.509M | 0.1% | $15.52 | $17.85 | — | COM | 89853L104 |
| — | CYCLACEL PHARMACEUTICALS | 2,760,717 | $2.485M | 0.1% | $0.90 | $0.90 | — | COM | 23254L306 |
| — | PLASMATECH BIOPHARMACEUTICALS | 787,851 | $2.474M | 0.1% | $3.14 | $3.50 | — | COM | 72754H109 |
| — | ARROWHEAD RESEARCH CORP | 3,598 | $2.434M | 0.1% | $676.49 | — | — | Put | 042797959 |
| — | CARDICA ORD SHS | 3,863,723 | $2.433M | 0.1% | $0.63 | $0.78 | — | COM | 14141R101 |
| — | INTRA CELLULAR THERAPIES INC | 100,000 | $2.388M | 0.1% | $23.88 | $23.88 | — | COM | 46116X101 |
| — | ACADIA PHARMACEUTICALS INC | 728 | $2.373M | 0.1% | $3259.62 | — | — | Put | 00404A959 |
| — | ENDO INTERNATIONAL PLC | 25,991 | $2.331M | 0.1% | $89.68 | $89.68 | — | SHS | G30401106 |
| — | LPATH INC. | 939,690 | $2.321M | 0.1% | $2.47 | $3.52 | — | COM | 548910306 |
| — | AGIOS PHARMACEUTICALS INC | 243 | $2.291M | 0.1% | $9427.98 | — | — | Call | 00847X904 |
| — | AGILENT TECHNOLOGIES INC | 540 | $2.244M | 0.1% | $4155.56 | — | — | Put | 00846U959 |
| — | AVALANCHE BIOTECHNOLOGIES INC | 54,943 | $2.226M | 0.1% | $40.51 | $47.07 | — | COM | 05337G107 |
| — | ROCKWELL MEDICAL INC | 2,000 | $2.186M | 0.1% | $1093.00 | — | — | Call | 774374902 |
| — | SUPERCONDUCTOR TECHNOLOGIES INC | 1,516,786 | $2.139M | 0.1% | $1.41 | $1.41 | — | COM | 867931404 |
| PBYI | PUMA BIOTECHNOLOGY INC | 9,044 | $2.135M | 0.1% | $236.07 * | $221.87 | -3.6% | COM | 74587V107 |
| — | THERAPEUTICSMD INC | 3,486 | $2.109M | 0.1% | $604.99 | — | — | Call | 88338N907 |
| — | EPIZYME INC | 111,536 | $2.095M | 0.1% | $18.78 | $18.78 | — | COM | 29428V104 |
| — | MEDICINES CO | 738 | $2.068M | 0.1% | $2802.17 | — | — | Put | 584688955 |
| — | ARROWHEAD RESEARCH CORP | 3,053 | $2.065M | 0.1% | $676.38 | — | — | Call | 042797909 |
| — | CELLECTAR BIOSCIENCES INC | 647,930 | $2.015M | 0.1% | $3.11 | $2.31 | — | COM | 15117F203 |
| — | PROGENICS PHARMACEUTICALS INC | 3,359 | $2.009M | 0.1% | $598.09 | — | — | Put | 743187956 |
| — | PUMA BIOTECHNOLOGY INC | 83 | $1.96M | 0.1% | $23614.46 | — | — | Call | 74587V907 |
| — | AMICUS THERAPEUTICS INC | 1,784 | $1.941M | 0.1% | $1088.00 | — | — | Call | 03152W909 |
| TRUP | TRUPANION INC | 240,000 | $1.92M | 0.1% | $8.00 * | $8.40 | -9.5% | COM | 898202106 |
| — | VANDA PHARMACEUTICALS INC | 2,019 | $1.878M | 0.1% | $930.16 | — | — | Call | 921659908 |
| — | SYNERGY PHARMACEUTICALS | 404,627 | $1.869M | 0.1% | $4.62 | $1.23 | — | *W | 871639118 |
| — | INTERCEPT PHARMACEUTICALS INC | 66 | $1.861M | 0.1% | $28196.97 | — | — | Put | 45845P958 |
| — | INCYTE CORP | 201 | $1.842M | 0.1% | $9164.18 | — | — | Call | 45337C902 |
| — | TRANSITION THERAPEUTICS INC | 268,400 | $1.833M | 0.1% | $6.83 | $6.83 | — | COM | 893716209 |
| — | PTC THERAPEUTICS INC | 300 | $1.826M | 0.1% | $6086.67 | — | — | Call | 69366J900 |
| — | AMICUS THERAPEUTICS INC | 1,651 | $1.796M | 0.1% | $1087.83 | — | — | Put | 03152W959 |
| — | CEMPRA INC | 517 | $1.774M | 0.1% | $3431.33 | — | — | Put | 15130J959 |
| — | CASTLIGHT HEALTH INC | 217,600 | $1.689M | 0.1% | $7.76 | $7.76 | — | CL B | 14862Q100 |
| — | OCERA THERAPEUTICS INC | 354,574 | $1.67M | 0.1% | $4.71 | $6.37 | — | COM | 67552A108 |
| — | REPROS THERAPEUTICS INC | 1,941 | $1.667M | 0.1% | $858.84 | — | — | Put | 76028H959 |
| — | BIOLINERX LTD | 744,401 | $1.571M | 0.1% | $2.11 | $1.62 | — | ADR | 09071M106 |
| — | REDHILL BIOPHARMA LTD | 107,956 | $1.57M | 0.1% | $14.54 | $14.54 | — | ADS | 757468103 |
| — | REPROS THERAPEUTICS INC | 1,753 | $1.506M | 0.1% | $859.10 | — | — | Call | 76028H909 |
| ARDX | ARDELYX INC | 112,174 | $1.468M | 0.1% | $13.09 * | $18.73 | 0.0% | COM | 039697107 |
| CYH | COMMUNITY HEALTH SYSTEMS INC | 27,569 | $1.441M | 0.1% | $52.27 * | $42.78 | -3.2% | COM | 203668108 |
| — | ARIAD PHARMACEUTICALS INC | 173,752 | $1.432M | 0.1% | $8.24 | $7.42 | — | COM | 04033A100 |
| — | ZOSANO PHARMA INC | 141,504 | $1.431M | 0.1% | $10.11 | $10.11 | — | COM | 98979H103 |
| — | AGILENT TECHNOLOGIES INC | 329 | $1.367M | 0.1% | $4155.02 | — | — | Call | 00846U909 |
| — | ALDER BIOPHARMACEUTICALS ORD SHS | 46,800 | $1.351M | 0.1% | $28.87 | $28.87 | — | COM | 014339105 |
| — | CEMPRA INC | 385 | $1.321M | 0.1% | $3431.17 | — | — | Call | 15130J909 |
| — | ARIAD PHARMACEUTICALS INC | 1,599 | $1.318M | 0.1% | $824.27 | — | — | Put | 04033A950 |
| — | SAREPTA THERAPEUTICS INC | 979 | $1.3M | 0.1% | $1327.89 | — | — | Put | 803607950 |
| — | ACADIA PHARMACEUTICALS INC | 398 | $1.297M | 0.1% | $3258.79 | — | — | Call | 00404A909 |
| — | OHR PHARMACEUTICAL INC | 5,069 | $1.288M | 0.1% | $254.09 | — | — | Call | 67778H900 |
| — | APPLIED DNA SCIENCES | 495,700 | $1.284M | 0.1% | $2.59 | $2.59 | — | COM | 03815U201 |
| — | SUNESIS PHARMACEUTICALS INC | 5,097 | $1.249M | 0.1% | $245.05 | — | — | Put | 867328951 |
| — | HEAT BIOLOGICS INC | 194,848 | $1.239M | 0.1% | $6.36 | $6.36 | — | COM | 42237K102 |
| — | FIBROGEN INC | 38,399 | $1.205M | 0.1% | $31.38 | $31.38 | — | COM | 31572Q808 |
| — | GENOCEA BIOSCIENCES INC | 100,000 | $1.186M | 0.0% | $11.86 | $11.86 | — | COM | 372427104 |
| — | HEARTWARE INTERNATIONAL INC | 133 | $1.167M | 0.0% | $8774.44 | — | — | Put | 422368950 |
| — | ELI LILLY & CO | 160 | $1.162M | 0.0% | $7262.50 | — | — | Put | 532457958 |
| — | ACHILLION PHARMACEUTICALS INC | 113,704 | $1.121M | 0.0% | $9.86 | $12.12 | — | COM | 00448Q201 |
| AXGN | AXOGEN ORD SHS | 318,136 | $1.113M | 0.0% | $3.50 | $3.44 | 0.0% | COM | 05463X106 |
| — | EXELIXIS INC | 4,319 | $1.11M | 0.0% | $257.00 | — | — | Call | 30161Q904 |
| — | INSPIREMD INC | 3,372,127 | $1.079M | 0.0% | $0.32 | $0.66 | — | COM | 45779A309 |
| VNDA | VANDA PHARMACEUTICALS INC | 113,165 | $1.052M | 0.0% | $9.30 * | $11.30 | 0.0% | COM | 921659108 |
| — | CTI BIOPHARMA CORP | 5,747 | $1.04M | 0.0% | $180.96 | — | — | Call | 12648L906 |
| — | BIODELIVERY SCIENCES INTERNATIONAL INC | 985 | $1.034M | 0.0% | $1049.75 | — | — | Put | 09060J956 |
| — | SKYSTAR BIO PHARMACEUTICAL CO | 255,435 | $999K | 0.0% | $3.91 | $4.19 | — | COM | 830884300 |
| — | XOMA CORP | 2,736 | $996K | 0.0% | $364.04 | — | — | Call | 98419J907 |
| — | SUNESIS PHARMACEUTICALS INC | 4,053 | $993K | 0.0% | $245.00 | — | — | Call | 867328901 |
| — | COLLABRX INC | 900,000 | $981K | 0.0% | $1.09 | $1.09 | — | COM | 19422J108 |
| — | SYNERGY PHARMACEUTICALS INC | 2,121 | $980K | 0.0% | $462.05 | — | — | Put | 871639958 |
| — | PLURISTEM THERAPEUTICS INC | 3,449 | $966K | 0.0% | $280.08 | — | — | Put | 72940R952 |
| — | NEUROCRINE BIOSCIENCES INC | 241 | $957K | 0.0% | $3970.95 | — | — | Put | 64125C959 |
| — | BIOCRYST PHARMACEUTICALS INC | 1,054 | $952K | 0.0% | $903.23 | — | — | Call | 09058V903 |
| — | KYTHERA BIOPHARMACEUTICALS INC | 188 | $943K | 0.0% | $5015.96 | — | — | Put | 501570955 |
| — | GALENA BIOPHARMA INC | 6,772 | $941K | 0.0% | $138.95 | — | — | Put | 363256958 |
| — | CASI PHARMACEUTICALS | 633,590 | $931K | 0.0% | $1.47 | $1.47 | — | COM | 1475U109 |
| — | MALLINCKRODT PUB LTD | 7,280 | $922K | 0.0% | $126.65 | $126.65 | — | SHS | G5785G107 |
| — | GW PHARMACEUTICALS PLC | 100 | $911K | 0.0% | $9110.00 | — | — | Call | 36197T903 |
| — | EDAP TMS SA | 2,687 | $906K | 0.0% | $337.18 | — | — | Put | 268311957 |
| — | MELA SCIENCES ORD SHS | 343,150 | $882K | 0.0% | $2.57 | $1.26 | — | COM | 55277R308 |
| — | CASTLIGHT HEALTH INC | 1,084 | $841K | 0.0% | $775.83 | — | — | Call | 14862Q900 |
| — | CEL SCI CORP | 2,624,375 | $840K | 0.0% | $0.32 | $0.42 | — | *W | 150837177 |
| — | PLASMATECH BIOPHARMACEUTICALS | 986,175 | $838K | 0.0% | $0.85 | $0.82 | — | *W | 72754H117 |
| — | ATHERSYS INC | 2,857 | $823K | 0.0% | $288.06 | — | — | Put | 04744L956 |
| — | ACELRX PHARMACEUTICALS INC | 208,928 | $806K | 0.0% | $3.86 | $3.86 | — | COM | 00444T100 |
| — | SYNTA PHARMACEUTICALS INC | 399,000 | $794K | 0.0% | $1.99 | $1.99 | — | COM | 87162T206 |
| CLLS | CELLECTIS S A | 22,700 | $785K | 0.0% | $34.58 | $34.58 | — | ADR | 15117K103 |
| — | BIOLASE TECHNOLOGY | 376,000 | $760K | 0.0% | $2.02 | $2.02 | — | COM | 090911108 |
| — | DYAX CORP | 452 | $757K | 0.0% | $1674.78 | — | — | Put | 26746E953 |
| — | RECEPTOS INC | 45 | $742K | 0.0% | $16488.89 | — | — | Put | 756207956 |
| — | NEUROMETRIX INC | 411,034 | $699K | 0.0% | $1.70 | $1.85 | — | COM | 641255302 |
| — | CYMABAY THERAPEUTICS | 100,000 | $692K | 0.0% | $6.92 | $6.84 | — | COM | 23257D103 |
| — | ONCOTHYREON INC | 417,952 | $681K | 0.0% | $1.63 | $1.92 | — | COM | 682324108 |
| — | INSMED INC | 326 | $678K | 0.0% | $2079.75 | — | — | Call | 457669907 |
| — | IDERA PHARMACEUTICALS INC | 1,820 | $675K | 0.0% | $370.88 | — | — | Put | 45168K956 |
| — | SUNESIS PHARMACEUTICALS INC | 274,800 | $673K | 0.0% | $2.45 | $2.45 | — | COM | 867328601 |
| — | ALKERMES PLC | 102 | $622K | 0.0% | $6098.04 | — | — | Call | G01767905 |
| — | CELSION CORPORATION | 230,699 | $616K | 0.0% | $2.67 | $2.58 | — | COM | 15117N404 |
| — | NUVASIVE INC | 134 | $616K | 0.0% | $4597.01 | — | — | Call | 670704905 |
| — | MEDICINES CO | 218 | $611K | 0.0% | $2802.75 | — | — | Call | 584688905 |
| — | CTI BIOPHARMA CORP | 331,627 | $600K | 0.0% | $1.81 | $2.22 | — | COM | 12648L106 |
| — | ACELRX PHARMACEUTICALS INC | 1,516 | $585K | 0.0% | $385.88 | — | — | Call | 00444T900 |
| — | AGIOS PHARMACEUTICALS INC | 62 | $585K | 0.0% | $9435.48 | — | — | Put | 00847X954 |
| — | KITE PHARMA INC | 98 | $565K | 0.0% | $5765.31 | — | — | Put | 49803L959 |
| — | MOBILEYE N.V. | 131 | $551K | 0.0% | $4206.11 | — | — | Call | N51488907 |
| — | MEI PHARMA INC. | 296,491 | $531K | 0.0% | $1.79 | $5.18 | — | COM | 55279B202 |
| — | IMMUNOMEDICS INC | 137,751 | $528K | 0.0% | $3.83 | $3.83 | — | COM | 452907108 |
| — | SYNAGEVA BIOPHARMA CORP | 54 | $527K | 0.0% | $9759.26 | — | — | Put | 87159A953 |
| — | CELLECTAR BIOSCIENCES INC | 660,685 | $515K | 0.0% | $0.78 | $0.61 | — | *W | 15117F112 |
| — | THERAPEUTICSMD INC | 83,274 | $504K | 0.0% | $6.05 | $4.45 | — | COM | 88338N107 |
| — | ARROWHEAD RESEARCH CORP | 74,204 | $502K | 0.0% | $6.77 | $6.77 | — | COM | 042797209 |
| — | OHR PHARMACEUTICAL INC | 1,962 | $498K | 0.0% | $253.82 | — | — | Put | 67778H950 |
| — | OHR PHARMACEUTICAL INC | 195,240 | $496K | 0.0% | $2.54 | $4.33 | — | COM | 67778H200 |
| — | PLURISTEM THERAPEUTICS INC | 175,000 | $490K | 0.0% | $2.80 | $2.80 | — | COM | 72940R102 |
| — | REVANCE THERAPEUTICS INC | 23,065 | $478K | 0.0% | $20.72 | $29.62 | — | COM | 761330109 |
| ESPR | ESPERION THERAPEUTICS INC | 5,000 | $463K | 0.0% | $92.60 * | $64.53 | 0.0% | COM | 29664W105 |
| — | IDERA PHARMACEUTICALS INC | 118,000 | $438K | 0.0% | $3.71 | $3.71 | — | COM | 45168K306 |
| — | INFINITY PHARMACEUTICALS INC | 300 | $419K | 0.0% | $1396.67 | — | — | Put | 45665G953 |
| CERS | CERUS ORD SHS | 100,000 | $417K | 0.0% | $4.17 * | $5.12 | 0.0% | COM | 157085101 |
| — | ISIS PHARMACEUTICALS INC | 65 | $414K | 0.0% | $6369.23 | — | — | Put | 464330959 |
| — | INTELLIPHARMACEUTICS INTERNATIONAL INC | 1,418 | $413K | 0.0% | $291.26 | — | — | Put | 458173951 |
| — | INTREXON CORP | 90 | $408K | 0.0% | $4533.33 | — | — | Put | 46122T952 |
| — | BIODELIVERY SCIENCES INTERNATIONAL INC | 37,300 | $392K | 0.0% | $10.51 | $10.51 | — | COM | 09060J106 |
| — | NANOSPHERE ORD SHS | 1,652,344 | $383K | 0.0% | $0.23 | $0.39 | — | COM | 63009F105 |
| — | OCULUS INNOVATIVE SCIENCES INC | 418,792 | $352K | 0.0% | $0.84 | $0.84 | — | COM | 67575P207 |
| — | AVALANCHE BIOTECHNOLOGIES INC | 81 | $328K | 0.0% | $4049.38 | — | — | Call | 05337G907 |
| — | BIOCRYST PHARMACEUTICALS INC | 358 | $323K | 0.0% | $902.23 | — | — | Put | 09058V953 |
| AGIO | AGIOS PHARMACEUTICALS INC | 3,163 | $298K | 0.0% | $94.21 * | $112.06 | 0.0% | COM | 00847X104 |
| ACHC | ACADIA PHARMACEUTICALS INC | 9,074 | $296K | 0.0% | $32.62 * | $64.13 | 0.0% | COM | 00404A109 |
| — | SYNAGEVA BIOPHARMA CORP | 3,013 | $294K | 0.0% | $97.58 | $97.58 | — | COM | 87159A103 |
| — | KERYX BIOPHARMACEUTICALS INC | 230 | $293K | 0.0% | $1273.91 | — | — | Put | 492515951 |
| SRPT | SAREPTA THERAPEUTICS INC | 21,943 | $291K | 0.0% | $13.26 | $36.12 | -63.1% | COM | 803607100 |
| — | HALOZYME THERAPEUTICS INC | 202 | $288K | 0.0% | $1425.74 | — | — | Put | 40637H959 |
| — | BELLEROPHON THERAPEUTICS INC | 30,000 | $275K | 0.0% | $9.17 | $9.17 | — | COM | 078771102 |
| — | HISTOGENICS CORP | 27,505 | $275K | 0.0% | $10.00 | $11.00 | — | COM | 43358V109 |
| — | OMEROS CORP | 120 | $264K | 0.0% | $2200.00 | — | — | Put | 682143952 |
| — | BIODEL INC | 217,500 | $259K | 0.0% | $1.19 | $1.72 | — | COM | 09064M204 |
| — | PHARMACYCLICS INC | 10 | $256K | 0.0% | $25600.00 | — | — | Put | 716933956 |
| — | MEI PHARMA INC. | 1,409 | $252K | 0.0% | $178.85 | — | — | Call | 55279B902 |
| — | CYTOSORBENTS CORP | 168 | $222K | 0.0% | $1321.43 | — | — | Put | 23283X956 |
| — | RECRO PHARMA INC | 24,391 | $221K | 0.0% | $9.06 | $3.94 | — | COM | 75629F109 |
| — | TONIX PHARMACEUTICALS CO. | 600,000 | $192K | 0.0% | $0.32 | $0.32 | — | COM | 890260201 |
| — | APPLIED DNA SCIENCES EQUITY WARRANTS | 186,095 | $190K | 0.0% | $1.02 | $1.02 | — | *W | 03815U110 |
| — | KERYX BIOPHARMACEUTICALS INC | 14,758 | $188K | 0.0% | $12.74 | $12.74 | — | COM | 492515101 |
| — | CELSION CORPORATION | 546 | $146K | 0.0% | $267.40 | — | — | Put | 15117N954 |
| — | FOAMIX PHARMACEUTICALS | 15,300 | $142K | 0.0% | $9.28 | $5.45 | — | SHS | M46135105 |
| — | CONATUS PHARMACEUTICALS INC | 197 | $140K | 0.0% | $710.66 | — | — | Call | 20600T908 |
| — | ACELRX PHARMACEUTICALS INC | 310 | $120K | 0.0% | $387.10 | — | — | Put | 00444T950 |
| — | ARCA BIOPHARMA ORD SHS | 140,317 | $112K | 0.0% | $0.80 | $0.80 | — | COM | 00211Y209 |
| — | TROVAGENE INC | 15,000 | $102K | 0.0% | $6.80 | $5.75 | — | COM | 897238309 |
| — | ATHERSYS INC | 345 | $99,000 | 0.0% | $286.96 | — | — | Call | 04744L906 |
| — | XENOPORT INC | 137 | $98,000 | 0.0% | $715.33 | — | — | Call | 98411C900 |
| — | DARA BIOSCIENCES | 117,370 | $86,000 | 0.0% | $0.73 | $0.88 | — | COM | 23703P304 |
| — | CYTRX CORP | 170 | $57,000 | 0.0% | $335.29 | — | — | Put | 232828959 |
| — | EXELIXIS INC | 220 | $57,000 | 0.0% | $259.09 | — | — | Put | 30161Q954 |
| — | APRICUS BIOSCIENCES INC | 338 | $57,000 | 0.0% | $168.64 | — | — | Put | 03832V959 |
| — | INTELLIPHARMACEUTICS INTERNATIONAL INC | 19,900 | $56,000 | 0.0% | $2.81 | $2.28 | — | COM | 458173101 |
| — | CYTORI THERAPEUTICS INC | 265 | $31,000 | 0.0% | $116.98 | — | — | Put | 23283K955 |
| — | BIODEL INC | 182 | $22,000 | 0.0% | $120.88 | — | — | Put | 09064M954 |
| — | SUPERCONDUCTOR TECHNOLOGIES INC | 135 | $19,000 | 0.0% | $140.74 | — | — | Put | 867931954 |