Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
—	ELI LILLY & CO	26,671	$223M	8.1%	$8348.99	—	—	Call	532457908
—	SPDR S&P 500 ETF TRUST	10,000	$206M	7.5%	$20585.20	—	—	Put	78462F953
—	ISHARES RUSSELL 2000 ETF	14,637	$183M	6.7%	$12485.89	—	—	Put	464287955
—	BIOGEN IDEC INC	4,345	$176M	6.4%	$40394.02	—	—	Call	09062X903
—	GILEAD SCIENCES INC	12,877	$151M	5.5%	$11708.01	—	—	Call	375558903
—	MERCK & CO INC	10,000	$56.93M	2.1%	$5693.00	—	—	Call	58933Y905
—	ABBVIE INC	8,015	$53.85M	2.0%	$6719.03	—	—	Call	00287Y909
—	BIOMARIN PHARMACEUTICAL INC	3,796	$51.92M	1.9%	$13678.08	—	—	Call	09061G901
—	ALNYLAM PHARMACEUTICALS INC	4,157	$49.83M	1.8%	$11987.01	—	—	Call	02043Q907
—	REGENERON PHARMACEUTICALS INC	907	$46.27M	1.7%	$51013.23	—	—	Put	75886F957
—	BIOGEN IDEC INC	1,110	$44.84M	1.6%	$40393.69	—	—	Put	09062X953
—	HEALTH CARE SELECT SECTOR SPDR	5,998	$44.64M	1.6%	$7441.98	—	—	Put	81369Y959
—	ISHARES 20+ YEAR TREASURY BOND ETF	3,500	$41.11M	1.5%	$11746.00	—	—	Put	464287952
—	TENET HEALTHCARE CORP	6,148	$35.59M	1.3%	$5788.06	—	—	Put	88033G957
—	GILEAD SCIENCES INC	2,935	$34.36M	1.3%	$11708.01	—	—	Put	375558953
—	TEVA PHARMACEUTICAL INDUSTRIES LTD	5,210	$30.79M	1.1%	$5909.98	—	—	Put	881624959
—	MERCK & CO INC	5,234	$29.8M	1.1%	$5692.97	—	—	Put	58933Y955
TLT	ISHARES 20+ YEAR TREASURY BOND ETF	246,000	$28.89M	1.1%	$117.46	$120.44	—	ETF	464287432
—	GW PHARMACEUTICALS PLC	2,062	$25.33M	0.9%	$12284.19	—	—	Put	36197T953
—	ABBVIE INC	3,704	$24.89M	0.9%	$6718.95	—	—	Put	00287Y959
—	EXXON MOBIL	2,933	$24.4M	0.9%	$8320.15	—	—	Put	30231G952
—	BLUEBIRD BIO INC	1,429	$24.06M	0.9%	$16836.95	—	—	Call	09609G900
—	BIOMARIN PHARMACEUTICAL INC	1,652	$22.6M	0.8%	$13677.97	—	—	Put	09061G951
—	MYLAN N.V.	3,256	$22.09M	0.8%	$6785.93	—	—	Put	N59465959
—	MOBILEYE N.V. REG.	4,122	$21.92M	0.8%	$5317.08	—	—	Put	N51488957
—	SAREPTA THERAPEUTICS INC	6,723	$20.46M	0.7%	$3042.99	—	—	Call	803607900
—	BRISTOL MYERS SQUIBB CO	3,073	$20.45M	0.7%	$6654.08	—	—	Call	110122908
—	ELI LILLY & CO	2,428	$20.27M	0.7%	$8348.85	—	—	Put	532457958
—	INTEROIL CORP	3,356	$20.2M	0.7%	$6019.96	—	—	Put	460951956
—	MYLAN N.V.	2,777	$18.84M	0.7%	$6786.10	—	—	Call	N59465909
MRK	MERCK & CO INC	314,285	$17.89M	0.7%	$56.93 *	$39.78	+1.1%	COM	58933Y105
—	PIONEER NATURAL RESOURCES CO	1,236	$17.14M	0.6%	$13868.93	—	—	Put	723787957
—	PERRIGO CO	925	$17.1M	0.6%	$18483.24	—	—	Call	G97822903
—	SPDR S&P BIOTECH ETF	664	$16.75M	0.6%	$25224.40	—	—	Put	78464A950
—	EDWARDS LIFESCIENCES CORP.	1,167	$16.62M	0.6%	$14243.36	—	—	Put	28176E958
—	REGENERON PHARMACEUTICALS INC	304	$15.51M	0.6%	$51013.16	—	—	Call	75886F907
—	GREAT BASIN SCIENTIFIC UNITS	856,163	$15.28M	0.6%	$17.85	$14.60	—	UNIT	39013L205
—	BLUEBIRD BIO INC	889	$14.97M	0.5%	$16836.90	—	—	Put	09609G950
XOM	EXXON MOBIL	178,310	$14.84M	0.5%	$83.20 *	$54.30	0.0%	COM	30231G102
—	ALEXION PHARMACEUTICALS INC	804	$14.53M	0.5%	$18077.11	—	—	Put	015351959
—	NEWLINK GENETICS CORP	3,123	$13.83M	0.5%	$4427.15	—	—	Call	651511907
—	MOBILEYE N.V. REG.	2,546	$13.54M	0.5%	$5316.97	—	—	Call	N51488907
—	RAPTOR PHARMACEUTICAL CORP	8,571	$13.53M	0.5%	$1579.05	—	—	Call	75382F906
—	MEDICINES CO 1.375%	11,213,000	$13.41M	0.5%	$1.20	$1.19	—	DBCV	584688AC9
—	REGULUS THERAPEUTIC INC	11,811	$12.95M	0.5%	$1096.01	—	—	Call	75915K901
—	MEDICINES CO	4,435	$12.69M	0.5%	$2861.10	—	—	Call	584688905
—	MANNKIND CORP	21,444	$12.2M	0.4%	$569.02	—	—	Put	56400P951
—	TENAX THERAPEUTICS INC	2,151	$12.17M	0.4%	$5656.90	—	—	Call	88032L900
—	OPKO HEALTH INC	7,496	$12.05M	0.4%	$1608.06	—	—	Put	68375N953
—	ANADARKO PETROLEUM CORP	1,523	$11.89M	0.4%	$7806.30	—	—	Put	032511957
—	MALLINCKRODT PLC	980	$11.54M	0.4%	$11772.45	—	—	Put	G5785G957
—	THORATEC CORP	2,486	$11.08M	0.4%	$4456.96	—	—	Call	885175907
—	DYNAVAX TECHNOLOGIES CORP	4,533	$10.62M	0.4%	$2342.60	—	—	Call	268158901
—	PIONEER NATURAL RESOURCES CO	76,273	$10.58M	0.4%	$138.69	$138.69	—	COM	723787107
—	EXACT SCIENCES CORP	3,491	$10.38M	0.4%	$2973.93	—	—	Put	30063P955
—	CELLDEX THERAPEUTICS INC	4,081	$10.29M	0.4%	$2521.93	—	—	Call	15117B903
—	OVASCIENCE INC	355,000	$10.27M	0.4%	$28.93	$2.26	—	COM	69014Q101
—	HERON THERAPEUTICS INC	3,285	$10.24M	0.4%	$3115.98	—	—	Call	427746902
—	SANGAMO BIOSCIENCES INC	9,121	$10.12M	0.4%	$1108.98	—	—	Call	800677906
—	ZOGENIX INC	5,963,095	$10.02M	0.4%	$1.68	$1.37	—	COM	98978L105
—	TENAX THERAPEUTICS INC	2,686,247	$9.913M	0.4%	$3.69	$3.82	—	COM	88032L100
—	RECEPTOS INC	505	$9.598M	0.4%	$19005.94	—	—	Call	756207906
—	HUMANA INC	500	$9.564M	0.3%	$19128.00	—	—	Call	444859902
—	MANNKIND CORP	16,456	$9.363M	0.3%	$568.97	—	—	Call	56400P901
—	UNITED THERAPEUTICS CORP	536	$9.324M	0.3%	$17395.52	—	—	Call	91307C902
—	INTEROIL CORP	153,144	$9.219M	0.3%	$60.20	$58.17	—	COM	460951106
—	HALOZYME THERAPEUTICS INC	4,014	$9.064M	0.3%	$2258.10	—	—	Call	40637H909
—	EXACT SCIENCES CORP	3,007	$8.943M	0.3%	$2974.06	—	—	Call	30063P905
—	PLURISTEM THERAPEUTICS INC	3,261,642	$8.219M	0.3%	$2.52	$2.53	—	COM	72940R102
—	BLUEPRINT MEDICINES ORD SHS	301,804	$7.995M	0.3%	$26.49	$26.49	—	COM	09627Y109
—	BIOMARIN PHARMACEUTICAL 0.75%	5,000,000	$7.768M	0.3%	$1.55	$1.49	—	NOTE	09061GAE1
—	NOVAVAX INC	6,899	$7.685M	0.3%	$1113.93	—	—	Put	670002954
—	INOVIO PHARMACEUTICALS	906,000	$7.393M	0.3%	$8.16	$8.16	—	COM	45773H201
—	OPKO HEALTH INC	4,500	$7.236M	0.3%	$1608.00	—	—	Call	68375N903
—	RECEPTOS INC	379	$7.203M	0.3%	$19005.28	—	—	Put	756207956
—	ANADARKO PETROLEUM CORP	90,971	$7.101M	0.3%	$78.06	$78.06	—	COM	032511107
—	NORTHWEST BIOTHERAPEUTICS INC	6,862	$6.814M	0.2%	$993.00	—	—	Put	66737P950
—	ISIS PHARMACEUTICALS INC	1,159	$6.67M	0.2%	$5754.96	—	—	Call	464330909
—	NEUROCRINE BIOSCIENCES INC	1,383	$6.605M	0.2%	$4775.85	—	—	Call	64125C909
—	NIVALIS THERAPEUTICS	430,041	$6.515M	0.2%	$15.15	$15.15	—	COM	65481J109
—	OVASCIENCE INC	2,200	$6.365M	0.2%	$2893.18	—	—	Call	69014Q901
—	LIPOCINE INC	725,000	$6.221M	0.2%	$8.58	$8.58	—	COM	53630X104
—	EXELIXIS INC 4.25%	6,900,000	$6.197M	0.2%	$0.90	$0.81	—	NOTE	30161QAC8
—	NEWLINK GENETICS CORP	1,397	$6.185M	0.2%	$4427.34	—	—	Put	651511957
—	ACHILLION PHARMACEUTICALS INC	6,916	$6.128M	0.2%	$886.06	—	—	Call	00448Q901
—	SPARK THERAPEUTICS INC	898	$5.412M	0.2%	$6026.73	—	—	Call	84652J903
—	NOVAVAX INC	4,700	$5.236M	0.2%	$1114.04	—	—	Call	670002904
—	AFFILIATED MANAGERS GROUP INC	238	$5.203M	0.2%	$21861.34	—	—	Put	008252958
—	BELLICUM PHARMACEUTICALS INC	241,039	$5.127M	0.2%	$21.27	$22.97	—	COM	079481107
—	SAREPTA THERAPEUTICS INC	1,677	$5.103M	0.2%	$3042.93	—	—	Put	803607950
—	THERAPEUTICSMD INC	6,457	$5.075M	0.2%	$785.97	—	—	Call	88338N907
—	TRANSENTERIX INC	1,685,800	$5.057M	0.2%	$3.00	$3.00	—	COM	89366M201
—	BARCLAYS BANK IPATH SandP 500 VIX	450,000	$5.031M	0.2%	$11.18	$11.18	—	IPATH	06740C519
—	BIOCRYST PHARMACEUTICALS INC	3,319	$4.955M	0.2%	$1492.92	—	—	Put	09058V953
—	ACADIA PHARMACEUTICALS INC	1,173	$4.913M	0.2%	$4188.41	—	—	Call	004225908
—	DERMIRA ORD SHS	276,994	$4.861M	0.2%	$17.55	$18.06	—	COM	24983L104
—	ONCOSEC MEDICAL INC	767,733	$4.86M	0.2%	$6.33	$6.33	—	COM	68234L207
—	ENDO INTERNATIONAL PLC	601	$4.787M	0.2%	$7965.06	—	—	Call	G30401906
—	IPATH S&P 500 VIX MID-TERM FUTURES ETN	4,270	$4.774M	0.2%	$1118.03	—	—	Call	06740C909
—	MALLINCKRODT PLC	40,539	$4.772M	0.2%	$117.71	$119.32	—	SHS	G5785G107
—	HCA HOLDINGS INC	524	$4.754M	0.2%	$9072.52	—	—	Call	40412C901
—	ALNYLAM PHARMACEUTICALS INC	395	$4.735M	0.2%	$11987.34	—	—	Put	02043Q957
—	SPARK THERAPEUTICS INC	759	$4.574M	0.2%	$6026.35	—	—	Put	84652J953
—	ANADARKO PETROLEUM CORP	580	$4.527M	0.2%	$7805.17	—	—	Call	032511907
—	COMMUNITY HEALTH SYSTEMS INC	707	$4.452M	0.2%	$6297.03	—	—	Put	203668958
—	CELLDEX THERAPEUTICS INC	1,762	$4.444M	0.2%	$2522.13	—	—	Put	15117B953
—	ZOGENIX INC	25,485	$4.281M	0.2%	$167.98	—	—	Call	98978L905
—	CIDARA THERAPEUTICS INC	294,982	$4.136M	0.2%	$14.02	$14.02	—	COM	171757107
—	VIGGLE ORD SHS	1,976,911	$4.053M	0.1%	$2.05	$2.05	—	COM	92672V204
—	IPATH S&P 500 VIX SHORT-TERM FUTURES ETN	2,000	$4.028M	0.1%	$2014.00	—	—	Call	06742E901
LAB	FLUIDIGM CORP	165,385	$4.002M	0.1%	$24.20 *	$31.56	0.0%	COM	34385P108
—	MOBILEYE N.V. REG.	73,832	$3.926M	0.1%	$53.17	$42.03	—	SHS	N51488117
—	LION BIOTECHNOLOGIES INC	427,244	$3.918M	0.1%	$9.17	$11.75	—	COM	53619R102
—	REGULUS THERAPEUTIC INC	344,667	$3.778M	0.1%	$10.96	$14.81	—	COM	75915K101
—	AGIOS PHARMACEUTICALS INC	336	$3.734M	0.1%	$11113.10	—	—	Put	00847X954
—	INTRA-CELLULAR THERAPIES INC	1,141	$3.645M	0.1%	$3194.57	—	—	Call	46116X901
—	TEKMIRA PHARMACEUTICALS CORP	305,351	$3.621M	0.1%	$11.86	$14.99	—	COM	87911B209
OPK	OPKO HEALTH INC	223,126	$3.588M	0.1%	$16.08 *	$13.53	+14.9%	COM	68375N103
SGMO	SANGAMO BIOSCIENCES INC	323,390	$3.586M	0.1%	$11.09 *	$15.66	-17.7%	COM	800677106
—	CHINA MOBILE LIMITED ADR	559	$3.583M	0.1%	$6409.66	—	—	Call	16941M909
—	ZS PHARMA INC	640	$3.353M	0.1%	$5239.06	—	—	Put	98979G955
—	QUEST RESOURCE HOLDING CORP	3,068,192	$3.314M	0.1%	$1.08	$1.65	—	COM	74836W104
—	PUMA BIOTECHNOLOGY INC	283	$3.304M	0.1%	$11674.91	—	—	Put	74587V957
—	ESPERION THERAPEUTICS INC	399	$3.262M	0.1%	$8175.44	—	—	Put	29664W955
NWBO	NORTHWEST BIOTHERAPEUTICS INC	328,400	$3.261M	0.1%	$9.93 *	$8.76	0.0%	COM	66737P600
—	AVALANCHE BIOTECHNOLOGIES INC	197,800	$3.212M	0.1%	$16.24	$24.80	—	COM	05337G107
—	BARCLAYS BANK IPATH SandP 500 VIX	158,000	$3.182M	0.1%	$20.14	$20.14	—	IPATH	06742E711
—	CESCA THERAPEUTICS INC.	3,706,516	$3.151M	0.1%	$0.85	$1.37	—	COM	157131103
—	CYTORI THERAPEUTICS INC	5,364,100	$2.988M	0.1%	$0.56	$0.56	—	COM	23283K105
—	ENDO INTERNATIONAL PLC	37,358	$2.976M	0.1%	$79.66	$86.64	—	SHS	G30401106
—	PTC THERAPEUTICS INC	611	$2.941M	0.1%	$4813.42	—	—	Call	69366J900
—	HCA HOLDINGS INC	324	$2.939M	0.1%	$9070.99	—	—	Put	40412C951
—	RICEBRAN TECHNOLOGIES ORD SHS	845,857	$2.876M	0.1%	$3.40	$4.09	—	COM	762831204
—	ALEXION PHARMACEUTICALS INC	15,895	$2.873M	0.1%	$180.75	$180.75	—	COM	015351109
—	FEI CO	340	$2.82M	0.1%	$8294.12	—	—	Call	30241L909
ASND	ASCENDIS PHARMA ADR	160,000	$2.813M	0.1%	$17.58	$17.35	—	ADR	04351P101
—	IMMUNOCELLULAR THERAPEUTICS	5,871,816	$2.771M	0.1%	$0.47	$0.48	—	COM	452536105
—	CEMPRA INC	79,553	$2.733M	0.1%	$34.35	$34.31	—	COM	15130J109
—	BRAINSTORM CELL THERAPEUTICS	743,647	$2.685M	0.1%	$3.61	$4.45	—	COM	10501E201
—	APPLIED GENETIC TECHNOLOGIES CORP	172,427	$2.645M	0.1%	$15.34	$19.39	—	COM	03820J100
—	ANACOR PHARMACEUTICALS INC	339	$2.625M	0.1%	$7743.36	—	—	Call	032420901
—	SYNERGY PHARMACEUTICALS INC	3,136	$2.603M	0.1%	$830.04	—	—	Put	871639958
—	BIOCRYST PHARMACEUTICALS INC	1,722	$2.571M	0.1%	$1493.03	—	—	Call	09058V903
—	DYNAVAX TECHNOLOGIES CORP	1,096	$2.567M	0.1%	$2342.15	—	—	Put	268158951
LXRX	LEXICON PHARMACEUTICALS INC	318,775	$2.566M	0.1%	$8.05 *	$7.34	0.0%	COM	528872302
EW	EDWARDS LIFESCIENCES CORP.	17,815	$2.537M	0.1%	$142.41 *	$22.57	0.0%	COM	28176E108
—	PROGENICS PHARMACEUTICALS INC	3,369	$2.513M	0.1%	$745.92	—	—	Put	743187956
—	ANI PHARMACEUTICALS INC	400	$2.482M	0.1%	$6205.00	—	—	Call	00182C903
—	IGNYTA INC.	164,100	$2.476M	0.1%	$15.09	$7.78	—	COM	451731103
—	NEUROMETRIX EQUITY WARRANTS	12,182,926	$2.437M	0.1%	$0.20	$0.20	—	*W	641255138
—	XOMA CORP	6,056	$2.35M	0.1%	$388.04	—	—	Call	98419J907
—	ANTERO MIDSTREAM PARTNERS LP	812	$2.326M	0.1%	$2864.53	—	—	Call	03673L903
—	GENOCEA BIOSCIENCES INC	168,580	$2.315M	0.1%	$13.73	$12.62	—	COM	372427104
—	FIBROGEN INC	98,100	$2.305M	0.1%	$23.50	$26.58	—	COM	31572Q808
—	MEDICINES CO	803	$2.297M	0.1%	$2860.52	—	—	Put	584688955
—	GW PHARMACEUTICALS PLC	18,405	$2.261M	0.1%	$122.85	$91.12	—	ADS	36197T103
—	PUMA BIOTECHNOLOGY INC	193	$2.253M	0.1%	$11673.58	—	—	Call	74587V907
—	XTL BIOPHARMACEUTICALS LTD	1,150,981	$2.21M	0.1%	$1.92	$2.30	—	ADR	98386D208
SRPT	SAREPTA THERAPEUTICS INC	71,600	$2.179M	0.1%	$30.43 *	$25.25	-19.0%	COM	803607100
—	INFINITY PHARMACEUTICALS INC	1,971	$2.158M	0.1%	$1094.88	—	—	Call	45665G903
OCUL	OCULAR THERAPEUTIX ORD SHS	100,000	$2.103M	0.1%	$21.03 *	$24.78	0.0%	COM	67576A100
ALDX	ALDEYRA THERAPEUTICS INC	266,953	$2.072M	0.1%	$7.76 *	$8.62	0.0%	COM	01438T106
—	CARDICA INC	4,134,400	$2.063M	0.1%	$0.50	$0.77	—	COM	14141R101
—	REVANCE THERAPEUTICS INC	614	$1.964M	0.1%	$3198.70	—	—	Call	761330909
—	INFRAREIT INC	690	$1.957M	0.1%	$2836.23	—	—	Call	45685L900
—	REPROS THERAPEUTICS INC	2,709	$1.937M	0.1%	$715.02	—	—	Put	76028H959
—	CONATUS PHARMACEUTICALS INC	373,493	$1.923M	0.1%	$5.15	$5.15	—	COM	20600T108
—	HALOZYME THERAPEUTICS INC	840	$1.897M	0.1%	$2258.33	—	—	Put	40637H959
—	VALEANT PHARMACEUTICALS INTERNATIONAL INC	85	$1.888M	0.1%	$22211.76	—	—	Put	91911K952
—	OCATA THERAPEUTICS ORD SHS	352,544	$1.858M	0.1%	$5.27	$5.27	—	COM	67457L100
—	PROGENICS PHARMACEUTICALS INC	247,706	$1.848M	0.1%	$7.46	$6.14	—	COM	743187106
—	GW PHARMACEUTICALS PLC	150	$1.843M	0.1%	$12286.67	—	—	Call	36197T903
—	SAGE THERAPEUTICS INC	25,080	$1.831M	0.1%	$73.01	$73.01	—	COM	78667J108
—	FOAMIX PHARMACEUTICALS	176,000	$1.804M	0.1%	$10.25	$9.83	—	SHS	M46135105
—	ACADIA PHARMACEUTICALS INC	430	$1.801M	0.1%	$4188.37	—	—	Put	004225958
—	ENDO INTERNATIONAL PLC	224	$1.784M	0.1%	$7964.29	—	—	Put	G30401956
—	AMICUS THERAPEUTICS INC	1,257	$1.779M	0.1%	$1415.27	—	—	Put	03152W959
—	SUPERCONDUCTOR TECHNOLOGIES INC.	1,692,586	$1.777M	0.1%	$1.05	$1.37	—	COM	867931404
REEMF	RARE ELEMENT RESOURCES LTD	4,212,092	$1.77M	0.1%	$0.42 *	$0.63	0.0%	COM	75381M102
PVCT	PROVECTUS BIOPHARMACEUTICALS INC.	3,275,929	$1.769M	0.1%	$0.54 *	$0.82	0.0%	COM	74373P108
—	CASTLIGHT HEALTH INC	2,149	$1.749M	0.1%	$813.87	—	—	Call	14862Q900
—	CEMPRA INC	501	$1.721M	0.1%	$3435.13	—	—	Call	15130J909
—	TOKAI PHARMACEUTICALS INC.	128,041	$1.703M	0.1%	$13.30	$13.30	—	COM	88907J107
—	CYCLACEL PHARMACEUTICALS INC	2,099,851	$1.68M	0.1%	$0.80	$0.90	—	COM	23254L306
—	VERTEX PHARMACEUTICALS INC	135	$1.667M	0.1%	$12348.15	—	—	Call	92532F900
—	CELLECTAR BIOSCIENCES INC	570,380	$1.643M	0.1%	$2.88	$2.31	—	COM	15117F203
—	DYNAVAX TECHNOLOGIES CORP	70,000	$1.64M	0.1%	$23.43	$23.43	—	COM	268158201
—	REPROS THERAPEUTICS INC	2,277	$1.628M	0.1%	$714.98	—	—	Call	76028H909
—	RAPTOR PHARMACEUTICAL CORP	1,030	$1.626M	0.1%	$1578.64	—	—	Put	75382F956
—	NUVASIVE INC	340	$1.611M	0.1%	$4738.24	—	—	Call	670704905
—	COMMUNITY HEALTH SYSTEMS INC	255	$1.606M	0.1%	$6298.04	—	—	Call	203668908
—	INTREXON CORP	324	$1.581M	0.1%	$4879.63	—	—	Call	46122T902
—	T2 BIOSYSTEMS INC	97,208	$1.578M	0.1%	$16.23	$17.85	—	COM	89853L104
—	SUNESIS PHARMACEUTICALS INC	5,097	$1.534M	0.1%	$300.96	—	—	Put	867328951
—	PEREGRINE PHARMACEUTICALS INC	67,578	$1.533M	0.1%	$22.68	$22.68	—	COM	713661304
—	MALLINCKRODT PLC	127	$1.495M	0.1%	$11771.65	—	—	Call	G5785G907
—	CELSION CORPORATION	633,396	$1.488M	0.1%	$2.35	$2.43	—	COM	15117N404
—	OCERA THERAPEUTICS ORD SHS	379,574	$1.442M	0.1%	$3.80	$6.20	—	COM	67552A108
—	MEDGENICS EQUITY WARRANTS	1,439,840	$1.44M	0.1%	$1.00	$1.00	—	*W	58436Q112
—	PARATEK PHARMACEUTICALS INC	55,613	$1.433M	0.1%	$25.77	$25.77	—	COM	699374302
—	ADVAXIS INC	697	$1.417M	0.1%	$2033.00	—	—	Put	007624958
PRQR	PROQR THERAPEUTICS ORD SHS	83,000	$1.384M	0.1%	$16.67 *	$16.02	+17.6%	SHS	N71542109
—	ARIAD PHARMACEUTICALS INC	165,270	$1.367M	0.0%	$8.27	$7.42	—	COM	04033A100
—	FORWARD PHARMA A/S	35,050	$1.334M	0.0%	$38.06	$28.31	—	ADR	34986J105
TRUP	TRUPANION INC	161,012	$1.327M	0.0%	$8.24	$8.40	-2.4%	COM	898202106
—	ARIAD PHARMACEUTICALS INC	1,599	$1.322M	0.0%	$826.77	—	—	Put	04033A950
—	CAPRICOR THERAPEUTICS INC	258,400	$1.305M	0.0%	$5.05	$5.05	—	COM	14070B101
—	ZOSANO PHARMA ORD SHS	173,225	$1.256M	0.0%	$7.25	$9.59	—	COM	98979H103
ORMP	ORAMED PHARMACEUTICALS	212,017	$1.204M	0.0%	$5.68 *	$6.38	0.0%	COM	68403P203
—	BIODEL INC	1,149,394	$1.184M	0.0%	$1.03	$1.16	—	COM	09064M204
—	TESARO INC	200	$1.176M	0.0%	$5880.00	—	—	Put	881569957
—	GALENA BIOPHARMA INC	6,832	$1.161M	0.0%	$169.94	—	—	Put	363256958
—	NEUROCRINE BIOSCIENCES INC	241	$1.151M	0.0%	$4775.93	—	—	Put	64125C959
—	STEMCELLS INC	2,117,234	$1.144M	0.0%	$0.54	$1.21	—	COM	85857R204
—	CTI BIOPHARMA CORP	5,747	$1.121M	0.0%	$195.06	—	—	Call	12648L906
—	SYNERGY PHARMACEUTICALS EQUITY WARRANTS	296,606	$1.112M	0.0%	$3.75	$1.23	—	*W	871639118
—	ORGANOVO HOLDINGS INC.	289,610	$1.092M	0.0%	$3.77	$3.77	—	COM	68620A104
—	FLUIDIGM CORP	445	$1.077M	0.0%	$2420.22	—	—	Call	34385P908
—	UNIQURE B.V.	382	$1.031M	0.0%	$2698.95	—	—	Call	N90064901
—	ZAFGEN INC	296	$1.025M	0.0%	$3462.84	—	—	Put	98885E953
—	ENTEROMEDICS INC	1,650,232	$1.023M	0.0%	$0.62	$0.62	—	COM	29365M208
—	PLURISTEM THERAPEUTICS INC	3,953	$996K	0.0%	$251.96	—	—	Put	72940R952
—	INSMED INC	399	$974K	0.0%	$2441.10	—	—	Put	457669957
—	AMICUS THERAPEUTICS INC	633	$896K	0.0%	$1415.48	—	—	Call	03152W909
—	OMEROS CORP	497	$894K	0.0%	$1798.79	—	—	Call	682143902
—	CALADRIUS BIOSCIENCES INC	475,363	$889K	0.0%	$1.87	$1.87	—	COM	128058104
CHRS	COHERUS BIOSCIENCES INC.	30,000	$867K	0.0%	$28.90 *	$25.28	0.0%	COM	19249H103
—	EXELIXIS INC	2,276	$856K	0.0%	$376.10	—	—	Call	30161Q904
—	MANNKIND CORP	147,304	$838K	0.0%	$5.69	$5.53	—	COM	56400P201
—	ABEONA THERAPEUTICS	159,758	$808K	0.0%	$5.06	$5.06	—	COM	00289Y107
—	INSMED INC	326	$796K	0.0%	$2441.72	—	—	Call	457669907
—	ALLIQUA BIOMEDICAL INC	150,000	$791K	0.0%	$5.27	$5.27	—	COM	019621200
—	TEKMIRA PHARMACEUTICALS CORP	657	$779K	0.0%	$1185.69	—	—	Call	87911B909
—	ZS PHARMA INC	14,848	$778K	0.0%	$52.40	$52.40	—	COM	98979G105
—	CYTOKINETICS INC	1,143	$768K	0.0%	$671.92	—	—	Put	23282W955
—	BIODELIVERY SCIENCES INTERNATIONAL INC	96,100	$765K	0.0%	$7.96	$8.95	—	COM	09060J106
—	SUNESIS PHARMACEUTICALS INC	245,112	$738K	0.0%	$3.01	$2.45	—	COM	867328601
—	NEUROMETRIX INC.	798,939	$727K	0.0%	$0.91	$1.39	—	COM	641255302
—	NXSTAGE MEDICAL INC	50,542	$722K	0.0%	$14.29	$14.29	—	COM	67072V103
—	IDERA PHARMACEUTICALS INC	1,924	$714K	0.0%	$371.10	—	—	Call	45168K906
—	ACELRX PHARMACEUTICALS INC	1,658	$703K	0.0%	$424.00	—	—	Call	00444T900
—	JUNO THERAPEUTICS	130	$693K	0.0%	$5330.77	—	—	Put	48205A959
—	BELLICUM PHARMACEUTICALS INC	325	$691K	0.0%	$2126.15	—	—	Put	079481957
—	EDAP TMS SA	2,061	$670K	0.0%	$325.08	—	—	Put	268311957
—	ROCKWELL MEDICAL INC	412	$664K	0.0%	$1611.65	—	—	Put	774374952
—	AMARIN CORPORATION PLC	2,673	$658K	0.0%	$246.17	—	—	Call	023111906
—	TRANSITION THERAPEUTICS INC	302,837	$636K	0.0%	$2.10	$6.29	—	COM	893716209
—	BIODELIVERY SCIENCES INTERNATIONAL INC	789	$628K	0.0%	$795.94	—	—	Put	09060J956
—	KITE PHARMA INC	102	$622K	0.0%	$6098.04	—	—	Put	49803L959
—	COLLABRX INC	883,324	$610K	0.0%	$0.69	$1.09	—	COM	19422J108
—	ACELRX PHARMACEUTICALS INC	142,700	$605K	0.0%	$4.24	$3.86	—	COM	00444T100
—	JUNO THERAPEUTICS	11,333	$604K	0.0%	$53.30	$53.30	—	COM	48205A109
—	OVASCIENCE INC	200	$579K	0.0%	$2895.00	—	—	Put	69014Q951
—	CHINA BIOLOGIC PRODUCTS INC	5,000	$576K	0.0%	$115.20	$115.20	—	COM	16938C106
—	PTC THERAPEUTICS INC	119	$573K	0.0%	$4815.13	—	—	Put	69366J950
—	GEVO INC	175,000	$572K	0.0%	$3.27	$3.27	—	COM	374396208
—	NANOSPHERE INC	169,031	$548K	0.0%	$3.24	$3.24	—	COM	63009F204
—	MELA SCIENCES INC.	454,352	$523K	0.0%	$1.15	$1.24	—	COM	55277R308
—	TESARO INC	89	$523K	0.0%	$5876.40	—	—	Call	881569907
—	BIOLASE INC	300,000	$522K	0.0%	$1.74	$2.02	—	COM	090911108
—	MEI PHARMA ORD SHS	295,491	$505K	0.0%	$1.71	$5.18	—	COM	55279B202
—	CELLECTAR BIOSCIENCES WARRANTS	656,513	$492K	0.0%	$0.75	$0.61	—	*W	15117F112
—	NOVO-NORDISK ADR	84	$460K	0.0%	$5476.19	—	—	Put	670100955
—	XOMA CORP	1,181	$458K	0.0%	$387.81	—	—	Put	98419J957
—	PROGENICS PHARMACEUTICALS INC	609	$454K	0.0%	$745.48	—	—	Call	743187906
—	INTREXON CORP	90	$439K	0.0%	$4877.78	—	—	Put	46122T952
—	SKYSTAR BIO PHARMACEUTICAL CO.	156,026	$415K	0.0%	$2.66	$4.19	—	COM	830884300
—	EXELIXIS INC	1,014	$381K	0.0%	$375.74	—	—	Put	30161Q954
—	ZAFGEN INC	110	$381K	0.0%	$3463.64	—	—	Call	98885E903
—	CEL SCI EQUITY WARRANTS	1,845,841	$369K	0.0%	$0.20	$0.42	—	*W	150837177
—	BIODELIVERY SCIENCES INTERNATIONAL INC	458	$365K	0.0%	$796.94	—	—	Call	09060J906
—	HEARTWARE INTERNATIONAL INC	50	$363K	0.0%	$7260.00	—	—	Call	422368900
—	OXIGENE INC	258,435	$362K	0.0%	$1.40	$1.40	—	COM	691828404
—	BELLICUM PHARMACEUTICALS INC	161	$342K	0.0%	$2124.22	—	—	Call	079481907
—	INFINITY PHARMACEUTICALS INC	300	$329K	0.0%	$1096.67	—	—	Put	45665G953
—	DYAX CORP	123	$326K	0.0%	$2650.41	—	—	Call	26746E903
—	TEVA PHARMACEUTICAL INDUSTRIES LTD	54	$319K	0.0%	$5907.41	—	—	Call	881624909
—	CYNAPSUS THERAPEUTICS INC	19,303	$314K	0.0%	$16.27	$16.27	—	COM	23257Y859
—	APPLIED DNA SCIENCES EQUITY WARRANTS	205,347	$306K	0.0%	$1.49	$1.06	—	*W	03815U110
—	VITAL THERAPIES INC	145	$306K	0.0%	$2110.34	—	—	Put	92847R954
—	AGIOS PHARMACEUTICALS INC	27	$300K	0.0%	$11111.11	—	—	Call	00847X904
—	REPROS THERAPEUTICS INC	41,643	$298K	0.0%	$7.16	$7.16	—	COM	76028H209
—	APPLIED DNA SCIENCES INC	93,368	$289K	0.0%	$3.10	$2.59	—	COM	03815U201
—	ROCKWELL MEDICAL INC	17,759	$286K	0.0%	$16.10	$16.10	—	COM	774374102
—	BELLEROPHON THERAPEUTICS ORD SHS	35,727	$283K	0.0%	$7.92	$8.97	—	COM	078771102
—	AMARIN CORPORATION PLC	1,118	$275K	0.0%	$245.97	—	—	Put	023111956
—	ATHERSYS INC	2,244	$272K	0.0%	$121.21	—	—	Put	04744L956
—	CYMABAY THERAPEUTICS INC	100,000	$269K	0.0%	$2.69	$6.84	—	COM	23257D103
—	THORATEC CORP	60	$267K	0.0%	$4450.00	—	—	Put	885175957
—	XENOPORT INC	434	$266K	0.0%	$612.90	—	—	Call	98411C900
—	TONIX PHARMACEUTICALS HOLDING CORP	29,026	$260K	0.0%	$8.96	$0.32	—	COM	890260201
—	INSPIREMD ORD SHS	927,876	$260K	0.0%	$0.28	$0.66	—	COM	45779A309
—	HEAT BIOLOGICS INC	43,034	$258K	0.0%	$6.00	$6.36	—	COM	42237K102
TEVA	TEVA PHARMACEUTICAL INDUSTRIES LTD	4,173	$247K	0.0%	$59.19	$59.19	—	ADR	881624209
AR	ANTERO RESOURCES CORP	8,580	$246K	0.0%	$28.67 *	$39.69	0.0%	COM	03674X106
—	INTELLIPHARMACEUTICS INTERNATIONAL INC	826	$243K	0.0%	$294.19	—	—	Put	458173951
—	OHR PHARMACEUTICAL ORD SHS	89,982	$226K	0.0%	$2.51	$4.33	—	COM	67778H200
—	KITE PHARMA INC	3,672	$224K	0.0%	$61.00	$61.00	—	COM	49803L109
ARDX	ARDELYX INC	13,757	$220K	0.0%	$15.99 *	$18.73	-32.7%	COM	039697107
—	DYAX CORP	75	$200K	0.0%	$2666.67	—	—	Put	26746E953
—	KERYX BIOPHARMACEUTICALS	188	$188K	0.0%	$1000.00	—	—	Put	492515951
—	HISTOGENICS CORP	27,505	$178K	0.0%	$6.47	$11.00	—	COM	43358V109
—	ACHILLION PHARMACEUTICALS INC	18,835	$167K	0.0%	$8.87	$12.12	—	COM	00448Q201
—	PROVECTUS BIOPHARMACEUTICALS EQUITY WARRANTS	749,337	$164K	0.0%	$0.22	$0.22	—	*W	74373P116
—	GREAT BASIN SCIENTIFIC INC	51,771	$153K	0.0%	$2.96	$2.96	—	COM	39013L106
—	CELSION CORPORATION	546	$128K	0.0%	$234.43	—	—	Put	15117N954
—	APRICUS BIOSCIENCES INC	712	$122K	0.0%	$171.35	—	—	Put	03832V959
—	IDERA PHARMACEUTICALS INC	257	$95,000	0.0%	$369.65	—	—	Put	45168K956
—	OPEXA THERAPEUTICS EQUITY WARRANTS	545,505	$93,000	0.0%	$0.17	$0.17	—	*W	68372T129
—	IDERA PHARMACEUTICALS INC	23,297	$86,000	0.0%	$3.69	$3.71	—	COM	45168K306
—	ACELRX PHARMACEUTICALS INC	186	$79,000	0.0%	$424.73	—	—	Put	00444T950
—	LPATH INC	268,658	$74,000	0.0%	$0.28	$3.52	—	COM	548910306
—	APRICUS BIOSCIENCES INC	37,160	$64,000	0.0%	$1.72	$1.72	—	COM	03832V109
—	CYTRX CORP	173	$64,000	0.0%	$369.94	—	—	Put	232828959
—	BIODEL INC	182	$19,000	0.0%	$104.40	—	—	Put	09064M954
—	ORIENT PAPER INC	103	$17,000	0.0%	$165.05	—	—	Put	68619F955
—	BIO PATH HOLDINGS INC.	13,873	$16,000	0.0%	$1.15	$1.15	—	COM	09057N102
—	CASI PHARMACEUTICALS INC.	243,201	$0	0.0%	$0.00	—	—	COM	14757U109