Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
—	ELI LILLY & CO	23,794	$200M	11.0%	$8425.99	—	—	Call	532457908
—	ISHARES RUSSELL 2000 ETF	17,499	$197M	10.8%	$11250.99	—	—	Put	464287955
—	SPDR S&P 500 ETF TRUST	9,000	$184M	10.1%	$20389.00	—	—	Put	78462F953
—	BIOGEN INC	3,437	$105M	5.8%	$30634.86	—	—	Call	09062X903
—	GILEAD SCIENCES INC	9,754	$98.7M	5.4%	$10119.03	—	—	Call	375558903
—	SPDR SERIES TRUST	5,880	$41.21M	2.3%	$7007.99	—	—	Put	78464A950
—	BIOGEN INC	1,240	$37.99M	2.1%	$30634.68	—	—	Put	09062X953
—	ABBVIE INC	5,739	$34M	1.9%	$5924.03	—	—	Call	00287Y909
IWM	ISHARES RUSSELL 2000 ETF	294,400	$33.12M	1.8%	$112.51	$109.20	—	ETF	464287655
—	ALKERMES PLC	3,156	$25.05M	1.4%	$7937.90	—	—	Put	G01767955
—	MEDICINES CO	6,348	$23.7M	1.3%	$3733.93	—	—	Call	584688905
—	ELI LILLY & CO	2,804	$23.63M	1.3%	$8426.18	—	—	Put	532457958
—	ZOGENIX INC	15,182	$22.38M	1.2%	$1473.98	—	—	Call	98978L904
—	GW PHARMACEUTICALS PLC	3,183	$22.1M	1.2%	$6944.08	—	—	Put	36197T953
—	ALEXION PHARMACEUTICALS INC	975	$18.6M	1.0%	$19074.87	—	—	Put	015351959
—	ACADIA PHARMACEUTICALS INC	4,175	$14.88M	0.8%	$3565.03	—	—	Put	004225958
—	MYLAN N.V.	2,732	$14.77M	0.8%	$5407.03	—	—	Put	N59465959
—	ABBVIE INC	2,452	$14.53M	0.8%	$5924.14	—	—	Put	00287Y959
—	BIOMARIN PHARMACEUTICAL INC	1,308	$13.7M	0.8%	$10476.30	—	—	Call	09061G901
—	ANACOR PHARMACEUTICALS INC	1,188	$13.42M	0.7%	$11297.14	—	—	Call	032420901
—	MYLAN N.V.	2,452	$13.26M	0.7%	$5407.01	—	—	Call	N59465909
—	SAREPTA THERAPEUTICS INC	3,302	$12.74M	0.7%	$3857.96	—	—	Put	803607950
—	UNITED THERAPEUTICS CORP	800	$12.53M	0.7%	$15661.25	—	—	Put	91307C952
—	APPLE INC	1,184	$12.46M	0.7%	$10526.18	—	—	Put	037833950
—	UNITED THERAPEUTICS CORP	778	$12.18M	0.7%	$15660.67	—	—	Call	91307C902
—	APPLE INC	1,110	$11.68M	0.6%	$10526.13	—	—	Call	037833900
—	BRISTOL-MYERS SQUIBB CO	1,649	$11.34M	0.6%	$6878.71	—	—	Call	110122908
—	GW PHARMACEUTICALS PLC	160,406	$11.14M	0.6%	$69.44	$79.22	—	ADS	36197T103
—	ACORDA THERAPEUTICS INC 1.75%	9,600,000	$11.11M	0.6%	$1.16	$0.90	—	NOTE	00484MAA4
—	SAREPTA THERAPEUTICS INC	2,862	$11.04M	0.6%	$3858.14	—	—	Call	803607900
ALKS	ALKERMES PLC	131,671	$10.45M	0.6%	$79.38 *	$70.02	0.0%	SHS	G01767105
—	REGULUS THERAPEUTIC INC	11,973	$10.44M	0.6%	$871.96	—	—	Call	75915K901
—	EDWARDS LIFESCIENCES CORP	1,200	$9.478M	0.5%	$7898.33	—	—	Put	28176E958
—	VAPOR CORP DEL	860,338	$9.369M	0.5%	$10.89	$10.38	—	UNIT	922099502
—	GILEAD SCIENCES INC	914	$9.249M	0.5%	$10119.26	—	—	Put	375558953
—	TENAX THERAPEUTICS INC.	2,693,537	$8.835M	0.5%	$3.28	$3.80	—	COM	88032L100
—	MOBILEYE N.V. REG.	2,011	$8.503M	0.5%	$4228.24	—	—	Put	N51488957
—	NEWLINK GENETICS CORP	2,231	$8.119M	0.4%	$3639.18	—	—	Call	651511907
—	BLUEPRINT MEDICINES CORP	3,000	$7.902M	0.4%	$2634.00	—	—	Call	09627Y909
—	TOBIRA THERAPEUTICS INC	877,342	$7.792M	0.4%	$8.88	$9.04	—	COM	88883P101
—	MOBILEYE N.V. REG.	171,672	$7.258M	0.4%	$42.28	$44.40	—	ORD	N51488117
—	NEUROCRINE BIOSCIENCES INC	1,277	$7.224M	0.4%	$5657.01	—	—	Call	64125C909
—	DEPOMED INC	3,970	$7.198M	0.4%	$1813.10	—	—	Call	249908904
—	IONIS PHARMACEUTICALS INC	1,159	$7.178M	0.4%	$6193.27	—	—	Call	462222900
—	CELLDEX THERAPEUTICS INC	4,468	$7.006M	0.4%	$1568.04	—	—	Call	15117B903
—	HALOZYME THERAPEUTICS INC	4,014	$6.956M	0.4%	$1732.93	—	—	Call	40637H909
—	ENDO INTERNATIONAL PLC	1,075	$6.581M	0.4%	$6121.86	—	—	Call	G30401906
BMRN	BIOMARIN PHARMACEUTICAL INC. 1.875%	5,000,000	$6.475M	0.4%	$1.29 *	$105.34	-1.0%	NOTE	09061G101
—	GLOBAL BLOOD THERAPEUTICS	342,857	$6.446M	0.4%	$18.80	$42.16	—	COM	37890U108
—	ACHILLION PHARMACEUTICALS INC	5,878	$6.342M	0.3%	$1078.94	—	—	Call	00448Q901
—	NEWLINK GENETICS CORP	171,266	$6.232M	0.3%	$36.39	$36.28	—	COM	651511107
—	THERAPEUTICSMD INC	5,994	$6.216M	0.3%	$1037.04	—	—	Call	88338N907
—	ROYAL PHILIPS NV	2,374	$6.042M	0.3%	$2545.07	—	—	Call	500472903
—	BELLICUM PHARMACEUTICALS INC	2,926	$5.931M	0.3%	$2027.00	—	—	Call	079481907
—	BARCLAYS BANK PLC	525,132	$5.85M	0.3%	$11.14	$11.17	—	ETN	06740C519
—	BLUEBIRD BIO INC	861	$5.529M	0.3%	$6421.60	—	—	Call	09609G900
UTHR	UNITED THERAPEUTICS CORP	34,779	$5.447M	0.3%	$156.62 *	$145.57	0.0%	COM	91307C102
—	NEVRO CORP	798	$5.387M	0.3%	$6750.63	—	—	Put	64157F953
—	ACADIA PHARMACEUTICALS INC	1,489	$5.308M	0.3%	$3564.81	—	—	Call	004225908
—	MANNKIND CORP	35,535	$5.153M	0.3%	$145.01	—	—	Call	56400P901
—	NOVO-NORDISK A/S	870	$5.053M	0.3%	$5808.05	—	—	Call	670100905
—	KITE PHARMA INC	808	$4.979M	0.3%	$6162.13	—	—	Put	49803L959
—	BIOMARIN PHARMACEUTICAL INC	475	$4.976M	0.3%	$10475.79	—	—	Put	09061G951
—	TENET HEALTHCARE CORP	1,545	$4.681M	0.3%	$3029.77	—	—	Call	88033G907
—	DYNAVAX TECHNOLOGIES CORP	1,907	$4.607M	0.3%	$2415.84	—	—	Call	268158901
—	OPKO HEALTH INC	4,500	$4.523M	0.2%	$1005.11	—	—	Call	68375N903
—	ALKERMES PLC	568	$4.509M	0.2%	$7938.38	—	—	Call	G01767905
ABUS	ARBUTUS BIOPHARMA CORP	1,000,000	$4.45M	0.2%	$4.45 *	$7.94	-30.9%	COM	03879J100
—	VERTEX PHARMACEUTICALS INC	341	$4.291M	0.2%	$12583.58	—	—	Call	92532F900
—	PACIRA PHARMACEUTICALS INC	553	$4.246M	0.2%	$7678.12	—	—	Call	695127900
—	HCA HOLDINGS INC	624	$4.22M	0.2%	$6762.82	—	—	Call	40412C901
—	INOVIO PHARMACEUTICALS INC	619,185	$4.161M	0.2%	$6.72	$8.16	—	COM	45773H201
ACAD	ACADIA PHARMACEUTICALS INC	113,838	$4.058M	0.2%	$35.65	$35.23	0.0%	COM	004225108
—	NIVALIS THERAPEUTICS INC	503,595	$3.898M	0.2%	$7.74	$13.40	—	COM	65481J109
—	TRANSENTERIX INC	15,481	$3.839M	0.2%	$247.98	—	—	Call	89366M901
—	TRANSENTERIX INC	1,521,505	$3.773M	0.2%	$2.48	$3.00	—	COM	89366M201
—	CELGENE CORP	313	$3.748M	0.2%	$11974.44	—	—	Call	151020904
—	LEXICON PHARMACEUTICALS INC	2,735	$3.64M	0.2%	$1330.90	—	—	Call	528872902
—	INTEC PHARMA LTD JERUSALEM	670,449	$3.594M	0.2%	$5.36	$5.58	—	SHS	M53644106
—	FLUIDIGM CORP	3,312	$3.58M	0.2%	$1080.92	—	—	Call	34385P908
—	RADIUS HEALTH INC	578	$3.557M	0.2%	$6153.98	—	—	Call	750469907
—	SPARK THERAPEUTICS INC	770	$3.489M	0.2%	$4531.17	—	—	Call	84652J903
—	AMICUS THERAPEUTICS INC	3,499	$3.394M	0.2%	$969.99	—	—	Put	03152W959
—	NOVAVAX INC	4,018	$3.371M	0.2%	$838.97	—	—	Call	670002904
—	BLUEBIRD BIO INC	516	$3.314M	0.2%	$6422.48	—	—	Put	09609G950
—	SKYLINE MEDICAL	453,944	$3.268M	0.2%	$7.20	$7.20	—	UNIT	83084T408
—	CYTORI THERAPEUTICS INC.	17,150,297	$3.19M	0.2%	$0.19	$0.25	—	COM	23283K105
—	BIODELIVERY SCIENCES INTERNATIONAL INC	617,496	$2.958M	0.2%	$4.79	$5.78	—	COM	09060J106
—	CEMPRA INC	94,763	$2.95M	0.2%	$31.13	$33.59	—	COM	15130J109
—	MANNKIND CORP	20,310	$2.945M	0.2%	$145.00	—	—	Put	56400P951
NWBO	NORTHWEST BIOTHERAPEUTICS INC	917,942	$2.937M	0.2%	$3.20 *	$7.43	-35.3%	COM	66737P600
—	RELYPSA INC	1,030	$2.919M	0.2%	$2833.98	—	—	Call	759531906
—	BLUEBIRD BIO INC	45,449	$2.919M	0.2%	$64.23	$64.23	—	COM	09609G100
—	ONCOSEC MEDICAL INC	1,224,359	$2.902M	0.2%	$2.37	$3.47	—	COM	68234L207
—	DYNAVAX TECHNOLOGIES CORP	120,000	$2.899M	0.2%	$24.16	$23.96	—	COM	268158201
—	ALEXION PHARMACEUTICALS INC	152	$2.899M	0.2%	$19072.37	—	—	Call	015351909
LAB	FLUIDIGM CORP	264,196	$2.856M	0.2%	$10.81 *	$19.90	-50.7%	COM	34385P108
—	REVANCE THERAPEUTICS INC	834	$2.849M	0.2%	$3416.07	—	—	Call	761330909
—	INTRA-CELLULAR THERAPIES INC	520	$2.797M	0.2%	$5378.85	—	—	Put	46116X951
—	PTC THERAPEUTICS INC	845	$2.738M	0.2%	$3240.24	—	—	Call	69366J900
ABBV	ABBVIE INC	46,166	$2.735M	0.2%	$59.24 *	$40.28	-5.8%	COM	00287Y109
—	CHINA MOBILE LIMITED	481	$2.709M	0.1%	$5632.02	—	—	Call	16941M909
—	INOVIO PHARMACEUTICALS INC	3,991	$2.682M	0.1%	$672.01	—	—	Call	45773H901
SRNE	SORRENTO THERAPEUTICS INC.	300,000	$2.613M	0.1%	$8.71 *	$12.61	-33.1%	COM	83587F202
—	VITAL THERAPIES INC	2,250	$2.592M	0.1%	$1152.00	—	—	Call	92847R904
—	T2 BIOSYSTEMS INC.	230,542	$2.522M	0.1%	$10.94	$13.31	—	COM	89853L104
OASMY	OASMIA PHARMACEUTICAL AB	663,138	$2.401M	0.1%	$3.62	$3.62	—	ADR	67421W109
—	AETERNA ZENTARIS INC	534,145	$2.393M	0.1%	$4.48	$4.48	—	COM	007975402
—	BENITEC BIOPHARMA LTD	597,115	$2.377M	0.1%	$3.98	$5.82	—	ADR	082053307
—	PARATEK PHARMACEUTICALS INC	122,613	$2.326M	0.1%	$18.97	$22.07	—	COM	699374302
—	OMEROS CORP	1,439	$2.264M	0.1%	$1573.31	—	—	Call	682143902
—	ANACOR PHARMACEUTICALS INC	20,000	$2.259M	0.1%	$112.95	$114.87	—	COM	032420101
—	MOMENTA PHARMACEUTICALS INC	150,030	$2.226M	0.1%	$14.84	$15.36	—	COM	60877T100
—	BRAINSTORM CELL THERAPEUTICS INC	769,534	$2.201M	0.1%	$2.86	$4.17	—	COM	10501E201
—	PTC THERAPEUTICS INC	669	$2.168M	0.1%	$3240.66	—	—	Put	69366J950
—	MEDICINES CO 1.375%	1,500,000	$2.152M	0.1%	$1.43	$1.19	—	DBCV	584688AC9
—	VASCULAR SOLUTIONS INC	623	$2.142M	0.1%	$3438.20	—	—	Put	92231M959
—	LION BIOTECHNOLOGIES INC	270,000	$2.084M	0.1%	$7.72	$10.32	—	COM	53619R102
—	LANNETT INC	516	$2.07M	0.1%	$4011.63	—	—	Call	516012901
—	REDHILL BIOPHARMA LTD	160,144	$2.063M	0.1%	$12.88	$12.91	—	ADS	757468103
—	PLURISTEM THERAPEUTICS INC.	1,812,668	$2.048M	0.1%	$1.13	$2.27	—	COM	72940R102
—	NEVRO CORP	301	$2.032M	0.1%	$6750.83	—	—	Call	64157F903
—	BIOCRYST PHARMACEUTICALS	1,937	$1.999M	0.1%	$1032.01	—	—	Put	09058V953
—	LIPOCINE INC	152,221	$1.968M	0.1%	$12.93	$8.58	—	COM	53630X104
—	MOBILEYE N.V. REG.	461	$1.949M	0.1%	$4227.77	—	—	Call	N51488907
RGNX	REGENXBIO INC.	116,860	$1.94M	0.1%	$16.60 *	$19.85	0.0%	COM	75901B107
—	FOAMIX PHARMACEUTICALS LTD	238,400	$1.933M	0.1%	$8.11	$9.14	—	SHS	M46135105
—	LION BIOTECHNOLOGIES INC	2,453	$1.894M	0.1%	$772.12	—	—	Call	53619R902
—	INVIVO THERAPEUTICS HOLDINGS CORP	2,600	$1.872M	0.1%	$720.00	—	—	Call	46186M909
—	AVALANCHE BIOTECHNOLOGIES INC	195,132	$1.858M	0.1%	$9.52	$13.94	—	COM	05337G107
ACUR	ACURA PHARMACEUTICALS INC	727,865	$1.841M	0.1%	$2.53 *	$3.40	-28.5%	COM	00509L802
—	REGULUS THERAPEUTIC INC	210,000	$1.831M	0.1%	$8.72	$14.53	—	COM	75915K101
GALT	GALECTIN THERAPEUTICS INC	1,086,615	$1.782M	0.1%	$1.64 *	$2.29	0.0%	COM	363225202
—	RICEBRAN TECHNOLOGIES	933,441	$1.773M	0.1%	$1.90	$3.90	—	COM	762831204
—	LA JOLLA PHARMACEUTICAL CO	65,158	$1.759M	0.1%	$27.00	$27.78	—	COM	503459604
—	ZELTIQ AESTHETICS INC SHS CALL 30 01/15/2016	610	$1.74M	0.1%	$2852.46	—	—	Call	98933Q908
BCRX	BIOCRYST PHARMACEUTICALS	165,529	$1.708M	0.1%	$10.32 *	$11.72	-15.1%	COM	09058V103
—	NEWLINK GENETICS CORP	466	$1.696M	0.1%	$3639.48	—	—	Put	651511957
—	DBV TECHNOLOGIES S A	46,587	$1.692M	0.1%	$36.32	$36.03	—	ADR	23306J101
MNOV	MEDICINOVA INC	474,803	$1.686M	0.1%	$3.55 *	$3.41	-7.0%	COM	58468P206
—	AMICUS THERAPEUTICS INC	1,737	$1.685M	0.1%	$970.06	—	—	Call	03152W909
—	XTL BIOPHARMACEUTICALS	1,111,962	$1.668M	0.1%	$1.50	$2.30	—	ADR	98386D208
—	SYNERGY PHARMACEUTICALS EQUITY WARRANTS 12/06/201	291,306	$1.652M	0.1%	$5.67	$1.23	—	*W	871639118
—	AMARIN CORPORATION PLC	8,683	$1.641M	0.1%	$188.99	—	—	Call	023111906
—	QUEST RESOURCE HOLDING CORP.	2,435,037	$1.631M	0.1%	$0.67	$1.62	—	COM	74836W104
—	IMMUNOCELLULAR THERAPEUTICS	4,443,914	$1.579M	0.1%	$0.36	$0.48	—	COM	452536105
—	INSMED INC	870	$1.579M	0.1%	$1814.94	—	—	Put	457669957
—	SYNERGY PHARMACEUTICALS INC	2,785	$1.579M	0.1%	$566.97	—	—	Call	871639908
—	UNIQURE NV	950	$1.571M	0.1%	$1653.68	—	—	Call	N90064901
—	DISCOVERY LABORATORIES INC*	7,339,548	$1.57M	0.1%	$0.21	$0.27	—	COM	254668403
—	INFINITY PHARMACEUTICALS INC	1,971	$1.547M	0.1%	$784.88	—	—	Call	45665G903
—	HALOZYME THERAPEUTICS INC	840	$1.456M	0.1%	$1733.33	—	—	Put	40637H959
—	RENNOVA HEALTH INC. WARRANTS	3,225,806	$1.427M	0.1%	$0.44	$0.44	—	*W	759757115
—	ALLIQUA BIOMEDICAL INC.	664,791	$1.423M	0.1%	$2.14	$3.13	—	COM	019621200
—	TROVAGENE INC	2,600	$1.404M	0.1%	$540.00	—	—	Call	897238909
—	MEDGENICS EQUITY WARRANTS EXP 03/31/201	1,529,526	$1.377M	0.1%	$0.90	$1.00	—	*W	58436Q112
—	DYNAVAX TECHNOLOGIES CORP	569	$1.375M	0.1%	$2416.52	—	—	Put	268158951
—	POZEN INC	199,800	$1.365M	0.1%	$6.83	$5.83	—	COM	73941U102
—	NEUROCRINE BIOSCIENCES INC	241	$1.363M	0.1%	$5655.60	—	—	Put	64125C959
—	FORWARD PHARMA A/S	70,000	$1.33M	0.1%	$19.00	$25.94	—	ADR	34986J105
—	TONIX PHARMACEUTICALS HOLDING CORP	1,733	$1.329M	0.1%	$766.88	—	—	Call	890260901
—	CARDICA INC.	8,569,181	$1.328M	0.1%	$0.15	$0.47	—	COM	14141R101
—	CEMPRA INC	415	$1.292M	0.1%	$3113.25	—	—	Put	15130J959
VRTX	VERTEX PHARMACEUTICALS INC	10,000	$1.258M	0.1%	$125.80 *	$128.47	-6.0%	COM	92532F100
—	OCERA THERAPEUTICS ORD SHS	385,300	$1.202M	0.1%	$3.12	$5.87	—	COM	67552A108
SGMO	SANGAMO BIOSCIENCES INC	131,100	$1.197M	0.1%	$9.13 *	$13.76	-44.0%	COM	800677106
—	TONIX PHARMACEUTICALS HOLDING CORP	155,557	$1.193M	0.1%	$7.67	$4.38	—	COM	890260201
—	CEMPRA INC	376	$1.17M	0.1%	$3111.70	—	—	Call	15130J909
—	ANACOR PHARMACEUTICALS INC	100	$1.13M	0.1%	$11300.00	—	—	Put	032420951
—	PORTOLA PHARMACEUTICALS INC	218	$1.122M	0.1%	$5146.79	—	—	Put	737010958
—	SANGAMO BIOSCIENCES INC	1,225	$1.118M	0.1%	$912.65	—	—	Call	800677906
—	NEURODERM LTD	651	$1.11M	0.1%	$1705.07	—	—	Put	M74231957
—	VASCULAR SOLUTIONS INC	30,626	$1.053M	0.1%	$34.38	$32.42	—	COM	92231M109
—	ALCOBRA LTD	167,500	$1.052M	0.1%	$6.28	$6.28	—	SHS	M2239P109
CSBR	CHAMPIONS ONCOLOGY INC	291,595	$1.041M	0.1%	$3.57 *	$5.49	-15.0%	COM	15870P307
—	MELA SCIENCES INC **	911,781	$1.021M	0.1%	$1.12	$1.18	—	COM	55277R308
—	KITE PHARMA INC	16,571	$1.021M	0.1%	$61.61	$55.82	—	COM	49803L109
—	WAFERGEN BIO SYSTEMS INC.	1,381,074	$1.014M	0.1%	$0.73	$0.73	—	COM	93041P308
—	ABEONA THERAPEUTICS INC	300,000	$1.008M	0.1%	$3.36	$4.52	—	COM	00289Y107
—	EXELIXIS INC	1,783	$1.006M	0.1%	$564.22	—	—	Call	30161Q904
—	GALENA BIOPHARMA INC	6,842	$1.006M	0.1%	$147.03	—	—	Put	363256958
—	CYMABAY THERAPEUTICS INC	593,900	$1.004M	0.1%	$1.69	$2.64	—	COM	23257D103
—	HEARTWARE INTERNATIONAL INC	19,900	$1.003M	0.1%	$50.40	$52.06	—	COM	422368100
—	HEARTWARE INTERNATIONAL INC	199	$1.003M	0.1%	$5040.20	—	—	Put	422368950
—	INOTEK PHARMACEUTICALS CORP	87,652	$993K	0.1%	$11.33	$9.40	—	COM	45780V102
—	ENDOLOGIX ORD SHS	100,000	$990K	0.1%	$9.90	$12.26	—	COM	29266S106
OPK	OPKO HEALTH INC	97,811	$983K	0.1%	$10.05	$13.34	-24.9%	COM	68375N103
—	INTREXON CORP	325	$980K	0.1%	$3015.38	—	—	Call	46122T902
—	OPKO HEALTH INC	953	$958K	0.1%	$1005.25	—	—	Put	68375N953
—	NEUROMETRIX EQUITY WARRANTS EX 05/29/202	3,117,833	$953K	0.1%	$0.31	$0.31	—	*W	641255153
—	VTV THERAPEUTICS INC	139,747	$952K	0.1%	$6.81	$6.52	—	CL A	918385105
NTRA	NATERA ORD SHS	86,623	$936K	0.1%	$10.81 *	$16.90	-43.7%	COM	632307104
—	ANTHERA PHARMACEUTICALS INC	2,000	$928K	0.1%	$464.00	—	—	Call	03674U901
—	MANNKIND CORP	635,903	$922K	0.1%	$1.45	$1.80	—	COM	56400P201
—	ANTARES PHARMA INC	758,718	$918K	0.1%	$1.21	$1.68	—	COM	036642106
—	NOVAVAX INC	1,080	$906K	0.0%	$838.89	—	—	Put	670002954
—	CYNAPSUS THERAPEUTICS INC	58,610	$905K	0.0%	$15.44	$16.14	—	COM	23257Y859
LXRX	LEXICON PHARMACEUTICALS INC	67,710	$901K	0.0%	$13.31 *	$7.34	+67.4%	COM	528872302
—	CLOVIS ONCOLOGY INC	250	$875K	0.0%	$3500.00	—	—	Call	189464900
—	TROVAGENE INC	160,140	$865K	0.0%	$5.40	$5.69	—	COM	897238309
—	BIODELIVERY SCIENCES INTERNATIONAL INC	1,800	$862K	0.0%	$478.89	—	—	Put	09060J956
—	BIODELIVERY SCIENCES INTERNATIONAL INC	1,800	$862K	0.0%	$478.89	—	—	Call	09060J906
OCUL	OCULAR THERAPEUTIX INC	90,000	$843K	0.0%	$9.37 *	$24.55	-56.0%	COM	67576A100
—	IDERA PHARMACEUTICALS INC	2,707	$836K	0.0%	$308.83	—	—	Call	45168K906
—	GENOCEA BIOSCIENCES INC	156,134	$823K	0.0%	$5.27	$8.18	—	COM	372427104
—	MIRATI THERAPEUTICS INC.	26,027	$822K	0.0%	$31.58	$34.42	—	COM	60468T105
—	NUVASIVE INC	15,000	$812K	0.0%	$54.13	$48.23	—	COM	670704105
—	CYCLACEL PHARMACEUTICALS INC.	1,510,806	$755K	0.0%	$0.50	$0.86	—	COM	23254L306
—	AQUINOX PHARMACEUTICALS INC	60,313	$753K	0.0%	$12.48	$14.07	—	COM	03842B101
—	CLOVIS ONCOLOGY INC	20,923	$732K	0.0%	$34.99	$34.99	—	COM	189464100
—	IGNYTA INC	54,099	$725K	0.0%	$13.40	$8.13	—	COM	451731103
PVCT	PROVECTUS BIOPHARMACEUTICALS INC	1,856,019	$724K	0.0%	$0.39 *	$0.82	-41.9%	COM	74373P108
—	BIOTIE THERAPIES OYJ	50,460	$714K	0.0%	$14.15	$13.32	—	ADR	09074D103
—	CTI BIOPHARMA CORP	575,669	$708K	0.0%	$1.23	$1.23	—	COM	12648L106
—	CTI BIOPHARMA CORP	5,747	$707K	0.0%	$123.02	—	—	Call	12648L906
—	GW PHARMACEUTICALS PLC	100	$694K	0.0%	$6940.00	—	—	Call	36197T903
—	ADAMAS PHARMACEUTICALS INC	243	$688K	0.0%	$2831.28	—	—	Call	00548A906
—	BELLICUM PHARMACEUTICALS INC	325	$659K	0.0%	$2027.69	—	—	Put	079481957
—	NEUROMETRIX INC	328,467	$650K	0.0%	$1.98	$1.98	—	COM	641255500
—	CELLECTAR BIOSCIENCES INC	857,600	$633K	0.0%	$0.74	$1.44	—	COM	15117F203
—	EYEGATE PHARMACEUTICALS INC	227,660	$624K	0.0%	$2.74	$2.85	—	COM	30233M107
—	ZAFGEN INC	981	$617K	0.0%	$628.95	—	—	Call	98885E903
—	THRESHOLD PHARMACEUTICALS INC.	1,268,717	$609K	0.0%	$0.48	$0.48	—	COM	885807206
—	PORTOLA PHARMACEUTICALS INC	117	$602K	0.0%	$5145.30	—	—	Call	737010908
—	CELATOR PHARMACEUTICALS INC.	337,462	$594K	0.0%	$1.76	$1.76	—	COM	15089R102
—	INSMED INC	326	$592K	0.0%	$1815.95	—	—	Call	457669907
—	ELEVEN BIOTHERAPEUTICS INC.	194,041	$584K	0.0%	$3.01	$2.48	—	COM	286221106
—	CAPRICOR THERAPEUTICS INC	185,664	$570K	0.0%	$3.07	$5.05	—	COM	14070B101
—	INTRA-CELLULAR THERAPIES INC	100	$538K	0.0%	$5380.00	—	—	Call	46116X901
—	OCATA THERAPEUTICS INC	624	$525K	0.0%	$841.35	—	—	Put	67457L950
—	AERIE PHARMACEUTICALS INC	215	$524K	0.0%	$2437.21	—	—	Call	00771V908
REEMF	RARE ELEMENT RESOURCES LTD	3,436,858	$519K	0.0%	$0.15 *	$0.63	-65.0%	COM	75381M102
—	PROGENICS PHARMACEUTICALS INC	840	$515K	0.0%	$613.10	—	—	Call	743187906
—	SUNEDISON INC	1,000	$509K	0.0%	$509.00	—	—	Call	86732Y909
—	BIODEL INC SHS	1,480,728	$507K	0.0%	$0.34	$0.89	—	COM	09064M204
—	SUPERCONDUCTOR TECHNOLOGIES ORD SHS	2,349,992	$493K	0.0%	$0.21	$0.60	—	COM	867931404
—	OVASCIENCE INC	500	$489K	0.0%	$978.00	—	—	Call	69014Q901
—	VAPOR CORP DEL	901,608	$487K	0.0%	$0.54	$0.54	—	COM	922099304
EW	EDWARDS LIFESCIENCES CORP	6,107	$482K	0.0%	$78.93 *	$23.77	+9.2%	COM	28176E108
—	SAGE THERAPEUTICS INC	8,123	$474K	0.0%	$58.35	$61.55	—	COM	78667J108
ALDX	ALDEYRA THERAPEUTICS INC.	68,699	$466K	0.0%	$6.78	$8.62	-22.1%	COM	01438T106
—	CASTLIGHT HEALTH INC	106,500	$455K	0.0%	$4.27	$4.27	—	CL B	14862Q100
—	LIPOCINE INC	350	$453K	0.0%	$1294.29	—	—	Call	53630X904
—	REGULUS THERAPEUTIC INC	500	$436K	0.0%	$872.00	—	—	Put	75915K951
ESPR	ESPERION THERAPEUTICS INC	19,000	$423K	0.0%	$22.26 *	$62.76	-59.8%	COM	29664W105
—	THERAPEUTICSMD INC	404	$419K	0.0%	$1037.13	—	—	Put	88338N957
—	SAGE THERAPEUTICS INC	71	$414K	0.0%	$5830.99	—	—	Call	78667J908
—	HISTOGENICS CORP.	117,665	$412K	0.0%	$3.50	$5.25	—	COM	43358V109
—	DEPOMED INC	225	$408K	0.0%	$1813.33	—	—	Put	249908954
—	AFFIMED NV	56,773	$404K	0.0%	$7.12	$6.16	—	COM	N01045108
—	INTREXON CORP	134	$404K	0.0%	$3014.93	—	—	Put	46122T952
—	CESCA THERAPEUTICS INC	2,124,558	$387K	0.0%	$0.18	$1.37	—	COM	157131103
—	CELLDEX THERAPEUTICS INC	238	$373K	0.0%	$1567.23	—	—	Put	15117B953
—	NORTHWEST BIOTHERAPEUTICS INC	1,165	$373K	0.0%	$320.17	—	—	Put	66737P950
—	ALEXION PHARMACEUTICALS INC	1,956	$373K	0.0%	$190.70	$164.23	—	COM	015351109
OMER	OMEROS CORP	23,450	$369K	0.0%	$15.74 *	$15.57	-11.3%	COM	682143102
—	RAPTOR PHARMACEUTICAL CORP	707	$368K	0.0%	$520.51	—	—	Call	75382F906
—	SERES THERAPEUTICS INC	10,495	$368K	0.0%	$35.06	$29.64	—	COM	81750R102
—	CELLECTAR BIOSCIENCES INC	653,712	$365K	0.0%	$0.56	$0.61	—	*W	15117F112
—	MACROGENICS INC	114	$353K	0.0%	$3096.49	—	—	Call	556099909
—	EDAP TMS SA	846	$349K	0.0%	$412.53	—	—	Put	268311957
PRQR	PROQR THERAPEUTICS N V	39,871	$346K	0.0%	$8.68 *	$13.99	-17.8%	SHS	N71542109
—	UNIQURE NV	208	$344K	0.0%	$1653.85	—	—	Put	N90064951
—	ENDO INTERNATIONAL PLC	55	$337K	0.0%	$6127.27	—	—	Put	G30401956
—	INTREXON CORP	10,995	$331K	0.0%	$30.10	$30.10	—	COM	46122T102
—	MEI PHARMA INC	200,000	$320K	0.0%	$1.60	$5.18	—	COM	55279B202
—	SPECTRANETICS CORP	210	$316K	0.0%	$1504.76	—	—	Call	84760C907
—	ALCOBRA LTD	500	$314K	0.0%	$628.00	—	—	Call	M2239P909
—	ZOSANO PHARMA CORP.	128,900	$287K	0.0%	$2.23	$9.59	—	COM	98979H103
—	DERMIRA INC	100	$280K	0.0%	$2800.00	—	—	Put	24983L954
—	HERON THERAPEUTICS INC	104	$278K	0.0%	$2673.08	—	—	Call	427746902
—	REPROS THERAPEUTICS INC	2,277	$276K	0.0%	$121.21	—	—	Call	76028H909
—	CONATUS PHARMACEUTICALS INC	88,210	$254K	0.0%	$2.88	$4.49	—	COM	20600T108
FOLD	AMICUS THERAPEUTICS INC	25,661	$249K	0.0%	$9.70 *	$9.01	0.0%	COM	03152W109
—	LPATH INC	1,106,870	$249K	0.0%	$0.22	$1.00	—	COM	548910306
—	MACROGENICS INC	80	$248K	0.0%	$3100.00	—	—	Put	556099959
—	SERES THERAPEUTICS INC	67	$235K	0.0%	$3507.46	—	—	Call	81750R902
—	FLAMEL TECHNOLOGIE SA	190	$232K	0.0%	$1221.05	—	—	Put	338488959
QURE	UNIQURE NV	13,131	$217K	0.0%	$16.53 *	$18.53	0.0%	SHS	N90064101
—	AMARIN CORPORATION PLC	1,118	$211K	0.0%	$188.73	—	—	Put	023111956
—	CANCER GENETICS INC	63,251	$209K	0.0%	$3.30	$3.30	—	COM	13739U104
—	PORTOLA PHARMACEUTICALS INC	3,900	$201K	0.0%	$51.54	$42.59	—	COM	737010108
—	BENITEC BIOPHARMA LTD 8/14/202	99,555	$199K	0.0%	$2.00	$0.36	—	*W	082053117
—	ROSETTA GENOMICS LTD	158,951	$196K	0.0%	$1.23	$1.23	—	SHS	M82183126
—	CERES INC	570,919	$186K	0.0%	$0.33	$0.33	—	COM	156773400
—	PIERIS PHARMACEUTICALS	75,208	$172K	0.0%	$2.29	$1.83	—	COM	720795103
—	PSIVIDA CORP	343	$165K	0.0%	$481.05	—	—	Put	74440J951
—	OXIGENE INC	214,924	$160K	0.0%	$0.74	$1.30	—	COM	691828404
—	EXELIXIS INC	280	$158K	0.0%	$564.29	—	—	Put	30161Q954
—	ARBUTUS BIOPHARMA CORP	351	$156K	0.0%	$444.44	—	—	Call	03879J900
—	FLAMEL TECHNOLOGIE SA	12,100	$148K	0.0%	$12.23	$12.23	—	ADR	338488109
—	ROCKWELL MEDICAL INC	129	$132K	0.0%	$1023.26	—	—	Put	774374952
—	ROCKWELL MEDICAL INC	12,900	$132K	0.0%	$10.23	$10.91	—	COM	774374102
—	EYEGATE PHARMACEUTICALS WARRANTS EXP 08/05/202	174,150	$131K	0.0%	$0.75	$1.02	—	*W	30233M115
—	TRANSITION THERAPEUTICS INC.	64,500	$124K	0.0%	$1.92	$5.35	—	COM	893716209
—	CELSION CORPORATION	546	$105K	0.0%	$192.31	—	—	Put	15117N954
—	ANTARES PHARMA INC	866	$105K	0.0%	$121.25	—	—	Call	036642906
—	NANOSPHERE ORD SHS	166,234	$102K	0.0%	$0.61	$3.13	—	COM	63009F204
—	OCULAR THERAPEUTIX INC	100	$94,000	0.0%	$940.00	—	—	Call	67576A900
—	INSPIREMD INC1.75WTS EXP 05/08/2018	92,787	$83,000	0.0%	$0.89	$0.66	—	COM	45779A309
—	KERYX BIOPHARMACEUTICALS	158	$80,000	0.0%	$506.33	—	—	Put	492515951
—	STEMCELLS INC.	184,158	$77,000	0.0%	$0.42	$1.21	—	COM	85857R204
—	XOMA CORP	500	$67,000	0.0%	$134.00	—	—	Call	98419J907
—	THRESHOLD PHARMACEUTICALS INC.	1,203	$58,000	0.0%	$48.21	—	—	Call	885807906
—	KITOV PHARMACEUTICALS HOLDINGS WARRANTS 11/20/202	114,720	$56,000	0.0%	$0.49	$0.49	—	*W	49803V115
—	HEAT BIOLOGICS INC	21,971	$54,000	0.0%	$2.46	$6.36	—	COM	42237K102
—	PERSEON EQUITY WARRANTS	1,887,892	$49,000	0.0%	$0.03	$0.19	—	*W	715270112
—	CYTRX CORP	170	$45,000	0.0%	$264.71	—	—	Call	232828909
—	RENNOVA HEALTH INC.	30,222	$41,000	0.0%	$1.36	$1.36	—	COM	759757107
—	CELSION CORP.	18,789	$36,000	0.0%	$1.92	$2.43	—	COM	15117N404
—	INTELLIPHARMACEUTICS INTERNATIONAL INC	165	$33,000	0.0%	$200.00	—	—	Put	458173951
—	OPEXA THERAPEUTICS EQUITY WARRANTS 03/13/201	99,268	$10,000	0.0%	$0.10	$0.10	—	*W	68372T202
—	BIODEL INC SHS	182	$6,000	0.0%	$32.97	—	—	Put	09064M954
—	PERSEON CORP.	16,451	$4,000	0.0%	$0.24	$0.31	—	COM	715270203