Location: Miami Beach, FL
CIK: 0001535610 · Show all filings
Period: Q1 2017 (← Previous) (Next →)
Filing Date: May 16, 2017
Total Value: $1.854B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| — | MERCK & CO INC | 42,423 | $270M | 14.5% | $6354.01 | — | — | Call | 58933Y905 |
| — | SPDR S&P 500 ETF TR | 6,100 | $144M | 7.8% | $23573.93 | — | — | Put | 78462F953 |
| — | SPDR S&P 500 ETF TR | 5,999 | $141M | 7.6% | $23573.93 | — | — | Call | 78462F903 |
| — | ABBVIE INC | 16,669 | $109M | 5.9% | $6515.99 | — | — | Call | 00287Y909 |
| — | BRISTOL MYERS SQUIBB CO. | 18,473 | $100M | 5.4% | $5437.99 | — | — | Put | 110122958 |
| — | BRISTOL MYERS SQUIBB CO. | 14,019 | $76.23M | 4.1% | $5437.98 | — | — | Call | 110122908 |
| — | SELECT SECTOR SPDR TR | 9,448 | $70.25M | 3.8% | $7435.97 | — | — | Put | 81369Y959 |
| — | ISHARES TR | 5,000 | $68.74M | 3.7% | $13748.00 | — | — | Call | 464287905 |
| — | GILEAD SCIENCES INC | 8,286 | $56.28M | 3.0% | $6792.06 | — | — | Call | 375558903 |
| — | AMGEN INC | 3,055 | $50.12M | 2.7% | $16406.87 | — | — | Put | 031162950 |
| — | ASTRAZENECA PLC | 14,674 | $45.7M | 2.5% | $3114.01 | — | — | Call | 046353908 |
| — | ISHARES TR | 3,100 | $42.62M | 2.3% | $13748.06 | — | — | Put | 464287955 |
| — | ALEXION PHARMACEUTICALS INC | 2,817 | $34.15M | 1.8% | $12123.89 | — | — | Call | 015351909 |
| — | SPDR S&P BIOTECH | 4,388 | $30.43M | 1.6% | $6933.91 | — | — | Put | 78464A950 |
| — | CIGNA CORP | 1,580 | $23.14M | 1.2% | $14648.73 | — | — | Call | 125509909 |
| — | MERCK & CO INC | 3,327 | $21.14M | 1.1% | $6354.07 | — | — | Put | 58933Y955 |
| — | CLOVIS ONCOLOGY INC | 3,252 | $20.7M | 1.1% | $6366.85 | — | — | Call | 189464900 |
| — | UNITED THERAPEUTICS CORP | 1,410 | $19.09M | 1.0% | $13538.30 | — | — | Call | 91307C902 |
| — | BIOMARIN PHARMACEUTICAL INC | 1,969 | $17.28M | 0.9% | $8778.06 | — | — | Call | 09061G901 |
| — | BLUEBIRD BIO INC | 1,899 | $17.26M | 0.9% | $9090.05 | — | — | Call | 09609G900 |
| — | VERTEX PHARMACEUTICALS INC | 1,376 | $15.05M | 0.8% | $10935.32 | — | — | Call | 92532F900 |
| — | ACORDA THERAPEUTICS INC | 6,998 | $14.7M | 0.8% | $2100.03 | — | — | Put | 00484M956 |
| — | PORTOLA PHARMACEUTICALS INC | 3,560 | $13.95M | 0.8% | $3919.10 | — | — | Call | 737010908 |
| — | ASTRAZENECA PLC | 4,238 | $13.2M | 0.7% | $3113.97 | — | — | Put | 046353958 |
| — | AMGEN INC | 798 | $13.09M | 0.7% | $16407.27 | — | — | Call | 031162900 |
| BMY | BRISTOL MYERS SQUIBB CO. | 239,180 | $13.01M | 0.7% | $54.38 * | $43.12 | -7.4% | COM | 110122108 |
| — | GW PHARMACEUTICALS PLC | 1,074 | $12.99M | 0.7% | $12094.04 | — | — | Call | 36197T903 |
| — | ALNYLAM PHARMACEUTICALS INC | 2,477 | $12.7M | 0.7% | $5125.15 | — | — | Put | 02043Q957 |
| — | UNITED THERAPEUTICS CORP | 899 | $12.17M | 0.7% | $13538.38 | — | — | Put | 91307C952 |
| — | SAREPTA THERAPEUTICS INC | 4,049 | $11.98M | 0.6% | $2959.99 | — | — | Call | 803607900 |
| — | TESARO INC | 697 | $10.72M | 0.6% | $15387.37 | — | — | Put | 881569957 |
| — | IONIS PHARMACEUTICALS INC | 2,523 | $10.14M | 0.5% | $4019.82 | — | — | Put | 462222950 |
| — | ALNYLAM PHARMACEUTICALS INC | 1,965 | $10.07M | 0.5% | $5125.19 | — | — | Call | 02043Q907 |
| — | INCYTE CORP | 671 | $8.969M | 0.5% | $13366.62 | — | — | Call | 45337C902 |
| — | DYNAVAX TECHNOLOGIES CORP | 11,760 | $6.997M | 0.4% | $594.98 | — | — | Call | 268158901 |
| — | AXOVANT SCIENCES LTD | 4,612 | $6.89M | 0.4% | $1493.93 | — | — | Call | G0750W904 |
| — | HCA HOLDINGS INC | 750 | $6.674M | 0.4% | $8898.67 | — | — | Call | 40412C901 |
| — | ALEXION PHARMACEUTICALS INC | 550 | $6.668M | 0.4% | $12123.64 | — | — | Put | 015351959 |
| — | NEWLINK GENETICS CORP | 2,627 | $6.331M | 0.3% | $2409.97 | — | — | Put | 651511957 |
| — | INCYTE CORP | 468 | $6.256M | 0.3% | $13367.52 | — | — | Put | 45337C952 |
| AMGN | AMGEN INC | 37,104 | $6.088M | 0.3% | $164.08 * | $112.70 | +12.9% | COM | 031162100 |
| — | ONCOBIOLOGICS INC | 2,238,470 | $5.999M | 0.3% | $2.68 | $3.48 | — | COM | 68235M105 |
| — | VERTEX PHARMACEUTICALS INC | 542 | $5.927M | 0.3% | $10935.42 | — | — | Put | 92532F950 |
| — | NEWLINK GENETICS CORP | 2,415 | $5.82M | 0.3% | $2409.94 | — | — | Call | 651511907 |
| — | GW PHARMACEUTICALS PLC | 463 | $5.6M | 0.3% | $12095.03 | — | — | Put | 36197T953 |
| — | AXOVANT SCIENCES LTD | 3,640 | $5.438M | 0.3% | $1493.96 | — | — | Put | G0750W954 |
| — | INSMED INC | 3,061 | $5.36M | 0.3% | $1751.06 | — | — | Put | 457669957 |
| — | IONIS PHARMACEUTICALS INC | 1,311 | $5.27M | 0.3% | $4019.83 | — | — | Call | 462222900 |
| — | JAZZ PHARMACEUTICALS PLC | 334 | $4.847M | 0.3% | $14511.98 | — | — | Call | G50871905 |
| — | ABBVIE INC | 714 | $4.652M | 0.3% | $6515.41 | — | — | Put | 00287Y959 |
| IONS | IONIS PHARMACEUTICALS INC | 115,694 | $4.651M | 0.3% | $40.20 * | $44.91 | 0.0% | COM | 462222100 |
| — | MOTIF BIO PLC | 755,875 | $4.604M | 0.2% | $6.09 | $6.04 | — | ADR | 619784101 |
| — | SEATTLE GENETICS INC | 690 | $4.337M | 0.2% | $6285.51 | — | — | Put | 812578952 |
| — | AMARIN CORP PLC | 13,355 | $4.274M | 0.2% | $320.03 | — | — | Call | 023111906 |
| — | HALOZYME THERAPEUTICS INC | 3,248 | $4.209M | 0.2% | $1295.87 | — | — | Call | 40637H909 |
| — | EXELIXIS INC | 1,700 | $3.684M | 0.2% | $2167.06 | — | — | Call | 30161Q904 |
| — | PROTHENA CORPORATION PLC | 660 | $3.682M | 0.2% | $5578.79 | — | — | Call | G72800908 |
| — | MONSANTO CO | 313 | $3.543M | 0.2% | $11319.49 | — | — | Call | 61166W901 |
| — | SPECTRANETICS CORP | 1,191 | $3.469M | 0.2% | $2912.68 | — | — | Put | 84760C957 |
| — | OTONOMY INC | 278,840 | $3.416M | 0.2% | $12.25 | $12.38 | — | COM | 68906L105 |
| — | MANNKIND CORP | 23,014 | $3.406M | 0.2% | $148.00 | — | — | Put | 56400P956 |
| — | BIOAMBER INC | 1,460,859 | $3.388M | 0.2% | $2.32 | $2.32 | — | COM | 09072Q106 |
| — | SAGE THERAPEUTICS INC | 462 | $3.283M | 0.2% | $7106.06 | — | — | Put | 78667J958 |
| — | LA JOLLA PHARMACEUTICAL CO | 1,053 | $3.143M | 0.2% | $2984.81 | — | — | Call | 503459904 |
| — | TESARO INC | 202 | $3.108M | 0.2% | $15386.14 | — | — | Call | 881569907 |
| — | AMICUS THERAPEUTICS INC | 4,353 | $3.104M | 0.2% | $713.07 | — | — | Call | 03152W909 |
| — | BIOLINERX LTD | 3,141,756 | $3.018M | 0.2% | $0.96 | $0.96 | — | ADR | 09071M106 |
| — | APPLIED DNA SCIENCES | 1,771,839 | $2.93M | 0.2% | $1.65 | $1.85 | — | COM | 03815U201 |
| — | COHERUS BIOSCIENCES INC | 1,336 | $2.826M | 0.2% | $2115.27 | — | — | Put | 19249H953 |
| — | EIGER BIOPHARMACEUTICALS ORD SHS | 238,907 | $2.735M | 0.1% | $11.45 | $15.78 | — | COM | 28249U105 |
| — | NEURALSTEM INC | 515,216 | $2.72M | 0.1% | $5.28 | $5.28 | — | COM | 64127R401 |
| — | ACHILLION PHARMACEUTICALS INC | 6,363 | $2.679M | 0.1% | $421.03 | — | — | Call | 00448Q901 |
| — | SIERRA ONCOLOGY INC | 1,746,261 | $2.672M | 0.1% | $1.53 | $1.53 | — | COM | 82640U107 |
| — | ULTRAGENYX PHARMACEUTICAL INC | 394 | $2.671M | 0.1% | $6779.19 | — | — | Put | 90400D958 |
| — | INTEC PHARMA LTD | 514,878 | $2.652M | 0.1% | $5.15 | $5.46 | — | SHS | M53644106 |
| — | CYTOKINETICS INC | 2,023 | $2.6M | 0.1% | $1285.22 | — | — | Call | 23282W905 |
| — | STEMLINE THERAPEUTICS INC | 290,087 | $2.48M | 0.1% | $8.55 | $10.74 | — | COM | 85858C107 |
| UTHR | UNITED THERAPEUTICS CORP | 17,342 | $2.348M | 0.1% | $135.39 * | $151.49 | 0.0% | COM | 91307C102 |
| — | PUMA BIOTECHNOLOGY INC | 626 | $2.329M | 0.1% | $3720.45 | — | — | Put | 74587V957 |
| — | FIBROGEN INC | 940 | $2.317M | 0.1% | $2464.89 | — | — | Call | 31572Q908 |
| — | KITE PHARMA INC | 291 | $2.284M | 0.1% | $7848.80 | — | — | Put | 49803L959 |
| — | AVEXIS INC | 300 | $2.281M | 0.1% | $7603.33 | — | — | Call | 05366U900 |
| — | LEXICON PHARMACEUTICALS INC | 1,563 | $2.241M | 0.1% | $1433.78 | — | — | Call | 528872902 |
| — | ARRAY BIOPHARMA INC | 2,500 | $2.235M | 0.1% | $894.00 | — | — | Put | 04269X955 |
| — | PARATEK PHARMACEUTICALS INC | 1,141 | $2.196M | 0.1% | $1924.63 | — | — | Call | 699374902 |
| — | HEAT BIOLOGICS INC | 2,445,240 | $2.176M | 0.1% | $0.89 | $0.89 | — | COM | 42237K102 |
| ABUS | ARBUTUS BIOPHARMA CORP | 648,200 | $2.107M | 0.1% | $3.25 * | $7.22 | -61.6% | COM | 03879J100 |
| — | SPECTRANETICS CORP | 72,000 | $2.097M | 0.1% | $29.13 | $29.13 | — | COM | 84760C107 |
| — | SAGE THERAPEUTICS INC | 288 | $2.047M | 0.1% | $7107.64 | — | — | Call | 78667J908 |
| — | CYTORI THERAPEUTICS INC | 1,271,303 | $2.034M | 0.1% | $1.60 | $2.09 | — | COM | 23283K204 |
| EDIT | EDITAS MEDICINE INC | 90,300 | $2.015M | 0.1% | $22.31 * | $20.49 | +1.1% | COM | 28106W103 |
| — | BLUEPRINT MEDICINES CORP | 50,000 | $2M | 0.1% | $40.00 | $40.00 | — | COM | 09627Y109 |
| CHRS | COHERUS BIOSCIENCES INC | 93,308 | $1.973M | 0.1% | $21.15 * | $25.64 | -4.0% | COM | 19249H103 |
| — | PARATEK PHARMACEUTICALS INC | 1,025 | $1.973M | 0.1% | $1924.88 | — | — | Put | 699374952 |
| NTLA | INTELLIA THERAPEUTICS INC | 140,000 | $1.973M | 0.1% | $14.09 * | $18.15 | -26.1% | COM | 45826J105 |
| — | HISTOGENICS CORP | 1,095,422 | $1.895M | 0.1% | $1.73 | $1.81 | — | COM | 43358V109 |
| — | STEMLINE THERAPEUTICS INC | 2,174 | $1.859M | 0.1% | $855.11 | — | — | Call | 85858C907 |
| — | SANGAMO THERAPEUTICS INC | 3,493 | $1.816M | 0.1% | $519.90 | — | — | Call | 800677906 |
| — | FLEXION THERAPEUTICS INC | 659 | $1.773M | 0.1% | $2690.44 | — | — | Put | 33938J956 |
| — | RADIUS HEALTH INC | 454 | $1.755M | 0.1% | $3865.64 | — | — | Put | 750469957 |
| — | EDITAS MEDICINE INC | 784 | $1.75M | 0.1% | $2232.14 | — | — | Call | 28106W903 |
| — | DURECT CORP | 1,659,610 | $1.743M | 0.1% | $1.05 | $1.21 | — | COM | 266605104 |
| — | AMAG PHARMACEUTICALS INC | 75,263 | $1.697M | 0.1% | $22.55 | $22.55 | — | COM | 00163U106 |
| — | WRIGHT MEDICAL GROUP N.V. | 535 | $1.665M | 0.1% | $3112.15 | — | — | Call | N96617908 |
| — | ACORDA THERAPEUTICS INC | 76,610 | $1.609M | 0.1% | $21.00 | $18.80 | — | COM | 00484M106 |
| — | AMICUS THERAPEUTICS INC | 2,241 | $1.598M | 0.1% | $713.07 | — | — | Put | 03152W959 |
| — | MEDICINES CO | 320 | $1.565M | 0.1% | $4890.63 | — | — | Call | 584688905 |
| — | SEATTLE GENETICS INC | 242 | $1.521M | 0.1% | $6285.12 | — | — | Call | 812578902 |
| — | GALENA BIOPHARMA INC | 2,465,860 | $1.504M | 0.1% | $0.61 | $0.62 | — | COM | 363256504 |
| — | GLOBAL BLOOD THERAPEUTICS INC | 405 | $1.492M | 0.1% | $3683.95 | — | — | Call | 37890U908 |
| — | ARRAY BIOPHARMA INC | 156,074 | $1.395M | 0.1% | $8.94 | $8.94 | — | COM | 04269X105 |
| — | FLEXION THERAPEUTICS INC | 516 | $1.389M | 0.1% | $2691.86 | — | — | Call | 33938J906 |
| — | CIDARA THERAPEUTICS INC | 177,600 | $1.385M | 0.1% | $7.80 | $11.17 | — | COM | 171757107 |
| — | ROKA BIOSCIENCE | 389,136 | $1.374M | 0.1% | $3.53 | $4.20 | — | COM | 775431208 |
| — | BARCLAYS BANK PLC | 50,000 | $1.315M | 0.1% | $26.30 | $34.08 | — | IPATH | 06740Q260 |
| — | ZOGENIX INC | 1,201 | $1.303M | 0.1% | $1084.93 | — | — | Put | 98978L954 |
| — | MIRATI THERAPEUTICS INC | 249,735 | $1.299M | 0.1% | $5.20 | $5.76 | — | COM | 60468T105 |
| — | BIODELIVERY SCIENCES INTERNATIONAL INC | 673,342 | $1.279M | 0.1% | $1.90 | $4.74 | — | COM | 09060J106 |
| — | GEVO INC | 1,148,755 | $1.274M | 0.1% | $1.11 | $1.11 | — | COM | 374396307 |
| — | ONCOSEC MEDICAL INC | 975,839 | $1.255M | 0.1% | $1.29 | $2.48 | — | COM | 68234L207 |
| — | OHR PHARMACEUTICAL INC | 1,509,315 | $1.253M | 0.1% | $0.83 | $1.34 | — | COM | 67778H200 |
| — | OPGEN INC | 1,073,894 | $1.235M | 0.1% | $1.15 | $1.35 | — | COM | 68373L109 |
| XENE | XENON PHARMACEUTICALS INC. | 296,478 | $1.186M | 0.1% | $4.00 * | $7.86 | 0.0% | COM | 98420N105 |
| — | ONCONOVA THERAPEUTICS INC | 384,360 | $1.165M | 0.1% | $3.03 | $2.60 | — | COM | 68232V306 |
| — | INSMED INC | 663 | $1.161M | 0.1% | $1751.13 | — | — | Call | 457669907 |
| — | ESPERION THERAPEUTICS INC | 320 | $1.13M | 0.1% | $3531.25 | — | — | Call | 29664W905 |
| — | EXELIXIS INC | 500 | $1.084M | 0.1% | $2168.00 | — | — | Put | 30161Q954 |
| — | ALLIQUA BIOMEDICAL INC. | 2,131,050 | $1.076M | 0.1% | $0.50 | $1.07 | — | COM | 019621200 |
| — | REDHILL BIOPHARMA LTD | 108,014 | $1.036M | 0.1% | $9.59 | $11.28 | — | COM | 757468103 |
| — | RADIUS HEALTH INC | 25,828 | $998K | 0.1% | $38.64 | $38.64 | — | COM | 750469207 |
| CTSO | CYTOSORBENTS CORP | 220,000 | $990K | 0.1% | $4.50 * | $5.59 | 0.0% | COM | 23283X206 |
| — | APPLIED DNA SCIENCES | 2,431,089 | $985K | 0.1% | $0.41 | $0.49 | — | *W | 03815U110 |
| — | SOPHIRIS BIO INC | 343,422 | $972K | 0.1% | $2.83 | $3.11 | — | COM | 83578Q209 |
| — | IMMUNOMEDICS INC | 1,497 | $969K | 0.1% | $647.29 | — | — | Call | 452907908 |
| — | SUCAMPO PHARMACEUTICALS INC | 85,000 | $935K | 0.1% | $11.00 | $13.25 | — | CL A | 864909106 |
| — | ESPERION THERAPEUTICS INC | 257 | $907K | 0.0% | $3529.18 | — | — | Put | 29664W955 |
| ALDX | ALDEYRA THERAPEUTICS INC | 179,627 | $898K | 0.0% | $5.00 * | $5.15 | 0.0% | COM | 01438T106 |
| — | BELLICUM PHARMACEUTICALS INC | 72,500 | $895K | 0.0% | $12.34 | $12.34 | — | COM | 079481107 |
| — | SYNTHETIC BIOLOGICS INC | 1,414,211 | $892K | 0.0% | $0.63 | $0.76 | — | COM | 87164U102 |
| — | ZOGENIX INC | 816 | $885K | 0.0% | $1084.56 | — | — | Call | 98978L904 |
| — | IGNYTA INC | 95,918 | $825K | 0.0% | $8.60 | $6.50 | — | COM | 451731103 |
| — | CARDIOME PHARMA CORP | 273,010 | $819K | 0.0% | $3.00 | $3.14 | — | COM | 14159U301 |
| — | VTV THERAPEUTICS INC | 123,797 | $811K | 0.0% | $6.55 | $6.52 | — | CL A | 918385105 |
| — | OVASCIENCE INC | 423,775 | $792K | 0.0% | $1.87 | $2.25 | — | COM | 69014Q101 |
| — | CAPRICOR THERAPEUTICS INC | 237,589 | $791K | 0.0% | $3.33 | $4.04 | — | COM | 14070B101 |
| — | ADVERUM BIOTECHNOLOGIES | 282,630 | $763K | 0.0% | $2.70 | $3.16 | — | COM | 00773U108 |
| — | ONCOBIOLOGICS INC | 930,592 | $763K | 0.0% | $0.82 | $0.74 | — | *W | 68235M113 |
| — | COMBIMATRIX CORP | 619,750 | $762K | 0.0% | $1.23 | $0.67 | — | *W | 20009T147 |
| — | CYTORI THERAPEUTICS INC | 1,261,647 | $757K | 0.0% | $0.60 | $0.76 | — | *W | 23283K121 |
| — | AMEDICA CORP. | 1,857,578 | $751K | 0.0% | $0.40 | $0.40 | — | COM | 023435209 |
| — | ANTHERA PHARMACEUTICALS INC | 1,757,697 | $748K | 0.0% | $0.43 | $0.59 | — | COM | 03674U201 |
| — | FORWARD PHARMA A/S | 34,000 | $733K | 0.0% | $21.56 | $23.00 | — | ADR | 34986J105 |
| — | DICERNA PHARMACEUTICALS INC | 200,000 | $680K | 0.0% | $3.40 | $3.89 | — | COM | 253031108 |
| — | GENETIC TECHNOLOGIES LTD | 570,073 | $678K | 0.0% | $1.19 | $1.08 | — | ADR | 37185R208 |
| — | DRAGONWAVE INC. | 466,696 | $677K | 0.0% | $1.45 | $1.45 | — | COM | 26144M400 |
| — | RICEBRAN TECHNOLOGIES | 779,555 | $670K | 0.0% | $0.86 | $3.41 | — | COM | 762831204 |
| — | CASCADIAN THERAPEUTICS INC | 161,670 | $669K | 0.0% | $4.14 | $4.14 | — | COM | 14740B606 |
| — | ZAFGEN INC | 143,318 | $668K | 0.0% | $4.66 | $3.18 | — | COM | 98885E103 |
| — | PALATIN TECHNOLOGIES INC | 2,025,729 | $663K | 0.0% | $0.33 | $0.48 | — | COM | 696077403 |
| — | SUNESIS PHARMACEUTICALS INC | 1,612 | $661K | 0.0% | $410.05 | — | — | Call | 867328900 |
| — | BLUEBIRD BIO INC | 72 | $654K | 0.0% | $9083.33 | — | — | Put | 09609G950 |
| — | DURECT CORP | 6,215 | $653K | 0.0% | $105.07 | — | — | Call | 266605904 |
| — | PTC THERAPEUTICS INC | 649 | $639K | 0.0% | $984.59 | — | — | Put | 69366J950 |
| — | HEMISPHERX BIOPHARMA INC | 1,170,793 | $638K | 0.0% | $0.54 | $1.23 | — | COM | 42366C301 |
| — | SUNESIS PHARMACEUTICALS INC | 154,162 | $632K | 0.0% | $4.10 | $3.62 | — | COM | 867328700 |
| — | ZOGENIX INC | 57,700 | $626K | 0.0% | $10.85 | $10.85 | — | COM | 98978L204 |
| — | TG THERAPEUTICS INC | 490 | $571K | 0.0% | $1165.31 | — | — | Call | 88322Q908 |
| — | TG THERAPEUTICS INC | 488 | $569K | 0.0% | $1165.98 | — | — | Put | 88322Q958 |
| — | BIO PATH HOLDINGS INC. | 687,398 | $569K | 0.0% | $0.83 | $1.95 | — | COM | 09057N102 |
| — | SIGMA LABS INC | 182,244 | $565K | 0.0% | $3.10 | $3.10 | — | COM | 826598302 |
| — | MOTIF BIO PLC | 411,372 | $555K | 0.0% | $1.35 | $1.29 | — | *W | 619784119 |
| — | ONCONOVA THERAPEUTICS INC | 650,750 | $544K | 0.0% | $0.84 | $1.55 | — | *W | 68232V116 |
| — | EDAP TMS SA | 1,943 | $540K | 0.0% | $277.92 | — | — | Put | 268311957 |
| PTCT | PTC THERAPEUTICS INC | 54,736 | $539K | 0.0% | $9.85 * | $12.10 | 0.0% | COM | 69366J200 |
| — | LEXICON PHARMACEUTICALS INC | 375 | $538K | 0.0% | $1434.67 | — | — | Put | 528872952 |
| — | CHECK CAP LTD | 249,832 | $527K | 0.0% | $2.11 | $1.98 | — | SHS | M2361E112 |
| — | AVEO PHARMACEUTICALS INC | 868,900 | $513K | 0.0% | $0.59 | $0.59 | — | COM | 053588109 |
| — | AMPLIPHI BIOSCIENCES ORD SHS | 304,919 | $507K | 0.0% | $1.66 | $0.82 | — | COM | 03211P202 |
| — | VERSARTIS INC | 237 | $506K | 0.0% | $2135.02 | — | — | Call | 92529L902 |
| — | RXI PHARMACEUTICALS CORP | 2,238,487 | $492K | 0.0% | $0.22 | $0.20 | — | *W | 74979C113 |
| — | PROTEOSTASIS THERAPEUTICS INC | 59,700 | $467K | 0.0% | $7.82 | $7.82 | — | COM | 74373B109 |
| — | AZURRX BIOPHARMA INC | 119,693 | $462K | 0.0% | $3.86 | $4.74 | — | COM | 05502L105 |
| — | ONCOBIOLOGICS INC | 930,272 | $456K | 0.0% | $0.49 | $0.97 | — | *W | 68235M121 |
| — | LION BIOTECHNOLOGIES INC | 60,156 | $448K | 0.0% | $7.45 | $8.51 | — | COM | 53619R102 |
| — | IMMUNOCELLULAR THERAPEUTICS | 139,912 | $445K | 0.0% | $3.18 | $2.05 | — | COM | 452536204 |
| — | CYTRX CORP | 989,600 | $440K | 0.0% | $0.44 | $0.59 | — | COM | 232828509 |
| — | ADAMAS PHARMACEUTICALS INC | 931 | $439K | 0.0% | $471.54 | — | — | Put | 00548A956 |
| — | STRATA SKIN SCIENCES INC | 708,021 | $428K | 0.0% | $0.60 | $0.79 | — | COM | 86272A107 |
| — | PORTOLA PHARMACEUTICALS INC | 107 | $419K | 0.0% | $3915.89 | — | — | Put | 737010958 |
| — | ALKERMES PLC | 708 | $418K | 0.0% | $590.40 | — | — | Call | G01767905 |
| LXRX | LEXICON PHARMACEUTICALS INC | 28,626 | $410K | 0.0% | $14.32 * | $16.04 | -7.5% | COM | 528872302 |
| PBYI | PUMA BIOTECHNOLOGY INC | 10,600 | $394K | 0.0% | $37.17 | $43.24 | -15.6% | COM | 74587V107 |
| — | GALENA BIOPHARMA INC | 6,084 | $371K | 0.0% | $60.98 | — | — | Call | 363256904 |
| — | INTELLIA THERAPEUTICS INC | 252 | $355K | 0.0% | $1408.73 | — | — | Call | 45826J905 |
| — | PSIVIDA CORP | 205,100 | $353K | 0.0% | $1.72 | $2.63 | — | COM | 74440J101 |
| — | VISTAGEN THERAPEUTICS INC | 173,479 | $340K | 0.0% | $1.96 | $3.90 | — | COM | 92840H202 |
| — | ADVAXIS INC | 414 | $338K | 0.0% | $816.43 | — | — | Put | 007624958 |
| — | GREAT PANTHER SILVER LTD | 2,017 | $331K | 0.0% | $164.11 | — | — | Put | 39115V951 |
| — | WINDTREE THERAPEUTICS INC | 287,522 | $328K | 0.0% | $1.14 | $1.88 | — | COM | 97382D105 |
| — | STEMLINE THERAPEUTICS INC | 372 | $318K | 0.0% | $854.84 | — | — | Put | 85858C957 |
| — | ACORDA THERAPEUTICS INC | 149 | $313K | 0.0% | $2100.67 | — | — | Call | 00484M906 |
| MNKD | MANNKIND CORP | 209,292 | $310K | 0.0% | $1.48 * | $2.62 | 0.0% | COM | 56400P706 |
| — | TENAX THERAPEUTICS INC | 1,163,363 | $300K | 0.0% | $0.26 | $3.75 | — | COM | 88032L100 |
| — | BRAINSTORM CELL THERAPEUTICS INC. | 69,544 | $296K | 0.0% | $4.26 | $4.26 | — | COM | 10501E901 |
| — | SANGAMO THERAPEUTICS INC | 556 | $289K | 0.0% | $519.78 | — | — | Put | 800677956 |
| — | INSPIREMD INC | 1,214,925 | $258K | 0.0% | $0.21 | $0.60 | — | *W | 45779A127 |
| — | INTRA-CELLULAR THERAPIES INC | 158 | $257K | 0.0% | $1626.58 | — | — | Call | 46116X901 |
| — | AXOVANT SCIENCES LTD | 16,715 | $250K | 0.0% | $14.96 | $12.58 | — | COM | G0750W104 |
| — | SIGMA LABS INC | 250,000 | $250K | 0.0% | $1.00 | $1.00 | — | *W | 826598112 |
| — | AMAG PHARMACEUTICALS INC | 109 | $246K | 0.0% | $2256.88 | — | — | Call | 00163U906 |
| — | ACCELERON PHARMA INC | 92 | $244K | 0.0% | $2652.17 | — | — | Call | 00434H908 |
| — | SAGE THERAPEUTICS INC | 3,379 | $240K | 0.0% | $71.03 | $71.03 | — | COM | 78667J108 |
| — | INSPIREMD INC | 239,335 | $237K | 0.0% | $0.99 | $0.99 | — | COM | 45779A804 |
| CSBR | CHAMPIONS ONCOLOGY INC | 71,700 | $227K | 0.0% | $3.17 * | $4.47 | -21.8% | COM | 15870P307 |
| — | ADVAXIS INC | 270 | $221K | 0.0% | $818.52 | — | — | Call | 007624908 |
| — | INOTEK PHARMACEUTICALS | 100,930 | $202K | 0.0% | $2.00 | $8.92 | — | COM | 45780V102 |
| — | GALECTIN THERAPEUTICS INC | 840 | $193K | 0.0% | $229.76 | — | — | Put | 363225952 |
| — | NEUROMETRIX INC | 302,104 | $187K | 0.0% | $0.62 | $1.25 | — | COM | 641255500 |
| PARNEUR | PARNELL PHARMACEUTICALS HOLDINGS LTD | 203,549 | $181K | 0.0% | $0.89 | $1.62 | — | COM | Q73622104 |
| — | THERAPEUTICSMD INC | 250 | $180K | 0.0% | $720.00 | — | — | Call | 88338N907 |
| — | FOAMIX PHARMACEUTICALS LTD | 35,037 | $173K | 0.0% | $4.94 | $8.92 | — | SHS | M46135105 |
| — | BIOBLAST PHARMA LTD | 219,905 | $167K | 0.0% | $0.76 | $2.49 | — | SHS | M20156101 |
| — | MANNKIND CORP | 1,127 | $167K | 0.0% | $148.18 | — | — | Call | 56400P906 |
| — | OTONOMY INC | 130 | $159K | 0.0% | $1223.08 | — | — | Put | 68906L955 |
| — | CAPNIA INC | 233,938 | $159K | 0.0% | $0.68 | $1.08 | — | COM | 14066L105 |
| — | CEL SCI CORP | 1,799,815 | $154K | 0.0% | $0.09 | $0.28 | — | COM | 150837508 |
| — | PTC THERAPEUTICS INC | 153 | $151K | 0.0% | $986.93 | — | — | Call | 69366J900 |
| — | NEUROMETRIX INC | 2,947,179 | $148K | 0.0% | $0.05 | $0.31 | — | *W | 641255153 |
| — | LION BIOTECHNOLOGIES INC | 195 | $145K | 0.0% | $743.59 | — | — | Call | 53619R902 |
| — | CHIMERIX INC | 21,200 | $135K | 0.0% | $6.37 | $5.54 | — | COM | 16934W106 |
| — | AURIS MEDICAL HOLDING AG | 144,900 | $133K | 0.0% | $0.92 | $0.92 | — | COM | H03579101 |
| — | DYNAVAX TECHNOLOGIES CORP | 219 | $130K | 0.0% | $593.61 | — | — | Put | 268158951 |
| — | IGNYTA INC | 143 | $123K | 0.0% | $860.14 | — | — | Call | 451731903 |
| — | MOLECULIN BIOTECH INC | 100,000 | $117K | 0.0% | $1.17 | $1.17 | — | COM | 60855D101 |
| — | NEURALSTEM INC | 222 | $117K | 0.0% | $527.03 | — | — | Put | 64127R951 |
| — | IMMUNOCELLULAR THERAPEUTICS | 418,767 | $113K | 0.0% | $0.27 | $0.48 | — | *W | 452536121 |
| — | RENNOVA HEALTH INC | 5,249,822 | $105K | 0.0% | $0.02 | $0.06 | — | *W | 759757123 |
| — | ARBUTUS BIOPHARMA CORP | 315 | $102K | 0.0% | $323.81 | — | — | Call | 03879J900 |
| — | OPKO HEALTH INC | 126 | $101K | 0.0% | $801.59 | — | — | Put | 68375N953 |
| — | FOAMIX PHARMACEUTICALS LTD | 184 | $91,000 | 0.0% | $494.57 | — | — | Call | M46135905 |
| — | AEVI GENOMIC MEDICINE INC | 450 | $84,000 | 0.0% | $186.67 | — | — | Call | 00835P905 |
| — | ZAFGEN INC | 148 | $69,000 | 0.0% | $466.22 | — | — | Call | 98885E903 |
| — | OREXIGEN THERAPEUTICS INC | 197 | $68,000 | 0.0% | $345.18 | — | — | Put | 686164952 |
| OASMY | OASMIA PHARMACEUTICAL AB | 35,054 | $66,000 | 0.0% | $1.88 | $1.88 | — | ADR | 67421W109 |
| — | CAN-FITE BIOPHARMA LTD | 30,017 | $57,000 | 0.0% | $1.90 | $1.90 | — | ADR | 13471N102 |
| — | EKSO BIONICS HOLDINGS INC | 130 | $53,000 | 0.0% | $407.69 | — | — | Put | 282644952 |
| — | INTELLIPHARMACEUTICS INTERNATIONAL INC | 20,412 | $51,000 | 0.0% | $2.50 | $2.50 | — | COM | 458173101 |
| — | AETERNA ZENTARIS INC | 166 | $50,000 | 0.0% | $301.20 | — | — | Put | 007975952 |
| — | RENNOVA HEALTH INC | 24,988 | $45,000 | 0.0% | $1.80 | $0.19 | — | COM | 759757107 |
| VCEL | VERICEL INC | 14,694 | $41,000 | 0.0% | $2.79 | $2.57 | +9.9% | COM | 92346J108 |
| — | ARDELYX INC. | 160 | $40,000 | 0.0% | $250.00 | — | — | Put | 039697957 |
| — | AEVI GENOMIC MEDICINE INC | 19,888 | $37,000 | 0.0% | $1.86 | $5.18 | — | COM | 00835P105 |
| — | BENITEC BIOPHARMA LTD | 125,163 | $37,000 | 0.0% | $0.30 | $0.35 | — | *W | 082053117 |
| — | MIRNA THERAPEUTICS INC | 11,054 | $24,000 | 0.0% | $2.17 | $1.80 | — | COM | 60470J103 |
| — | CURIS INC | 187 | $10,000 | 0.0% | $53.48 | — | — | Put | 231269951 |
| — | HESS CORP | 250 | $2,000 | 0.0% | $8.00 | — | — | Call | 42809H907 |