Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	ELI LILLY & CO	23,675	$174M	10.1%	—	—	Call	532457908
—	SPDR S&P 500 ETF TR	6,000	$134M	7.8%	—	—	Put	78462F953
—	ISHARES TR	7,419	$100M	5.8%	—	—	Put	464287955
—	REGENERON PHARMACEUTICALS INC	2,198	$80.69M	4.7%	—	—	Put	75886F957
—	MERCK & CO	12,648	$74.46M	4.3%	—	—	Call	58933Y905
REGN	REGENERON PHARMACEUTICALS INC	162,517	$59.66M	3.5%	$387.29	-2.4%	COM	75886F107
SRPT	SAREPTA THERAPEUTICS INC	2,014,787	$55.27M	3.2%	$34.22	+17.4%	COM	803607100
—	AMGEN INC	3,694	$54.01M	3.1%	—	—	Put	031162950
—	SAREPTA THERAPEUTICS INC	19,251	$52.8M	3.1%	—	—	Put	803607950
—	BRISTOL MYERS SQUIBB CO	8,478	$49.55M	2.9%	—	—	Put	110122958
—	HCA HOLDINGS INC	6,491	$48.05M	2.8%	—	—	Call	40412C901
AMGN	AMGEN INC	252,795	$36.96M	2.2%	$112.70	+1.5%	COM	031162100
—	BRISTOL MYERS SQUIBB CO	5,419	$31.67M	1.8%	—	—	Call	110122908
—	TEVA PHARMACEUTICAL INDUSTRIES LTD	8,638	$31.31M	1.8%	—	—	Call	881624909
—	GILEAD SCIENCES INC	4,317	$30.91M	1.8%	—	—	Call	375558903
—	ELI LILLY & CO	4,043	$29.74M	1.7%	—	—	Put	532457958
—	SPDR S&P BIOTECH ETF	4,623	$27.36M	1.6%	—	—	Put	78464A950
—	TESARO INC	1,866	$25.09M	1.5%	—	—	Call	881569907
—	EXPRESS SCRIPTS HOLDING CO	2,897	$19.93M	1.2%	—	—	Call	30219G908
—	ALEXION PHARMACEUTICALS INC	1,586	$19.41M	1.1%	—	—	Call	015351909
—	ACADIA PHARMACEUTICALS INC	6,470	$18.66M	1.1%	—	—	Call	004225908
BMY	BRISTOL MYERS SQUIBB CO	289,183	$16.9M	1.0%	$43.12	-8.3%	COM	110122108
—	MYLAN N.V.	4,162	$15.88M	0.9%	—	—	Call	N59465909
—	UNITED THERAPEUTICS CORP	1,100	$15.78M	0.9%	—	—	Put	91307C952
LLY	ELI LILLY & CO	213,113	$15.67M	0.9%	$64.22	0.0%	COM	532457108
—	ZOGENIX INC	12,366	$15.03M	0.9%	—	—	Call	98978L904
—	CLOVIS ONCOLOGY INC	3,378	$15.01M	0.9%	—	—	Call	189464900
—	ABBVIE INC	2,204	$13.8M	0.8%	—	—	Call	00287Y909
—	ASTRAZENECA PLC	4,753	$12.98M	0.8%	—	—	Call	004635308
—	ACORDA THERAPEUTICS INC	6,145	$11.55M	0.7%	—	—	Put	00484M956
—	HORIZON PHARMA PLC	5,962	$9.647M	0.6%	—	—	Call	G4617B905
—	ALKERMES PLC	1,639	$9.11M	0.5%	—	—	Call	G01767905
—	RETROPHIN INC	4,798	$9.083M	0.5%	—	—	Call	761299906
—	EXPRESS SCRIPTS HOLDING CO	1,191	$8.193M	0.5%	—	—	Put	30219G958
—	EXELIXIS INC	5,392	$8.039M	0.5%	—	—	Put	30161Q954
—	VERTEX PHARMACEUTICALS INC	1,070	$7.883M	0.5%	—	—	Call	92532F900
—	ALNYLAM PHARMACEUTICALS INC	2,056	$7.698M	0.4%	—	—	Put	02043Q957
—	TESARO INC	563	$7.571M	0.4%	—	—	Put	881569957
—	REGENERON PHARMACEUTICALS INC	202	$7.415M	0.4%	—	—	Call	75886F907
—	ABBVIE INC	1,178	$7.377M	0.4%	—	—	Put	00287Y959
—	AXOVANT SCIENCES LTD	5,726	$7.112M	0.4%	—	—	Call	G0750W904
—	ONCOBIOLOGICS INC	2,238,470	$6.738M	0.4%	$3.48	—	COM	68235M105
—	PUMA BIOTECHNOLOGY INC	2,177	$6.683M	0.4%	—	—	Call	74587V907
—	PTC THERAPEUTICS INC	5,940	$6.481M	0.4%	—	—	Call	69366J900
—	HUMANA INC	291	$5.937M	0.3%	—	—	Call	444859902
BIIB	BIOGEN INC	20,000	$5.672M	0.3%	$296.43	0.0%	COM	09062X103
—	HESS CORP	902	$5.619M	0.3%	—	—	Call	42809H907
—	KITE PHARMA INC	1,171	$5.251M	0.3%	—	—	Call	49803L909
—	PUMA BIOTECHNOLOGY INC	1,699	$5.216M	0.3%	—	—	Put	74587V957
—	MOTIF BIO PLC	847,826	$5.121M	0.3%	$6.04	—	COM	619784101
—	AMICUS THERAPEUTICS INC	10,216	$5.077M	0.3%	—	—	Call	03152W909
—	IONIS PHARMACEUTICALS INC	1,054	$5.041M	0.3%	—	—	Call	462222900
—	ACORDA THERAPEUTICS INC	263,947	$4.962M	0.3%	$18.80	—	COM	00484M106
—	ALNYLAM PHARMACEUTICALS INC	1,240	$4.643M	0.3%	—	—	Call	02043Q907
—	SYNERGY PHARMACEUTICALS INC	7,536	$4.589M	0.3%	—	—	Call	871639908
—	RADIUS HEALTH INC	1,190	$4.526M	0.3%	—	—	Put	750469957
—	HORIZON PHARMA PLC	2,791	$4.516M	0.3%	—	—	Put	G4617B955
—	NEUROCRINE BIOSCIENCES INC	1,153	$4.462M	0.3%	—	—	Call	64125C909
—	AMGEN INC	301	$4.401M	0.3%	—	—	Call	031162900
—	SAGE THERAPEUTICS INC	849	$4.335M	0.3%	—	—	Call	78667J908
—	ACHILLION PHARMACEUTICALS INC	10,087	$4.166M	0.2%	—	—	Call	00448Q901
—	PORTOLA PHARMACEUTICALS INC	1,803	$4.046M	0.2%	—	—	Call	737010908
—	MEDICINES CO	1,172	$3.978M	0.2%	—	—	Put	584688955
—	APPLIED DNA SCIENCES	2,109,601	$3.903M	0.2%	$1.85	—	COM	03815U201
—	STEMLINE THERAPEUTICS INC	357,806	$3.829M	0.2%	$10.74	—	COM	85858C107
—	MEDICINES CO	112,392	$3.815M	0.2%	$34.14	—	COM	584688105
—	AMARIN CORPORATION PLC	12,346	$3.803M	0.2%	—	—	Call	023111906
—	UNITED THERAPEUTICS CORP	263	$3.772M	0.2%	—	—	Call	91307C902
—	LA JOLLA PHARMACEUTICAL CO	210,978	$3.698M	0.2%	$19.43	—	COM	503459604
—	BLUEBIRD BIO INC	597	$3.665M	0.2%	—	—	Call	09609G900
—	IONIS PHARMACEUTICALS INC	737	$3.525M	0.2%	—	—	Put	462222950
—	MONSANTO CO	313	$3.293M	0.2%	—	—	Call	61166W901
—	AXOVANT SCIENCES LTD	2,638	$3.276M	0.2%	—	—	Put	G0750W954
—	BIOGEN INC	115	$3.261M	0.2%	—	—	Call	09062X903
PBYI	PUMA BIOTECHNOLOGY INC	103,243	$3.17M	0.2%	$43.24	0.0%	COM	74587V107
—	CIDARA THERAPEUTICS INC	292,398	$3.041M	0.2%	$11.17	—	COM	171757107
—	TENAX THERAPEUTICS INC	1,516,835	$2.958M	0.2%	$3.75	—	COM	88032L100
—	LA JOLLA PHARMACEUTICAL CO	1,687	$2.957M	0.2%	—	—	Call	503459904
—	INTEC PHARMA LTD	514,100	$2.93M	0.2%	$5.46	—	SHS	M53644106
—	BIOGEN INC	100	$2.836M	0.2%	—	—	Put	09062X953
—	EIGER BIOPHARMACEUTICALS INC	240,541	$2.802M	0.2%	$15.78	—	COM	28249U105
—	INTRA-CELLULAR THERAPIES INC	1,781	$2.688M	0.2%	—	—	Call	46116X901
—	HALOZYME THERAPEUTICS INC	2,708	$2.676M	0.2%	—	—	Call	40637H909
—	EXELIXIS INC	1,783	$2.658M	0.2%	—	—	Call	30161Q904
—	GW PHARMACEUTICALS PLC	234	$2.615M	0.2%	—	—	Call	36197T903
—	COHERUS BIOSCIENCES INC	912	$2.567M	0.1%	—	—	Put	19249H953
—	FIBROGEN INC	1,189	$2.544M	0.1%	—	—	Call	31572Q908
—	INSMED INC	1,913	$2.531M	0.1%	—	—	Put	457669957
—	CYTORI THERAPEUTICS INC	1,651,835	$2.494M	0.1%	$2.09	—	COM	23283K204
—	PROTHENA CORPORATION PLC	490	$2.41M	0.1%	—	—	Call	G72800908
—	TENAX THERAPEUTICS INC	12,237	$2.386M	0.1%	—	—	Call	88032L900
—	SYNTHETIC BIOLOGICS INC	3,031,953	$2.312M	0.1%	$0.76	—	COM	87164U102
—	AGIOS PHARMACEUTICALS INC	545	$2.274M	0.1%	—	—	Call	00847X904
—	PACIRA PHARMACEUTICALS INC	700	$2.261M	0.1%	—	—	Call	695127900
—	VERTEX PHARMACEUTICALS INC	296	$2.181M	0.1%	—	—	Put	92532F950
—	ENDO INTERNATIONAL PLC	1,323	$2.179M	0.1%	—	—	Put	G30401956
—	LEXICON PHARMACEUTICALS INC	1,563	$2.162M	0.1%	—	—	Call	528872902
—	GW PHARMACEUTICALS PLC	192	$2.146M	0.1%	—	—	Put	36197T953
—	OPKO HEALTH INC	2,275	$2.116M	0.1%	—	—	Put	68375N953
—	ENDO INTERNATIONAL PLC	126,139	$2.078M	0.1%	$20.97	—	SHS	G30401106
—	SIENTRA INC	2,413	$2.056M	0.1%	—	—	Put	82621J955
—	DURECT CORP	1,528,516	$2.048M	0.1%	$1.22	—	COM	266605104
—	REDHILL BIOPHARMA LTD	191,785	$2.006M	0.1%	$11.28	—	ADS	757468103
ABUS	ARBUTUS BIOPHARMA CORP	792,617	$1.942M	0.1%	$7.22	-59.7%	COM	03879J100
—	INSMED INC	1,459	$1.93M	0.1%	—	—	Call	457669907
—	SANGAMO BIOSCIENCES INC	6,177	$1.884M	0.1%	—	—	Call	800677906
EDIT	EDITAS MEDICINE INC.	115,000	$1.866M	0.1%	$20.49	-25.9%	COM	28106W103
—	CLOVIS ONCOLOGY INC	420	$1.866M	0.1%	—	—	Put	189464950
—	PIERIS PHARMACEUTICALS INC	1,296,034	$1.814M	0.1%	$1.64	—	COM	720795103
OPK	OPKO HEALTH INC	190,955	$1.776M	0.1%	$10.35	0.0%	COM	68375N103
—	WAFERGEN BIO SYSTEMS INC	358,535	$1.771M	0.1%	$4.94	—	COM	93041P506
—	CYTRX CORP	4,697,802	$1.749M	0.1%	$0.59	—	COM	232828509
—	BARCLAYS BANK PLC	50,000	$1.743M	0.1%	$34.08	—	IPATH	06740Q260
—	OHR PHARMACEUTICAL INC	1,156,393	$1.735M	0.1%	$1.50	—	COM	67778H200
NTLA	INTELLIA THERAPEUTICS INC	130,000	$1.704M	0.1%	$18.52	-18.9%	COM	45826J105
—	PARATEK PHARMACEUTICALS INC	110,000	$1.694M	0.1%	$17.47	—	COM	699374302
—	SAREPTA THERAPEUTICS INC	611	$1.676M	0.1%	—	—	Call	803607900
—	NEWLINK GENETICS CORP	1,580	$1.624M	0.1%	—	—	Call	651511907
—	EXPRESS SCRIPTS HOLDING CO	23,494	$1.616M	0.1%	$68.78	—	COM	30219G108
—	ACADIA PHARMACEUTICALS INC	548	$1.58M	0.1%	—	—	Put	004225958
—	HISTOGENICS CORP	944,891	$1.578M	0.1%	$1.82	—	COM	43358V109
—	LION BIOTECHNOLOGIES INC	226,081	$1.571M	0.1%	$8.51	—	COM	53619R102
—	FORWARD PHARMA A/S	104,273	$1.565M	0.1%	$23.00	—	ADR	34986J105
—	MEDICINES CO	457	$1.551M	0.1%	—	—	Call	584688905
—	ROKA BIOSCIENCE INC	365,220	$1.549M	0.1%	$4.24	—	COM	775431208
VCYT	VERACYTE INC	193,999	$1.502M	0.1%	$7.48	0.0%	COM	92337F107
—	ONCOSEC MEDICAL INC	1,173,946	$1.444M	0.1%	$2.48	—	COM	68234L207
—	AETERNA ZENTARIS INC	400,560	$1.442M	0.1%	$3.75	—	COM	007975402
—	PRONAI THERAPEUTICS INC.	940,841	$1.402M	0.1%	$1.84	—	COM	74346L101
—	SOPHIRIS BIO INC	496,729	$1.391M	0.1%	$3.11	—	COM	83578Q209
—	OPKO HEALTH INC	1,491	$1.387M	0.1%	—	—	Call	68375N903
—	CHECK CAP LTD	575,113	$1.352M	0.1%	$1.98	—	SHS	M2361E112
—	KITE PHARMA INC	291	$1.305M	0.1%	—	—	Put	49803L959
—	AXOVANT SCIENCES LTD	100,998	$1.254M	0.1%	$12.58	—	COM	G0750W104
—	BIODELIVERY SCIENCES INTL INC.	698,235	$1.222M	0.1%	$4.74	—	COM	09060J106
—	CARDIOME PHARMA CORP	437,720	$1.208M	0.1%	$3.14	—	COM	14159U301
—	NEVRO CORP	165	$1.199M	0.1%	—	—	Call	64157F903
—	GENETIC TECHNOLOGIES LTD	1,070,333	$1.156M	0.1%	$1.08	—	SHS	37185R208
—	APPLIED DNA SCIENCES	2,277,612	$1.139M	0.1%	$0.50	—	*W	03815U110
—	REXAHN PHARMACEUTICALS INC	7,326,681	$1.04M	0.1%	$0.33	—	COM	761640101
—	IGNYTA INC	195,000	$1.034M	0.1%	$6.50	—	COM	451731103
—	AGENUS INC	2,503	$1.031M	0.1%	—	—	Put	00847G955
—	ONCONOVA THERAPEUTICS INC	452,804	$1.028M	0.1%	$2.60	—	COM	68232V306
—	SUCAMPO PHARMACEUTICALS INC	75,000	$1.016M	0.1%	$13.55	—	CL A	864909106
—	CAPRICOR THERAPEUTICS INC	372,046	$990K	0.1%	$4.04	—	COM	14070B101
—	ZAFGEN INC.	310,000	$986K	0.1%	$3.18	—	COM	98885E103
—	FOAMIX PHARMACEUTICALS LTD	881	$978K	0.1%	—	—	Call	M46135905
LXRX	LEXICON PHARMACEUTICALS INC	70,040	$969K	0.1%	$16.04	0.0%	COM	528872302
—	HEMISPHERX BIOPHARMA INC	1,391,286	$960K	0.1%	$1.23	—	COM	42366C301
—	DURECT CORP	6,927	$928K	0.1%	—	—	Call	266605904
—	INOTEK PHARMACEUTICALS CORP	150,930	$921K	0.1%	$8.92	—	COM	45780V102
—	RICEBRAN TECHNOLOGIES	875,286	$902K	0.1%	$3.41	—	COM	762831204
RGNX	REGENXBIO INC	48,400	$898K	0.1%	$14.34	+33.3%	COM	75901B107
—	BIO PATH HOLDINGS INC.	664,046	$896K	0.1%	$1.99	—	COM	09057N102
—	LION BIOTECHNOLOGIES INC	1,260	$876K	0.1%	—	—	Put	53619R952
—	CYTORI THERAPEUTICS INC	1,273,712	$866K	0.1%	$0.76	—	*W	23283K121
—	PALATIN TECHNOLOGIES INC	1,672,573	$853K	0.0%	$0.51	—	COM	696077403
—	ADVERUM BIOTECHNOLOGIES INC.	283,306	$822K	0.0%	$3.16	—	COM	00773U108
CHRS	COHERUS BIOSCIENCES INC	28,618	$806K	0.0%	$27.98	0.0%	COM	19249H103
—	VANDA PHARMACEUTICALS INC	503	$802K	0.0%	—	—	Call	921659908
—	SUNESIS PHARMACEUTICALS INC	221,326	$801K	0.0%	$3.62	—	COM	867328700
—	DYNAVAX TECHNOLOGIES CORP	1,979	$782K	0.0%	—	—	Call	268158901
—	RETROPHIN INC	408	$772K	0.0%	—	—	Put	761299956
—	ACTINIUM PHARMACEUTICALS INC	868,608	$760K	0.0%	$1.35	—	COM	00507W107
—	ACORDA THERAPEUTICS INC	398	$748K	0.0%	—	—	Call	00484M906
—	HCA HOLDINGS INC	100	$740K	0.0%	—	—	Put	40412C951
—	INSPIREMD INC	1,210,106	$726K	0.0%	$0.60	—	*W	45779A127
—	ONCOBIOLOGICS INC	930,272	$726K	0.0%	$0.97	—	*W	68235M121
—	AEVI GENOMIC MEDICINE INC.	138,195	$716K	0.0%	$5.18	—	COM	00835P105
XBI	SPDR S&P BIOTECH ETF	11,700	$693K	0.0%	$59.23	—	ETF	78464A870
—	OCERA THERAPEUTICS INC	328,632	$690K	0.0%	$5.54	—	COM	67552A108
—	BIOBLAST PHARMA LTD	660,157	$687K	0.0%	$2.49	—	SHS	M20156101
—	AMPLIPHI BIOSCIENCES CORP	1,518,814	$668K	0.0%	$0.82	—	COM	03211P202
—	VISTAGEN THERAPEUTICS INC	176,384	$658K	0.0%	$3.90	—	COM	92840H202
—	PTC THERAPEUTICS INC	597	$651K	0.0%	—	—	Put	69366J950
—	ALCOBRA LTD	3,102	$651K	0.0%	—	—	Call	M2239P909
—	ALLIQUA BIOMEDICAL INC	1,100,398	$649K	0.0%	$1.60	—	COM	019621200
—	FOAMIX PHARMACEUTICALS LTD	58,338	$648K	0.0%	$8.92	—	SHS	M46135105
CSBR	CHAMPIONS ONCOLOGY INC	253,504	$641K	0.0%	$4.47	-56.5%	COM	15870P307
—	VTV THERAPEUTICS INC	132,547	$640K	0.0%	$6.52	—	CL A	918385105
—	BRAINSTORM CELL THERAPEUTICS	250,766	$637K	0.0%	$4.17	—	COM	10501E201
INSM	INSMED INC	48,043	$636K	0.0%	$13.64	0.0%	COM	457669307
—	SIENTRA INC	70,973	$605K	0.0%	$8.52	—	COM	82621J105
—	OPGEN INC	525,146	$604K	0.0%	$1.55	—	COM	68373L109
—	LA JOLLA PHARMACEUTICAL CO	336	$589K	0.0%	—	—	Put	503459954
—	NEWLINK GENETICS CORP	56,289	$579K	0.0%	$23.87	—	COM	651511107
—	AMICUS THERAPEUTICS INC	1,140	$567K	0.0%	—	—	Put	03152W959
—	AZURRX BIOPHARMA INC.	118,993	$564K	0.0%	$4.74	—	COM	05502L105
—	MOTIF BIO PLC	426,170	$550K	0.0%	$1.29	—	*W	619784119
—	SUPERCONDUCTOR TECHNOLOGIES	434,747	$535K	0.0%	$2.06	—	COM	867931503
—	BLUEPRINT MEDICINES CORP	190	$533K	0.0%	—	—	Put	09627Y959
—	HALOZYME THERAPEUTICS INC	532	$526K	0.0%	—	—	Put	40637H959
—	SAGE THERAPEUTICS INC	102	$521K	0.0%	—	—	Put	78667J958
ALNY	ALNYLAM PHARMACEUTICALS INC	13,823	$518K	0.0%	$41.87	0.0%	COM	02043Q107
—	PACIRA PHARMACEUTICALS INC	159	$514K	0.0%	—	—	Put	695127950
—	NEURODERM LTD	23,033	$511K	0.0%	$22.19	—	SHS	M74231107
—	MANNKIND CORP	7,842	$499K	0.0%	—	—	Put	56400P951
—	ARBUTUS BIOPHARMA CORP	2,033	$498K	0.0%	—	—	Call	03879J900
—	MIRATI THERAPEUTICS INC	99,735	$474K	0.0%	$6.61	—	COM	60468T105
—	FLEXION THERAPEUTICS INC	248	$472K	0.0%	—	—	Put	33938J956
—	STRATA SKIN SCIENCES INC	1,034,820	$455K	0.0%	$0.79	—	COM	86272A107
—	RXI PHARMACEUTICALS CORP	2,270,283	$454K	0.0%	$0.20	—	*W	74979C113
VCEL	VERICEL INC	149,900	$450K	0.0%	$2.57	0.0%	COM	92346J108
—	XTL BIOPHARMACEUTICALS LTD	724,134	$434K	0.0%	$2.30	—	ADR	98386D208
—	ONCONOVA THERAPEUTICS INC	691,072	$428K	0.0%	$1.55	—	*W	68232V116
—	CEL SCI CORP	6,360,207	$427K	0.0%	$0.28	—	COM	150837508
—	OPHTHOTECH CORP	883	$426K	0.0%	—	—	Call	683745903
—	CELSION CORP	1,333,093	$416K	0.0%	$0.96	—	COM	15117N404
—	WINDTREE THERAPEUTICS INC	334,414	$415K	0.0%	$1.88	—	COM	97382D105
—	BELLEROPHON THERAPEUTICS INC	789,857	$414K	0.0%	$0.52	—	COM	078771102
—	THERAPEUTICSMD INC	703	$406K	0.0%	—	—	Call	88338N907
—	CELLECTAR BIOSCIENCES INC	323,515	$395K	0.0%	$1.22	—	COM	15117F302
—	TG THERAPEUTICS INC	848	$394K	0.0%	—	—	Put	88322Q958
—	BENITEC BIOPHARMA LTD	254,445	$389K	0.0%	$1.53	—	ADR	082053307
—	GENVEC INC	120,544	$387K	0.0%	$3.21	—	COM	37246C406
—	DEXTERA SURGICAL INC	397,863	$382K	0.0%	$1.80	—	COM	252366109
—	STEMLINE THERAPEUTICS INC	356	$381K	0.0%	—	—	Call	85858C907
—	CHIMERIX INC	79,900	$368K	0.0%	$5.54	—	COM	16934W106
—	COMBIMATRIX CORP	844,917	$363K	0.0%	$0.67	—	*W	20009T147
—	PSIVIDA CORP	205,100	$351K	0.0%	$2.63	—	COM	74440J101
—	AMARIN CORPORATION PLC	1,118	$344K	0.0%	—	—	Put	023111956
—	THERAPEUTICSMD INC	586	$338K	0.0%	—	—	Put	88338N957
—	DEPOMED INC	186	$335K	0.0%	—	—	Call	249908904
—	IMMUNOCELLULAR THERAPEUTICS	160,129	$328K	0.0%	$2.05	—	COM	452536204
—	BIOCEPT INC	411,432	$319K	0.0%	$0.78	—	COM	09072V204
—	EYEGATE PHARMACEUTICALS INC	192,721	$314K	0.0%	$2.36	—	COM	30233M107
—	INOTEK PHARMACEUTICALS CORP	500	$305K	0.0%	—	—	Put	45780V952
FOLD	AMICUS THERAPEUTICS INC	60,309	$300K	0.0%	$6.92	0.0%	COM	03152W109
—	ADVAXIS INC	414	$296K	0.0%	—	—	Put	007624958
—	DICERNA PHARMACEUTICALS INC	100,000	$288K	0.0%	$4.38	—	COM	253031108
—	RXI PHARMACEUTICALS CORP	397,371	$284K	0.0%	$0.71	—	COM	74979C501
—	BIOPHARMX CORP	708,046	$265K	0.0%	$0.96	—	COM	09072X101
—	DYNAVAX TECHNOLOGIES CORP	66,091	$261K	0.0%	$15.82	—	COM	268158201
—	ROSETTA GENOMICS LTD	591,339	$248K	0.0%	$0.42	—	SHS	M82183126
—	PORTOLA PHARMACEUTICALS INC	107	$240K	0.0%	—	—	Put	737010958
—	FLEXION THERAPEUTICS INC	126	$240K	0.0%	—	—	Call	33938J906
—	AETERNA ZENTARIS INC	614	$221K	0.0%	—	—	Put	007975952
—	NEUROMETRIX INC	3,017,747	$211K	0.0%	$0.31	—	*W	641255153
—	FLEXION THERAPEUTICS INC	10,914	$208K	0.0%	$12.31	—	COM	33938J106
PRQR	PROQR THERAPEUTICS N V	40,000	$196K	0.0%	$7.45	-30.9%	SHS	N71542109
—	JUNO THERAPEUTICS INC	103	$194K	0.0%	—	—	Call	48205A909
—	ADVAXIS INC	270	$193K	0.0%	—	—	Call	007624908
SGMO	SANGAMO BIOSCIENCES INC	63,204	$193K	0.0%	$4.39	-17.1%	COM	800677106
—	ALCOBRA LTD	91,858	$193K	0.0%	$2.80	—	SHS	M2239P109
—	IMMUNOCELLULAR THERAPEUTICS	383,471	$192K	0.0%	$0.50	—	*W	452536121
—	HERON THERAPEUTICS INC	141	$185K	0.0%	—	—	Call	427746902
—	IMMUNOMEDICS INC	50,000	$184K	0.0%	$68.00	—	COM	452907108
—	MIRNA THERAPEUTICS INC	100,200	$180K	0.0%	$1.80	—	COM	60470J103
—	CELLECT BIOTECHNOLOGY LTD	57,348	$177K	0.0%	$4.60	—	ADS	15116C102
—	RENNOVA HEALTH INC	2,022,213	$167K	0.0%	$0.19	—	COM	759757107
—	LEXICON PHARMACEUTICALS INC	121	$167K	0.0%	—	—	Put	528872952
—	ZOGENIX INC	136	$165K	0.0%	—	—	Put	98978L954
—	GALENA BIOPHARMA INC	847	$164K	0.0%	—	—	Put	363256954
—	OTONOMY ORD SHS	10,000	$159K	0.0%	$15.90	—	COM	68906L105
—	ONCOBIOLOGICS INC	930,592	$154K	0.0%	$0.74	—	*W	68235M113
—	CAPNIA INC	179,002	$145K	0.0%	$1.20	—	COM	14066L105
—	THERAPEUTICSMD INC	24,955	$144K	0.0%	$6.82	—	COM	88338N107
PARNEUR	PARNELL PHARMACEUTICALS HOLDINGS LTD	200,549	$138K	0.0%	$1.63	—	COM	Q73622104
—	LION BIOTECHNOLOGIES INC	195	$136K	0.0%	—	—	Call	53619R990
—	NEKTAR THERAPEUTICS	110	$135K	0.0%	—	—	Call	640268908
—	NEUROMETRIX INC	166,268	$123K	0.0%	$1.76	—	COM	641255500
—	CEMPRA INC	43,121	$121K	0.0%	$2.81	—	COM	15130J109
—	AKARI THERAPEUTICS PLC	17,428	$120K	0.0%	$14.89	—	ADR	00972G108
—	RENNOVA HEALTH INC	4,926,013	$118K	0.0%	$0.06	—	*W	759757123
—	ALCOBRA LTD	559	$117K	0.0%	—	—	Put	M2239P959
—	EDAP TMS S A	341	$112K	0.0%	—	—	Put	268311957
—	DYNAVAX TECHNOLOGIES CORP	258	$102K	0.0%	—	—	Put	268158951
—	CANCER GENETICS INC	71,971	$97,000	0.0%	$2.48	—	COM	13739U104
—	ASTERIAS BIOTHERAPEUTICS INC	200	$92,000	0.0%	—	—	Call	04624N907
—	NIVALIS THERAPEUTICS INC	40,004	$90,000	0.0%	$11.19	—	COM	65481J109
—	CELLECTAR BIOSCIENCES INC	201,889	$85,000	0.0%	$0.89	—	*W	15117F120
—	ZOSANO PHARMA ORD SHS	103,600	$81,000	0.0%	$9.59	—	COM	98979H103
ACUR	ACURA PHARMACEUTICALS INC.	103,444	$79,000	0.0%	$3.40	-69.3%	COM	00509L802
EDAP	EDAP TMS S A	22,993	$76,000	0.0%	$3.31	—	ADR	268311107
—	ADVAXIS INC	10,443	$75,000	0.0%	$7.18	—	COM	007624208
—	OVASCIENCE INC	48,450	$74,000	0.0%	$5.21	—	COM	69014Q101
—	ENTEROMEDICS INC	33,387	$67,000	0.0%	$2.01	—	COM	29365M505
—	ATHERSYS INC	43,263	$66,000	0.0%	$2.17	—	COM	04744L106
—	INOTEK PHARMACEUTICALS CORP	106	$65,000	0.0%	—	—	Call	45780V902
—	ANTHERA PHARMACEUTICALS INC	987	$64,000	0.0%	—	—	Call	03674U901
—	NEURALSTEM INC	229,521	$63,000	0.0%	$0.29	—	COM	64127R302
—	ANTHERA PHARMACEUTICALS INC	91,055	$59,000	0.0%	$3.62	—	COM	03674U201
—	MEDIGUS LTD	87,876	$50,000	0.0%	$1.32	—	ADR	58471G102
—	GREAT PANTHER SILVER LTD	269	$45,000	0.0%	—	—	Put	39115V951
—	GALENA BIOPHARMA INC	23,298	$45,000	0.0%	$1.93	—	COM	363256504
—	ADAMIS PHARMACEUTICALS CORP	134	$42,000	0.0%	—	—	Put	00547W958
—	VIKING THERAPEUTICS INC	86,349	$39,000	0.0%	$0.29	—	*W	92686J114
—	TENAX THERAPEUTICS INC	169	$33,000	0.0%	—	—	Put	88032L950
—	RIGEL PHARMACEUTICALS INC	12,350	$29,000	0.0%	$2.23	—	COM	766559603
—	GALECTIN THERAPEUTICS INC	235	$23,000	0.0%	—	—	Put	363225952
—	NOVAVAX INC	159	$20,000	0.0%	—	—	Call	670002904
—	BENITEC BIOPHARMA LTD	98,146	$10,000	0.0%	$0.36	—	*W	082053117
—	EYEGATE PHARMACEUTICALS INC	20,604	$6,000	0.0%	$1.02	—	*W	30233M115