Location: Miami Beach, FL
CIK: 0001535610 · Show all filings
Period: Q4 2016 (← Previous) (Next →)
Filing Date: Feb 14, 2017
Total Value: $1.719B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| — | ELI LILLY & CO | 23,675 | $174M | 10.1% | $7355.02 | — | — | Call | 532457908 |
| — | SPDR S&P 500 ETF TR | 6,000 | $134M | 7.8% | $22353.00 | — | — | Put | 78462F953 |
| — | ISHARES TR | 7,419 | $100M | 5.8% | $13484.97 | — | — | Put | 464287955 |
| — | REGENERON PHARMACEUTICALS INC | 2,198 | $80.69M | 4.7% | $36708.83 | — | — | Put | 75886F957 |
| — | MERCK & CO | 12,648 | $74.46M | 4.3% | $5887.02 | — | — | Call | 58933Y905 |
| REGN | REGENERON PHARMACEUTICALS INC | 162,517 | $59.66M | 3.5% | $367.09 * | $387.29 | -2.4% | COM | 75886F107 |
| SRPT | SAREPTA THERAPEUTICS INC | 2,014,787 | $55.27M | 3.2% | $27.43 * | $34.22 | +17.4% | COM | 803607100 |
| — | AMGEN INC | 3,694 | $54.01M | 3.1% | $14621.01 | — | — | Put | 031162950 |
| — | SAREPTA THERAPEUTICS INC | 19,251 | $52.8M | 3.1% | $2742.97 | — | — | Put | 803607950 |
| — | BRISTOL MYERS SQUIBB CO | 8,478 | $49.55M | 2.9% | $5843.95 | — | — | Put | 110122958 |
| — | HCA HOLDINGS INC | 6,491 | $48.05M | 2.8% | $7401.94 | — | — | Call | 40412C901 |
| AMGN | AMGEN INC | 252,795 | $36.96M | 2.2% | $146.21 * | $112.70 | +1.5% | COM | 031162100 |
| — | BRISTOL MYERS SQUIBB CO | 5,419 | $31.67M | 1.8% | $5844.07 | — | — | Call | 110122908 |
| — | TEVA PHARMACEUTICAL INDUSTRIES LTD | 8,638 | $31.31M | 1.8% | $3625.03 | — | — | Call | 881624909 |
| — | GILEAD SCIENCES INC | 4,317 | $30.91M | 1.8% | $7160.99 | — | — | Call | 375558903 |
| — | ELI LILLY & CO | 4,043 | $29.74M | 1.7% | $7354.93 | — | — | Put | 532457958 |
| — | SPDR S&P BIOTECH ETF | 4,623 | $27.36M | 1.6% | $5919.10 | — | — | Put | 78464A950 |
| — | TESARO INC | 1,866 | $25.09M | 1.5% | $13448.02 | — | — | Call | 881569907 |
| — | EXPRESS SCRIPTS HOLDING CO | 2,897 | $19.93M | 1.2% | $6878.84 | — | — | Call | 30219G908 |
| — | ALEXION PHARMACEUTICALS INC | 1,586 | $19.41M | 1.1% | $12235.18 | — | — | Call | 015351909 |
| — | ACADIA PHARMACEUTICALS INC | 6,470 | $18.66M | 1.1% | $2883.93 | — | — | Call | 004225908 |
| BMY | BRISTOL MYERS SQUIBB CO | 289,183 | $16.9M | 1.0% | $58.44 * | $43.12 | -8.3% | COM | 110122108 |
| — | MYLAN N.V. | 4,162 | $15.88M | 0.9% | $3814.99 | — | — | Call | N59465909 |
| — | UNITED THERAPEUTICS CORP | 1,100 | $15.78M | 0.9% | $14342.73 | — | — | Put | 91307C952 |
| LLY | ELI LILLY & CO | 213,113 | $15.67M | 0.9% | $73.55 * | $64.22 | 0.0% | COM | 532457108 |
| — | ZOGENIX INC | 12,366 | $15.03M | 0.9% | $1215.03 | — | — | Call | 98978L904 |
| — | CLOVIS ONCOLOGY INC | 3,378 | $15.01M | 0.9% | $4441.98 | — | — | Call | 189464900 |
| — | ABBVIE INC | 2,204 | $13.8M | 0.8% | $6261.80 | — | — | Call | 00287Y909 |
| — | ASTRAZENECA PLC | 4,753 | $12.98M | 0.8% | $2731.96 | — | — | Call | 004635308 |
| — | ACORDA THERAPEUTICS INC | 6,145 | $11.55M | 0.7% | $1880.07 | — | — | Put | 00484M956 |
| — | HORIZON PHARMA PLC | 5,962 | $9.647M | 0.6% | $1618.08 | — | — | Call | G4617B905 |
| — | ALKERMES PLC | 1,639 | $9.11M | 0.5% | $5558.27 | — | — | Call | G01767905 |
| — | RETROPHIN INC | 4,798 | $9.083M | 0.5% | $1893.08 | — | — | Call | 761299906 |
| — | EXPRESS SCRIPTS HOLDING CO | 1,191 | $8.193M | 0.5% | $6879.09 | — | — | Put | 30219G958 |
| — | EXELIXIS INC | 5,392 | $8.039M | 0.5% | $1490.91 | — | — | Put | 30161Q954 |
| — | VERTEX PHARMACEUTICALS INC | 1,070 | $7.883M | 0.5% | $7367.29 | — | — | Call | 92532F900 |
| — | ALNYLAM PHARMACEUTICALS INC | 2,056 | $7.698M | 0.4% | $3744.16 | — | — | Put | 02043Q957 |
| — | TESARO INC | 563 | $7.571M | 0.4% | $13447.60 | — | — | Put | 881569957 |
| — | REGENERON PHARMACEUTICALS INC | 202 | $7.415M | 0.4% | $36707.92 | — | — | Call | 75886F907 |
| — | ABBVIE INC | 1,178 | $7.377M | 0.4% | $6262.31 | — | — | Put | 00287Y959 |
| — | AXOVANT SCIENCES LTD | 5,726 | $7.112M | 0.4% | $1242.05 | — | — | Call | G0750W904 |
| — | ONCOBIOLOGICS INC | 2,238,470 | $6.738M | 0.4% | $3.01 | $3.48 | — | COM | 68235M105 |
| — | PUMA BIOTECHNOLOGY INC | 2,177 | $6.683M | 0.4% | $3069.82 | — | — | Call | 74587V907 |
| — | PTC THERAPEUTICS INC | 5,940 | $6.481M | 0.4% | $1091.08 | — | — | Call | 69366J900 |
| — | HUMANA INC | 291 | $5.937M | 0.3% | $20402.06 | — | — | Call | 444859902 |
| BIIB | BIOGEN INC | 20,000 | $5.672M | 0.3% | $283.60 * | $296.43 | 0.0% | COM | 09062X103 |
| — | HESS CORP | 902 | $5.619M | 0.3% | $6229.49 | — | — | Call | 42809H907 |
| — | KITE PHARMA INC | 1,171 | $5.251M | 0.3% | $4484.20 | — | — | Call | 49803L909 |
| — | PUMA BIOTECHNOLOGY INC | 1,699 | $5.216M | 0.3% | $3070.04 | — | — | Put | 74587V957 |
| — | MOTIF BIO PLC | 847,826 | $5.121M | 0.3% | $6.04 | $6.04 | — | COM | 619784101 |
| — | AMICUS THERAPEUTICS INC | 10,216 | $5.077M | 0.3% | $496.97 | — | — | Call | 03152W909 |
| — | IONIS PHARMACEUTICALS INC | 1,054 | $5.041M | 0.3% | $4782.73 | — | — | Call | 462222900 |
| — | ACORDA THERAPEUTICS INC | 263,947 | $4.962M | 0.3% | $18.80 | $18.80 | — | COM | 00484M106 |
| — | ALNYLAM PHARMACEUTICALS INC | 1,240 | $4.643M | 0.3% | $3744.35 | — | — | Call | 02043Q907 |
| — | SYNERGY PHARMACEUTICALS INC | 7,536 | $4.589M | 0.3% | $608.94 | — | — | Call | 871639908 |
| — | RADIUS HEALTH INC | 1,190 | $4.526M | 0.3% | $3803.36 | — | — | Put | 750469957 |
| — | HORIZON PHARMA PLC | 2,791 | $4.516M | 0.3% | $1618.06 | — | — | Put | G4617B955 |
| — | NEUROCRINE BIOSCIENCES INC | 1,153 | $4.462M | 0.3% | $3869.90 | — | — | Call | 64125C909 |
| — | AMGEN INC | 301 | $4.401M | 0.3% | $14621.26 | — | — | Call | 031162900 |
| — | SAGE THERAPEUTICS INC | 849 | $4.335M | 0.3% | $5106.01 | — | — | Call | 78667J908 |
| — | ACHILLION PHARMACEUTICALS INC | 10,087 | $4.166M | 0.2% | $413.01 | — | — | Call | 00448Q901 |
| — | PORTOLA PHARMACEUTICALS INC | 1,803 | $4.046M | 0.2% | $2244.04 | — | — | Call | 737010908 |
| — | MEDICINES CO | 1,172 | $3.978M | 0.2% | $3394.20 | — | — | Put | 584688955 |
| — | APPLIED DNA SCIENCES | 2,109,601 | $3.903M | 0.2% | $1.85 | $1.85 | — | COM | 03815U201 |
| — | STEMLINE THERAPEUTICS INC | 357,806 | $3.829M | 0.2% | $10.70 | $10.74 | — | COM | 85858C107 |
| — | MEDICINES CO | 112,392 | $3.815M | 0.2% | $33.94 | $34.14 | — | COM | 584688105 |
| — | AMARIN CORPORATION PLC | 12,346 | $3.803M | 0.2% | $308.03 | — | — | Call | 023111906 |
| — | UNITED THERAPEUTICS CORP | 263 | $3.772M | 0.2% | $14342.21 | — | — | Call | 91307C902 |
| — | LA JOLLA PHARMACEUTICAL CO | 210,978 | $3.698M | 0.2% | $17.53 | $19.43 | — | COM | 503459604 |
| — | BLUEBIRD BIO INC | 597 | $3.665M | 0.2% | $6139.03 | — | — | Call | 09609G900 |
| — | IONIS PHARMACEUTICALS INC | 737 | $3.525M | 0.2% | $4782.90 | — | — | Put | 462222950 |
| — | MONSANTO CO | 313 | $3.293M | 0.2% | $10520.77 | — | — | Call | 61166W901 |
| — | AXOVANT SCIENCES LTD | 2,638 | $3.276M | 0.2% | $1241.85 | — | — | Put | G0750W954 |
| — | BIOGEN INC | 115 | $3.261M | 0.2% | $28356.52 | — | — | Call | 09062X903 |
| PBYI | PUMA BIOTECHNOLOGY INC | 103,243 | $3.17M | 0.2% | $30.70 * | $43.24 | 0.0% | COM | 74587V107 |
| — | CIDARA THERAPEUTICS INC | 292,398 | $3.041M | 0.2% | $10.40 | $11.17 | — | COM | 171757107 |
| — | TENAX THERAPEUTICS INC | 1,516,835 | $2.958M | 0.2% | $1.95 | $3.75 | — | COM | 88032L100 |
| — | LA JOLLA PHARMACEUTICAL CO | 1,687 | $2.957M | 0.2% | $1752.82 | — | — | Call | 503459904 |
| — | INTEC PHARMA LTD | 514,100 | $2.93M | 0.2% | $5.70 | $5.46 | — | SHS | M53644106 |
| — | BIOGEN INC | 100 | $2.836M | 0.2% | $28360.00 | — | — | Put | 09062X953 |
| — | EIGER BIOPHARMACEUTICALS INC | 240,541 | $2.802M | 0.2% | $11.65 | $15.78 | — | COM | 28249U105 |
| — | INTRA-CELLULAR THERAPIES INC | 1,781 | $2.688M | 0.2% | $1509.26 | — | — | Call | 46116X901 |
| — | HALOZYME THERAPEUTICS INC | 2,708 | $2.676M | 0.2% | $988.18 | — | — | Call | 40637H909 |
| — | EXELIXIS INC | 1,783 | $2.658M | 0.2% | $1490.75 | — | — | Call | 30161Q904 |
| — | GW PHARMACEUTICALS PLC | 234 | $2.615M | 0.2% | $11175.21 | — | — | Call | 36197T903 |
| — | COHERUS BIOSCIENCES INC | 912 | $2.567M | 0.1% | $2814.69 | — | — | Put | 19249H953 |
| — | FIBROGEN INC | 1,189 | $2.544M | 0.1% | $2139.61 | — | — | Call | 31572Q908 |
| — | INSMED INC | 1,913 | $2.531M | 0.1% | $1323.05 | — | — | Put | 457669957 |
| — | CYTORI THERAPEUTICS INC | 1,651,835 | $2.494M | 0.1% | $1.51 | $2.09 | — | COM | 23283K204 |
| — | PROTHENA CORPORATION PLC | 490 | $2.41M | 0.1% | $4918.37 | — | — | Call | G72800908 |
| — | TENAX THERAPEUTICS INC | 12,237 | $2.386M | 0.1% | $194.98 | — | — | Call | 88032L900 |
| — | SYNTHETIC BIOLOGICS INC | 3,031,953 | $2.312M | 0.1% | $0.76 | $0.76 | — | COM | 87164U102 |
| — | AGIOS PHARMACEUTICALS INC | 545 | $2.274M | 0.1% | $4172.48 | — | — | Call | 00847X904 |
| — | PACIRA PHARMACEUTICALS INC | 700 | $2.261M | 0.1% | $3230.00 | — | — | Call | 695127900 |
| — | VERTEX PHARMACEUTICALS INC | 296 | $2.181M | 0.1% | $7368.24 | — | — | Put | 92532F950 |
| — | ENDO INTERNATIONAL PLC | 1,323 | $2.179M | 0.1% | $1647.01 | — | — | Put | G30401956 |
| — | LEXICON PHARMACEUTICALS INC | 1,563 | $2.162M | 0.1% | $1383.24 | — | — | Call | 528872902 |
| — | GW PHARMACEUTICALS PLC | 192 | $2.146M | 0.1% | $11177.08 | — | — | Put | 36197T953 |
| — | OPKO HEALTH INC | 2,275 | $2.116M | 0.1% | $930.11 | — | — | Put | 68375N953 |
| — | ENDO INTERNATIONAL PLC | 126,139 | $2.078M | 0.1% | $16.47 | $20.97 | — | SHS | G30401106 |
| — | SIENTRA INC | 2,413 | $2.056M | 0.1% | $852.05 | — | — | Put | 82621J955 |
| — | DURECT CORP | 1,528,516 | $2.048M | 0.1% | $1.34 | $1.22 | — | COM | 266605104 |
| — | REDHILL BIOPHARMA LTD | 191,785 | $2.006M | 0.1% | $10.46 | $11.28 | — | ADS | 757468103 |
| ABUS | ARBUTUS BIOPHARMA CORP | 792,617 | $1.942M | 0.1% | $2.45 * | $7.22 | -59.7% | COM | 03879J100 |
| — | INSMED INC | 1,459 | $1.93M | 0.1% | $1322.82 | — | — | Call | 457669907 |
| — | SANGAMO BIOSCIENCES INC | 6,177 | $1.884M | 0.1% | $305.00 | — | — | Call | 800677906 |
| — | CLOVIS ONCOLOGY INC | 420 | $1.866M | 0.1% | $4442.86 | — | — | Put | 189464950 |
| EDIT | EDITAS MEDICINE INC. | 115,000 | $1.866M | 0.1% | $16.23 * | $20.49 | -25.9% | COM | 28106W103 |
| — | PIERIS PHARMACEUTICALS INC | 1,296,034 | $1.814M | 0.1% | $1.40 | $1.64 | — | COM | 720795103 |
| OPK | OPKO HEALTH INC | 190,955 | $1.776M | 0.1% | $9.30 * | $10.35 | 0.0% | COM | 68375N103 |
| — | WAFERGEN BIO SYSTEMS INC | 358,535 | $1.771M | 0.1% | $4.94 | $4.94 | — | COM | 93041P506 |
| — | CYTRX CORP | 4,697,802 | $1.749M | 0.1% | $0.37 | $0.59 | — | COM | 232828509 |
| — | BARCLAYS BANK PLC | 50,000 | $1.743M | 0.1% | $34.86 | $34.08 | — | IPATH | 06740Q260 |
| — | OHR PHARMACEUTICAL INC | 1,156,393 | $1.735M | 0.1% | $1.50 | $1.50 | — | COM | 67778H200 |
| NTLA | INTELLIA THERAPEUTICS INC | 130,000 | $1.704M | 0.1% | $13.11 * | $18.52 | -18.9% | COM | 45826J105 |
| — | PARATEK PHARMACEUTICALS INC | 110,000 | $1.694M | 0.1% | $15.40 | $17.47 | — | COM | 699374302 |
| — | SAREPTA THERAPEUTICS INC | 611 | $1.676M | 0.1% | $2743.04 | — | — | Call | 803607900 |
| — | NEWLINK GENETICS CORP | 1,580 | $1.624M | 0.1% | $1027.85 | — | — | Call | 651511907 |
| — | EXPRESS SCRIPTS HOLDING CO | 23,494 | $1.616M | 0.1% | $68.78 | $68.78 | — | COM | 30219G108 |
| — | ACADIA PHARMACEUTICALS INC | 548 | $1.58M | 0.1% | $2883.21 | — | — | Put | 004225958 |
| — | HISTOGENICS CORP | 944,891 | $1.578M | 0.1% | $1.67 | $1.82 | — | COM | 43358V109 |
| — | LION BIOTECHNOLOGIES INC | 226,081 | $1.571M | 0.1% | $6.95 | $8.51 | — | COM | 53619R102 |
| — | FORWARD PHARMA A/S | 104,273 | $1.565M | 0.1% | $15.01 | $23.00 | — | ADR | 34986J105 |
| — | MEDICINES CO | 457 | $1.551M | 0.1% | $3393.87 | — | — | Call | 584688905 |
| — | ROKA BIOSCIENCE INC | 365,220 | $1.549M | 0.1% | $4.24 | $4.24 | — | COM | 775431208 |
| VCYT | VERACYTE INC | 193,999 | $1.502M | 0.1% | $7.74 * | $7.48 | 0.0% | COM | 92337F107 |
| — | ONCOSEC MEDICAL INC | 1,173,946 | $1.444M | 0.1% | $1.23 | $2.48 | — | COM | 68234L207 |
| — | AETERNA ZENTARIS INC | 400,560 | $1.442M | 0.1% | $3.60 | $3.75 | — | COM | 007975402 |
| — | PRONAI THERAPEUTICS INC. | 940,841 | $1.402M | 0.1% | $1.49 | $1.84 | — | COM | 74346L101 |
| — | SOPHIRIS BIO INC | 496,729 | $1.391M | 0.1% | $2.80 | $3.11 | — | COM | 83578Q209 |
| — | OPKO HEALTH INC | 1,491 | $1.387M | 0.1% | $930.25 | — | — | Call | 68375N903 |
| — | CHECK CAP LTD | 575,113 | $1.352M | 0.1% | $2.35 | $1.98 | — | SHS | M2361E112 |
| — | KITE PHARMA INC | 291 | $1.305M | 0.1% | $4484.54 | — | — | Put | 49803L959 |
| — | AXOVANT SCIENCES LTD | 100,998 | $1.254M | 0.1% | $12.42 | $12.58 | — | COM | G0750W104 |
| — | BIODELIVERY SCIENCES INTL INC. | 698,235 | $1.222M | 0.1% | $1.75 | $4.74 | — | COM | 09060J106 |
| — | CARDIOME PHARMA CORP | 437,720 | $1.208M | 0.1% | $2.76 | $3.14 | — | COM | 14159U301 |
| — | NEVRO CORP | 165 | $1.199M | 0.1% | $7266.67 | — | — | Call | 64157F903 |
| — | GENETIC TECHNOLOGIES LTD | 1,070,333 | $1.156M | 0.1% | $1.08 | $1.08 | — | SHS | 37185R208 |
| — | APPLIED DNA SCIENCES | 2,277,612 | $1.139M | 0.1% | $0.50 | $0.50 | — | *W | 03815U110 |
| — | REXAHN PHARMACEUTICALS INC | 7,326,681 | $1.04M | 0.1% | $0.14 | $0.33 | — | COM | 761640101 |
| — | IGNYTA INC | 195,000 | $1.034M | 0.1% | $5.30 | $6.50 | — | COM | 451731103 |
| — | AGENUS INC | 2,503 | $1.031M | 0.1% | $411.91 | — | — | Put | 00847G955 |
| — | ONCONOVA THERAPEUTICS INC | 452,804 | $1.028M | 0.1% | $2.27 | $2.60 | — | COM | 68232V306 |
| — | SUCAMPO PHARMACEUTICALS INC | 75,000 | $1.016M | 0.1% | $13.55 | $13.55 | — | CL A | 864909106 |
| — | CAPRICOR THERAPEUTICS INC | 372,046 | $990K | 0.1% | $2.66 | $4.04 | — | COM | 14070B101 |
| — | ZAFGEN INC. | 310,000 | $986K | 0.1% | $3.18 | $3.18 | — | COM | 98885E103 |
| — | FOAMIX PHARMACEUTICALS LTD | 881 | $978K | 0.1% | $1110.10 | — | — | Call | M46135905 |
| LXRX | LEXICON PHARMACEUTICALS INC | 70,040 | $969K | 0.1% | $13.83 * | $16.04 | 0.0% | COM | 528872302 |
| — | HEMISPHERX BIOPHARMA INC | 1,391,286 | $960K | 0.1% | $0.69 | $1.23 | — | COM | 42366C301 |
| — | DURECT CORP | 6,927 | $928K | 0.1% | $133.97 | — | — | Call | 266605904 |
| — | INOTEK PHARMACEUTICALS CORP | 150,930 | $921K | 0.1% | $6.10 | $8.92 | — | COM | 45780V102 |
| — | RICEBRAN TECHNOLOGIES | 875,286 | $902K | 0.1% | $1.03 | $3.41 | — | COM | 762831204 |
| RGNX | REGENXBIO INC | 48,400 | $898K | 0.1% | $18.55 * | $14.34 | +33.3% | COM | 75901B107 |
| — | BIO PATH HOLDINGS INC. | 664,046 | $896K | 0.1% | $1.35 | $1.99 | — | COM | 09057N102 |
| — | LION BIOTECHNOLOGIES INC | 1,260 | $876K | 0.1% | $695.24 | — | — | Put | 53619R952 |
| — | CYTORI THERAPEUTICS INC | 1,273,712 | $866K | 0.1% | $0.68 | $0.76 | — | *W | 23283K121 |
| — | PALATIN TECHNOLOGIES INC | 1,672,573 | $853K | 0.0% | $0.51 | $0.51 | — | COM | 696077403 |
| — | ADVERUM BIOTECHNOLOGIES INC. | 283,306 | $822K | 0.0% | $2.90 | $3.16 | — | COM | 00773U108 |
| CHRS | COHERUS BIOSCIENCES INC | 28,618 | $806K | 0.0% | $28.16 | $27.98 | 0.0% | COM | 19249H103 |
| — | VANDA PHARMACEUTICALS INC | 503 | $802K | 0.0% | $1594.43 | — | — | Call | 921659908 |
| — | SUNESIS PHARMACEUTICALS INC | 221,326 | $801K | 0.0% | $3.62 | $3.62 | — | COM | 867328700 |
| — | DYNAVAX TECHNOLOGIES CORP | 1,979 | $782K | 0.0% | $395.15 | — | — | Call | 268158901 |
| — | RETROPHIN INC | 408 | $772K | 0.0% | $1892.16 | — | — | Put | 761299956 |
| — | ACTINIUM PHARMACEUTICALS INC | 868,608 | $760K | 0.0% | $0.87 | $1.35 | — | COM | 00507W107 |
| — | ACORDA THERAPEUTICS INC | 398 | $748K | 0.0% | $1879.40 | — | — | Call | 00484M906 |
| — | HCA HOLDINGS INC | 100 | $740K | 0.0% | $7400.00 | — | — | Put | 40412C951 |
| — | INSPIREMD INC | 1,210,106 | $726K | 0.0% | $0.60 | $0.60 | — | *W | 45779A127 |
| — | ONCOBIOLOGICS INC | 930,272 | $726K | 0.0% | $0.78 | $0.97 | — | *W | 68235M121 |
| — | AEVI GENOMIC MEDICINE INC. | 138,195 | $716K | 0.0% | $5.18 | $5.18 | — | COM | 00835P105 |
| XBI | SPDR S&P BIOTECH ETF | 11,700 | $693K | 0.0% | $59.23 | $59.23 | — | ETF | 78464A870 |
| — | OCERA THERAPEUTICS INC | 328,632 | $690K | 0.0% | $2.10 | $5.54 | — | COM | 67552A108 |
| — | BIOBLAST PHARMA LTD | 660,157 | $687K | 0.0% | $1.04 | $2.49 | — | SHS | M20156101 |
| — | AMPLIPHI BIOSCIENCES CORP | 1,518,814 | $668K | 0.0% | $0.44 | $0.82 | — | COM | 03211P202 |
| — | VISTAGEN THERAPEUTICS INC | 176,384 | $658K | 0.0% | $3.73 | $3.90 | — | COM | 92840H202 |
| — | PTC THERAPEUTICS INC | 597 | $651K | 0.0% | $1090.45 | — | — | Put | 69366J950 |
| — | ALCOBRA LTD | 3,102 | $651K | 0.0% | $209.86 | — | — | Call | M2239P909 |
| — | ALLIQUA BIOMEDICAL INC | 1,100,398 | $649K | 0.0% | $0.59 | $1.60 | — | COM | 019621200 |
| — | FOAMIX PHARMACEUTICALS LTD | 58,338 | $648K | 0.0% | $11.11 | $8.92 | — | SHS | M46135105 |
| CSBR | CHAMPIONS ONCOLOGY INC | 253,504 | $641K | 0.0% | $2.53 * | $4.47 | -56.5% | COM | 15870P307 |
| — | VTV THERAPEUTICS INC | 132,547 | $640K | 0.0% | $4.83 | $6.52 | — | CL A | 918385105 |
| — | BRAINSTORM CELL THERAPEUTICS | 250,766 | $637K | 0.0% | $2.54 | $4.17 | — | COM | 10501E201 |
| INSM | INSMED INC | 48,043 | $636K | 0.0% | $13.24 * | $13.64 | 0.0% | COM | 457669307 |
| — | SIENTRA INC | 70,973 | $605K | 0.0% | $8.52 | $8.52 | — | COM | 82621J105 |
| — | OPGEN INC | 525,146 | $604K | 0.0% | $1.15 | $1.55 | — | COM | 68373L109 |
| — | LA JOLLA PHARMACEUTICAL CO | 336 | $589K | 0.0% | $1752.98 | — | — | Put | 503459954 |
| — | NEWLINK GENETICS CORP | 56,289 | $579K | 0.0% | $10.29 | $23.87 | — | COM | 651511107 |
| — | AMICUS THERAPEUTICS INC | 1,140 | $567K | 0.0% | $497.37 | — | — | Put | 03152W959 |
| — | AZURRX BIOPHARMA INC. | 118,993 | $564K | 0.0% | $4.74 | $4.74 | — | COM | 05502L105 |
| — | MOTIF BIO PLC | 426,170 | $550K | 0.0% | $1.29 | $1.29 | — | *W | 619784119 |
| — | SUPERCONDUCTOR TECHNOLOGIES | 434,747 | $535K | 0.0% | $1.23 | $2.06 | — | COM | 867931503 |
| — | BLUEPRINT MEDICINES CORP | 190 | $533K | 0.0% | $2805.26 | — | — | Put | 09627Y959 |
| — | HALOZYME THERAPEUTICS INC | 532 | $526K | 0.0% | $988.72 | — | — | Put | 40637H959 |
| — | SAGE THERAPEUTICS INC | 102 | $521K | 0.0% | $5107.84 | — | — | Put | 78667J958 |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 13,823 | $518K | 0.0% | $37.47 * | $41.87 | 0.0% | COM | 02043Q107 |
| — | PACIRA PHARMACEUTICALS INC | 159 | $514K | 0.0% | $3232.70 | — | — | Put | 695127950 |
| — | NEURODERM LTD | 23,033 | $511K | 0.0% | $22.19 | $22.19 | — | SHS | M74231107 |
| — | MANNKIND CORP | 7,842 | $499K | 0.0% | $63.63 | — | — | Put | 56400P951 |
| — | ARBUTUS BIOPHARMA CORP | 2,033 | $498K | 0.0% | $244.96 | — | — | Call | 03879J900 |
| — | MIRATI THERAPEUTICS INC | 99,735 | $474K | 0.0% | $4.75 | $6.61 | — | COM | 60468T105 |
| — | FLEXION THERAPEUTICS INC | 248 | $472K | 0.0% | $1903.23 | — | — | Put | 33938J956 |
| — | STRATA SKIN SCIENCES INC | 1,034,820 | $455K | 0.0% | $0.44 | $0.79 | — | COM | 86272A107 |
| — | RXI PHARMACEUTICALS CORP | 2,270,283 | $454K | 0.0% | $0.20 | $0.20 | — | *W | 74979C113 |
| VCEL | VERICEL INC | 149,900 | $450K | 0.0% | $3.00 * | $2.57 | 0.0% | COM | 92346J108 |
| — | XTL BIOPHARMACEUTICALS LTD | 724,134 | $434K | 0.0% | $0.60 | $2.30 | — | ADR | 98386D208 |
| — | ONCONOVA THERAPEUTICS INC | 691,072 | $428K | 0.0% | $0.62 | $1.55 | — | *W | 68232V116 |
| — | CEL SCI CORP | 6,360,207 | $427K | 0.0% | $0.07 | $0.28 | — | COM | 150837508 |
| — | OPHTHOTECH CORP | 883 | $426K | 0.0% | $482.45 | — | — | Call | 683745903 |
| — | CELSION CORP | 1,333,093 | $416K | 0.0% | $0.31 | $0.96 | — | COM | 15117N404 |
| — | WINDTREE THERAPEUTICS INC | 334,414 | $415K | 0.0% | $1.24 | $1.88 | — | COM | 97382D105 |
| — | BELLEROPHON THERAPEUTICS INC | 789,857 | $414K | 0.0% | $0.52 | $0.52 | — | COM | 078771102 |
| — | THERAPEUTICSMD INC | 703 | $406K | 0.0% | $577.52 | — | — | Call | 88338N907 |
| — | CELLECTAR BIOSCIENCES INC | 323,515 | $395K | 0.0% | $1.22 | $1.22 | — | COM | 15117F302 |
| — | TG THERAPEUTICS INC | 848 | $394K | 0.0% | $464.62 | — | — | Put | 88322Q958 |
| — | BENITEC BIOPHARMA LTD | 254,445 | $389K | 0.0% | $1.53 | $1.53 | — | ADR | 082053307 |
| — | GENVEC INC | 120,544 | $387K | 0.0% | $3.21 | $3.21 | — | COM | 37246C406 |
| — | DEXTERA SURGICAL INC | 397,863 | $382K | 0.0% | $0.96 | $1.80 | — | COM | 252366109 |
| — | STEMLINE THERAPEUTICS INC | 356 | $381K | 0.0% | $1070.22 | — | — | Call | 85858C907 |
| — | CHIMERIX INC | 79,900 | $368K | 0.0% | $4.61 | $5.54 | — | COM | 16934W106 |
| — | COMBIMATRIX CORP | 844,917 | $363K | 0.0% | $0.43 | $0.67 | — | *W | 20009T147 |
| — | PSIVIDA CORP | 205,100 | $351K | 0.0% | $1.71 | $2.63 | — | COM | 74440J101 |
| — | AMARIN CORPORATION PLC | 1,118 | $344K | 0.0% | $307.69 | — | — | Put | 023111956 |
| — | THERAPEUTICSMD INC | 586 | $338K | 0.0% | $576.79 | — | — | Put | 88338N957 |
| — | DEPOMED INC | 186 | $335K | 0.0% | $1801.08 | — | — | Call | 249908904 |
| — | IMMUNOCELLULAR THERAPEUTICS | 160,129 | $328K | 0.0% | $2.05 | $2.05 | — | COM | 452536204 |
| — | BIOCEPT INC | 411,432 | $319K | 0.0% | $0.78 | $0.78 | — | COM | 09072V204 |
| — | EYEGATE PHARMACEUTICALS INC | 192,721 | $314K | 0.0% | $1.63 | $2.36 | — | COM | 30233M107 |
| — | INOTEK PHARMACEUTICALS CORP | 500 | $305K | 0.0% | $610.00 | — | — | Put | 45780V952 |
| FOLD | AMICUS THERAPEUTICS INC | 60,309 | $300K | 0.0% | $4.97 * | $6.92 | 0.0% | COM | 03152W109 |
| — | ADVAXIS INC | 414 | $296K | 0.0% | $714.98 | — | — | Put | 007624958 |
| — | DICERNA PHARMACEUTICALS INC | 100,000 | $288K | 0.0% | $2.88 | $4.38 | — | COM | 253031108 |
| — | RXI PHARMACEUTICALS CORP | 397,371 | $284K | 0.0% | $0.71 | $0.71 | — | COM | 74979C501 |
| — | BIOPHARMX CORP | 708,046 | $265K | 0.0% | $0.37 | $0.96 | — | COM | 09072X101 |
| — | DYNAVAX TECHNOLOGIES CORP | 66,091 | $261K | 0.0% | $3.95 | $15.82 | — | COM | 268158201 |
| — | ROSETTA GENOMICS LTD | 591,339 | $248K | 0.0% | $0.42 | $0.42 | — | SHS | M82183126 |
| — | FLEXION THERAPEUTICS INC | 126 | $240K | 0.0% | $1904.76 | — | — | Call | 33938J906 |
| — | PORTOLA PHARMACEUTICALS INC | 107 | $240K | 0.0% | $2242.99 | — | — | Put | 737010958 |
| — | AETERNA ZENTARIS INC | 614 | $221K | 0.0% | $359.93 | — | — | Put | 007975952 |
| — | NEUROMETRIX INC | 3,017,747 | $211K | 0.0% | $0.07 | $0.31 | — | *W | 641255153 |
| — | FLEXION THERAPEUTICS INC | 10,914 | $208K | 0.0% | $19.06 | $12.31 | — | COM | 33938J106 |
| PRQR | PROQR THERAPEUTICS N V | 40,000 | $196K | 0.0% | $4.90 * | $7.45 | -30.9% | SHS | N71542109 |
| — | JUNO THERAPEUTICS INC | 103 | $194K | 0.0% | $1883.50 | — | — | Call | 48205A909 |
| SGMO | SANGAMO BIOSCIENCES INC | 63,204 | $193K | 0.0% | $3.05 * | $4.39 | -17.1% | COM | 800677106 |
| — | ADVAXIS INC | 270 | $193K | 0.0% | $714.81 | — | — | Call | 007624908 |
| — | ALCOBRA LTD | 91,858 | $193K | 0.0% | $2.10 | $2.80 | — | SHS | M2239P109 |
| — | IMMUNOCELLULAR THERAPEUTICS | 383,471 | $192K | 0.0% | $0.50 | $0.50 | — | *W | 452536121 |
| — | HERON THERAPEUTICS INC | 141 | $185K | 0.0% | $1312.06 | — | — | Call | 427746902 |
| — | IMMUNOMEDICS INC | 50,000 | $184K | 0.0% | $3.68 | $68.00 | — | COM | 452907108 |
| — | MIRNA THERAPEUTICS INC | 100,200 | $180K | 0.0% | $1.80 | $1.80 | — | COM | 60470J103 |
| — | CELLECT BIOTECHNOLOGY LTD | 57,348 | $177K | 0.0% | $3.09 | $4.60 | — | ADS | 15116C102 |
| — | LEXICON PHARMACEUTICALS INC | 121 | $167K | 0.0% | $1380.17 | — | — | Put | 528872952 |
| — | RENNOVA HEALTH INC | 2,022,213 | $167K | 0.0% | $0.08 | $0.19 | — | COM | 759757107 |
| — | ZOGENIX INC | 136 | $165K | 0.0% | $1213.24 | — | — | Put | 98978L954 |
| — | GALENA BIOPHARMA INC | 847 | $164K | 0.0% | $193.62 | — | — | Put | 363256954 |
| — | OTONOMY ORD SHS | 10,000 | $159K | 0.0% | $15.90 | $15.90 | — | COM | 68906L105 |
| — | ONCOBIOLOGICS INC | 930,592 | $154K | 0.0% | $0.17 | $0.74 | — | *W | 68235M113 |
| — | CAPNIA INC | 179,002 | $145K | 0.0% | $0.81 | $1.20 | — | COM | 14066L105 |
| — | THERAPEUTICSMD INC | 24,955 | $144K | 0.0% | $5.77 | $6.82 | — | COM | 88338N107 |
| PARNEUR | PARNELL PHARMACEUTICALS HOLDINGS LTD | 200,549 | $138K | 0.0% | $0.69 | $1.63 | — | COM | Q73622104 |
| — | LION BIOTECHNOLOGIES INC | 195 | $136K | 0.0% | $697.44 | — | — | Call | 53619R990 |
| — | NEKTAR THERAPEUTICS | 110 | $135K | 0.0% | $1227.27 | — | — | Call | 640268908 |
| — | NEUROMETRIX INC | 166,268 | $123K | 0.0% | $0.74 | $1.76 | — | COM | 641255500 |
| — | CEMPRA INC | 43,121 | $121K | 0.0% | $2.81 | $2.81 | — | COM | 15130J109 |
| — | AKARI THERAPEUTICS PLC | 17,428 | $120K | 0.0% | $6.89 | $14.89 | — | ADR | 00972G108 |
| — | RENNOVA HEALTH INC | 4,926,013 | $118K | 0.0% | $0.02 | $0.06 | — | *W | 759757123 |
| — | ALCOBRA LTD | 559 | $117K | 0.0% | $209.30 | — | — | Put | M2239P959 |
| — | EDAP TMS S A | 341 | $112K | 0.0% | $328.45 | — | — | Put | 268311957 |
| — | DYNAVAX TECHNOLOGIES CORP | 258 | $102K | 0.0% | $395.35 | — | — | Put | 268158951 |
| — | CANCER GENETICS INC | 71,971 | $97,000 | 0.0% | $1.35 | $2.48 | — | COM | 13739U104 |
| — | ASTERIAS BIOTHERAPEUTICS INC | 200 | $92,000 | 0.0% | $460.00 | — | — | Call | 04624N907 |
| — | NIVALIS THERAPEUTICS INC | 40,004 | $90,000 | 0.0% | $2.25 | $11.19 | — | COM | 65481J109 |
| — | CELLECTAR BIOSCIENCES INC | 201,889 | $85,000 | 0.0% | $0.42 | $0.89 | — | *W | 15117F120 |
| — | ZOSANO PHARMA ORD SHS | 103,600 | $81,000 | 0.0% | $0.78 | $9.59 | — | COM | 98979H103 |
| ACUR | ACURA PHARMACEUTICALS INC. | 103,444 | $79,000 | 0.0% | $0.76 * | $3.40 | -69.3% | COM | 00509L802 |
| EDAP | EDAP TMS S A | 22,993 | $76,000 | 0.0% | $3.31 | $3.31 | — | ADR | 268311107 |
| — | ADVAXIS INC | 10,443 | $75,000 | 0.0% | $7.18 | $7.18 | — | COM | 007624208 |
| — | OVASCIENCE INC | 48,450 | $74,000 | 0.0% | $1.53 | $5.21 | — | COM | 69014Q101 |
| — | ENTEROMEDICS INC | 33,387 | $67,000 | 0.0% | $2.01 | $2.01 | — | COM | 29365M505 |
| — | ATHERSYS INC | 43,263 | $66,000 | 0.0% | $1.53 | $2.17 | — | COM | 04744L106 |
| — | INOTEK PHARMACEUTICALS CORP | 106 | $65,000 | 0.0% | $613.21 | — | — | Call | 45780V902 |
| — | ANTHERA PHARMACEUTICALS INC | 987 | $64,000 | 0.0% | $64.84 | — | — | Call | 03674U901 |
| — | NEURALSTEM INC | 229,521 | $63,000 | 0.0% | $0.27 | $0.29 | — | COM | 64127R302 |
| — | ANTHERA PHARMACEUTICALS INC | 91,055 | $59,000 | 0.0% | $0.65 | $3.62 | — | COM | 03674U201 |
| — | MEDIGUS LTD | 87,876 | $50,000 | 0.0% | $0.57 | $1.32 | — | ADR | 58471G102 |
| — | GALENA BIOPHARMA INC | 23,298 | $45,000 | 0.0% | $1.93 | $1.93 | — | COM | 363256504 |
| — | GREAT PANTHER SILVER LTD | 269 | $45,000 | 0.0% | $167.29 | — | — | Put | 39115V951 |
| — | ADAMIS PHARMACEUTICALS CORP | 134 | $42,000 | 0.0% | $313.43 | — | — | Put | 00547W958 |
| — | VIKING THERAPEUTICS INC | 86,349 | $39,000 | 0.0% | $0.45 | $0.29 | — | *W | 92686J114 |
| — | TENAX THERAPEUTICS INC | 169 | $33,000 | 0.0% | $195.27 | — | — | Put | 88032L950 |
| — | RIGEL PHARMACEUTICALS INC | 12,350 | $29,000 | 0.0% | $2.35 | $2.23 | — | COM | 766559603 |
| — | GALECTIN THERAPEUTICS INC | 235 | $23,000 | 0.0% | $97.87 | — | — | Put | 363225952 |
| — | NOVAVAX INC | 159 | $20,000 | 0.0% | $125.79 | — | — | Call | 670002904 |
| — | BENITEC BIOPHARMA LTD | 98,146 | $10,000 | 0.0% | $0.10 | $0.36 | — | *W | 082053117 |
| — | EYEGATE PHARMACEUTICALS INC | 20,604 | $6,000 | 0.0% | $0.29 | $1.02 | — | *W | 30233M115 |