GREAT POINT PARTNERS LLC Quant / Systematic

CIK: 0001281446 · Show all filings

Period: Q4 2021 (← Previous) (Next →)

Filing Date: Feb 14, 2022

Total Value ($000): $450,122 (100.0% shares, 0.0% debt)

Holdings (36)

— ARENA PHARMACEUTICALS INC 11.0%

Value ($000) $49,320 Shares 530,670 Est. Cost $60.39 Unrealized —

EXEL EXELIXIS INC 7.1%

Value ($000) $31,990 Shares 1,750,000 Est. Cost $21.47 Unrealized -10.9%

XENE XENON PHARMACEUTICALS INC 6.6%

Value ($000) $29,678 Shares 950,000 Est. Cost $20.67 Unrealized +44.6%

TVTX TRAVERE THERAPEUTICS INC 5.5%

Value ($000) $24,832 Shares 800,000 Est. Cost $24.95 Unrealized +12.9%

ANAB ANAPTYSBIO INC 4.6%

Value ($000) $20,581 Shares 592,250 Est. Cost $24.89 Unrealized +27.4%

VRTX VERTEX PHARMACEUTICALS INC 4.1%

Value ($000) $18,666 Shares 85,000 Est. Cost $195.24 Unrealized -0.4%

BCAB BIOATLA INC 3.8%

Value ($000) $16,966 Shares 864,300 Est. Cost $38.65 Unrealized -33.8%

GLPG GALAPAGOS NV 3.7%

Value ($000) $16,539 Shares 300,000 Est. Cost $55.13 Unrealized —

RLMD RELMADA THERAPEUTICS INC 3.6%

Value ($000) $16,161 Shares 717,320 Est. Cost $22.24 Unrealized 0.0%

MGNX MACROGENICS INC 3.6%

Value ($000) $16,050 Shares 1,000,000 Est. Cost $18.17 Unrealized +3.6%

CYTK CYTOKINETICS INC 3.5%

Value ($000) $15,953 Shares 350,000 Est. Cost $29.44 Unrealized +31.1%

— TRICIDA INC 3.0%

Value ($000) $13,384 Shares 1,400,000 Est. Cost $4.49 Unrealized —

— RIGEL PHARMACEUTICALS INC 2.9%

Value ($000) $13,250 Shares 5,000,000 Est. Cost $3.25 Unrealized —

SRPT SAREPTA THERAPEUTICS INC 2.9%

Value ($000) $13,094 Shares 145,405 Est. Cost $85.49 Unrealized 0.0%

BCYC BICYCLE THERAPEUTICS PLC 2.7%

Value ($000) $12,174 Shares 200,000 Est. Cost $60.87 Unrealized —

PCVX VAXCYTE INC 2.6%

Value ($000) $11,895 Shares 500,000 Est. Cost $23.45 Unrealized -0.8%

RNAM AVIDITY BIOSCIENCES INC 2.6%

Value ($000) $11,885 Shares 500,000 Est. Cost $23.88 Unrealized 0.0%

ACRS ACLARIS THERAPEUTICS INC 2.6%

Value ($000) $11,632 Shares 800,000 Est. Cost $15.70 Unrealized -3.5%

RCKT ROCKET PHARMACEUTICALS INC 2.4%

Value ($000) $10,926 Shares 500,526 Est. Cost $38.30 Unrealized -28.8%

SLN SILENCE THERAPEUTICS PLC 2.4%

Value ($000) $10,618 Shares 444,443 Est. Cost $23.89 Unrealized —

DYN DYNE THERAPEUTICS INC 2.2%

Value ($000) $10,047 Shares 845,000 Est. Cost $18.15 Unrealized -22.6%

— PASSAGE BIO INC 2.1%

Value ($000) $9,640 Shares 1,518,095 Est. Cost $6.35 Unrealized —

PRQR PROQR THRAPEUTICS N V 2.0%

Value ($000) $8,980 Shares 1,121,122 Est. Cost $7.59 Unrealized +0.4%

URGN UROGEN PHARMA LTD 1.8%

Value ($000) $8,306 Shares 873,424 Est. Cost $15.60 Unrealized -9.6%

— CHINOOK THERAPEUTICS INC 1.4%

Value ($000) $6,362 Shares 390,041 Est. Cost $16.31 Unrealized —

— KINIKSA PHARMACEUTICALS LTD 1.4%

Value ($000) $6,317 Shares 536,738 Est. Cost $11.43 Unrealized —

— PIERIS PHARMACEUTICALS INC 1.3%

Value ($000) $5,859 Shares 1,550,000 Est. Cost $3.78 Unrealized —

KALV KALVISTA PHARMACEUTICALS INC 1.2%

Value ($000) $5,450 Shares 411,937 Est. Cost $15.92 Unrealized 0.0%

— MAGENTA THERAPEUTICS INC 1.2%

Value ($000) $5,183 Shares 1,170,000 Est. Cost $9.65 Unrealized —

PYXS PYXIS ONCOLOGY INC 1.0%

Value ($000) $4,388 Shares 400,000 Est. Cost $11.45 Unrealized 0.0%

— AEGLEA BIOTHERAPEUTICS INC 1.0%

Value ($000) $4,324 Shares 910,251 Est. Cost $7.47 Unrealized —

— NEKTAR THERAPEUTICS 0.6%

Value ($000) $2,755 Shares 203,900 Est. Cost $17.96 Unrealized —

ABUS ARBUTUS BIOPHARMA CORP 0.6%

Value ($000) $2,602 Shares 668,907 Est. Cost $3.88 Unrealized 0.0%

CABA CABALETTA BIO INC 0.4%

Value ($000) $1,791 Shares 472,433 Est. Cost $10.67 Unrealized 0.0%

RFL RAFAEL HLDGS INC 0.3%

Value ($000) $1,457 Shares 285,714 Est. Cost $45.91 Unrealized -70.7%

— POINT BIOPHARMA GLOBAL INC 0.2%

Value ($000) $1,067 Shares 190,520 Est. Cost $5.60 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
—	ARENA PHARMACEUTICALS INC	530,670	$49,320	11.0%	$60.39	—	COM NEW	040047607
EXEL	EXELIXIS INC	1,750,000	$31,990	7.1%	$21.47	-10.9%	COM	30161Q104
XENE	XENON PHARMACEUTICALS INC	950,000	$29,678	6.6%	$20.67	+44.6%	COM	98420N105
TVTX	TRAVERE THERAPEUTICS INC	800,000	$24,832	5.5%	$24.95	+12.9%	COM	89422G107
ANAB	ANAPTYSBIO INC	592,250	$20,581	4.6%	$24.89	+27.4%	COM	032724106
VRTX	VERTEX PHARMACEUTICALS INC	85,000	$18,666	4.1%	$195.24	-0.4%	COM	92532F100
BCAB	BIOATLA INC	864,300	$16,966	3.8%	$38.65	-33.8%	COM	09077B104
GLPG	GALAPAGOS NV	300,000	$16,539	3.7%	$55.13	—	SPON ADR	36315X101
RLMD	RELMADA THERAPEUTICS INC	717,320	$16,161	3.6%	$22.24	0.0%	COM	75955J402
MGNX	MACROGENICS INC	1,000,000	$16,050	3.6%	$18.17	+3.6%	COM	556099109
CYTK	CYTOKINETICS INC	350,000	$15,953	3.5%	$29.44	+31.1%	COM NEW	23282W605
—	TRICIDA INC	1,400,000	$13,384	3.0%	$4.49	—	COM	89610F101
—	RIGEL PHARMACEUTICALS INC	5,000,000	$13,250	2.9%	$3.25	—	COM NEW	766559603
SRPT	SAREPTA THERAPEUTICS INC	145,405	$13,094	2.9%	$85.49	0.0%	COM	803607100
BCYC	BICYCLE THERAPEUTICS PLC	200,000	$12,174	2.7%	$60.87	—	SPONSORED ADS	088786108
PCVX	VAXCYTE INC	500,000	$11,895	2.6%	$23.45	-0.8%	COM	92243G108
RNAM	AVIDITY BIOSCIENCES INC	500,000	$11,885	2.6%	$23.88	0.0%	COM	05370A108
ACRS	ACLARIS THERAPEUTICS INC	800,000	$11,632	2.6%	$15.70	-3.5%	COM	00461U105
RCKT	ROCKET PHARMACEUTICALS INC	500,526	$10,926	2.4%	$38.30	-28.8%	COM	77313F106
SLN	SILENCE THERAPEUTICS PLC	444,443	$10,618	2.4%	$23.89	—	ADS	82686Q101
DYN	DYNE THERAPEUTICS INC	845,000	$10,047	2.2%	$18.15	-22.6%	COM	26818M108
—	PASSAGE BIO INC	1,518,095	$9,640	2.1%	$6.35	—	COM	702712100
PRQR	PROQR THRAPEUTICS N V	1,121,122	$8,980	2.0%	$7.59	+0.4%	SHS EURO	N71542109
URGN	UROGEN PHARMA LTD	873,424	$8,306	1.8%	$15.60	-9.6%	COM	M96088105
—	CHINOOK THERAPEUTICS INC	390,041	$6,362	1.4%	$16.31	—	COM	16961L106
—	KINIKSA PHARMACEUTICALS LTD	536,738	$6,317	1.4%	$11.43	—	COM CL A	G5269C101
—	PIERIS PHARMACEUTICALS INC	1,550,000	$5,859	1.3%	$3.78	—	COM	720795103
KALV	KALVISTA PHARMACEUTICALS INC	411,937	$5,450	1.2%	$15.92	0.0%	COM	483497103
—	MAGENTA THERAPEUTICS INC	1,170,000	$5,183	1.2%	$9.65	—	COM	55910K108
PYXS	PYXIS ONCOLOGY INC	400,000	$4,388	1.0%	$11.45	0.0%	COMMON STOCK	747324101
—	AEGLEA BIOTHERAPEUTICS INC	910,251	$4,324	1.0%	$7.47	—	COM	00773J103
—	NEKTAR THERAPEUTICS	203,900	$2,755	0.6%	$17.96	—	Call	640268108
ABUS	ARBUTUS BIOPHARMA CORP	668,907	$2,602	0.6%	$3.88	0.0%	COM	03879J100
CABA	CABALETTA BIO INC	472,433	$1,791	0.4%	$10.67	0.0%	COM	12674W109
RFL	RAFAEL HLDGS INC	285,714	$1,457	0.3%	$45.91	-70.7%	COM CL B	75062E106
—	POINT BIOPHARMA GLOBAL INC	190,520	$1,067	0.2%	$5.60	—	COM	730541109