GREAT POINT PARTNERS LLC Quant / Systematic

CIK: 0001281446 · Show all filings

Period: Q1 2022 (← Previous) (Next →)

Filing Date: May 16, 2022

Total Value ($000): $413,781 (100.0% shares, 0.0% debt)

Holdings (30)

EXEL EXELIXIS INC 7.1%

Value ($000) $29,471 Shares 1,300,000 Est. Cost $21.47 Unrealized -9.0%

XENE XENON PHARMACEUTICALS INC 6.8%

Value ($000) $28,124 Shares 920,000 Est. Cost $20.67 Unrealized +44.8%

TVTX TRAVERE THERAPEUTICS INC 6.3%

Value ($000) $26,028 Shares 1,010,000 Est. Cost $25.28 Unrealized +5.0%

BCYC BICYCLE THERAPEUTICS PLC 5.8%

Value ($000) $24,160 Shares 550,592 Est. Cost $50.05 Unrealized —

JAZZ JAZZ PHARMACEUTICALS PLC 5.8%

Value ($000) $24,129 Shares 155,000 Est. Cost $145.12 Unrealized 0.0%

CYTK CYTOKINETICS INC 5.8%

Value ($000) $23,927 Shares 650,000 Est. Cost $32.25 Unrealized +10.2%

— CHINOOK THERAPEUTICS INC 5.6%

Value ($000) $23,291 Shares 1,423,682 Est. Cost $16.35 Unrealized —

GLPG GALAPAGOS NV 5.4%

Value ($000) $22,327 Shares 360,000 Est. Cost $56.28 Unrealized —

VRTX VERTEX PHARMACEUTICALS INC 5.4%

Value ($000) $22,182 Shares 85,000 Est. Cost $195.24 Unrealized +21.6%

PCVX VAXCYTE INC 5.2%

Value ($000) $21,376 Shares 885,153 Est. Cost $22.75 Unrealized -4.0%

RLMD RELMADA THERAPEUTICS INC 5.2%

Value ($000) $21,322 Shares 790,000 Est. Cost $22.09 Unrealized -6.4%

ANAB ANAPTYSBIO INC 4.2%

Value ($000) $17,318 Shares 700,000 Est. Cost $25.71 Unrealized +17.7%

— POINT BIOPHARMA GLOBAL INC 4.0%

Value ($000) $16,418 Shares 2,060,000 Est. Cost $7.75 Unrealized —

ACRS ACLARIS THERAPEUTICS INC 3.9%

Value ($000) $16,248 Shares 942,445 Est. Cost $15.39 Unrealized -11.4%

KALV KALVISTA PHARMACEUTICALS INC 3.1%

Value ($000) $12,886 Shares 874,197 Est. Cost $15.10 Unrealized -4.8%

— RIGEL PHARMACEUTICALS INC 2.9%

Value ($000) $11,960 Shares 4,000,000 Est. Cost $3.25 Unrealized —

— KINIKSA PHARMACEUTICALS LTD 2.7%

Value ($000) $11,114 Shares 1,118,067 Est. Cost $10.66 Unrealized —

— TRICIDA INC 2.5%

Value ($000) $10,275 Shares 1,250,000 Est. Cost $4.49 Unrealized —

RNAM AVIDITY BIOSCIENCES INC 2.2%

Value ($000) $9,235 Shares 500,000 Est. Cost $23.88 Unrealized -28.9%

SLN SILENCE THERAPEUTICS PLC 2.0%

Value ($000) $8,444 Shares 444,443 Est. Cost $23.89 Unrealized —

URGN UROGEN PHARMA LTD 1.8%

Value ($000) $7,608 Shares 873,424 Est. Cost $15.60 Unrealized -50.0%

— PIERIS PHARMACEUTICALS INC 1.6%

Value ($000) $6,663 Shares 2,199,076 Est. Cost $3.56 Unrealized —

ARDX ARDELYX INC 1.2%

Value ($000) $5,095 Shares 4,761,905 Est. Cost $0.89 Unrealized 0.0%

VTYX VENTYX BIOSCIENCES INC 1.1%

Value ($000) $4,564 Shares 336,334 Est. Cost $13.36 Unrealized 0.0%

ABOS ACUMEN PHARMACEUTICALS INC 0.9%

Value ($000) $3,630 Shares 928,282 Est. Cost $5.44 Unrealized 0.0%

— MAGENTA THERAPEUTICS INC 0.8%

Value ($000) $3,393 Shares 1,170,000 Est. Cost $9.65 Unrealized —

— CINCOR PHARMA INC 0.3%

Value ($000) $1,397 Shares 79,670 Est. Cost $17.53 Unrealized —

— NEKTAR THERAPEUTICS 0.1%

Value ($000) $539 Shares 100,000 Est. Cost — Unrealized —

— PASSAGE BIO INC 0.1%

Value ($000) $353 Shares 113,900 Est. Cost $6.35 Unrealized —

RFL RAFAEL HLDGS INC 0.1%

Value ($000) $304 Shares 121,000 Est. Cost $45.91 Unrealized -92.5%

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
EXEL	EXELIXIS INC	1,300,000	$29,471	7.1%	$21.47	-9.0%	COM	30161Q104
XENE	XENON PHARMACEUTICALS INC	920,000	$28,124	6.8%	$20.67	+44.8%	COM	98420N105
TVTX	TRAVERE THERAPEUTICS INC	1,010,000	$26,028	6.3%	$25.28	+5.0%	COM	89422G107
BCYC	BICYCLE THERAPEUTICS PLC	550,592	$24,160	5.8%	$50.05	—	SPONSORED ADS	088786108
JAZZ	JAZZ PHARMACEUTICALS PLC	155,000	$24,129	5.8%	$145.12	0.0%	SHS USD	G50871105
CYTK	CYTOKINETICS INC	650,000	$23,927	5.8%	$32.25	+10.2%	COM NEW	23282W605
—	CHINOOK THERAPEUTICS INC	1,423,682	$23,291	5.6%	$16.35	—	COM	16961L106
GLPG	GALAPAGOS NV	360,000	$22,327	5.4%	$56.28	—	SPON ADR	36315X101
VRTX	VERTEX PHARMACEUTICALS INC	85,000	$22,182	5.4%	$195.24	+21.6%	COM	92532F100
PCVX	VAXCYTE INC	885,153	$21,376	5.2%	$22.75	-4.0%	COM	92243G108
RLMD	RELMADA THERAPEUTICS INC	790,000	$21,322	5.2%	$22.09	-6.4%	COM	75955J402
ANAB	ANAPTYSBIO INC	700,000	$17,318	4.2%	$25.71	+17.7%	COM	032724106
—	POINT BIOPHARMA GLOBAL INC	2,060,000	$16,418	4.0%	$7.75	—	COM	730541109
ACRS	ACLARIS THERAPEUTICS INC	942,445	$16,248	3.9%	$15.39	-11.4%	COM	00461U105
KALV	KALVISTA PHARMACEUTICALS INC	874,197	$12,886	3.1%	$15.10	-4.8%	COM	483497103
—	RIGEL PHARMACEUTICALS INC	4,000,000	$11,960	2.9%	$3.25	—	COM NEW	766559603
—	KINIKSA PHARMACEUTICALS LTD	1,118,067	$11,114	2.7%	$10.66	—	COM CL A	G5269C101
—	TRICIDA INC	1,250,000	$10,275	2.5%	$4.49	—	COM	89610F101
RNAM	AVIDITY BIOSCIENCES INC	500,000	$9,235	2.2%	$23.88	-28.9%	COM	05370A108
SLN	SILENCE THERAPEUTICS PLC	444,443	$8,444	2.0%	$23.89	—	ADS	82686Q101
URGN	UROGEN PHARMA LTD	873,424	$7,608	1.8%	$15.60	-50.0%	COM	M96088105
—	PIERIS PHARMACEUTICALS INC	2,199,076	$6,663	1.6%	$3.56	—	COM	720795103
ARDX	ARDELYX INC	4,761,905	$5,095	1.2%	$0.89	0.0%	COM	039697107
VTYX	VENTYX BIOSCIENCES INC	336,334	$4,564	1.1%	$13.36	0.0%	COM	92332V107
ABOS	ACUMEN PHARMACEUTICALS INC	928,282	$3,630	0.9%	$5.44	0.0%	COM	00509G209
—	MAGENTA THERAPEUTICS INC	1,170,000	$3,393	0.8%	$9.65	—	COM	55910K108
—	CINCOR PHARMA INC	79,670	$1,397	0.3%	$17.53	—	COM	17240Y109
—	NEKTAR THERAPEUTICS	100,000	$539	0.1%	—	—	Call	640268108
—	PASSAGE BIO INC	113,900	$353	0.1%	$6.35	—	COM	702712100
RFL	RAFAEL HLDGS INC	121,000	$304	0.1%	$45.91	-92.5%	COM CL B	75062E106