Location: San Diego, CA
CIK: 0001232621 · Show all filings
Period: Q3 2022 (← Previous) (Next →)
Filing Date: Nov 14, 2022
Total Value: $815M (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| ANAB | ANAPTYSBIO INC | 2,628,678 | $67.06M | 8.2% | $25.51 * | $21.51 | +9.0% | COM | 032724106 |
| — | BIOHAVEN PHARMACTL HLDG CO L | 280,000 | $42.33M | 5.2% | $151.17 | $145.71 | — | COM | G11196105 |
| — | BLUEBIRD BIO INC | 6,335,528 | $40.1M | 4.9% | $6.33 | $4.46 | — | COM | 09609G100 |
| TARS | TARSUS PHARMACEUTICALS INC | 2,089,856 | $35.78M | 4.4% | $17.12 * | $15.52 | +2.3% | COM | 87650L103 |
| ALT | ALTIMMUNE INC | 2,600,450 | $33.21M | 4.1% | $12.77 * | $9.48 | +55.7% | COM NEW | 02155H200 |
| — | INTRA-CELLULAR THERAPIES INC | 640,000 | $29.78M | 3.7% | $46.53 | $61.19 | — | COM | 46116X101 |
| HRTX | HERON THERAPEUTICS INC | 6,840,000 | $28.86M | 3.5% | $4.22 * | $10.44 | -62.5% | COM | 427746102 |
| BIO | BIO RAD LABS INC | 64,000 | $26.7M | 3.3% | $417.14 * | $570.32 | -12.6% | CL A | 090572207 |
| KALV | KALVISTA PHARMACEUTICALS INC | 1,800,000 | $26.12M | 3.2% | $14.51 * | $12.23 | +14.3% | COM | 483497103 |
| — | ALBIREO PHARMA INC | 1,099,516 | $21.29M | 2.6% | $19.36 | $23.92 | — | COM | 01345P106 |
| RCKT | ROCKET PHARMACEUTICALS INC | 1,265,900 | $20.2M | 2.5% | $15.96 * | $16.31 | -4.3% | COM | 77313F106 |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 100,000 | $20.02M | 2.5% | $200.16 * | $190.74 | 0.0% | COM | 02043Q107 |
| IMCR | IMMUNOCORE HLDGS PLC | 405,600 | $19.04M | 2.3% | $46.94 | $30.74 | — | ADS | 45258D105 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 882,925 | $18.11M | 2.2% | $20.51 * | $15.92 | +12.9% | COM | 92790C104 |
| — | ITEOS THERAPEUTICS INC | 937,500 | $17.86M | 2.2% | $19.05 | $27.47 | — | COM | 46565G104 |
| BCAB | BIOATLA INC | 1,967,051 | $15.15M | 1.9% | $7.70 * | $6.39 | +2.4% | COM | 09077B104 |
| BCRX | BIOCRYST PHARMACEUTICALS INC | 1,200,000 | $15.12M | 1.9% | $12.60 * | $10.32 | +24.8% | COM | 09058V103 |
| RLMD | RELMADA THERAPEUTICS INC | 400,000 | $14.81M | 1.8% | $37.02 * | $21.81 | +27.0% | COM | 75955J402 |
| ONC | BEIGENE LTD | 105,000 | $14.16M | 1.7% | $134.82 | $134.82 | — | SPONSORED ADR | 07725L102 |
| HRMY | HARMONY BIOSCIENCES HLDGS IN | 310,000 | $13.73M | 1.7% | $44.29 * | $41.04 | +18.8% | COM | 413197104 |
| — | TWITTER INC | 300,000 | $13.15M | 1.6% | $43.84 | $43.84 | — | COM | 90184L102 |
| — | VERU INC | 1,100,000 | $12.67M | 1.6% | $11.52 | $11.30 | — | COM | 92536C103 |
| INSM | INSMED INC | 500,000 | $10.77M | 1.3% | $21.54 * | $23.98 | 0.0% | COM PAR $.01 | 457669307 |
| GLPG | GALAPAGOS NV | 224,950 | $9.592M | 1.2% | $42.64 | $62.02 | — | SPON ADR | 36315X101 |
| MIRM | MIRUM PHARMACEUTICALS INC | 450,000 | $9.455M | 1.2% | $21.01 * | $23.97 | +0.5% | COM | 604749101 |
| IONS | IONIS PHARMACEUTICALS INC | 200,000 | $8.846M | 1.1% | $44.23 * | $32.73 | +28.7% | COM | 462222100 |
| NKTX | NKARTA INC | 662,872 | $8.723M | 1.1% | $13.16 * | $12.95 | +10.5% | COM | 65487U108 |
| AZN | ASTRAZENECA PLC | 150,000 | $8.226M | 1.0% | $54.84 | $54.84 | — | SPONSORED ADR | 046353108 |
| — | ALLAKOS INC | 1,323,393 | $8.099M | 1.0% | $6.12 | $9.79 | — | COM | 01671P100 |
| DAWN | DAY ONE BIOPHARMACEUTICALS I | 400,000 | $8.012M | 1.0% | $20.03 * | $21.27 | 0.0% | COM | 23954D109 |
| CGEM | CULLINAN ONCOLOGY INC | 624,016 | $8M | 1.0% | $12.82 * | $11.39 | +18.3% | COM | 230031106 |
| — | REVANCE THERAPEUTICS INC | 287,500 | $7.763M | 1.0% | $27.00 | $27.00 | — | COM | 761330109 |
| — | KINIKSA PHARMACEUTICALS LTD | 600,000 | $7.704M | 0.9% | $12.84 | $9.90 | — | COM CL A | G5269C101 |
| CHRS | COHERUS BIOSCIENCES INC | 750,000 | $7.208M | 0.9% | $9.61 * | $17.20 | -41.2% | COM | 19249H103 |
| — | IMMUNOGEN INC | 1,500,000 | $7.17M | 0.9% | $4.78 | $7.42 | — | COM | 45253H101 |
| ENTA | ENANTA PHARMACEUTICALS INC | 137,700 | $7.142M | 0.9% | $51.87 * | $62.12 | -5.9% | COM | 29251M106 |
| ASND | ASCENDIS PHARMA A/S | 66,090 | $6.824M | 0.8% | $103.25 | $103.25 | — | SPONSORED ADR | 04351P101 |
| — | TCR2 THERAPEUTICS INC | 3,741,606 | $6.735M | 0.8% | $1.80 | $2.76 | — | COM | 87808K106 |
| — | CONCERT PHARMACEUTICALS INC | 1,003,017 | $6.72M | 0.8% | $6.70 | $6.70 | — | COM | 206022105 |
| BBIO | BRIDGEBIO PHARMA INC | 585,424 | $5.819M | 0.7% | $9.94 * | $10.39 | 0.0% | COM | 10806X102 |
| RCUS | ARCUS BIOSCIENCES INC | 200,000 | $5.232M | 0.6% | $26.16 | $33.51 | -21.1% | COM | 03969F109 |
| CTMX | CYTOMX THERAPEUTICS INC | 3,500,000 | $5.075M | 0.6% | $1.45 * | $1.65 | -6.9% | COM | 23284F105 |
| CLDX | CELLDEX THERAPEUTICS INC NEW | 160,219 | $4.504M | 0.6% | $28.11 * | $30.66 | 0.0% | COM NEW | 15117B202 |
| GNFTY | GENFIT S A | 1,197,522 | $4.371M | 0.5% | $3.65 | $4.78 | — | ADS | 372279109 |
| — | 2SEVENTY BIO INC | 300,000 | $4.365M | 0.5% | $14.55 | $17.06 | — | COMMON STOCK | 901384107 |
| BNTX | BIONTECH SE | 30,000 | $4.046M | 0.5% | $134.87 | $170.55 | — | SPONSORED ADS | 09075V102 |
| BABA | ALIBABA GROUP HLDG LTD | 50,000 | $4M | 0.5% | $80.00 | $113.68 | — | SPONSORED ADS | 01609W102 |
| — | HEALTH SCIENCES ACQ CORP 2 | 392,500 | $3.886M | 0.5% | $9.90 | $9.90 | — | ORD SHS | G4411D109 |
| ALDX | ALDEYRA THERAPEUTICS INC | 700,000 | $3.738M | 0.5% | $5.34 * | $6.00 | 0.0% | COM | 01438T106 |
| — | FORTRESS BIOTECH INC | 4,194,483 | $3.607M | 0.4% | $0.86 | $1.14 | — | COM | 34960Q109 |
| — | GRAPHITE BIO INC | 1,100,000 | $3.487M | 0.4% | $3.17 | $2.75 | — | COM | 38870X104 |
| — | SPRINGWORKS THERAPEUTICS INC | 120,000 | $3.424M | 0.4% | $28.53 | $28.53 | — | COM | 85205L107 |
| — | ASLAN PHARMACEUTICALS LTD | 5,654,925 | $3.386M | 0.4% | $0.60 | $0.93 | — | ADS | 04522R101 |
| ESPR | ESPERION THERAPEUTICS INC NE | 500,000 | $3.35M | 0.4% | $6.70 * | $6.87 | 0.0% | COM | 29664W105 |
| ATYR | ATYR PHARMA INC | 1,113,453 | $3.34M | 0.4% | $3.00 * | $5.98 | -44.0% | COM NEW | 002120202 |
| CRSP | CRISPR THERAPEUTICS AG | 50,000 | $3.268M | 0.4% | $65.36 * | $72.47 | 0.0% | NAMEN AKT | H17182108 |
| LEGN | LEGEND BIOTECH CORP | 80,000 | $3.264M | 0.4% | $40.80 | $44.43 | — | SPONSORED ADS | 52490G102 |
| ANIP | ANI PHARMACEUTICALS INC | 100,000 | $3.214M | 0.4% | $32.14 * | $42.97 | -20.3% | COM | 00182C103 |
| EGRX | EAGLE PHARMACEUTICALS INC | 118,857 | $3.14M | 0.4% | $26.42 * | $36.69 | 0.0% | COM | 269796108 |
| AXSM | AXSOME THERAPEUTICS INC | 70,000 | $3.123M | 0.4% | $44.61 * | $49.97 | 0.0% | COM | 05464T104 |
| — | CLENE INC | 1,100,000 | $3.08M | 0.4% | $2.80 | $2.80 | — | COMMON STOCK | 185634102 |
| GOSS | GOSSAMER BIO INC | 250,000 | $2.995M | 0.4% | $11.98 * | $12.41 | 0.0% | COM | 38341P102 |
| PYXS | PYXIS ONCOLOGY INC | 1,411,569 | $2.781M | 0.3% | $1.97 * | $2.66 | -1.8% | COMMON STOCK | 747324101 |
| — | BLUEPRINT MEDICINES CORP | 40,000 | $2.636M | 0.3% | $65.90 | $65.90 | — | COM | 09627Y109 |
| — | CHEMOCENTRYX INC | 50,000 | $2.583M | 0.3% | $51.66 | $24.78 | — | COM | 16383L106 |
| VNDA | VANDA PHARMACEUTICALS INC | 256,696 | $2.536M | 0.3% | $9.88 * | $13.15 | -19.7% | COM | 921659108 |
| ADMA | ADMA BIOLOGICS INC | 992,840 | $2.413M | 0.3% | $2.43 | $2.40 | 0.0% | COM | 000899104 |
| BEAM | BEAM THERAPEUTICS INC | 50,000 | $2.382M | 0.3% | $47.64 * | $57.05 | 0.0% | COM | 07373V105 |
| SPRY | SILVERBACK THERAPEUTICS INC | 409,463 | $2.162M | 0.3% | $5.28 * | $4.93 | 0.0% | COM | 82835W108 |
| — | BELLUS HEALTH INC NEW | 200,000 | $2.112M | 0.3% | $10.56 | $8.05 | — | COM NEW | 07987C204 |
| MLTX | MOONLAKE IMMUNOTHERAPEUTICS | 259,054 | $2.01M | 0.2% | $7.76 * | $6.29 | +12.0% | CLASS A ORD | 61559X104 |
| — | ALIGOS THERAPEUTICS INC | 1,674,166 | $1.842M | 0.2% | $1.10 | $1.20 | — | COM | 01626L105 |
| — | CTI BIOPHARMA CORP | 300,000 | $1.746M | 0.2% | $5.82 | $5.82 | — | COM | 12648L601 |
| TCRX | TSCAN THERAPEUTICS INC | 557,915 | $1.702M | 0.2% | $3.05 * | $3.16 | +3.7% | COM | 89854M101 |
| AUPH | AURINIA PHARMACEUTICALS INC | 200,000 | $1.504M | 0.2% | $7.52 * | $8.66 | 0.0% | COM | 05156V102 |
| — | INSPIRATO INCORPORATED | 612,345 | $1.445M | 0.2% | $2.36 | $6.07 | — | COM CL A | 45791E107 |
| — | VINCERX PHARMA INC | 1,030,634 | $1.422M | 0.2% | $1.38 | $16.05 | — | COM NEW | 92731L106 |
| — | MIRATI THERAPEUTICS INC | 20,000 | $1.397M | 0.2% | $69.85 | $69.85 | — | COM | 60468T105 |
| — | NEKTAR THERAPEUTICS | 430,037 | $1.376M | 0.2% | $3.20 | $5.39 | — | COM | 640268108 |
| EQ | EQUILLIUM INC | 600,000 | $1.332M | 0.2% | $2.22 * | $5.23 | -54.3% | COM | 29446K106 |
| — | TRITIUM DCFC LIMITED | 400,000 | $1.276M | 0.2% | $3.19 | $7.07 | — | ORDINARY SHARES | Q9225T108 |
| — | LEAP THERAPEUTICS INC | 1,250,000 | $1.1M | 0.1% | $0.88 | $4.01 | — | COM | 52187K101 |
| — | DYNAVAX TECHNOLOGIES CORP | 100,000 | $1.044M | 0.1% | $10.44 | $10.44 | — | COM NEW | 268158201 |
| — | ORCHARD THERAPEUTICS PLC | 2,000,000 | $1M | 0.1% | $0.50 | $0.58 | — | SPON ADS | 68570P101 |
| ALEC | ALECTOR INC | 100,000 | $946K | 0.1% | $9.46 * | $15.82 | -31.6% | COM | 014442107 |
| — | PARDES BIOSCIENCES INC | 500,000 | $925K | 0.1% | $1.85 | $2.18 | — | COM | 69945Q105 |
| ARVN | ARVINAS INC | 20,000 | $890K | 0.1% | $44.50 * | $48.55 | 0.0% | COM | 04335A105 |
| OLMA | OLEMA PHARMACEUTICALS INC | 318,926 | $880K | 0.1% | $2.76 * | $3.17 | +33.7% | COM | 68062P106 |
| — | METACRINE INC | 1,718,220 | $833K | 0.1% | $0.48 | $0.48 | — | COM | 59101E103 |
| — | HOMOLOGY MEDICINES INC | 214,898 | $346K | 0.0% | $1.61 | $3.04 | — | COM | 438083107 |
| — | BOLT BIOTHERAPEUTICS INC | 200,000 | $296K | 0.0% | $1.48 | $2.04 | — | COM | 097702104 |
| EOLS | EVOLUS INC | 36,514 | $294K | 0.0% | $8.05 * | $10.60 | 0.0% | COM | 30052C107 |
| MOLN | MOLECULAR PARTNERS AG | 15,681 | $105K | 0.0% | $6.70 | $6.70 | — | ADS | 60853G106 |
| — | INSPIRATO INCORPORATED | 365,000 | $88,000 | 0.0% | $0.24 | $1.94 | — | *W EXP 02/11/2027 | 45791E115 |
| — | ACELRX PHARMACEUTICALS INC | 388,468 | $81,000 | 0.0% | $0.21 | $0.21 | — | COM | 00444T100 |