Location: San Diego, CA
CIK: 0001232621 · Show all filings
Period: Q4 2022 (← Previous) (Next →)
Filing Date: Feb 14, 2023
Total Value: $688M (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| ANAB | ANAPTYSBIO INC | 2,628,678 | $81.46M | 11.8% | $30.99 * | $21.51 | +31.3% | COM | 032724106 |
| ALT | ALTIMMUNE INC | 2,700,450 | $44.42M | 6.5% | $16.45 * | $9.55 | +17.6% | COM NEW | 02155H200 |
| — | BLUEBIRD BIO INC | 4,635,528 | $32.08M | 4.7% | $6.92 | $4.46 | — | COM | 09609G100 |
| TARS | TARSUS PHARMACEUTICALS INC | 2,001,585 | $29.34M | 4.3% | $14.66 * | $15.52 | +6.6% | COM | 87650L103 |
| BCAB | BIOATLA INC | 3,124,076 | $25.77M | 3.7% | $8.25 | $7.10 | +16.9% | COM | 09077B104 |
| ALNY | ALNYLAM PHARMACEUTICALS INC | 105,000 | $24.95M | 3.6% | $237.65 * | $191.81 | +11.2% | COM | 02043Q107 |
| AXSM | AXSOME THERAPEUTICS INC | 320,000 | $24.68M | 3.6% | $77.13 * | $57.63 | +3.7% | COM | 05464T104 |
| IMCR | IMMUNOCORE HLDGS PLC | 405,600 | $23.15M | 3.4% | $57.07 | $30.74 | — | ADS | 45258D105 |
| MIRM | MIRUM PHARMACEUTICALS INC | 1,120,000 | $21.84M | 3.2% | $19.50 | $21.45 | -7.9% | COM | 604749101 |
| KALV | KALVISTA PHARMACEUTICALS INC | 3,196,446 | $21.61M | 3.1% | $6.76 * | $9.23 | -42.0% | COM | 483497103 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 692,925 | $20.24M | 2.9% | $29.21 * | $15.92 | +44.7% | COM | 92790C104 |
| ONC | BEIGENE LTD | 85,000 | $18.69M | 2.7% | $219.94 | $134.82 | — | SPONSORED ADR | 07725L102 |
| BCRX | BIOCRYST PHARMACEUTICALS INC | 1,450,000 | $16.65M | 2.4% | $11.48 * | $10.69 | +16.7% | COM | 09058V103 |
| HRMY | HARMONY BIOSCIENCES HLDGS IN | 281,200 | $15.49M | 2.3% | $55.10 | $41.04 | +34.0% | COM | 413197104 |
| PCVX | VAXCYTE INC | 300,000 | $14.38M | 2.1% | $47.95 * | $39.24 | 0.0% | COM | 92243G108 |
| MRNA | MODERNA INC | 80,000 | $14.37M | 2.1% | $179.62 * | $163.51 | 0.0% | COM | 60770K107 |
| — | INTRA-CELLULAR THERAPIES INC | 240,000 | $12.7M | 1.8% | $52.92 | $61.19 | — | COM | 46116X101 |
| AZN | ASTRAZENECA PLC | 170,000 | $11.53M | 1.7% | $67.80 | $56.36 | — | SPONSORED ADR | 046353108 |
| NKTX | NKARTA INC | 1,870,000 | $11.2M | 1.6% | $5.99 * | $11.10 | -9.1% | COM | 65487U108 |
| HRTX | HERON THERAPEUTICS INC | 3,755,934 | $9.39M | 1.4% | $2.50 * | $10.44 | -69.1% | COM | 427746102 |
| ENTA | ENANTA PHARMACEUTICALS INC | 200,000 | $9.304M | 1.4% | $46.52 * | $56.97 | -20.0% | COM | 29251M106 |
| — | KINIKSA PHARMACEUTICALS LTD | 600,000 | $8.988M | 1.3% | $14.98 | $9.90 | — | COM CL A | G5269C101 |
| — | ALBIREO PHARMA INC | 411,968 | $8.903M | 1.3% | $21.61 | $23.92 | — | COM | 01345P106 |
| BIO | BIO RAD LABS INC | 21,000 | $8.83M | 1.3% | $420.49 * | $570.32 | -29.2% | CL A | 090572207 |
| CGEM | CULLINAN ONCOLOGY INC | 809,231 | $8.537M | 1.2% | $10.55 * | $11.56 | +5.1% | COM | 230031106 |
| IONS | IONIS PHARMACEUTICALS INC | 200,000 | $7.554M | 1.1% | $37.77 * | $32.73 | +28.5% | COM | 462222100 |
| LLY | LILLY ELI & CO | 20,000 | $7.317M | 1.1% | $365.84 * | $345.79 | 0.0% | COM | 532457108 |
| — | THIRD HARMONIC BIO INC | 1,700,000 | $7.31M | 1.1% | $4.30 | $4.30 | — | COM | 88427A107 |
| — | CONCERT PHARMACEUTICALS INC | 1,150,000 | $6.716M | 1.0% | $5.84 | $6.59 | — | COM | 206022105 |
| — | IMMUNOGEN INC | 1,274,853 | $6.323M | 0.9% | $4.96 | $7.42 | — | COM | 45253H101 |
| EOLS | EVOLUS INC | 809,488 | $6.079M | 0.9% | $7.51 * | $7.87 | -1.6% | COM | 30052C107 |
| CTMX | CYTOMX THERAPEUTICS INC | 3,510,445 | $5.617M | 0.8% | $1.60 * | $1.65 | -10.4% | COM | 23284F105 |
| — | ADICET BIO INC | 600,000 | $5.364M | 0.8% | $8.94 | $8.94 | — | COM | 007002108 |
| GNFTY | GENFIT S A | 1,197,522 | $5.256M | 0.8% | $4.39 | $4.78 | — | ADS | 372279109 |
| GLPG | GALAPAGOS NV | 114,950 | $5.101M | 0.7% | $44.38 | $62.02 | — | SPON ADR | 36315X101 |
| CYTK | CYTOKINETICS INC | 110,000 | $5.04M | 0.7% | $45.82 * | $42.95 | 0.0% | COM NEW | 23282W605 |
| PYXS | PYXIS ONCOLOGY INC | 3,470,700 | $4.651M | 0.7% | $1.34 * | $1.97 | -23.9% | COMMON STOCK | 747324101 |
| BNTX | BIONTECH SE | 30,000 | $4.507M | 0.7% | $150.22 | $170.55 | — | SPONSORED ADS | 09075V102 |
| ASND | ASCENDIS PHARMA A/S | 36,090 | $4.408M | 0.6% | $122.13 | $103.25 | — | SPONSORED ADR | 04351P101 |
| BABA | ALIBABA GROUP HLDG LTD | 50,000 | $4.404M | 0.6% | $88.09 | $113.68 | — | SPONSORED ADS | 01609W102 |
| — | ITEOS THERAPEUTICS INC | 216,700 | $4.232M | 0.6% | $19.53 | $27.47 | — | COM | 46565G104 |
| — | HEALTH SCIENCES ACQ CORP 2 | 392,500 | $3.917M | 0.6% | $9.98 | $9.90 | — | ORD SHS | G4411D109 |
| — | ALLAKOS INC | 447,967 | $3.772M | 0.5% | $8.42 | $9.79 | — | COM | 01671P100 |
| BEAM | BEAM THERAPEUTICS INC | 95,000 | $3.715M | 0.5% | $39.11 * | $51.24 | -12.6% | COM | 07373V105 |
| AMLX | AMYLYX PHARMACEUTICALS INC | 100,000 | $3.695M | 0.5% | $36.95 * | $35.49 | 0.0% | COM | 03237H101 |
| — | GRAPHITE BIO INC | 1,100,000 | $3.652M | 0.5% | $3.32 | $2.75 | — | COM | 38870X104 |
| SPRY | ARS PHARMACEUTICALS INC | 409,463 | $3.493M | 0.5% | $8.53 * | $4.93 | +31.7% | COM | 82835W108 |
| EGRX | EAGLE PHARMACEUTICALS INC | 118,857 | $3.474M | 0.5% | $29.23 * | $36.69 | -13.3% | COM | 269796108 |
| INSM | INSMED INC | 166,203 | $3.321M | 0.5% | $19.98 * | $23.98 | -19.4% | COM PAR $.01 | 457669307 |
| — | DYNAVAX TECHNOLOGIES CORP | 300,000 | $3.192M | 0.5% | $10.64 | $10.57 | — | COM NEW | 268158201 |
| ZYME | ZYMEWORKS DEL INC | 400,000 | $3.144M | 0.5% | $7.86 * | $7.03 | 0.0% | COM | 98985Y108 |
| RCUS | ARCUS BIOSCIENCES INC | 147,920 | $3.059M | 0.4% | $20.68 * | $33.51 | -17.9% | COM | 03969F109 |
| LEGN | LEGEND BIOTECH CORP | 60,000 | $2.995M | 0.4% | $49.92 | $44.43 | — | SPONSORED ADS | 52490G102 |
| — | TCR2 THERAPEUTICS INC | 2,738,947 | $2.736M | 0.4% | $1.00 | $2.76 | — | COM | 87808K106 |
| — | MIRATI THERAPEUTICS INC | 60,000 | $2.719M | 0.4% | $45.31 | $53.49 | — | COM | 60468T105 |
| — | ALIGOS THERAPEUTICS INC | 2,816,391 | $2.684M | 0.4% | $0.95 | $1.10 | — | COM | 01626L105 |
| MLTX | MOONLAKE IMMUNOTHERAPEUTICS | 245,714 | $2.58M | 0.4% | $10.50 * | $6.29 | +41.5% | CLASS A ORD | 61559X104 |
| — | 2SEVENTY BIO INC | 250,000 | $2.342M | 0.3% | $9.37 | $17.06 | — | COMMON STOCK | 901384107 |
| BHVN | BIOHAVEN LTD | 140,000 | $1.943M | 0.3% | $13.88 | $14.12 | 0.0% | COM | G1110E107 |
| — | ASLAN PHARMACEUTICALS LTD | 5,364,925 | $1.931M | 0.3% | $0.36 | $0.93 | — | ADS | 04522R101 |
| — | METACRINE INC | 4,250,000 | $1.904M | 0.3% | $0.45 | $0.46 | — | COM | 59101E103 |
| ALDX | ALDEYRA THERAPEUTICS INC | 272,293 | $1.895M | 0.3% | $6.96 * | $6.00 | -4.7% | COM | 01438T106 |
| — | CTI BIOPHARMA CORP | 300,000 | $1.803M | 0.3% | $6.01 | $5.82 | — | COM | 12648L601 |
| — | TONIX PHARMACEUTICALS HLDG C | 4,500,419 | $1.754M | 0.3% | $0.39 | $0.39 | — | COM NEW | 890260862 |
| — | BLUEPRINT MEDICINES CORP | 40,000 | $1.752M | 0.3% | $43.81 | $65.90 | — | COM | 09627Y109 |
| — | ATHIRA PHARMA INC | 485,234 | $1.538M | 0.2% | $3.17 | $3.17 | — | COM | 04746L104 |
| ARVN | ARVINAS INC | 30,000 | $1.026M | 0.1% | $34.21 * | $46.39 | -9.3% | COM | 04335A105 |
| CLDX | CELLDEX THERAPEUTICS INC NEW | 21,192 | $945K | 0.1% | $44.57 * | $30.66 | +16.5% | COM NEW | 15117B202 |
| CHRS | COHERUS BIOSCIENCES INC | 115,900 | $918K | 0.1% | $7.92 * | $17.20 | -55.3% | COM | 19249H103 |
| — | SIO GENE THERAPIES INC | 2,000,000 | $870K | 0.1% | $0.43 | $0.43 | — | COM | 829399104 |
| AUPH | AURINIA PHARMACEUTICALS INC | 200,000 | $864K | 0.1% | $4.32 * | $8.66 | -33.0% | COM | 05156V102 |
| TCRX | TSCAN THERAPEUTICS INC | 514,655 | $798K | 0.1% | $1.55 * | $3.16 | -22.4% | COM | 89854M101 |
| OLMA | OLEMA PHARMACEUTICALS INC | 318,926 | $781K | 0.1% | $2.45 * | $3.17 | -8.0% | COM | 68062P106 |
| — | ORCHARD THERAPEUTICS PLC | 2,000,000 | $742K | 0.1% | $0.37 | $0.58 | — | SPON ADS | 68570P101 |
| — | BOLT BIOTHERAPEUTICS INC | 400,000 | $520K | 0.1% | $1.30 | $1.67 | — | COM | 097702104 |
| — | ELEVATION ONCOLOGY INC | 479,854 | $456K | 0.1% | $0.95 | $0.95 | — | COM | 28623U101 |
| TLPH | ACELRX PHARMACEUTICALS INC | 195,000 | $441K | 0.1% | $2.26 * | $2.81 | 0.0% | COM NEW | 00444T209 |
| CRSP | CRISPR THERAPEUTICS AG | 10,000 | $407K | 0.1% | $40.65 * | $72.47 | -26.8% | NAMEN AKT | H17182108 |
| — | NEKTAR THERAPEUTICS | 164,190 | $371K | 0.1% | $2.26 | $5.39 | — | COM | 640268108 |
| — | SURFACE ONCOLOGY INC | 429,647 | $352K | 0.1% | $0.82 | $0.82 | — | COM | 86877M209 |
| RLMD | RELMADA THERAPEUTICS INC | 100,000 | $349K | 0.1% | $3.49 * | $21.81 | -59.7% | COM | 75955J402 |
| ATYR | ATYR PHARMA INC | 123,430 | $270K | 0.0% | $2.19 * | $5.98 | -60.6% | COM NEW | 002120202 |
| GOSS | GOSSAMER BIO INC | 100,000 | $217K | 0.0% | $2.17 * | $12.41 | -33.7% | COM | 38341P102 |
| MOLN | MOLECULAR PARTNERS AG | 22,000 | $144K | 0.0% | $6.55 | $6.65 | — | ADS | 60853G106 |
| — | VINCERX PHARMA INC | 101,762 | $104K | 0.0% | $1.02 | $16.05 | — | COM NEW | 92731L106 |
| RVPH | REVIVA PHARMACEUTCLS HLDGS I | 24,125 | $103K | 0.0% | $4.25 * | $3.81 | 0.0% | COM | 76152G100 |
| LIANY | LIANBIO | 59,600 | $97,744 | 0.0% | $1.64 | $1.64 | — | SPONSORED ADS | 53000N108 |
| — | RENEO PHARMACEUTICALS INC | 30,587 | $71,268 | 0.0% | $2.33 | $2.33 | — | COM | 75974E103 |
| — | PARDES BIOSCIENCES INC | 33,748 | $57,034 | 0.0% | $1.69 | $2.18 | — | COM | 69945Q105 |