Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q1 2019 (← Previous) (Next →)

Filing Date: Jul 30, 2019

Total Value: $2.397B (100.0% shares, 0.0% debt)

Holdings (37)

BMRN BIOMARIN PHARMACEUTICAL INC 9.8%

Value $235M Shares 2,641,485 Est. Cost $80.19 Unrealized +15.6%

INSM INSMED INC 9.3%

Value $222M Shares 7,653,617 Est. Cost $16.83 Unrealized +54.0%

— ABIOMED INC 8.3%

Value $200M Shares 698,654 Est. Cost $35.35 Unrealized —

UTHR UNITED THERAPEUTICS CORP DEL 8.0%

Value $192M Shares 1,632,025 Est. Cost $88.73 Unrealized +31.3%

— ALEXION PHARMACEUTICALS INC 6.9%

Value $166M Shares 1,229,030 Est. Cost $121.54 Unrealized —

STAA STAAR SURGICAL CO 6.0%

Value $144M Shares 4,218,902 Est. Cost $13.06 Unrealized +170.9%

— SAGE THERAPEUTICS INC 5.7%

Value $136M Shares 857,681 Est. Cost $48.62 Unrealized —

— CLOVIS ONCOLOGY INC 5.4%

Value $130M Shares 5,239,304 Est. Cost $51.30 Unrealized —

— IMMUNOMEDICS INC 5.1%

Value $123M Shares 6,381,555 Est. Cost $13.36 Unrealized —

FOLD AMICUS THERAPEUTICS INC 4.3%

Value $104M Shares 7,619,833 Est. Cost $7.42 Unrealized +64.6%

VNDA VANDA PHARMACEUTICALS INC 3.9%

Value $93.01M Shares 5,055,050 Est. Cost $11.21 Unrealized +103.3%

— WRIGHT MED GROUP N V 3.6%

Value $87.16M Shares 2,771,394 Est. Cost $23.42 Unrealized —

— EPIZYME INC 3.6%

Value $85.93M Shares 6,935,074 Est. Cost $15.12 Unrealized —

— AIMMUNE THERAPEUTICS INC 3.5%

Value $83.79M Shares 3,748,939 Est. Cost $22.88 Unrealized —

ACAD ACADIA PHARMACEUTICALS INC 2.5%

Value $60.37M Shares 2,248,403 Est. Cost $27.39 Unrealized -14.7%

ALGN ALIGN TECHNOLOGY INC 2.0%

Value $47.03M Shares 165,405 Est. Cost $114.31 Unrealized +108.8%

PBYI PUMA BIOTECHNOLOGY INC 1.9%

Value $45.8M Shares 1,180,780 Est. Cost $30.02 Unrealized +1.7%

— AMAG PHARMACEUTICALS INC 1.8%

Value $44.07M Shares 3,421,306 Est. Cost $29.07 Unrealized —

— KARYOPHARM THERAPEUTICS INC 1.3%

Value $30.73M Shares 5,262,263 Est. Cost $17.42 Unrealized —

EXAS EXACT SCIENCES CORP 1.1%

Value $27.28M Shares 314,889 Est. Cost $13.61 Unrealized +525.3%

— MOMENTA PHARMACEUTICALS INC 1.1%

Value $26.76M Shares 1,841,613 Est. Cost $14.12 Unrealized —

— ALDER BIOPHARMACEUTICALS INC 1.1%

Value $25.41M Shares 1,861,630 Est. Cost $11.48 Unrealized —

— CELGENE CORP 1.0%

Value $25.13M Shares 266,333 Est. Cost $89.02 Unrealized —

PRTA PROTHENA CORP PLC 0.6%

Value $13.45M Shares 1,108,510 Est. Cost $32.98 Unrealized -62.1%

KLDO KALEIDO BIOSCIENCES INC 0.5%

Value $12.57M Shares 866,666 Est. Cost $13.76 Unrealized 0.0%

GILD GILEAD SCIENCES INC 0.5%

Value $11.44M Shares 175,900 Est. Cost $62.02 Unrealized -18.0%

— RIGEL PHARMACEUTICALS INC 0.4%

Value $10.24M Shares 3,985,945 Est. Cost $3.40 Unrealized —

— DICERNA PHARMACEUTICALS INC 0.3%

Value $7.338M Shares 500,913 Est. Cost $5.39 Unrealized —

— ALIMERA SCIENCES INC 0.1%

Value $3.195M Shares 3,013,793 Est. Cost $4.88 Unrealized —

— ZOGENIX INC 0.1%

Value $1.623M Shares 29,500 Est. Cost $13.36 Unrealized —

— SUNESIS PHARMACEUTICALS INC 0.1%

Value $1.412M Shares 1,162,473 Est. Cost $4.37 Unrealized —

CYTK CYTOKINETICS INC 0.0%

Value $1.001M Shares 123,686 Est. Cost $6.71 Unrealized +9.5%

— MARINUS PHARMACEUTICALS INC 0.0%

Value $477K Shares 114,221 Est. Cost $4.18 Unrealized —

— SOPHIRIS BIO INC 0.0%

Value $245K Shares 247,000 Est. Cost $2.60 Unrealized —

— IDERA PHARMACEUTICALS INC 0.0%

Value $196K Shares 77,044 Est. Cost $8.90 Unrealized —

— MELINTA THERAPEUTICS INC 0.0%

Value $36,000 Shares 10,137 Est. Cost $3.55 Unrealized —

— HISTOGENICS CORP 0.0%

Value $35,000 Shares 302,922 Est. Cost $11.00 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
BMRN	BIOMARIN PHARMACEUTICAL INC	2,641,485	$235M	9.8%	$80.19	+15.6%	COM	09061G101
INSM	INSMED INC	7,653,617	$222M	9.3%	$16.83	+54.0%	COM PAR $.01	457669307
—	ABIOMED INC	698,654	$200M	8.3%	$35.35	—	COM	003654100
UTHR	UNITED THERAPEUTICS CORP DEL	1,632,025	$192M	8.0%	$88.73	+31.3%	COM	91307C102
—	ALEXION PHARMACEUTICALS INC	1,229,030	$166M	6.9%	$121.54	—	COM	015351109
STAA	STAAR SURGICAL CO	4,218,902	$144M	6.0%	$13.06	+170.9%	COM PAR $0.01	852312305
—	SAGE THERAPEUTICS INC	857,681	$136M	5.7%	$48.62	—	COM	78667J108
—	CLOVIS ONCOLOGY INC	5,239,304	$130M	5.4%	$51.30	—	COM	189464100
—	IMMUNOMEDICS INC	6,381,555	$123M	5.1%	$13.36	—	COM	452907108
FOLD	AMICUS THERAPEUTICS INC	7,619,833	$104M	4.3%	$7.42	+64.6%	COM	03152W109
VNDA	VANDA PHARMACEUTICALS INC	5,055,050	$93.01M	3.9%	$11.21	+103.3%	COM	921659108
—	WRIGHT MED GROUP N V	2,771,394	$87.16M	3.6%	$23.42	—	ORD SHS	N96617118
—	EPIZYME INC	6,935,074	$85.93M	3.6%	$15.12	—	COM	29428V104
—	AIMMUNE THERAPEUTICS INC	3,748,939	$83.79M	3.5%	$22.88	—	COM	00900T107
ACAD	ACADIA PHARMACEUTICALS INC	2,248,403	$60.37M	2.5%	$27.39	-14.7%	COM	004225108
ALGN	ALIGN TECHNOLOGY INC	165,405	$47.03M	2.0%	$114.31	+108.8%	COM	016255101
PBYI	PUMA BIOTECHNOLOGY INC	1,180,780	$45.8M	1.9%	$30.02	+1.7%	COM	74587V107
—	AMAG PHARMACEUTICALS INC	3,421,306	$44.07M	1.8%	$29.07	—	COM	00163U106
—	KARYOPHARM THERAPEUTICS INC	5,262,263	$30.73M	1.3%	$17.42	—	COM	48576U106
EXAS	EXACT SCIENCES CORP	314,889	$27.28M	1.1%	$13.61	+525.3%	COM	30063P105
—	MOMENTA PHARMACEUTICALS INC	1,841,613	$26.76M	1.1%	$14.12	—	COM	60877T100
—	ALDER BIOPHARMACEUTICALS INC	1,861,630	$25.41M	1.1%	$11.48	—	COM	014339105
—	CELGENE CORP	266,333	$25.13M	1.0%	$89.02	—	COM	151020104
PRTA	PROTHENA CORP PLC	1,108,510	$13.45M	0.6%	$32.98	-62.1%	SHS	G72800108
KLDO	KALEIDO BIOSCIENCES INC	866,666	$12.57M	0.5%	$13.76	0.0%	COM	483347100
GILD	GILEAD SCIENCES INC	175,900	$11.44M	0.5%	$62.02	-18.0%	COM	375558103
—	RIGEL PHARMACEUTICALS INC	3,985,945	$10.24M	0.4%	$3.40	—	COM NEW	766559603
—	DICERNA PHARMACEUTICALS INC	500,913	$7.338M	0.3%	$5.39	—	COM	253031108
—	ALIMERA SCIENCES INC	3,013,793	$3.195M	0.1%	$4.88	—	COM	016259103
—	ZOGENIX INC	29,500	$1.623M	0.1%	$13.36	—	COM NEW	98978L204
—	SUNESIS PHARMACEUTICALS INC	1,162,473	$1.412M	0.1%	$4.37	—	COM PAR	867328700
CYTK	CYTOKINETICS INC	123,686	$1.001M	0.0%	$6.71	+9.5%	COM NEW	23282W605
—	MARINUS PHARMACEUTICALS INC	114,221	$477K	0.0%	$4.18	—	COM	56854Q101
—	SOPHIRIS BIO INC	247,000	$245K	0.0%	$2.60	—	COM NEW	83578Q209
—	IDERA PHARMACEUTICALS INC	77,044	$196K	0.0%	$8.90	—	COM PAR	45168K405
—	MELINTA THERAPEUTICS INC	10,137	$36,000	0.0%	$3.55	—	COM NEW	58549G209
—	HISTOGENICS CORP	302,922	$35,000	0.0%	$11.00	—	COM	43358V109