Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q4 2018 (← Previous) (Next →)

Filing Date: Feb 14, 2019

Total Value: $1.878B (100.0% shares, 0.0% debt)

Holdings (36)

— ABIOMED INC 11.9%

Value $224M Shares 689,550 Share Price $325.04 Est. Cost/Share $32.04 Unrealized @ Report Date —

BMRN BIOMARIN PHARMACEUTICAL INC 11.6%

Value $218M Shares 2,559,733 Share Price $85.15 * Est. Cost/Share $79.79 Unrealized @ Report Date +19.2%

UTHR UNITED THERAPEUTICS CORP DEL 9.5%

Value $178M Shares 1,632,025 Share Price $108.90 * Est. Cost/Share $88.73 Unrealized @ Report Date +30.7%

STAA STAAR SURGICAL CO 7.0%

Value $132M Shares 4,147,988 Share Price $31.91 * Est. Cost/Share $12.68 Unrealized @ Report Date +207.3%

— ALEXION PHARMACEUTICALS INC 6.2%

Value $117M Shares 1,204,328 Share Price $97.36 Est. Cost/Share $121.26 Unrealized @ Report Date —

VNDA VANDA PHARMACEUTICALS INC 5.8%

Value $109M Shares 4,155,670 Share Price $26.13 * Est. Cost/Share $8.70 Unrealized @ Report Date +170.2%

INSM INSMED INC 5.3%

Value $100M Shares 7,653,617 Share Price $13.12 * Est. Cost/Share $16.83 Unrealized @ Report Date -5.2%

— CLOVIS ONCOLOGY INC 5.0%

Value $94.1M Shares 5,239,304 Share Price $17.96 Est. Cost/Share $51.30 Unrealized @ Report Date —

— SAGE THERAPEUTICS INC 4.3%

Value $81.52M Shares 850,977 Share Price $95.79 Est. Cost/Share $48.62 Unrealized @ Report Date —

— WRIGHT MED GROUP N V 4.0%

Value $75.44M Shares 2,771,394 Share Price $27.22 Est. Cost/Share $23.42 Unrealized @ Report Date —

— IMMUNOMEDICS INC 3.9%

Value $74.01M Shares 5,186,255 Share Price $14.27 Est. Cost/Share $12.01 Unrealized @ Report Date —

FOLD AMICUS THERAPEUTICS INC 3.8%

Value $70.91M Shares 7,401,321 Share Price $9.58 * Est. Cost/Share $7.28 Unrealized @ Report Date +51.0%

— AMAG PHARMACEUTICALS INC 2.7%

Value $51.35M Shares 3,380,506 Share Price $15.19 Est. Cost/Share $29.26 Unrealized @ Report Date —

— KARYOPHARM THERAPEUTICS INC 2.3%

Value $43.9M Shares 4,685,352 Share Price $9.37 Est. Cost/Share $18.85 Unrealized @ Report Date —

— EPIZYME INC 2.3%

Value $42.72M Shares 6,935,074 Share Price $6.16 Est. Cost/Share $15.12 Unrealized @ Report Date —

— CELGENE CORP 1.8%

Value $34.14M Shares 532,667 Share Price $64.09 Est. Cost/Share $89.02 Unrealized @ Report Date —

— AIMMUNE THERAPEUTICS INC 1.8%

Value $33.19M Shares 1,387,589 Share Price $23.92 Est. Cost/Share $23.79 Unrealized @ Report Date —

ALGN ALIGN TECHNOLOGY INC 1.7%

Value $32.84M Shares 156,823 Share Price $209.43 * Est. Cost/Share $107.51 Unrealized @ Report Date +135.0%

ACAD ACADIA PHARMACEUTICALS INC 1.7%

Value $32.76M Shares 2,026,063 Share Price $16.17 * Est. Cost/Share $27.84 Unrealized @ Report Date -30.2%

PBYI PUMA BIOTECHNOLOGY INC 1.3%

Value $23.6M Shares 1,159,900 Share Price $20.35 * Est. Cost/Share $30.01 Unrealized @ Report Date 0.0%

— MOMENTA PHARMACEUTICALS INC 1.1%

Value $20.33M Shares 1,841,613 Share Price $11.04 Est. Cost/Share $14.12 Unrealized @ Report Date —

EXAS EXACT SCIENCES CORP 1.1%

Value $19.87M Shares 314,889 Share Price $63.10 * Est. Cost/Share $13.61 Unrealized @ Report Date +404.1%

— ALDER BIOPHARMACEUTICALS INC 1.0%

Value $19.08M Shares 1,861,630 Share Price $10.25 Est. Cost/Share $11.48 Unrealized @ Report Date —

PRTA PROTHENA CORP PLC 0.6%

Value $11.42M Shares 1,108,510 Share Price $10.30 * Est. Cost/Share $32.98 Unrealized @ Report Date -64.0%

GILD GILEAD SCIENCES INC 0.6%

Value $11M Shares 175,900 Share Price $62.55 * Est. Cost/Share $62.02 Unrealized @ Report Date -14.5%

— RIGEL PHARMACEUTICALS INC 0.5%

Value $9.168M Shares 3,985,945 Share Price $2.30 Est. Cost/Share $3.40 Unrealized @ Report Date —

— SHIRE PLC 0.4%

Value $8.343M Shares 47,938 Share Price $174.04 Est. Cost/Share $197.13 Unrealized @ Report Date —

— DICERNA PHARMACEUTICALS INC 0.3%

Value $5.355M Shares 500,913 Share Price $10.69 Est. Cost/Share $5.39 Unrealized @ Report Date —

— ALIMERA SCIENCES INC 0.1%

Value $2.164M Shares 3,013,793 Share Price $0.72 Est. Cost/Share $4.88 Unrealized @ Report Date —

— ZOGENIX INC 0.1%

Value $1.076M Shares 29,500 Share Price $36.47 Est. Cost/Share $13.36 Unrealized @ Report Date —

CYTK CYTOKINETICS INC 0.0%

Value $782K Shares 123,686 Share Price $6.32 * Est. Cost/Share $6.71 Unrealized @ Report Date +9.3%

— SUNESIS PHARMACEUTICALS INC 0.0%

Value $483K Shares 1,162,473 Share Price $0.42 Est. Cost/Share $4.37 Unrealized @ Report Date —

— IDERA PHARMACEUTICALS INC 0.0%

Value $213K Shares 77,044 Share Price $2.76 Est. Cost/Share $8.90 Unrealized @ Report Date —

— SOPHIRIS BIO INC 0.0%

Value $205K Shares 247,000 Share Price $0.83 Est. Cost/Share $2.60 Unrealized @ Report Date —

— MELINTA THERAPEUTICS INC 0.0%

Value $40,000 Shares 50,689 Share Price $0.79 Est. Cost/Share $15.80 Unrealized @ Report Date —

— HISTOGENICS CORP 0.0%

Value $27,000 Shares 302,922 Share Price $0.09 Est. Cost/Share $11.00 Unrealized @ Report Date —

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
—	ABIOMED INC	689,550	$224M	11.9%	$325.04	$32.04	—	COM	003654100
BMRN	BIOMARIN PHARMACEUTICAL INC	2,559,733	$218M	11.6%	$85.15 *	$79.79	+19.2%	COM	09061G101
UTHR	UNITED THERAPEUTICS CORP DEL	1,632,025	$178M	9.5%	$108.90 *	$88.73	+30.7%	COM	91307C102
STAA	STAAR SURGICAL CO	4,147,988	$132M	7.0%	$31.91 *	$12.68	+207.3%	COM PAR $0.01	852312305
—	ALEXION PHARMACEUTICALS INC	1,204,328	$117M	6.2%	$97.36	$121.26	—	COM	015351109
VNDA	VANDA PHARMACEUTICALS INC	4,155,670	$109M	5.8%	$26.13 *	$8.70	+170.2%	COM	921659108
INSM	INSMED INC	7,653,617	$100M	5.3%	$13.12 *	$16.83	-5.2%	COM PAR $.01	457669307
—	CLOVIS ONCOLOGY INC	5,239,304	$94.1M	5.0%	$17.96	$51.30	—	COM	189464100
—	SAGE THERAPEUTICS INC	850,977	$81.52M	4.3%	$95.79	$48.62	—	COM	78667J108
—	WRIGHT MED GROUP N V	2,771,394	$75.44M	4.0%	$27.22	$23.42	—	ORD SHS 0.03 PAR	N96617118
—	IMMUNOMEDICS INC	5,186,255	$74.01M	3.9%	$14.27	$12.01	—	COM	452907108
FOLD	AMICUS THERAPEUTICS INC	7,401,321	$70.91M	3.8%	$9.58 *	$7.28	+51.0%	COM	03152W109
—	AMAG PHARMACEUTICALS INC	3,380,506	$51.35M	2.7%	$15.19	$29.26	—	COM	00163U106
—	KARYOPHARM THERAPEUTICS INC	4,685,352	$43.9M	2.3%	$9.37	$18.85	—	COM	48576U106
—	EPIZYME INC	6,935,074	$42.72M	2.3%	$6.16	$15.12	—	COM	29428V104
—	CELGENE CORP	532,667	$34.14M	1.8%	$64.09	$89.02	—	COM	151020104
—	AIMMUNE THERAPEUTICS INC	1,387,589	$33.19M	1.8%	$23.92	$23.79	—	COM	00900T107
ALGN	ALIGN TECHNOLOGY INC	156,823	$32.84M	1.7%	$209.43 *	$107.51	+135.0%	COM	016255101
ACAD	ACADIA PHARMACEUTICALS INC	2,026,063	$32.76M	1.7%	$16.17 *	$27.84	-30.2%	COM	004225108
PBYI	PUMA BIOTECHNOLOGY INC	1,159,900	$23.6M	1.3%	$20.35 *	$30.01	0.0%	COM	74587V107
—	MOMENTA PHARMACEUTICALS INC	1,841,613	$20.33M	1.1%	$11.04	$14.12	—	COM	60877T100
EXAS	EXACT SCIENCES CORP	314,889	$19.87M	1.1%	$63.10 *	$13.61	+404.1%	COM	30063P105
—	ALDER BIOPHARMACEUTICALS INC	1,861,630	$19.08M	1.0%	$10.25	$11.48	—	COM	014339105
PRTA	PROTHENA CORP PLC	1,108,510	$11.42M	0.6%	$10.30 *	$32.98	-64.0%	SHS	G72800108
GILD	GILEAD SCIENCES INC	175,900	$11M	0.6%	$62.55 *	$62.02	-14.5%	COM	375558103
—	RIGEL PHARMACEUTICALS INC	3,985,945	$9.168M	0.5%	$2.30	$3.40	—	COM NEW	766559603
—	SHIRE PLC	47,938	$8.343M	0.4%	$174.04	$197.13	—	SPONSORED ADR	82481R106
—	DICERNA PHARMACEUTICALS INC	500,913	$5.355M	0.3%	$10.69	$5.39	—	COM	253031108
—	ALIMERA SCIENCES INC	3,013,793	$2.164M	0.1%	$0.72	$4.88	—	COM	016259103
—	ZOGENIX INC	29,500	$1.076M	0.1%	$36.47	$13.36	—	COM NEW	98978L204
CYTK	CYTOKINETICS INC	123,686	$782K	0.0%	$6.32 *	$6.71	+9.3%	COM NEW	23282W605
—	SUNESIS PHARMACEUTICALS INC	1,162,473	$483K	0.0%	$0.42	$4.37	—	COM PAR	867328700
—	IDERA PHARMACEUTICALS INC	77,044	$213K	0.0%	$2.76	$8.90	—	COM PAR	45168K405
—	SOPHIRIS BIO INC	247,000	$205K	0.0%	$0.83	$2.60	—	COM NEW	83578Q209
—	MELINTA THERAPEUTICS INC	50,689	$40,000	0.0%	$0.79	$15.80	—	COM	58549G100
—	HISTOGENICS CORP	302,922	$27,000	0.0%	$0.09	$11.00	—	COM	43358V109