Palo Alto Investors LP Long-Term Concentrated

CIK: 0001306923 · Show all filings

Period: Q2 2019 (← Previous) (Next →)

Filing Date: Aug 14, 2019

Total Value ($000): $2,056,939 (100.0% shares, 0.0% debt)

Holdings (39)

BMRN BIOMARIN PHARMACEUTICAL INC 10.9%

Value ($000) $223,245 Shares 2,606,485 Est. Cost $80.19 Unrealized +6.7%

INSM INSMED INC 9.8%

Value ($000) $202,007 Shares 7,890,917 Est. Cost $17.16 Unrealized +62.3%

— ABIOMED INC 8.9%

Value ($000) $183,998 Shares 706,354 Est. Cost $37.80 Unrealized —

— SAGE THERAPEUTICS INC 7.1%

Value ($000) $145,562 Shares 795,031 Est. Cost $48.62 Unrealized —

— ALEXION PHARMACEUTICALS INC 6.5%

Value ($000) $134,095 Shares 1,023,780 Est. Cost $121.54 Unrealized —

STAA STAAR SURGICAL CO 6.1%

Value ($000) $124,485 Shares 4,237,051 Est. Cost $13.06 Unrealized +121.0%

UTHR UNITED THERAPEUTICS CORP DEL 5.9%

Value ($000) $121,211 Shares 1,552,792 Est. Cost $88.73 Unrealized +5.4%

FOLD AMICUS THERAPEUTICS INC 4.7%

Value ($000) $97,298 Shares 7,796,299 Est. Cost $7.54 Unrealized +68.3%

— IMMUNOMEDICS INC 4.5%

Value ($000) $92,607 Shares 6,676,755 Est. Cost $13.38 Unrealized —

— EPIZYME INC 4.2%

Value ($000) $87,035 Shares 6,935,074 Est. Cost $15.12 Unrealized —

— WRIGHT MED GROUP N V 4.0%

Value ($000) $82,643 Shares 2,771,394 Est. Cost $23.42 Unrealized —

— AIMMUNE THERAPEUTICS INC 3.9%

Value ($000) $79,711 Shares 3,828,564 Est. Cost $22.84 Unrealized —

— CLOVIS ONCOLOGY INC 3.7%

Value ($000) $76,451 Shares 5,141,304 Est. Cost $51.30 Unrealized —

VNDA VANDA PHARMACEUTICALS INC 3.5%

Value ($000) $71,226 Shares 5,055,050 Est. Cost $11.21 Unrealized +42.0%

ACAD ACADIA PHARMACEUTICALS INC 3.0%

Value ($000) $61,714 Shares 2,308,803 Est. Cost $27.34 Unrealized -6.6%

ALGN ALIGN TECHNOLOGY INC 2.0%

Value ($000) $40,372 Shares 147,505 Est. Cost $114.31 Unrealized +164.2%

EXAS EXACT SCIENCES CORP 1.8%

Value ($000) $37,169 Shares 314,889 Est. Cost $13.61 Unrealized +640.1%

— AMAG PHARMACEUTICALS INC 1.6%

Value ($000) $33,721 Shares 3,375,506 Est. Cost $29.07 Unrealized —

— KARYOPHARM THERAPEUTICS INC 1.5%

Value ($000) $31,521 Shares 5,262,263 Est. Cost $17.42 Unrealized —

— MOMENTA PHARMACEUTICALS INC 1.2%

Value ($000) $23,895 Shares 1,919,313 Est. Cost $14.06 Unrealized —

— ALDER BIOPHARMACEUTICALS INC 1.1%

Value ($000) $21,911 Shares 1,861,630 Est. Cost $11.48 Unrealized —

PBYI PUMA BIOTECHNOLOGY INC 0.9%

Value ($000) $17,866 Shares 1,405,680 Est. Cost $28.90 Unrealized -20.3%

GILD GILEAD SCIENCES INC 0.6%

Value ($000) $11,884 Shares 175,900 Est. Cost $62.02 Unrealized -18.1%

PRTA PROTHENA CORP PLC 0.6%

Value ($000) $11,717 Shares 1,108,510 Est. Cost $32.98 Unrealized -68.9%

— RIGEL PHARMACEUTICALS INC 0.5%

Value ($000) $10,403 Shares 3,985,945 Est. Cost $3.40 Unrealized —

KLDO KALEIDO BIOSCIENCES INC 0.5%

Value ($000) $10,053 Shares 866,666 Est. Cost $13.76 Unrealized +5.8%

— CELGENE CORP 0.5%

Value ($000) $9,880 Shares 106,883 Est. Cost $89.02 Unrealized —

— DICERNA PHARMACEUTICALS INC 0.3%

Value ($000) $5,226 Shares 331,813 Est. Cost $5.39 Unrealized —

— ALIMERA SCIENCES INC 0.1%

Value ($000) $2,682 Shares 3,013,793 Est. Cost $4.88 Unrealized —

— ZOGENIX INC 0.1%

Value ($000) $1,410 Shares 29,500 Est. Cost $13.36 Unrealized —

CYTK CYTOKINETICS INC 0.1%

Value ($000) $1,391 Shares 123,686 Est. Cost $6.71 Unrealized +43.6%

— SUNESIS PHARMACEUTICALS INC 0.0%

Value ($000) $845 Shares 1,162,473 Est. Cost $4.37 Unrealized —

— MARINUS PHARMACEUTICALS INC 0.0%

Value ($000) $520 Shares 125,321 Est. Cost $4.17 Unrealized —

ALDX ALDEYRA THERAPEUTICS INC 0.0%

Value ($000) $441 Shares 73,500 Est. Cost $7.53 Unrealized 0.0%

— SOPHIRIS BIO INC 0.0%

Value ($000) $209 Shares 247,000 Est. Cost $2.60 Unrealized —

— IDERA PHARMACEUTICALS INC 0.0%

Value ($000) $206 Shares 77,044 Est. Cost $8.90 Unrealized —

— MINERVA NEUROSCIENCES INC 0.0%

Value ($000) $204 Shares 36,319 Est. Cost $5.62 Unrealized —

— MELINTA THERAPEUTICS INC 0.0%

Value ($000) $67 Shares 10,137 Est. Cost $3.55 Unrealized —

— HISTOGENICS CORP 0.0%

Value ($000) $58 Shares 302,922 Est. Cost $11.00 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
BMRN	BIOMARIN PHARMACEUTICAL INC	2,606,485	$223,245	10.9%	$80.19	+6.7%	COM	09061G101
INSM	INSMED INC	7,890,917	$202,007	9.8%	$17.16	+62.3%	COM PAR $.01	457669307
—	ABIOMED INC	706,354	$183,998	8.9%	$37.80	—	COM	003654100
—	SAGE THERAPEUTICS INC	795,031	$145,562	7.1%	$48.62	—	COM	78667J108
—	ALEXION PHARMACEUTICALS INC	1,023,780	$134,095	6.5%	$121.54	—	COM	015351109
STAA	STAAR SURGICAL CO	4,237,051	$124,485	6.1%	$13.06	+121.0%	COM PAR $0.01	852312305
UTHR	UNITED THERAPEUTICS CORP DEL	1,552,792	$121,211	5.9%	$88.73	+5.4%	COM	91307C102
FOLD	AMICUS THERAPEUTICS INC	7,796,299	$97,298	4.7%	$7.54	+68.3%	COM	03152W109
—	IMMUNOMEDICS INC	6,676,755	$92,607	4.5%	$13.38	—	COM	452907108
—	EPIZYME INC	6,935,074	$87,035	4.2%	$15.12	—	COM	29428V104
—	WRIGHT MED GROUP N V	2,771,394	$82,643	4.0%	$23.42	—	ORD SHS	N96617118
—	AIMMUNE THERAPEUTICS INC	3,828,564	$79,711	3.9%	$22.84	—	COM	00900T107
—	CLOVIS ONCOLOGY INC	5,141,304	$76,451	3.7%	$51.30	—	COM	189464100
VNDA	VANDA PHARMACEUTICALS INC	5,055,050	$71,226	3.5%	$11.21	+42.0%	COM	921659108
ACAD	ACADIA PHARMACEUTICALS INC	2,308,803	$61,714	3.0%	$27.34	-6.6%	COM	004225108
ALGN	ALIGN TECHNOLOGY INC	147,505	$40,372	2.0%	$114.31	+164.2%	COM	016255101
EXAS	EXACT SCIENCES CORP	314,889	$37,169	1.8%	$13.61	+640.1%	COM	30063P105
—	AMAG PHARMACEUTICALS INC	3,375,506	$33,721	1.6%	$29.07	—	COM	00163U106
—	KARYOPHARM THERAPEUTICS INC	5,262,263	$31,521	1.5%	$17.42	—	COM	48576U106
—	MOMENTA PHARMACEUTICALS INC	1,919,313	$23,895	1.2%	$14.06	—	COM	60877T100
—	ALDER BIOPHARMACEUTICALS INC	1,861,630	$21,911	1.1%	$11.48	—	COM	014339105
PBYI	PUMA BIOTECHNOLOGY INC	1,405,680	$17,866	0.9%	$28.90	-20.3%	COM	74587V107
GILD	GILEAD SCIENCES INC	175,900	$11,884	0.6%	$62.02	-18.1%	COM	375558103
PRTA	PROTHENA CORP PLC	1,108,510	$11,717	0.6%	$32.98	-68.9%	SHS	G72800108
—	RIGEL PHARMACEUTICALS INC	3,985,945	$10,403	0.5%	$3.40	—	COM NEW	766559603
KLDO	KALEIDO BIOSCIENCES INC	866,666	$10,053	0.5%	$13.76	+5.8%	COM	483347100
—	CELGENE CORP	106,883	$9,880	0.5%	$89.02	—	COM	151020104
—	DICERNA PHARMACEUTICALS INC	331,813	$5,226	0.3%	$5.39	—	COM	253031108
—	ALIMERA SCIENCES INC	3,013,793	$2,682	0.1%	$4.88	—	COM	016259103
—	ZOGENIX INC	29,500	$1,410	0.1%	$13.36	—	COM NEW	98978L204
CYTK	CYTOKINETICS INC	123,686	$1,391	0.1%	$6.71	+43.6%	COM NEW	23282W605
—	SUNESIS PHARMACEUTICALS INC	1,162,473	$845	0.0%	$4.37	—	COM PAR	867328700
—	MARINUS PHARMACEUTICALS INC	125,321	$520	0.0%	$4.17	—	COM	56854Q101
ALDX	ALDEYRA THERAPEUTICS INC	73,500	$441	0.0%	$7.53	0.0%	COM	01438T106
—	SOPHIRIS BIO INC	247,000	$209	0.0%	$2.60	—	COM NEW	83578Q209
—	IDERA PHARMACEUTICALS INC	77,044	$206	0.0%	$8.90	—	COM PAR	45168K405
—	MINERVA NEUROSCIENCES INC	36,319	$204	0.0%	$5.62	—	COM	603380106
—	MELINTA THERAPEUTICS INC	10,137	$67	0.0%	$3.55	—	COM NEW	58549G209
—	HISTOGENICS CORP	302,922	$58	0.0%	$11.00	—	COM	43358V109