Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q2 2019 (← Previous) (Next →)

Filing Date: Aug 14, 2019

Total Value: $2.057B (100.0% shares, 0.0% debt)

Holdings (39)

BMRN BIOMARIN PHARMACEUTICAL INC 10.9%

Value $223M Shares 2,606,485 Share Price $85.65 Est. Cost/Share $80.19 Unrealized @ Report Date +6.7%

INSM INSMED INC 9.8%

Value $202M Shares 7,890,917 Share Price $25.60 * Est. Cost/Share $17.16 Unrealized @ Report Date +62.3%

— ABIOMED INC 8.9%

Value $184M Shares 706,354 Share Price $260.49 Est. Cost/Share $37.80 Unrealized @ Report Date —

— SAGE THERAPEUTICS INC 7.1%

Value $146M Shares 795,031 Share Price $183.09 Est. Cost/Share $48.62 Unrealized @ Report Date —

— ALEXION PHARMACEUTICALS INC 6.5%

Value $134M Shares 1,023,780 Share Price $130.98 Est. Cost/Share $121.54 Unrealized @ Report Date —

STAA STAAR SURGICAL CO 6.1%

Value $124M Shares 4,237,051 Share Price $29.38 Est. Cost/Share $13.06 Unrealized @ Report Date +121.0%

UTHR UNITED THERAPEUTICS CORP DEL 5.9%

Value $121M Shares 1,552,792 Share Price $78.06 * Est. Cost/Share $88.73 Unrealized @ Report Date +5.4%

FOLD AMICUS THERAPEUTICS INC 4.7%

Value $97.3M Shares 7,796,299 Share Price $12.48 Est. Cost/Share $7.54 Unrealized @ Report Date +68.3%

— IMMUNOMEDICS INC 4.5%

Value $92.61M Shares 6,676,755 Share Price $13.87 Est. Cost/Share $13.38 Unrealized @ Report Date —

— EPIZYME INC 4.2%

Value $87.03M Shares 6,935,074 Share Price $12.55 Est. Cost/Share $15.12 Unrealized @ Report Date —

— WRIGHT MED GROUP N V 4.0%

Value $82.64M Shares 2,771,394 Share Price $29.82 Est. Cost/Share $23.42 Unrealized @ Report Date —

— AIMMUNE THERAPEUTICS INC 3.9%

Value $79.71M Shares 3,828,564 Share Price $20.82 Est. Cost/Share $22.84 Unrealized @ Report Date —

— CLOVIS ONCOLOGY INC 3.7%

Value $76.45M Shares 5,141,304 Share Price $14.87 Est. Cost/Share $51.30 Unrealized @ Report Date —

VNDA VANDA PHARMACEUTICALS INC 3.5%

Value $71.23M Shares 5,055,050 Share Price $14.09 * Est. Cost/Share $11.21 Unrealized @ Report Date +42.0%

ACAD ACADIA PHARMACEUTICALS INC 3.0%

Value $61.71M Shares 2,308,803 Share Price $26.73 * Est. Cost/Share $27.34 Unrealized @ Report Date -6.6%

ALGN ALIGN TECHNOLOGY INC 2.0%

Value $40.37M Shares 147,505 Share Price $273.70 * Est. Cost/Share $114.31 Unrealized @ Report Date +164.2%

EXAS EXACT SCIENCES CORP 1.8%

Value $37.17M Shares 314,889 Share Price $118.04 * Est. Cost/Share $13.61 Unrealized @ Report Date +640.1%

— AMAG PHARMACEUTICALS INC 1.6%

Value $33.72M Shares 3,375,506 Share Price $9.99 Est. Cost/Share $29.07 Unrealized @ Report Date —

— KARYOPHARM THERAPEUTICS INC 1.5%

Value $31.52M Shares 5,262,263 Share Price $5.99 Est. Cost/Share $17.42 Unrealized @ Report Date —

— MOMENTA PHARMACEUTICALS INC 1.2%

Value $23.89M Shares 1,919,313 Share Price $12.45 Est. Cost/Share $14.06 Unrealized @ Report Date —

— ALDER BIOPHARMACEUTICALS INC 1.1%

Value $21.91M Shares 1,861,630 Share Price $11.77 Est. Cost/Share $11.48 Unrealized @ Report Date —

PBYI PUMA BIOTECHNOLOGY INC 0.9%

Value $17.87M Shares 1,405,680 Share Price $12.71 * Est. Cost/Share $28.90 Unrealized @ Report Date -20.3%

GILD GILEAD SCIENCES INC 0.6%

Value $11.88M Shares 175,900 Share Price $67.56 * Est. Cost/Share $62.02 Unrealized @ Report Date -18.1%

PRTA PROTHENA CORP PLC 0.6%

Value $11.72M Shares 1,108,510 Share Price $10.57 * Est. Cost/Share $32.98 Unrealized @ Report Date -68.9%

— RIGEL PHARMACEUTICALS INC 0.5%

Value $10.4M Shares 3,985,945 Share Price $2.61 Est. Cost/Share $3.40 Unrealized @ Report Date —

KLDO KALEIDO BIOSCIENCES INC 0.5%

Value $10.05M Shares 866,666 Share Price $11.60 * Est. Cost/Share $13.76 Unrealized @ Report Date +5.8%

— CELGENE CORP 0.5%

Value $9.88M Shares 106,883 Share Price $92.44 Est. Cost/Share $89.02 Unrealized @ Report Date —

— DICERNA PHARMACEUTICALS INC 0.3%

Value $5.226M Shares 331,813 Share Price $15.75 Est. Cost/Share $5.39 Unrealized @ Report Date —

— ALIMERA SCIENCES INC 0.1%

Value $2.682M Shares 3,013,793 Share Price $0.89 Est. Cost/Share $4.88 Unrealized @ Report Date —

— ZOGENIX INC 0.1%

Value $1.41M Shares 29,500 Share Price $47.80 Est. Cost/Share $13.36 Unrealized @ Report Date —

CYTK CYTOKINETICS INC 0.1%

Value $1.391M Shares 123,686 Share Price $11.25 * Est. Cost/Share $6.71 Unrealized @ Report Date +43.6%

— SUNESIS PHARMACEUTICALS INC 0.0%

Value $845K Shares 1,162,473 Share Price $0.73 Est. Cost/Share $4.37 Unrealized @ Report Date —

— MARINUS PHARMACEUTICALS INC 0.0%

Value $520K Shares 125,321 Share Price $4.15 Est. Cost/Share $4.17 Unrealized @ Report Date —

ALDX ALDEYRA THERAPEUTICS INC 0.0%

Value $441K Shares 73,500 Share Price $6.00 * Est. Cost/Share $7.53 Unrealized @ Report Date 0.0%

— SOPHIRIS BIO INC 0.0%

Value $209K Shares 247,000 Share Price $0.85 Est. Cost/Share $2.60 Unrealized @ Report Date —

— IDERA PHARMACEUTICALS INC 0.0%

Value $206K Shares 77,044 Share Price $2.67 Est. Cost/Share $8.90 Unrealized @ Report Date —

— MINERVA NEUROSCIENCES INC 0.0%

Value $204K Shares 36,319 Share Price $5.62 Est. Cost/Share $5.62 Unrealized @ Report Date —

— MELINTA THERAPEUTICS INC 0.0%

Value $67,000 Shares 10,137 Share Price $6.61 Est. Cost/Share $3.55 Unrealized @ Report Date —

— HISTOGENICS CORP 0.0%

Value $58,000 Shares 302,922 Share Price $0.19 Est. Cost/Share $11.00 Unrealized @ Report Date —

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
BMRN	BIOMARIN PHARMACEUTICAL INC	2,606,485	$223M	10.9%	$85.65	$80.19	+6.7%	COM	09061G101
INSM	INSMED INC	7,890,917	$202M	9.8%	$25.60 *	$17.16	+62.3%	COM PAR $.01	457669307
—	ABIOMED INC	706,354	$184M	8.9%	$260.49	$37.80	—	COM	003654100
—	SAGE THERAPEUTICS INC	795,031	$146M	7.1%	$183.09	$48.62	—	COM	78667J108
—	ALEXION PHARMACEUTICALS INC	1,023,780	$134M	6.5%	$130.98	$121.54	—	COM	015351109
STAA	STAAR SURGICAL CO	4,237,051	$124M	6.1%	$29.38	$13.06	+121.0%	COM PAR $0.01	852312305
UTHR	UNITED THERAPEUTICS CORP DEL	1,552,792	$121M	5.9%	$78.06 *	$88.73	+5.4%	COM	91307C102
FOLD	AMICUS THERAPEUTICS INC	7,796,299	$97.3M	4.7%	$12.48	$7.54	+68.3%	COM	03152W109
—	IMMUNOMEDICS INC	6,676,755	$92.61M	4.5%	$13.87	$13.38	—	COM	452907108
—	EPIZYME INC	6,935,074	$87.03M	4.2%	$12.55	$15.12	—	COM	29428V104
—	WRIGHT MED GROUP N V	2,771,394	$82.64M	4.0%	$29.82	$23.42	—	ORD SHS	N96617118
—	AIMMUNE THERAPEUTICS INC	3,828,564	$79.71M	3.9%	$20.82	$22.84	—	COM	00900T107
—	CLOVIS ONCOLOGY INC	5,141,304	$76.45M	3.7%	$14.87	$51.30	—	COM	189464100
VNDA	VANDA PHARMACEUTICALS INC	5,055,050	$71.23M	3.5%	$14.09 *	$11.21	+42.0%	COM	921659108
ACAD	ACADIA PHARMACEUTICALS INC	2,308,803	$61.71M	3.0%	$26.73 *	$27.34	-6.6%	COM	004225108
ALGN	ALIGN TECHNOLOGY INC	147,505	$40.37M	2.0%	$273.70 *	$114.31	+164.2%	COM	016255101
EXAS	EXACT SCIENCES CORP	314,889	$37.17M	1.8%	$118.04 *	$13.61	+640.1%	COM	30063P105
—	AMAG PHARMACEUTICALS INC	3,375,506	$33.72M	1.6%	$9.99	$29.07	—	COM	00163U106
—	KARYOPHARM THERAPEUTICS INC	5,262,263	$31.52M	1.5%	$5.99	$17.42	—	COM	48576U106
—	MOMENTA PHARMACEUTICALS INC	1,919,313	$23.89M	1.2%	$12.45	$14.06	—	COM	60877T100
—	ALDER BIOPHARMACEUTICALS INC	1,861,630	$21.91M	1.1%	$11.77	$11.48	—	COM	014339105
PBYI	PUMA BIOTECHNOLOGY INC	1,405,680	$17.87M	0.9%	$12.71 *	$28.90	-20.3%	COM	74587V107
GILD	GILEAD SCIENCES INC	175,900	$11.88M	0.6%	$67.56 *	$62.02	-18.1%	COM	375558103
PRTA	PROTHENA CORP PLC	1,108,510	$11.72M	0.6%	$10.57 *	$32.98	-68.9%	SHS	G72800108
—	RIGEL PHARMACEUTICALS INC	3,985,945	$10.4M	0.5%	$2.61	$3.40	—	COM NEW	766559603
KLDO	KALEIDO BIOSCIENCES INC	866,666	$10.05M	0.5%	$11.60 *	$13.76	+5.8%	COM	483347100
—	CELGENE CORP	106,883	$9.88M	0.5%	$92.44	$89.02	—	COM	151020104
—	DICERNA PHARMACEUTICALS INC	331,813	$5.226M	0.3%	$15.75	$5.39	—	COM	253031108
—	ALIMERA SCIENCES INC	3,013,793	$2.682M	0.1%	$0.89	$4.88	—	COM	016259103
—	ZOGENIX INC	29,500	$1.41M	0.1%	$47.80	$13.36	—	COM NEW	98978L204
CYTK	CYTOKINETICS INC	123,686	$1.391M	0.1%	$11.25 *	$6.71	+43.6%	COM NEW	23282W605
—	SUNESIS PHARMACEUTICALS INC	1,162,473	$845K	0.0%	$0.73	$4.37	—	COM PAR	867328700
—	MARINUS PHARMACEUTICALS INC	125,321	$520K	0.0%	$4.15	$4.17	—	COM	56854Q101
ALDX	ALDEYRA THERAPEUTICS INC	73,500	$441K	0.0%	$6.00 *	$7.53	0.0%	COM	01438T106
—	SOPHIRIS BIO INC	247,000	$209K	0.0%	$0.85	$2.60	—	COM NEW	83578Q209
—	IDERA PHARMACEUTICALS INC	77,044	$206K	0.0%	$2.67	$8.90	—	COM PAR	45168K405
—	MINERVA NEUROSCIENCES INC	36,319	$204K	0.0%	$5.62	$5.62	—	COM	603380106
—	MELINTA THERAPEUTICS INC	10,137	$67,000	0.0%	$6.61	$3.55	—	COM NEW	58549G209
—	HISTOGENICS CORP	302,922	$58,000	0.0%	$0.19	$11.00	—	COM	43358V109