Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q3 2019 (← Previous) (Next →)

Filing Date: Nov 14, 2019

Total Value: $1.501B (100.0% shares, 0.0% debt)

Holdings (37)

BMRN BIOMARIN PHARMACEUTICAL INC 9.9%

Value $149M Shares 2,209,504 Share Price $67.40 * Est. Cost/Share $80.19 Unrealized @ Report Date -3.9%

INSM INSMED INC 8.5%

Value $128M Shares 7,239,649 Share Price $17.64 * Est. Cost/Share $17.16 Unrealized @ Report Date +12.5%

— ABIOMED INC 7.8%

Value $116M Shares 654,428 Share Price $177.89 Est. Cost/Share $37.80 Unrealized @ Report Date —

UTHR UNITED THERAPEUTICS CORP 7.6%

Value $114M Shares 1,424,401 Share Price $79.75 Est. Cost/Share $88.73 Unrealized @ Report Date -9.2%

STAA STAAR SURGICAL CO 6.7%

Value $100M Shares 3,890,693 Share Price $25.78 * Est. Cost/Share $13.06 Unrealized @ Report Date +132.7%

— SAGE THERAPEUTICS INC 6.4%

Value $95.52M Shares 680,894 Share Price $140.29 Est. Cost/Share $48.62 Unrealized @ Report Date —

— ALEXION PHARMACEUTICALS INC 6.2%

Value $93.82M Shares 957,950 Share Price $97.94 Est. Cost/Share $121.54 Unrealized @ Report Date —

— IMMUNOMEDICS INC 5.5%

Value $82M Shares 6,184,320 Share Price $13.26 Est. Cost/Share $13.38 Unrealized @ Report Date —

ACAD ACADIA PHARMACEUTICALS INC 5.2%

Value $78.34M Shares 2,176,677 Share Price $35.99 * Est. Cost/Share $27.34 Unrealized @ Report Date +10.9%

— AIMMUNE THERAPEUTICS INC 4.8%

Value $72.7M Shares 3,471,740 Share Price $20.94 Est. Cost/Share $22.84 Unrealized @ Report Date —

— EPIZYME INC 4.4%

Value $65.55M Shares 6,354,659 Share Price $10.31 Est. Cost/Share $15.12 Unrealized @ Report Date —

VNDA VANDA PHARMACEUTICALS INC 4.1%

Value $60.84M Shares 4,581,176 Share Price $13.28 * Est. Cost/Share $11.21 Unrealized @ Report Date +24.3%

FOLD AMICUS THERAPEUTICS INC 3.8%

Value $57.45M Shares 7,162,920 Share Price $8.02 * Est. Cost/Share $7.54 Unrealized @ Report Date +44.0%

— WRIGHT MEDICAL GROUP NV 3.4%

Value $51.46M Shares 2,494,255 Share Price $20.63 Est. Cost/Share $23.42 Unrealized @ Report Date —

— KARYOPHARM THERAPEUTICS INC 3.1%

Value $46.58M Shares 4,842,150 Share Price $9.62 Est. Cost/Share $17.42 Unrealized @ Report Date —

— AMAG PHARMACEUTICALS INC 2.4%

Value $35.56M Shares 3,078,874 Share Price $11.55 Est. Cost/Share $29.07 Unrealized @ Report Date —

— ALDER BIOPHARMACEUTICALS INC 2.3%

Value $35.11M Shares 1,861,630 Share Price $18.86 Est. Cost/Share $11.48 Unrealized @ Report Date —

ALGN ALIGN TECHNOLOGY INC 1.8%

Value $26.69M Shares 147,505 Share Price $180.92 * Est. Cost/Share $114.31 Unrealized @ Report Date +81.9%

— MOMENTA PHARMACEUTICALS INC 1.5%

Value $22.77M Shares 1,757,122 Share Price $12.96 Est. Cost/Share $14.06 Unrealized @ Report Date —

— CLOVIS ONCOLOGY INC 1.2%

Value $18.55M Shares 4,720,744 Share Price $3.93 Est. Cost/Share $51.30 Unrealized @ Report Date —

PBYI PUMA BIOTECHNOLOGY INC 1.0%

Value $15.13M Shares 1,405,680 Share Price $10.76 Est. Cost/Share $28.90 Unrealized @ Report Date -62.6%

PRTA PROTHENA CORP PLC 0.5%

Value $7.875M Shares 1,004,449 Share Price $7.84 * Est. Cost/Share $32.98 Unrealized @ Report Date -73.1%

— RIGEL PHARMACEUTICALS INC 0.4%

Value $6.708M Shares 3,587,351 Share Price $1.87 Est. Cost/Share $3.40 Unrealized @ Report Date —

KLDO KALEIDO BIOSCIENCES INC 0.4%

Value $5.934M Shares 787,999 Share Price $7.53 * Est. Cost/Share $13.76 Unrealized @ Report Date -36.9%

— DICERNA PHARMACEUTICALS INC 0.3%

Value $4.765M Shares 331,813 Share Price $14.36 Est. Cost/Share $5.39 Unrealized @ Report Date —

GILD GILEAD SCIENCES INC 0.2%

Value $2.491M Shares 39,300 Share Price $63.38 * Est. Cost/Share $62.02 Unrealized @ Report Date -17.8%

— CELGENE CORP 0.1%

Value $2.173M Shares 21,883 Share Price $99.30 Est. Cost/Share $89.02 Unrealized @ Report Date —

— ALIMERA SCIENCES INC 0.1%

Value $1.707M Shares 3,013,793 Share Price $0.57 Est. Cost/Share $4.88 Unrealized @ Report Date —

CYTK CYTOKINETICS INC 0.1%

Value $1.408M Shares 123,686 Share Price $11.38 * Est. Cost/Share $6.71 Unrealized @ Report Date +87.0%

— ZOGENIX INC 0.1%

Value $1.181M Shares 29,500 Share Price $40.03 Est. Cost/Share $13.36 Unrealized @ Report Date —

— SUNESIS PHARMACEUTICALS INC 0.1%

Value $837K Shares 1,162,473 Share Price $0.72 Est. Cost/Share $4.37 Unrealized @ Report Date —

ALDX ALDEYRA THERAPEUTICS INC 0.0%

Value $387K Shares 73,500 Share Price $5.27 * Est. Cost/Share $7.53 Unrealized @ Report Date -28.5%

— MINERVA NEUROSCIENCES INC 0.0%

Value $281K Shares 36,319 Share Price $7.74 Est. Cost/Share $5.62 Unrealized @ Report Date —

— IDERA PHARMACEUTICALS INC 0.0%

Value $223K Shares 77,044 Share Price $2.89 Est. Cost/Share $8.90 Unrealized @ Report Date —

— MARINUS PHARMACEUTICALS INC 0.0%

Value $193K Shares 125,321 Share Price $1.54 Est. Cost/Share $4.17 Unrealized @ Report Date —

— SOPHIRIS BIO INC 0.0%

Value $144K Shares 247,000 Share Price $0.58 Est. Cost/Share $2.60 Unrealized @ Report Date —

— MELINTA THERAPEUTICS INC 0.0%

Value $39,000 Shares 10,137 Share Price $3.85 Est. Cost/Share $3.55 Unrealized @ Report Date —

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
BMRN	BIOMARIN PHARMACEUTICAL INC	2,209,504	$149M	9.9%	$67.40 *	$80.19	-3.9%	COM	09061G101
INSM	INSMED INC	7,239,649	$128M	8.5%	$17.64 *	$17.16	+12.5%	COM	457669307
—	ABIOMED INC	654,428	$116M	7.8%	$177.89	$37.80	—	COM	003654100
UTHR	UNITED THERAPEUTICS CORP	1,424,401	$114M	7.6%	$79.75	$88.73	-9.2%	COM	91307C102
STAA	STAAR SURGICAL CO	3,890,693	$100M	6.7%	$25.78 *	$13.06	+132.7%	COM	852312305
—	SAGE THERAPEUTICS INC	680,894	$95.52M	6.4%	$140.29	$48.62	—	COM	78667J108
—	ALEXION PHARMACEUTICALS INC	957,950	$93.82M	6.2%	$97.94	$121.54	—	COM	015351109
—	IMMUNOMEDICS INC	6,184,320	$82M	5.5%	$13.26	$13.38	—	COM	452907108
ACAD	ACADIA PHARMACEUTICALS INC	2,176,677	$78.34M	5.2%	$35.99 *	$27.34	+10.9%	COM	004225108
—	AIMMUNE THERAPEUTICS INC	3,471,740	$72.7M	4.8%	$20.94	$22.84	—	COM	00900T107
—	EPIZYME INC	6,354,659	$65.55M	4.4%	$10.31	$15.12	—	COM	29428V104
VNDA	VANDA PHARMACEUTICALS INC	4,581,176	$60.84M	4.1%	$13.28 *	$11.21	+24.3%	COM	921659108
FOLD	AMICUS THERAPEUTICS INC	7,162,920	$57.45M	3.8%	$8.02 *	$7.54	+44.0%	COM	03152W109
—	WRIGHT MEDICAL GROUP NV	2,494,255	$51.46M	3.4%	$20.63	$23.42	—	COM	N96617118
—	KARYOPHARM THERAPEUTICS INC	4,842,150	$46.58M	3.1%	$9.62	$17.42	—	COM	48576U106
—	AMAG PHARMACEUTICALS INC	3,078,874	$35.56M	2.4%	$11.55	$29.07	—	COM	00163U106
—	ALDER BIOPHARMACEUTICALS INC	1,861,630	$35.11M	2.3%	$18.86	$11.48	—	COM	014339105
ALGN	ALIGN TECHNOLOGY INC	147,505	$26.69M	1.8%	$180.92 *	$114.31	+81.9%	COM	016255101
—	MOMENTA PHARMACEUTICALS INC	1,757,122	$22.77M	1.5%	$12.96	$14.06	—	COM	60877T100
—	CLOVIS ONCOLOGY INC	4,720,744	$18.55M	1.2%	$3.93	$51.30	—	COM	189464100
PBYI	PUMA BIOTECHNOLOGY INC	1,405,680	$15.13M	1.0%	$10.76	$28.90	-62.6%	COM	74587V107
PRTA	PROTHENA CORP PLC	1,004,449	$7.875M	0.5%	$7.84 *	$32.98	-73.1%	COM	G72800108
—	RIGEL PHARMACEUTICALS INC	3,587,351	$6.708M	0.4%	$1.87	$3.40	—	COM	766559603
KLDO	KALEIDO BIOSCIENCES INC	787,999	$5.934M	0.4%	$7.53 *	$13.76	-36.9%	COM	483347100
—	DICERNA PHARMACEUTICALS INC	331,813	$4.765M	0.3%	$14.36	$5.39	—	COM	253031108
GILD	GILEAD SCIENCES INC	39,300	$2.491M	0.2%	$63.38 *	$62.02	-17.8%	COM	375558103
—	CELGENE CORP	21,883	$2.173M	0.1%	$99.30	$89.02	—	COM	151020104
—	ALIMERA SCIENCES INC	3,013,793	$1.707M	0.1%	$0.57	$4.88	—	COM	016259103
CYTK	CYTOKINETICS INC	123,686	$1.408M	0.1%	$11.38 *	$6.71	+87.0%	COM	23282W605
—	ZOGENIX INC	29,500	$1.181M	0.1%	$40.03	$13.36	—	COM	98978L204
—	SUNESIS PHARMACEUTICALS INC	1,162,473	$837K	0.1%	$0.72	$4.37	—	COM	867328700
ALDX	ALDEYRA THERAPEUTICS INC	73,500	$387K	0.0%	$5.27 *	$7.53	-28.5%	COM	01438T106
—	MINERVA NEUROSCIENCES INC	36,319	$281K	0.0%	$7.74	$5.62	—	COM	603380106
—	IDERA PHARMACEUTICALS INC	77,044	$223K	0.0%	$2.89	$8.90	—	COM	45168K405
—	MARINUS PHARMACEUTICALS INC	125,321	$193K	0.0%	$1.54	$4.17	—	COM	56854Q101
—	SOPHIRIS BIO INC	247,000	$144K	0.0%	$0.58	$2.60	—	COM	83578Q209
—	MELINTA THERAPEUTICS INC	10,137	$39,000	0.0%	$3.85	$3.55	—	COM	58549G209