Palo Alto Investors LP Long-Term Concentrated

CIK: 0001306923 · Show all filings

Period: Q3 2019 (← Previous) (Next →)

Filing Date: Nov 14, 2019

Total Value ($000): $1,501,359 (100.0% shares, 0.0% debt)

Holdings (37)

BMRN BIOMARIN PHARMACEUTICAL INC 9.9%

Value ($000) $148,921 Shares 2,209,504 Est. Cost $80.19 Unrealized -3.9%

INSM INSMED INC 8.5%

Value ($000) $127,707 Shares 7,239,649 Est. Cost $17.16 Unrealized +12.5%

— ABIOMED INC 7.8%

Value ($000) $116,416 Shares 654,428 Est. Cost $37.80 Unrealized —

UTHR UNITED THERAPEUTICS CORP 7.6%

Value ($000) $113,596 Shares 1,424,401 Est. Cost $88.73 Unrealized -9.2%

STAA STAAR SURGICAL CO 6.7%

Value ($000) $100,302 Shares 3,890,693 Est. Cost $13.06 Unrealized +132.7%

— SAGE THERAPEUTICS INC 6.4%

Value ($000) $95,523 Shares 680,894 Est. Cost $48.62 Unrealized —

— ALEXION PHARMACEUTICALS INC 6.2%

Value ($000) $93,822 Shares 957,950 Est. Cost $121.54 Unrealized —

— IMMUNOMEDICS INC 5.5%

Value ($000) $82,004 Shares 6,184,320 Est. Cost $13.38 Unrealized —

ACAD ACADIA PHARMACEUTICALS INC 5.2%

Value ($000) $78,339 Shares 2,176,677 Est. Cost $27.34 Unrealized +10.9%

— AIMMUNE THERAPEUTICS INC 4.8%

Value ($000) $72,698 Shares 3,471,740 Est. Cost $22.84 Unrealized —

— EPIZYME INC 4.4%

Value ($000) $65,548 Shares 6,354,659 Est. Cost $15.12 Unrealized —

VNDA VANDA PHARMACEUTICALS INC 4.1%

Value ($000) $60,838 Shares 4,581,176 Est. Cost $11.21 Unrealized +24.3%

FOLD AMICUS THERAPEUTICS INC 3.8%

Value ($000) $57,447 Shares 7,162,920 Est. Cost $7.54 Unrealized +44.0%

— WRIGHT MEDICAL GROUP NV 3.4%

Value ($000) $51,456 Shares 2,494,255 Est. Cost $23.42 Unrealized —

— KARYOPHARM THERAPEUTICS INC 3.1%

Value ($000) $46,581 Shares 4,842,150 Est. Cost $17.42 Unrealized —

— AMAG PHARMACEUTICALS INC 2.4%

Value ($000) $35,561 Shares 3,078,874 Est. Cost $29.07 Unrealized —

— ALDER BIOPHARMACEUTICALS INC 2.3%

Value ($000) $35,110 Shares 1,861,630 Est. Cost $11.48 Unrealized —

ALGN ALIGN TECHNOLOGY INC 1.8%

Value ($000) $26,687 Shares 147,505 Est. Cost $114.31 Unrealized +81.9%

— MOMENTA PHARMACEUTICALS INC 1.5%

Value ($000) $22,772 Shares 1,757,122 Est. Cost $14.06 Unrealized —

— CLOVIS ONCOLOGY INC 1.2%

Value ($000) $18,553 Shares 4,720,744 Est. Cost $51.30 Unrealized —

PBYI PUMA BIOTECHNOLOGY INC 1.0%

Value ($000) $15,132 Shares 1,405,680 Est. Cost $28.90 Unrealized -62.6%

PRTA PROTHENA CORP PLC 0.5%

Value ($000) $7,875 Shares 1,004,449 Est. Cost $32.98 Unrealized -73.1%

— RIGEL PHARMACEUTICALS INC 0.4%

Value ($000) $6,708 Shares 3,587,351 Est. Cost $3.40 Unrealized —

KLDO KALEIDO BIOSCIENCES INC 0.4%

Value ($000) $5,934 Shares 787,999 Est. Cost $13.76 Unrealized -36.9%

— DICERNA PHARMACEUTICALS INC 0.3%

Value ($000) $4,765 Shares 331,813 Est. Cost $5.39 Unrealized —

GILD GILEAD SCIENCES INC 0.2%

Value ($000) $2,491 Shares 39,300 Est. Cost $62.02 Unrealized -17.8%

— CELGENE CORP 0.1%

Value ($000) $2,173 Shares 21,883 Est. Cost $89.02 Unrealized —

— ALIMERA SCIENCES INC 0.1%

Value ($000) $1,707 Shares 3,013,793 Est. Cost $4.88 Unrealized —

CYTK CYTOKINETICS INC 0.1%

Value ($000) $1,408 Shares 123,686 Est. Cost $6.71 Unrealized +87.0%

— ZOGENIX INC 0.1%

Value ($000) $1,181 Shares 29,500 Est. Cost $13.36 Unrealized —

— SUNESIS PHARMACEUTICALS INC 0.1%

Value ($000) $837 Shares 1,162,473 Est. Cost $4.37 Unrealized —

ALDX ALDEYRA THERAPEUTICS INC 0.0%

Value ($000) $387 Shares 73,500 Est. Cost $7.53 Unrealized -28.5%

— MINERVA NEUROSCIENCES INC 0.0%

Value ($000) $281 Shares 36,319 Est. Cost $5.62 Unrealized —

— IDERA PHARMACEUTICALS INC 0.0%

Value ($000) $223 Shares 77,044 Est. Cost $8.90 Unrealized —

— MARINUS PHARMACEUTICALS INC 0.0%

Value ($000) $193 Shares 125,321 Est. Cost $4.17 Unrealized —

— SOPHIRIS BIO INC 0.0%

Value ($000) $144 Shares 247,000 Est. Cost $2.60 Unrealized —

— MELINTA THERAPEUTICS INC 0.0%

Value ($000) $39 Shares 10,137 Est. Cost $3.55 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
BMRN	BIOMARIN PHARMACEUTICAL INC	2,209,504	$148,921	9.9%	$80.19	-3.9%	COM	09061G101
INSM	INSMED INC	7,239,649	$127,707	8.5%	$17.16	+12.5%	COM	457669307
—	ABIOMED INC	654,428	$116,416	7.8%	$37.80	—	COM	003654100
UTHR	UNITED THERAPEUTICS CORP	1,424,401	$113,596	7.6%	$88.73	-9.2%	COM	91307C102
STAA	STAAR SURGICAL CO	3,890,693	$100,302	6.7%	$13.06	+132.7%	COM	852312305
—	SAGE THERAPEUTICS INC	680,894	$95,523	6.4%	$48.62	—	COM	78667J108
—	ALEXION PHARMACEUTICALS INC	957,950	$93,822	6.2%	$121.54	—	COM	015351109
—	IMMUNOMEDICS INC	6,184,320	$82,004	5.5%	$13.38	—	COM	452907108
ACAD	ACADIA PHARMACEUTICALS INC	2,176,677	$78,339	5.2%	$27.34	+10.9%	COM	004225108
—	AIMMUNE THERAPEUTICS INC	3,471,740	$72,698	4.8%	$22.84	—	COM	00900T107
—	EPIZYME INC	6,354,659	$65,548	4.4%	$15.12	—	COM	29428V104
VNDA	VANDA PHARMACEUTICALS INC	4,581,176	$60,838	4.1%	$11.21	+24.3%	COM	921659108
FOLD	AMICUS THERAPEUTICS INC	7,162,920	$57,447	3.8%	$7.54	+44.0%	COM	03152W109
—	WRIGHT MEDICAL GROUP NV	2,494,255	$51,456	3.4%	$23.42	—	COM	N96617118
—	KARYOPHARM THERAPEUTICS INC	4,842,150	$46,581	3.1%	$17.42	—	COM	48576U106
—	AMAG PHARMACEUTICALS INC	3,078,874	$35,561	2.4%	$29.07	—	COM	00163U106
—	ALDER BIOPHARMACEUTICALS INC	1,861,630	$35,110	2.3%	$11.48	—	COM	014339105
ALGN	ALIGN TECHNOLOGY INC	147,505	$26,687	1.8%	$114.31	+81.9%	COM	016255101
—	MOMENTA PHARMACEUTICALS INC	1,757,122	$22,772	1.5%	$14.06	—	COM	60877T100
—	CLOVIS ONCOLOGY INC	4,720,744	$18,553	1.2%	$51.30	—	COM	189464100
PBYI	PUMA BIOTECHNOLOGY INC	1,405,680	$15,132	1.0%	$28.90	-62.6%	COM	74587V107
PRTA	PROTHENA CORP PLC	1,004,449	$7,875	0.5%	$32.98	-73.1%	COM	G72800108
—	RIGEL PHARMACEUTICALS INC	3,587,351	$6,708	0.4%	$3.40	—	COM	766559603
KLDO	KALEIDO BIOSCIENCES INC	787,999	$5,934	0.4%	$13.76	-36.9%	COM	483347100
—	DICERNA PHARMACEUTICALS INC	331,813	$4,765	0.3%	$5.39	—	COM	253031108
GILD	GILEAD SCIENCES INC	39,300	$2,491	0.2%	$62.02	-17.8%	COM	375558103
—	CELGENE CORP	21,883	$2,173	0.1%	$89.02	—	COM	151020104
—	ALIMERA SCIENCES INC	3,013,793	$1,707	0.1%	$4.88	—	COM	016259103
CYTK	CYTOKINETICS INC	123,686	$1,408	0.1%	$6.71	+87.0%	COM	23282W605
—	ZOGENIX INC	29,500	$1,181	0.1%	$13.36	—	COM	98978L204
—	SUNESIS PHARMACEUTICALS INC	1,162,473	$837	0.1%	$4.37	—	COM	867328700
ALDX	ALDEYRA THERAPEUTICS INC	73,500	$387	0.0%	$7.53	-28.5%	COM	01438T106
—	MINERVA NEUROSCIENCES INC	36,319	$281	0.0%	$5.62	—	COM	603380106
—	IDERA PHARMACEUTICALS INC	77,044	$223	0.0%	$8.90	—	COM	45168K405
—	MARINUS PHARMACEUTICALS INC	125,321	$193	0.0%	$4.17	—	COM	56854Q101
—	SOPHIRIS BIO INC	247,000	$144	0.0%	$2.60	—	COM	83578Q209
—	MELINTA THERAPEUTICS INC	10,137	$39	0.0%	$3.55	—	COM	58549G209