Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q4 2019 (← Previous) (Next →)

Filing Date: Apr 8, 2020

Total Value: $1.816B (100.0% shares, 0.0% debt)

Holdings (37)

BMRN BIOMARIN PHARMACEUTICAL INC 9.4%

Value $171M Shares 2,021,136 Share Price $84.55 * Est. Cost/Share $80.19 Unrealized @ Report Date -5.8%

INSM INSMED INC 9.0%

Value $164M Shares 6,848,760 Share Price $23.88 * Est. Cost/Share $17.16 Unrealized @ Report Date +18.5%

— EPIZYME INC 8.3%

Value $151M Shares 6,145,945 Share Price $24.60 Est. Cost/Share $15.12 Unrealized @ Report Date —

STAA STAAR SURGICAL CO 7.3%

Value $133M Shares 3,778,938 Share Price $35.17 * Est. Cost/Share $13.06 Unrealized @ Report Date +152.6%

— IMMUNOMEDICS INC 6.9%

Value $125M Shares 5,923,195 Share Price $21.16 Est. Cost/Share $13.38 Unrealized @ Report Date —

UTHR UNITED THERAPEUTICS CORP 6.3%

Value $114M Shares 1,288,902 Share Price $88.08 Est. Cost/Share $88.73 Unrealized @ Report Date -0.8%

— AIMMUNE THERAPEUTICS INC 6.2%

Value $113M Shares 3,380,441 Share Price $33.47 Est. Cost/Share $22.84 Unrealized @ Report Date —

— ABIOMED INC 5.3%

Value $96.24M Shares 564,168 Share Price $170.59 Est. Cost/Share $37.80 Unrealized @ Report Date —

— ALEXION PHARMACEUTICALS INC 5.2%

Value $94.97M Shares 878,100 Share Price $108.15 Est. Cost/Share $121.54 Unrealized @ Report Date —

— KARYOPHARM THERAPEUTICS INC 4.8%

Value $88.09M Shares 4,595,001 Share Price $19.17 Est. Cost/Share $17.42 Unrealized @ Report Date —

ACAD ACADIA PHARMACEUTICALS INC 4.5%

Value $81.51M Shares 1,905,374 Share Price $42.78 Est. Cost/Share $27.34 Unrealized @ Report Date +59.1%

— WRIGHT MEDICAL GROUP NV 4.1%

Value $75.07M Shares 2,463,055 Share Price $30.48 Est. Cost/Share $23.42 Unrealized @ Report Date —

VNDA VANDA PHARMACEUTICALS INC 4.1%

Value $74.26M Shares 4,525,476 Share Price $16.41 * Est. Cost/Share $11.21 Unrealized @ Report Date +34.9%

FOLD AMICUS THERAPEUTICS INC 4.0%

Value $72.21M Shares 7,413,920 Share Price $9.74 * Est. Cost/Share $7.59 Unrealized @ Report Date +20.5%

— CLOVIS ONCOLOGY INC 2.9%

Value $52.71M Shares 5,056,286 Share Price $10.43 Est. Cost/Share $48.59 Unrealized @ Report Date —

— SAGE THERAPEUTICS INC 2.6%

Value $47.18M Shares 653,594 Share Price $72.19 Est. Cost/Share $48.62 Unrealized @ Report Date —

— AMAG PHARMACEUTICALS INC 2.0%

Value $37.05M Shares 3,044,374 Share Price $12.17 Est. Cost/Share $29.07 Unrealized @ Report Date —

ALGN ALIGN TECHNOLOGY INC 2.0%

Value $35.58M Shares 127,505 Share Price $279.04 * Est. Cost/Share $114.31 Unrealized @ Report Date +118.1%

— MOMENTA PHARMACEUTICALS INC 1.8%

Value $33.25M Shares 1,685,372 Share Price $19.73 Est. Cost/Share $14.06 Unrealized @ Report Date —

PRTA PROTHENA CORP PLC 0.9%

Value $15.71M Shares 992,749 Share Price $15.83 * Est. Cost/Share $32.98 Unrealized @ Report Date -67.5%

PBYI PUMA BIOTECHNOLOGY INC 0.6%

Value $11.8M Shares 1,349,180 Share Price $8.75 * Est. Cost/Share $28.90 Unrealized @ Report Date -71.4%

— RIGEL PHARMACEUTICALS INC 0.4%

Value $7.581M Shares 3,542,551 Share Price $2.14 Est. Cost/Share $3.40 Unrealized @ Report Date —

— DICERNA PHARMACEUTICALS INC 0.4%

Value $7.31M Shares 331,813 Share Price $22.03 Est. Cost/Share $5.39 Unrealized @ Report Date —

KLDO KALEIDO BIOSCIENCES INC 0.2%

Value $3.956M Shares 787,999 Share Price $5.02 * Est. Cost/Share $13.76 Unrealized @ Report Date -53.8%

GILD GILEAD SCIENCES INC 0.1%

Value $2.554M Shares 39,300 Share Price $64.99 * Est. Cost/Share $62.02 Unrealized @ Report Date -17.3%

— ZOGENIX INC 0.1%

Value $1.538M Shares 29,500 Share Price $52.14 Est. Cost/Share $13.36 Unrealized @ Report Date —

— ALIMERA SCIENCES INC 0.1%

Value $1.523M Shares 200,919 Share Price $7.58 Est. Cost/Share $4.88 Unrealized @ Report Date —

— REVANCE THERAPEUTICS INC 0.1%

Value $1.438M Shares 88,590 Share Price $16.23 Est. Cost/Share $16.23 Unrealized @ Report Date —

CYTK CYTOKINETICS INC 0.1%

Value $1.312M Shares 123,686 Share Price $10.61 * Est. Cost/Share $6.71 Unrealized @ Report Date +53.0%

— INTRA-CELLULAR THERAPIES INC 0.1%

Value $1.283M Shares 37,400 Share Price $34.30 Est. Cost/Share $34.30 Unrealized @ Report Date —

ALDX ALDEYRA THERAPEUTICS INC 0.0%

Value $427K Shares 73,500 Share Price $5.81 Est. Cost/Share $7.53 Unrealized @ Report Date -23.3%

— SUNESIS PHARMACEUTICALS INC 0.0%

Value $393K Shares 1,162,473 Share Price $0.34 Est. Cost/Share $4.37 Unrealized @ Report Date —

— MARINUS PHARMACEUTICALS INC 0.0%

Value $271K Shares 125,321 Share Price $2.16 Est. Cost/Share $4.17 Unrealized @ Report Date —

— MINERVA NEUROSCIENCES INC 0.0%

Value $258K Shares 36,319 Share Price $7.10 Est. Cost/Share $5.62 Unrealized @ Report Date —

— IDERA PHARMACEUTICALS INC 0.0%

Value $140K Shares 77,044 Share Price $1.82 Est. Cost/Share $8.90 Unrealized @ Report Date —

— SOPHIRIS BIO INC 0.0%

Value $91,000 Shares 247,000 Share Price $0.37 Est. Cost/Share $2.60 Unrealized @ Report Date —

— MELINTA THERAPEUTICS INC 0.0%

Value $5,000 Shares 10,137 Share Price $0.49 Est. Cost/Share $3.55 Unrealized @ Report Date —

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
BMRN	BIOMARIN PHARMACEUTICAL INC	2,021,136	$171M	9.4%	$84.55 *	$80.19	-5.8%	COM	09061G101
INSM	INSMED INC	6,848,760	$164M	9.0%	$23.88 *	$17.16	+18.5%	COM	457669307
—	EPIZYME INC	6,145,945	$151M	8.3%	$24.60	$15.12	—	COM	29428V104
STAA	STAAR SURGICAL CO	3,778,938	$133M	7.3%	$35.17 *	$13.06	+152.6%	COM	852312305
—	IMMUNOMEDICS INC	5,923,195	$125M	6.9%	$21.16	$13.38	—	COM	452907108
UTHR	UNITED THERAPEUTICS CORP	1,288,902	$114M	6.3%	$88.08	$88.73	-0.8%	COM	91307C102
—	AIMMUNE THERAPEUTICS INC	3,380,441	$113M	6.2%	$33.47	$22.84	—	COM	00900T107
—	ABIOMED INC	564,168	$96.24M	5.3%	$170.59	$37.80	—	COM	003654100
—	ALEXION PHARMACEUTICALS INC	878,100	$94.97M	5.2%	$108.15	$121.54	—	COM	015351109
—	KARYOPHARM THERAPEUTICS INC	4,595,001	$88.09M	4.8%	$19.17	$17.42	—	COM	48576U106
ACAD	ACADIA PHARMACEUTICALS INC	1,905,374	$81.51M	4.5%	$42.78	$27.34	+59.1%	COM	004225108
—	WRIGHT MEDICAL GROUP NV	2,463,055	$75.07M	4.1%	$30.48	$23.42	—	COM	N96617118
VNDA	VANDA PHARMACEUTICALS INC	4,525,476	$74.26M	4.1%	$16.41 *	$11.21	+34.9%	COM	921659108
FOLD	AMICUS THERAPEUTICS INC	7,413,920	$72.21M	4.0%	$9.74 *	$7.59	+20.5%	COM	03152W109
—	CLOVIS ONCOLOGY INC	5,056,286	$52.71M	2.9%	$10.43	$48.59	—	COM	189464100
—	SAGE THERAPEUTICS INC	653,594	$47.18M	2.6%	$72.19	$48.62	—	COM	78667J108
—	AMAG PHARMACEUTICALS INC	3,044,374	$37.05M	2.0%	$12.17	$29.07	—	COM	00163U106
ALGN	ALIGN TECHNOLOGY INC	127,505	$35.58M	2.0%	$279.04 *	$114.31	+118.1%	COM	016255101
—	MOMENTA PHARMACEUTICALS INC	1,685,372	$33.25M	1.8%	$19.73	$14.06	—	COM	60877T100
PRTA	PROTHENA CORP PLC	992,749	$15.71M	0.9%	$15.83 *	$32.98	-67.5%	COM	G72800108
PBYI	PUMA BIOTECHNOLOGY INC	1,349,180	$11.8M	0.6%	$8.75 *	$28.90	-71.4%	COM	74587V107
—	RIGEL PHARMACEUTICALS INC	3,542,551	$7.581M	0.4%	$2.14	$3.40	—	COM	766559603
—	DICERNA PHARMACEUTICALS INC	331,813	$7.31M	0.4%	$22.03	$5.39	—	COM	253031108
KLDO	KALEIDO BIOSCIENCES INC	787,999	$3.956M	0.2%	$5.02 *	$13.76	-53.8%	COM	483347100
GILD	GILEAD SCIENCES INC	39,300	$2.554M	0.1%	$64.99 *	$62.02	-17.3%	COM	375558103
—	ZOGENIX INC	29,500	$1.538M	0.1%	$52.14	$13.36	—	COM	98978L204
—	ALIMERA SCIENCES INC	200,919	$1.523M	0.1%	$7.58	$4.88	—	COM	016259103
—	REVANCE THERAPEUTICS INC	88,590	$1.438M	0.1%	$16.23	$16.23	—	COM	761330109
CYTK	CYTOKINETICS INC	123,686	$1.312M	0.1%	$10.61 *	$6.71	+53.0%	COM	23282W605
—	INTRA-CELLULAR THERAPIES INC	37,400	$1.283M	0.1%	$34.30	$34.30	—	COM	46116X101
ALDX	ALDEYRA THERAPEUTICS INC	73,500	$427K	0.0%	$5.81	$7.53	-23.3%	COM	01438T106
—	SUNESIS PHARMACEUTICALS INC	1,162,473	$393K	0.0%	$0.34	$4.37	—	COM	867328700
—	MARINUS PHARMACEUTICALS INC	125,321	$271K	0.0%	$2.16	$4.17	—	COM	56854Q101
—	MINERVA NEUROSCIENCES INC	36,319	$258K	0.0%	$7.10	$5.62	—	COM	603380106
—	IDERA PHARMACEUTICALS INC	77,044	$140K	0.0%	$1.82	$8.90	—	COM	45168K405
—	SOPHIRIS BIO INC	247,000	$91,000	0.0%	$0.37	$2.60	—	COM	83578Q209
—	MELINTA THERAPEUTICS INC	10,137	$5,000	0.0%	$0.49	$3.55	—	COM	58549G209