Palo Alto Investors LP Long-Term Concentrated

CIK: 0001306923 · Show all filings

Period: Q1 2020 (← Previous) (Next →)

Filing Date: May 15, 2020

Total Value ($000): $1,194,223 (100.0% shares, 0.0% debt)

Holdings (37)

BMRN BIOMARIN PHARMACEUTICAL INC 10.9%

Value ($000) $130,482 Shares 1,544,163 Est. Cost $80.19 Unrealized +7.5%

STAA STAAR SURGICAL CO 8.9%

Value ($000) $105,765 Shares 3,278,523 Est. Cost $13.06 Unrealized +158.0%

INSM INSMED INC 8.1%

Value ($000) $97,072 Shares 6,055,623 Est. Cost $17.16 Unrealized +38.1%

— EPIZYME INC 7.2%

Value ($000) $86,108 Shares 5,551,803 Est. Cost $15.12 Unrealized —

UTHR UNITED THERAPEUTICS CORP 7.0%

Value ($000) $83,121 Shares 876,575 Est. Cost $88.73 Unrealized +7.1%

— KARYOPHARM THERAPEUTICS INC 6.9%

Value ($000) $82,601 Shares 4,299,901 Est. Cost $17.42 Unrealized —

— ABIOMED INC 6.1%

Value ($000) $72,978 Shares 502,745 Est. Cost $37.80 Unrealized —

— IMMUNOMEDICS INC 6.0%

Value ($000) $71,319 Shares 5,290,746 Est. Cost $13.38 Unrealized —

ACAD ACADIA PHARMACEUTICALS INC 5.8%

Value ($000) $68,932 Shares 1,631,524 Est. Cost $27.34 Unrealized +50.7%

FOLD AMICUS THERAPEUTICS INC 5.8%

Value ($000) $68,816 Shares 7,447,618 Est. Cost $7.59 Unrealized +25.2%

— ALEXION PHARMACEUTICALS INC 4.8%

Value ($000) $57,689 Shares 642,491 Est. Cost $121.54 Unrealized —

— AIMMUNE THERAPEUTICS INC 4.0%

Value ($000) $47,524 Shares 3,295,712 Est. Cost $22.84 Unrealized —

VNDA VANDA PHARMACEUTICALS INC 3.6%

Value ($000) $42,837 Shares 4,134,846 Est. Cost $11.21 Unrealized +10.6%

— MOMENTA PHARMACEUTICALS INC 3.5%

Value ($000) $41,560 Shares 1,527,956 Est. Cost $14.06 Unrealized —

— CLOVIS ONCOLOGY INC 2.5%

Value ($000) $29,484 Shares 4,635,789 Est. Cost $48.59 Unrealized —

— AMAG PHARMACEUTICALS INC 1.6%

Value ($000) $18,557 Shares 3,002,748 Est. Cost $29.07 Unrealized —

— SAGE THERAPEUTICS INC 1.4%

Value ($000) $16,849 Shares 586,674 Est. Cost $48.62 Unrealized —

ALGN ALIGN TECHNOLOGY INC 1.1%

Value ($000) $13,256 Shares 76,205 Est. Cost $114.31 Unrealized +109.5%

PBYI PUMA BIOTECHNOLOGY INC 1.0%

Value ($000) $11,784 Shares 1,396,163 Est. Cost $28.26 Unrealized -65.6%

— REVANCE THERAPEUTICS INC 0.8%

Value ($000) $9,112 Shares 615,705 Est. Cost $15.01 Unrealized —

PRTA PROTHENA CORP PLC 0.7%

Value ($000) $8,296 Shares 775,296 Est. Cost $32.98 Unrealized -63.3%

— WRIGHT MEDICAL GROUP NV 0.6%

Value ($000) $6,960 Shares 242,940 Est. Cost $23.42 Unrealized —

— DICERNA PHARMACEUTICALS INC 0.5%

Value ($000) $6,095 Shares 331,813 Est. Cost $5.39 Unrealized —

— RIGEL PHARMACEUTICALS INC 0.5%

Value ($000) $5,526 Shares 3,542,551 Est. Cost $3.40 Unrealized —

KLDO KALEIDO BIOSCIENCES INC 0.4%

Value ($000) $4,846 Shares 787,999 Est. Cost $13.76 Unrealized -52.6%

CYTK CYTOKINETICS INC 0.1%

Value ($000) $1,458 Shares 123,686 Est. Cost $6.71 Unrealized +90.0%

— ALIMERA SCIENCES INC 0.1%

Value ($000) $804 Shares 200,919 Est. Cost $4.88 Unrealized —

— ZOGENIX INC 0.1%

Value ($000) $730 Shares 29,500 Est. Cost $13.36 Unrealized —

SNDX SYNDAX PHARMACEUTICALS INC 0.1%

Value ($000) $725 Shares 66,100 Est. Cost $9.38 Unrealized 0.0%

— RETROPHIN INC 0.1%

Value ($000) $686 Shares 47,000 Est. Cost $14.60 Unrealized —

— INTRA-CELLULAR THERAPIES INC 0.0%

Value ($000) $575 Shares 37,400 Est. Cost $34.30 Unrealized —

— SUNESIS PHARMACEUTICALS INC 0.0%

Value ($000) $482 Shares 1,162,473 Est. Cost $4.37 Unrealized —

URGN UROGEN PHARMA LTD 0.0%

Value ($000) $437 Shares 24,500 Est. Cost $27.01 Unrealized 0.0%

— MARINUS PHARMACEUTICALS INC 0.0%

Value ($000) $254 Shares 125,321 Est. Cost $4.17 Unrealized —

— MINERVA NEUROSCIENCES INC 0.0%

Value ($000) $219 Shares 36,319 Est. Cost $5.62 Unrealized —

ALDX ALDEYRA THERAPEUTICS INC 0.0%

Value ($000) $182 Shares 73,500 Est. Cost $7.53 Unrealized -40.2%

— IDERA PHARMACEUTICALS INC 0.0%

Value ($000) $102 Shares 77,044 Est. Cost $8.90 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
BMRN	BIOMARIN PHARMACEUTICAL INC	1,544,163	$130,482	10.9%	$80.19	+7.5%	COM	09061G101
STAA	STAAR SURGICAL CO	3,278,523	$105,765	8.9%	$13.06	+158.0%	COM	852312305
INSM	INSMED INC	6,055,623	$97,072	8.1%	$17.16	+38.1%	COM	457669307
—	EPIZYME INC	5,551,803	$86,108	7.2%	$15.12	—	COM	29428V104
UTHR	UNITED THERAPEUTICS CORP	876,575	$83,121	7.0%	$88.73	+7.1%	COM	91307C102
—	KARYOPHARM THERAPEUTICS INC	4,299,901	$82,601	6.9%	$17.42	—	COM	48576U106
—	ABIOMED INC	502,745	$72,978	6.1%	$37.80	—	COM	003654100
—	IMMUNOMEDICS INC	5,290,746	$71,319	6.0%	$13.38	—	COM	452907108
ACAD	ACADIA PHARMACEUTICALS INC	1,631,524	$68,932	5.8%	$27.34	+50.7%	COM	004225108
FOLD	AMICUS THERAPEUTICS INC	7,447,618	$68,816	5.8%	$7.59	+25.2%	COM	03152W109
—	ALEXION PHARMACEUTICALS INC	642,491	$57,689	4.8%	$121.54	—	COM	015351109
—	AIMMUNE THERAPEUTICS INC	3,295,712	$47,524	4.0%	$22.84	—	COM	00900T107
VNDA	VANDA PHARMACEUTICALS INC	4,134,846	$42,837	3.6%	$11.21	+10.6%	COM	921659108
—	MOMENTA PHARMACEUTICALS INC	1,527,956	$41,560	3.5%	$14.06	—	COM	60877T100
—	CLOVIS ONCOLOGY INC	4,635,789	$29,484	2.5%	$48.59	—	COM	189464100
—	AMAG PHARMACEUTICALS INC	3,002,748	$18,557	1.6%	$29.07	—	COM	00163U106
—	SAGE THERAPEUTICS INC	586,674	$16,849	1.4%	$48.62	—	COM	78667J108
ALGN	ALIGN TECHNOLOGY INC	76,205	$13,256	1.1%	$114.31	+109.5%	COM	016255101
PBYI	PUMA BIOTECHNOLOGY INC	1,396,163	$11,784	1.0%	$28.26	-65.6%	COM	74587V107
—	REVANCE THERAPEUTICS INC	615,705	$9,112	0.8%	$15.01	—	COM	761330109
PRTA	PROTHENA CORP PLC	775,296	$8,296	0.7%	$32.98	-63.3%	COM	G72800108
—	WRIGHT MEDICAL GROUP NV	242,940	$6,960	0.6%	$23.42	—	COM	N96617118
—	DICERNA PHARMACEUTICALS INC	331,813	$6,095	0.5%	$5.39	—	COM	253031108
—	RIGEL PHARMACEUTICALS INC	3,542,551	$5,526	0.5%	$3.40	—	COM	766559603
KLDO	KALEIDO BIOSCIENCES INC	787,999	$4,846	0.4%	$13.76	-52.6%	COM	483347100
CYTK	CYTOKINETICS INC	123,686	$1,458	0.1%	$6.71	+90.0%	COM	23282W605
—	ALIMERA SCIENCES INC	200,919	$804	0.1%	$4.88	—	COM	016259103
—	ZOGENIX INC	29,500	$730	0.1%	$13.36	—	COM	98978L204
SNDX	SYNDAX PHARMACEUTICALS INC	66,100	$725	0.1%	$9.38	0.0%	COM	87164F105
—	RETROPHIN INC	47,000	$686	0.1%	$14.60	—	COM	761299106
—	INTRA-CELLULAR THERAPIES INC	37,400	$575	0.0%	$34.30	—	COM	46116X101
—	SUNESIS PHARMACEUTICALS INC	1,162,473	$482	0.0%	$4.37	—	COM	867328700
URGN	UROGEN PHARMA LTD	24,500	$437	0.0%	$27.01	0.0%	COM	M96088105
—	MARINUS PHARMACEUTICALS INC	125,321	$254	0.0%	$4.17	—	COM	56854Q101
—	MINERVA NEUROSCIENCES INC	36,319	$219	0.0%	$5.62	—	COM	603380106
ALDX	ALDEYRA THERAPEUTICS INC	73,500	$182	0.0%	$7.53	-40.2%	COM	01438T106
—	IDERA PHARMACEUTICALS INC	77,044	$102	0.0%	$8.90	—	COM	45168K405