Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q1 2020 (← Previous) (Next →)

Filing Date: May 15, 2020

Total Value: $1.194B (100.0% shares, 0.0% debt)

Holdings (37)

BMRN BIOMARIN PHARMACEUTICAL INC 10.9%

Value $130M Shares 1,544,163 Share Price $84.50 Est. Cost/Share $80.19 Unrealized @ Report Date +7.5%

STAA STAAR SURGICAL CO 8.9%

Value $106M Shares 3,278,523 Share Price $32.26 * Est. Cost/Share $13.06 Unrealized @ Report Date +158.0%

INSM INSMED INC 8.1%

Value $97.07M Shares 6,055,623 Share Price $16.03 * Est. Cost/Share $17.16 Unrealized @ Report Date +38.1%

— EPIZYME INC 7.2%

Value $86.11M Shares 5,551,803 Share Price $15.51 Est. Cost/Share $15.12 Unrealized @ Report Date —

UTHR UNITED THERAPEUTICS CORP 7.0%

Value $83.12M Shares 876,575 Share Price $94.82 Est. Cost/Share $88.73 Unrealized @ Report Date +7.1%

— KARYOPHARM THERAPEUTICS INC 6.9%

Value $82.6M Shares 4,299,901 Share Price $19.21 Est. Cost/Share $17.42 Unrealized @ Report Date —

— ABIOMED INC 6.1%

Value $72.98M Shares 502,745 Share Price $145.16 Est. Cost/Share $37.80 Unrealized @ Report Date —

— IMMUNOMEDICS INC 6.0%

Value $71.32M Shares 5,290,746 Share Price $13.48 Est. Cost/Share $13.38 Unrealized @ Report Date —

ACAD ACADIA PHARMACEUTICALS INC 5.8%

Value $68.93M Shares 1,631,524 Share Price $42.25 * Est. Cost/Share $27.34 Unrealized @ Report Date +50.7%

FOLD AMICUS THERAPEUTICS INC 5.8%

Value $68.82M Shares 7,447,618 Share Price $9.24 * Est. Cost/Share $7.59 Unrealized @ Report Date +25.2%

— ALEXION PHARMACEUTICALS INC 4.8%

Value $57.69M Shares 642,491 Share Price $89.79 Est. Cost/Share $121.54 Unrealized @ Report Date —

— AIMMUNE THERAPEUTICS INC 4.0%

Value $47.52M Shares 3,295,712 Share Price $14.42 Est. Cost/Share $22.84 Unrealized @ Report Date —

VNDA VANDA PHARMACEUTICALS INC 3.6%

Value $42.84M Shares 4,134,846 Share Price $10.36 * Est. Cost/Share $11.21 Unrealized @ Report Date +10.6%

— MOMENTA PHARMACEUTICALS INC 3.5%

Value $41.56M Shares 1,527,956 Share Price $27.20 Est. Cost/Share $14.06 Unrealized @ Report Date —

— CLOVIS ONCOLOGY INC 2.5%

Value $29.48M Shares 4,635,789 Share Price $6.36 Est. Cost/Share $48.59 Unrealized @ Report Date —

— AMAG PHARMACEUTICALS INC 1.6%

Value $18.56M Shares 3,002,748 Share Price $6.18 Est. Cost/Share $29.07 Unrealized @ Report Date —

— SAGE THERAPEUTICS INC 1.4%

Value $16.85M Shares 586,674 Share Price $28.72 Est. Cost/Share $48.62 Unrealized @ Report Date —

ALGN ALIGN TECHNOLOGY INC 1.1%

Value $13.26M Shares 76,205 Share Price $173.95 * Est. Cost/Share $114.31 Unrealized @ Report Date +109.5%

PBYI PUMA BIOTECHNOLOGY INC 1.0%

Value $11.78M Shares 1,396,163 Share Price $8.44 * Est. Cost/Share $28.26 Unrealized @ Report Date -65.6%

— REVANCE THERAPEUTICS INC 0.8%

Value $9.112M Shares 615,705 Share Price $14.80 Est. Cost/Share $15.01 Unrealized @ Report Date —

PRTA PROTHENA CORP PLC 0.7%

Value $8.296M Shares 775,296 Share Price $10.70 * Est. Cost/Share $32.98 Unrealized @ Report Date -63.3%

— WRIGHT MEDICAL GROUP NV 0.6%

Value $6.96M Shares 242,940 Share Price $28.65 Est. Cost/Share $23.42 Unrealized @ Report Date —

— DICERNA PHARMACEUTICALS INC 0.5%

Value $6.095M Shares 331,813 Share Price $18.37 Est. Cost/Share $5.39 Unrealized @ Report Date —

— RIGEL PHARMACEUTICALS INC 0.5%

Value $5.526M Shares 3,542,551 Share Price $1.56 Est. Cost/Share $3.40 Unrealized @ Report Date —

KLDO KALEIDO BIOSCIENCES INC 0.4%

Value $4.846M Shares 787,999 Share Price $6.15 * Est. Cost/Share $13.76 Unrealized @ Report Date -52.6%

CYTK CYTOKINETICS INC 0.1%

Value $1.458M Shares 123,686 Share Price $11.79 * Est. Cost/Share $6.71 Unrealized @ Report Date +90.0%

— ALIMERA SCIENCES INC 0.1%

Value $804K Shares 200,919 Share Price $4.00 Est. Cost/Share $4.88 Unrealized @ Report Date —

— ZOGENIX INC 0.1%

Value $730K Shares 29,500 Share Price $24.75 Est. Cost/Share $13.36 Unrealized @ Report Date —

SNDX SYNDAX PHARMACEUTICALS INC 0.1%

Value $725K Shares 66,100 Share Price $10.97 * Est. Cost/Share $9.38 Unrealized @ Report Date 0.0%

— RETROPHIN INC 0.1%

Value $686K Shares 47,000 Share Price $14.60 Est. Cost/Share $14.60 Unrealized @ Report Date —

— INTRA-CELLULAR THERAPIES INC 0.0%

Value $575K Shares 37,400 Share Price $15.37 Est. Cost/Share $34.30 Unrealized @ Report Date —

— SUNESIS PHARMACEUTICALS INC 0.0%

Value $482K Shares 1,162,473 Share Price $0.41 Est. Cost/Share $4.37 Unrealized @ Report Date —

URGN UROGEN PHARMA LTD 0.0%

Value $437K Shares 24,500 Share Price $17.84 * Est. Cost/Share $27.01 Unrealized @ Report Date 0.0%

— MARINUS PHARMACEUTICALS INC 0.0%

Value $254K Shares 125,321 Share Price $2.03 Est. Cost/Share $4.17 Unrealized @ Report Date —

— MINERVA NEUROSCIENCES INC 0.0%

Value $219K Shares 36,319 Share Price $6.03 Est. Cost/Share $5.62 Unrealized @ Report Date —

ALDX ALDEYRA THERAPEUTICS INC 0.0%

Value $182K Shares 73,500 Share Price $2.48 * Est. Cost/Share $7.53 Unrealized @ Report Date -40.2%

— IDERA PHARMACEUTICALS INC 0.0%

Value $102K Shares 77,044 Share Price $1.32 Est. Cost/Share $8.90 Unrealized @ Report Date —

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
BMRN	BIOMARIN PHARMACEUTICAL INC	1,544,163	$130M	10.9%	$84.50	$80.19	+7.5%	COM	09061G101
STAA	STAAR SURGICAL CO	3,278,523	$106M	8.9%	$32.26 *	$13.06	+158.0%	COM	852312305
INSM	INSMED INC	6,055,623	$97.07M	8.1%	$16.03 *	$17.16	+38.1%	COM	457669307
—	EPIZYME INC	5,551,803	$86.11M	7.2%	$15.51	$15.12	—	COM	29428V104
UTHR	UNITED THERAPEUTICS CORP	876,575	$83.12M	7.0%	$94.82	$88.73	+7.1%	COM	91307C102
—	KARYOPHARM THERAPEUTICS INC	4,299,901	$82.6M	6.9%	$19.21	$17.42	—	COM	48576U106
—	ABIOMED INC	502,745	$72.98M	6.1%	$145.16	$37.80	—	COM	003654100
—	IMMUNOMEDICS INC	5,290,746	$71.32M	6.0%	$13.48	$13.38	—	COM	452907108
ACAD	ACADIA PHARMACEUTICALS INC	1,631,524	$68.93M	5.8%	$42.25 *	$27.34	+50.7%	COM	004225108
FOLD	AMICUS THERAPEUTICS INC	7,447,618	$68.82M	5.8%	$9.24 *	$7.59	+25.2%	COM	03152W109
—	ALEXION PHARMACEUTICALS INC	642,491	$57.69M	4.8%	$89.79	$121.54	—	COM	015351109
—	AIMMUNE THERAPEUTICS INC	3,295,712	$47.52M	4.0%	$14.42	$22.84	—	COM	00900T107
VNDA	VANDA PHARMACEUTICALS INC	4,134,846	$42.84M	3.6%	$10.36 *	$11.21	+10.6%	COM	921659108
—	MOMENTA PHARMACEUTICALS INC	1,527,956	$41.56M	3.5%	$27.20	$14.06	—	COM	60877T100
—	CLOVIS ONCOLOGY INC	4,635,789	$29.48M	2.5%	$6.36	$48.59	—	COM	189464100
—	AMAG PHARMACEUTICALS INC	3,002,748	$18.56M	1.6%	$6.18	$29.07	—	COM	00163U106
—	SAGE THERAPEUTICS INC	586,674	$16.85M	1.4%	$28.72	$48.62	—	COM	78667J108
ALGN	ALIGN TECHNOLOGY INC	76,205	$13.26M	1.1%	$173.95 *	$114.31	+109.5%	COM	016255101
PBYI	PUMA BIOTECHNOLOGY INC	1,396,163	$11.78M	1.0%	$8.44 *	$28.26	-65.6%	COM	74587V107
—	REVANCE THERAPEUTICS INC	615,705	$9.112M	0.8%	$14.80	$15.01	—	COM	761330109
PRTA	PROTHENA CORP PLC	775,296	$8.296M	0.7%	$10.70 *	$32.98	-63.3%	COM	G72800108
—	WRIGHT MEDICAL GROUP NV	242,940	$6.96M	0.6%	$28.65	$23.42	—	COM	N96617118
—	DICERNA PHARMACEUTICALS INC	331,813	$6.095M	0.5%	$18.37	$5.39	—	COM	253031108
—	RIGEL PHARMACEUTICALS INC	3,542,551	$5.526M	0.5%	$1.56	$3.40	—	COM	766559603
KLDO	KALEIDO BIOSCIENCES INC	787,999	$4.846M	0.4%	$6.15 *	$13.76	-52.6%	COM	483347100
CYTK	CYTOKINETICS INC	123,686	$1.458M	0.1%	$11.79 *	$6.71	+90.0%	COM	23282W605
—	ALIMERA SCIENCES INC	200,919	$804K	0.1%	$4.00	$4.88	—	COM	016259103
—	ZOGENIX INC	29,500	$730K	0.1%	$24.75	$13.36	—	COM	98978L204
SNDX	SYNDAX PHARMACEUTICALS INC	66,100	$725K	0.1%	$10.97 *	$9.38	0.0%	COM	87164F105
—	RETROPHIN INC	47,000	$686K	0.1%	$14.60	$14.60	—	COM	761299106
—	INTRA-CELLULAR THERAPIES INC	37,400	$575K	0.0%	$15.37	$34.30	—	COM	46116X101
—	SUNESIS PHARMACEUTICALS INC	1,162,473	$482K	0.0%	$0.41	$4.37	—	COM	867328700
URGN	UROGEN PHARMA LTD	24,500	$437K	0.0%	$17.84 *	$27.01	0.0%	COM	M96088105
—	MARINUS PHARMACEUTICALS INC	125,321	$254K	0.0%	$2.03	$4.17	—	COM	56854Q101
—	MINERVA NEUROSCIENCES INC	36,319	$219K	0.0%	$6.03	$5.62	—	COM	603380106
ALDX	ALDEYRA THERAPEUTICS INC	73,500	$182K	0.0%	$2.48 *	$7.53	-40.2%	COM	01438T106
—	IDERA PHARMACEUTICALS INC	77,044	$102K	0.0%	$1.32	$8.90	—	COM	45168K405