Opaleye Management Inc. Quant / Systematic

CIK: 0001595855 · Show all filings

Period: Q1 2020 (← Previous) (Next →)

Filing Date: May 15, 2020

Total Value ($000): $377,363 (100.0% shares, 0.0% debt)

Holdings (44)

— ARTARA THERAPEUTICS INC 13.8%

Value ($000) $52,142 Shares 2,208,472 Est. Cost $23.61 Unrealized —

— FORTY SEVEN INC 9.7%

Value ($000) $36,784 Shares 385,500 Est. Cost $14.45 Unrealized —

OCUL OCULAR THERAPEUTIX INC 6.7%

Value ($000) $25,356 Shares 5,122,500 Est. Cost $3.71 Unrealized +33.1%

— APTOSE BIOSCIENCES INC 6.3%

Value ($000) $23,891 Shares 4,022,000 Est. Cost $5.04 Unrealized —

— NEOLEUKIN THERAPEUTICS INC 4.2%

Value ($000) $15,932 Shares 1,400,000 Est. Cost $5.58 Unrealized —

CDXS CODEXIS INC 4.1%

Value ($000) $15,624 Shares 1,400,000 Est. Cost $3.62 Unrealized +285.6%

— EIDOS THERAPEUTICS INC 4.1%

Value ($000) $15,459 Shares 315,550 Est. Cost $22.78 Unrealized —

ETON ETON PHARMACEUTICALS INC 4.0%

Value ($000) $14,924 Shares 3,640,000 Est. Cost $6.16 Unrealized -5.2%

— CHEMOCENTRYX INC 3.9%

Value ($000) $14,529 Shares 361,600 Est. Cost $20.86 Unrealized —

STXS STEREOTAXIS INC 3.1%

Value ($000) $11,662 Shares 3,861,500 Est. Cost $2.93 Unrealized +40.8%

QURE UNIQURE NV 2.6%

Value ($000) $9,965 Shares 210,000 Est. Cost $44.91 Unrealized +27.9%

— ODONATE THERAPEUTICS INC 2.6%

Value ($000) $9,940 Shares 360,000 Est. Cost $24.77 Unrealized —

— HARROW HEALTH 2.5%

Value ($000) $9,550 Shares 2,500,000 Est. Cost $4.17 Unrealized —

— AVENUE THERAPEUTICS INC 2.5%

Value ($000) $9,253 Shares 1,035,000 Est. Cost $5.67 Unrealized —

— DECIPHERA PHARMACEUTICALS IN 2.4%

Value ($000) $9,140 Shares 222,000 Est. Cost $22.57 Unrealized —

XOMA XOMA CORP DEL 2.1%

Value ($000) $7,875 Shares 387,000 Est. Cost $8.56 Unrealized +169.8%

— FORTRESS BIOTECH INC 1.9%

Value ($000) $7,239 Shares 3,830,000 Est. Cost $2.21 Unrealized —

— KALA PHARMACEUTICALS INC 1.9%

Value ($000) $7,234 Shares 782,000 Est. Cost $9.25 Unrealized —

— MOLECULAR TEMPLATES INC 1.9%

Value ($000) $7,089 Shares 533,400 Est. Cost $13.29 Unrealized —

— CERECOR INC 1.4%

Value ($000) $5,464 Shares 2,203,100 Est. Cost $2.99 Unrealized —

CRNX CRINETICS PHARMACEUTICALS INC 1.4%

Value ($000) $5,421 Shares 368,750 Est. Cost $20.17 Unrealized +1.6%

— FIBROGEN INC 1.3%

Value ($000) $5,074 Shares 146,000 Est. Cost $26.18 Unrealized —

EDAP EDAP TMS SA 1.3%

Value ($000) $4,979 Shares 2,193,500 Est. Cost $4.04 Unrealized —

— MYOVANT SCIENCES LTD 1.3%

Value ($000) $4,953 Shares 656,000 Est. Cost $7.55 Unrealized —

TGTX TG THERAPEUTICS INC 1.3%

Value ($000) $4,851 Shares 493,000 Est. Cost $7.37 Unrealized +71.4%

— KADMON HOLDINGS INC 1.3%

Value ($000) $4,828 Shares 1,152,250 Est. Cost $4.47 Unrealized —

— ZYMEWORKS INC 1.3%

Value ($000) $4,718 Shares 133,000 Est. Cost $20.38 Unrealized —

— TRICIDA INC 1.1%

Value ($000) $4,268 Shares 194,000 Est. Cost $31.08 Unrealized —

CPRX CATALYST PHARMACEUTICALS INC 1.1%

Value ($000) $4,043 Shares 1,050,000 Est. Cost $4.10 Unrealized 0.0%

— VERASTEM INC 1.0%

Value ($000) $3,865 Shares 1,463,900 Est. Cost $2.64 Unrealized —

— MAGENTA THERAPEUTICS INC 0.7%

Value ($000) $2,730 Shares 434,712 Est. Cost $13.47 Unrealized —

— MINERVA NEUROSCIENCES INC 0.7%

Value ($000) $2,710 Shares 450,100 Est. Cost $6.02 Unrealized —

MGNX MACROGENICS INC 0.7%

Value ($000) $2,458 Shares 422,300 Est. Cost $9.47 Unrealized -4.1%

— CIDARA THERAPEUTICS INC 0.6%

Value ($000) $2,247 Shares 906,056 Est. Cost $2.48 Unrealized —

— FLEXION THERAPEUTICS INC 0.6%

Value ($000) $2,216 Shares 281,600 Est. Cost $18.93 Unrealized —

— RADIUS HEALTH INC 0.6%

Value ($000) $2,171 Shares 167,000 Est. Cost $22.65 Unrealized —

— AMARIN CORP PLC 0.5%

Value ($000) $1,820 Shares 455,000 Est. Cost $4.04 Unrealized —

KALV KALVISTA PHARMACEUTICALS INC 0.5%

Value ($000) $1,721 Shares 225,000 Est. Cost $13.49 Unrealized 0.0%

— PROVENTION BIO INC 0.4%

Value ($000) $1,527 Shares 166,000 Est. Cost $9.20 Unrealized —

— SELECTA BIOSCIENCES INC 0.2%

Value ($000) $940 Shares 390,000 Est. Cost $2.41 Unrealized —

TELA TELA BIO INC 0.2%

Value ($000) $633 Shares 81,000 Est. Cost $12.23 Unrealized +10.4%

ACAD ACADIA PHARMACEUTICALS INC 0.0%

Value ($000) $63 Shares 1,500 Est. Cost $16.79 Unrealized +145.4%

— OCULAR THERAPEUTIX INC 0.0%

Value ($000) $53 Shares 1,000 Est. Cost — Unrealized —

— BIOLINERX LTD 0.0%

Value ($000) $22 Shares 16,667 Est. Cost $1426.15 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
—	ARTARA THERAPEUTICS INC	2,208,472	$52,142	13.8%	$23.61	—	COM	04300J107
—	FORTY SEVEN INC	385,500	$36,784	9.7%	$14.45	—	COM	34983P104
OCUL	OCULAR THERAPEUTIX INC	5,122,500	$25,356	6.7%	$3.71	+33.1%	COM	67576A100
—	APTOSE BIOSCIENCES INC	4,022,000	$23,891	6.3%	$5.04	—	COM NEW	03835T200
—	NEOLEUKIN THERAPEUTICS INC	1,400,000	$15,932	4.2%	$5.58	—	COM	64049K104
CDXS	CODEXIS INC	1,400,000	$15,624	4.1%	$3.62	+285.6%	COM	192005106
—	EIDOS THERAPEUTICS INC	315,550	$15,459	4.1%	$22.78	—	COM	28249H104
ETON	ETON PHARMACEUTICALS INC	3,640,000	$14,924	4.0%	$6.16	-5.2%	COM	29772L108
—	CHEMOCENTRYX INC	361,600	$14,529	3.9%	$20.86	—	COM	16383L106
STXS	STEREOTAXIS INC	3,861,500	$11,662	3.1%	$2.93	+40.8%	COM NEW	85916J409
QURE	UNIQURE NV	210,000	$9,965	2.6%	$44.91	+27.9%	SHS	N90064101
—	ODONATE THERAPEUTICS INC	360,000	$9,940	2.6%	$24.77	—	COM	676079106
—	HARROW HEALTH	2,500,000	$9,550	2.5%	$4.17	—	COM	45323A201
—	AVENUE THERAPEUTICS INC	1,035,000	$9,253	2.5%	$5.67	—	COM NEW	05360L205
—	DECIPHERA PHARMACEUTICALS IN	222,000	$9,140	2.4%	$22.57	—	COM	24344T101
XOMA	XOMA CORP DEL	387,000	$7,875	2.1%	$8.56	+169.8%	COM NEW	98419J206
—	FORTRESS BIOTECH INC	3,830,000	$7,239	1.9%	$2.21	—	COM	034960Q19
—	KALA PHARMACEUTICALS INC	782,000	$7,234	1.9%	$9.25	—	COM	483119103
—	MOLECULAR TEMPLATES INC	533,400	$7,089	1.9%	$13.29	—	COM	608550109
—	CERECOR INC	2,203,100	$5,464	1.4%	$2.99	—	COM	15671L109
CRNX	CRINETICS PHARMACEUTICALS INC	368,750	$5,421	1.4%	$20.17	+1.6%	COM	22663K107
—	FIBROGEN INC	146,000	$5,074	1.3%	$26.18	—	COM	31572Q808
EDAP	EDAP TMS SA	2,193,500	$4,979	1.3%	$4.04	—	SPONSORED ADR	268311107
—	MYOVANT SCIENCES LTD	656,000	$4,953	1.3%	$7.55	—	COM	G637AM102
TGTX	TG THERAPEUTICS INC	493,000	$4,851	1.3%	$7.37	+71.4%	COM	88322Q108
—	KADMON HOLDINGS INC	1,152,250	$4,828	1.3%	$4.47	—	COM	48283N106
—	ZYMEWORKS INC	133,000	$4,718	1.3%	$20.38	—	COM	98985W102
—	TRICIDA INC	194,000	$4,268	1.1%	$31.08	—	COM	89610F101
CPRX	CATALYST PHARMACEUTICALS INC	1,050,000	$4,043	1.1%	$4.10	0.0%	COM	14888U101
—	VERASTEM INC	1,463,900	$3,865	1.0%	$2.64	—	COM	92337C104
—	MAGENTA THERAPEUTICS INC	434,712	$2,730	0.7%	$13.47	—	COM	55910K108
—	MINERVA NEUROSCIENCES INC	450,100	$2,710	0.7%	$6.02	—	COM	603380106
MGNX	MACROGENICS INC	422,300	$2,458	0.7%	$9.47	-4.1%	COM	556099109
—	CIDARA THERAPEUTICS INC	906,056	$2,247	0.6%	$2.48	—	COM	171757107
—	FLEXION THERAPEUTICS INC	281,600	$2,216	0.6%	$18.93	—	COM	33938J106
—	RADIUS HEALTH INC	167,000	$2,171	0.6%	$22.65	—	COM NEW	750469207
—	AMARIN CORP PLC	455,000	$1,820	0.5%	$4.04	—	SPONSORED ADR	023111206
KALV	KALVISTA PHARMACEUTICALS INC	225,000	$1,721	0.5%	$13.49	0.0%	COM	483497103
—	PROVENTION BIO INC	166,000	$1,527	0.4%	$9.20	—	COM	74374N102
—	SELECTA BIOSCIENCES INC	390,000	$940	0.2%	$2.41	—	COM	816212104
TELA	TELA BIO INC	81,000	$633	0.2%	$12.23	+10.4%	COM	872381108
ACAD	ACADIA PHARMACEUTICALS INC	1,500	$63	0.0%	$16.79	+145.4%	COM	004225108
—	OCULAR THERAPEUTIX INC	1,000	$53	0.0%	—	—	Call	67576A900
—	BIOLINERX LTD	16,667	$22	0.0%	$1426.15	—	SPONSORED ADR	09071M106