Opaleye Management Inc. Quant / Systematic

CIK: 0001595855 · Show all filings

Period: Q4 2021 (← Previous) (Next →)

Filing Date: Feb 14, 2022

Total Value ($000): $471,486 (100.0% shares, 0.0% debt)

Holdings (39)

CDXS CODEXIS INC 8.9%

Value ($000) $42,058 Shares 1,345,000 Est. Cost $3.62 Unrealized +807.3%

OCUL OCULAR THERAPEUTIX INC 8.8%

Value ($000) $41,644 Shares 5,974,800 Est. Cost $5.00 Unrealized +55.4%

— CHIMERIX INC 7.6%

Value ($000) $35,879 Shares 5,580,000 Est. Cost $4.24 Unrealized —

CLDX CELLDEX THERAPEUTICS INC 6.9%

Value ($000) $32,612 Shares 844,000 Est. Cost $4.43 Unrealized +883.3%

HROW HARROW HEALTH INC 6.0%

Value ($000) $28,382 Shares 3,285,000 Est. Cost $5.29 Unrealized +86.9%

CYTK CYTOKINETICS INC 5.6%

Value ($000) $26,436 Shares 580,000 Est. Cost $18.45 Unrealized +109.2%

CRNX CRINETICS PHARMACEUTICALS INC 4.4%

Value ($000) $20,580 Shares 724,400 Est. Cost $21.12 Unrealized +16.8%

TARA PROTARA THERAPEUTICS INC 3.8%

Value ($000) $17,996 Shares 2,650,000 Est. Cost $29.10 Unrealized -76.3%

SMLR SEMLER SCIENTIFIC INC 3.3%

Value ($000) $15,764 Shares 172,000 Est. Cost $114.32 Unrealized -2.0%

STXS STEREOTAXIS INC 3.3%

Value ($000) $15,664 Shares 2,526,500 Est. Cost $2.93 Unrealized +103.6%

KROS KEROS THERAPEUTICS INC 3.3%

Value ($000) $15,549 Shares 265,750 Est. Cost $52.08 Unrealized -4.2%

— KINIKSA PHARMACEUTICALS LTD 2.6%

Value ($000) $12,064 Shares 1,025,000 Est. Cost $15.94 Unrealized —

PTGX PROTAGONIST THERAPEUTICS INC 2.5%

Value ($000) $11,696 Shares 342,000 Est. Cost $23.39 Unrealized +35.1%

PRQR PROQR THERAPEUTICS NV 2.4%

Value ($000) $11,498 Shares 1,435,510 Est. Cost $5.23 Unrealized +45.7%

ETON ETON PHARMACEUTICALS INC 2.2%

Value ($000) $10,232 Shares 2,385,000 Est. Cost $6.31 Unrealized -24.2%

— SUTRO BIOPHARMA INC 2.1%

Value ($000) $10,118 Shares 680,000 Est. Cost $16.93 Unrealized —

— MERUS N.V. 2.1%

Value ($000) $10,106 Shares 317,800 Est. Cost $28.71 Unrealized —

LRMR LARIMAR THERAPEUTICS INC 2.0%

Value ($000) $9,534 Shares 883,602 Est. Cost $11.37 Unrealized -2.2%

— FORTRESS BIOTECH INC 2.0%

Value ($000) $9,375 Shares 3,750,000 Est. Cost $2.69 Unrealized —

— REATA PHARMACEUTICALS INC 1.8%

Value ($000) $8,702 Shares 330,000 Est. Cost $26.37 Unrealized —

— TRACON PHARMACEUTICALS INC 1.8%

Value ($000) $8,462 Shares 3,055,000 Est. Cost $5.83 Unrealized —

— GINKGO BIOWORKS HOLDINGS INC 1.6%

Value ($000) $7,726 Shares 929,780 Est. Cost $8.31 Unrealized —

PCVX VAXCYTE INC 1.6%

Value ($000) $7,513 Shares 315,800 Est. Cost $38.73 Unrealized -40.0%

MGNX MACROGENICS INC 1.6%

Value ($000) $7,415 Shares 462,000 Est. Cost $17.19 Unrealized +9.5%

XOMA XOMA CORP DEL 1.5%

Value ($000) $7,055 Shares 338,350 Est. Cost $10.28 Unrealized +127.5%

TELA TELA BIO INC 1.2%

Value ($000) $5,758 Shares 449,867 Est. Cost $13.29 Unrealized -4.7%

HYPR HYPERFINE INC 1.2%

Value ($000) $5,523 Shares 763,075 Est. Cost $9.78 Unrealized 0.0%

BBIO BRIDGEBIO PHARMA INC 1.2%

Value ($000) $5,473 Shares 328,100 Est. Cost $65.42 Unrealized -35.3%

— NEOLEUKIN THERAPEUTICS INC 1.1%

Value ($000) $5,048 Shares 1,047,300 Est. Cost $5.58 Unrealized —

FDMT 4D MOLECULAR THERAPEUTICS INC 1.1%

Value ($000) $5,024 Shares 229,000 Est. Cost $24.51 Unrealized 0.0%

— VERASTEM INC 1.0%

Value ($000) $4,766 Shares 2,325,000 Est. Cost $1.49 Unrealized —

— SIERRA ONCOLOGY INC 0.8%

Value ($000) $3,604 Shares 165,778 Est. Cost $16.88 Unrealized —

— MEI PHARMA INC 0.7%

Value ($000) $3,511 Shares 1,315,000 Est. Cost $4.13 Unrealized —

— NUCANA PLC 0.6%

Value ($000) $2,830 Shares 1,189,000 Est. Cost $2.46 Unrealized —

— AVALO THERAPEUTICS INC 0.5%

Value ($000) $2,481 Shares 1,459,400 Est. Cost $2.18 Unrealized —

— SYNLOGIC INC 0.4%

Value ($000) $2,057 Shares 850,000 Est. Cost $2.42 Unrealized —

— AVEO BIOSCIENCES INC 0.3%

Value ($000) $1,235 Shares 263,400 Est. Cost $7.21 Unrealized —

LQDA LIQUIDIA CORPORATION 0.0%

Value ($000) $82 Shares 16,800 Est. Cost $3.99 Unrealized 0.0%

— BIOLINERX LTD 0.0%

Value ($000) $34 Shares 16,667 Est. Cost $1.74 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
CDXS	CODEXIS INC	1,345,000	$42,058	8.9%	$3.62	+807.3%	COM	192005106
OCUL	OCULAR THERAPEUTIX INC	5,974,800	$41,644	8.8%	$5.00	+55.4%	COM	67576A100
—	CHIMERIX INC	5,580,000	$35,879	7.6%	$4.24	—	COM	16934W106
CLDX	CELLDEX THERAPEUTICS INC	844,000	$32,612	6.9%	$4.43	+883.3%	COM NEW	15117B202
HROW	HARROW HEALTH INC	3,285,000	$28,382	6.0%	$5.29	+86.9%	COM	415858109
CYTK	CYTOKINETICS INC	580,000	$26,436	5.6%	$18.45	+109.2%	COM NEW	23282W605
CRNX	CRINETICS PHARMACEUTICALS INC	724,400	$20,580	4.4%	$21.12	+16.8%	COM	22663K107
TARA	PROTARA THERAPEUTICS INC	2,650,000	$17,996	3.8%	$29.10	-76.3%	COM STK	74365U107
SMLR	SEMLER SCIENTIFIC INC	172,000	$15,764	3.3%	$114.32	-2.0%	COM	81684M104
STXS	STEREOTAXIS INC	2,526,500	$15,664	3.3%	$2.93	+103.6%	COM NEW	85916J409
KROS	KEROS THERAPEUTICS INC	265,750	$15,549	3.3%	$52.08	-4.2%	COM	492327101
—	KINIKSA PHARMACEUTICALS LTD	1,025,000	$12,064	2.6%	$15.94	—	COM CL A	G5269C101
PTGX	PROTAGONIST THERAPEUTICS INC	342,000	$11,696	2.5%	$23.39	+35.1%	COM	74366E102
PRQR	PROQR THERAPEUTICS NV	1,435,510	$11,498	2.4%	$5.23	+45.7%	SHS EURO	N71542109
ETON	ETON PHARMACEUTICALS INC	2,385,000	$10,232	2.2%	$6.31	-24.2%	COM	29772L108
—	SUTRO BIOPHARMA INC	680,000	$10,118	2.1%	$16.93	—	COM	869367102
—	MERUS N.V.	317,800	$10,106	2.1%	$28.71	—	COM	N5749R100
LRMR	LARIMAR THERAPEUTICS INC	883,602	$9,534	2.0%	$11.37	-2.2%	COM	517125100
—	FORTRESS BIOTECH INC	3,750,000	$9,375	2.0%	$2.69	—	COM	34960Q109
—	REATA PHARMACEUTICALS INC	330,000	$8,702	1.8%	$26.37	—	CLASS A	75615P103
—	TRACON PHARMACEUTICALS INC	3,055,000	$8,462	1.8%	$5.83	—	COM NEW	89237H209
—	GINKGO BIOWORKS HOLDINGS INC	929,780	$7,726	1.6%	$8.31	—	CLASS A SHARES	37611X100
PCVX	VAXCYTE INC	315,800	$7,513	1.6%	$38.73	-40.0%	COM	92243G108
MGNX	MACROGENICS INC	462,000	$7,415	1.6%	$17.19	+9.5%	COM	556099109
XOMA	XOMA CORP DEL	338,350	$7,055	1.5%	$10.28	+127.5%	COM NEW	98419J206
TELA	TELA BIO INC	449,867	$5,758	1.2%	$13.29	-4.7%	COM	872381108
HYPR	HYPERFINE INC	763,075	$5,523	1.2%	$9.78	0.0%	COM CL A	44916K106
BBIO	BRIDGEBIO PHARMA INC	328,100	$5,473	1.2%	$65.42	-35.3%	COM	10806X102
—	NEOLEUKIN THERAPEUTICS INC	1,047,300	$5,048	1.1%	$5.58	—	COM	64049K104
FDMT	4D MOLECULAR THERAPEUTICS INC	229,000	$5,024	1.1%	$24.51	0.0%	COM	35104E100
—	VERASTEM INC	2,325,000	$4,766	1.0%	$1.49	—	COM	92337C104
—	SIERRA ONCOLOGY INC	165,778	$3,604	0.8%	$16.88	—	COM NEW	82640U404
—	MEI PHARMA INC	1,315,000	$3,511	0.7%	$4.13	—	COM NEW	55279B202
—	NUCANA PLC	1,189,000	$2,830	0.6%	$2.46	—	SPONSORED ADR	67022C106
—	AVALO THERAPEUTICS INC	1,459,400	$2,481	0.5%	$2.18	—	COM	05338F108
—	SYNLOGIC INC	850,000	$2,057	0.4%	$2.42	—	COM	87166L100
—	AVEO BIOSCIENCES INC	263,400	$1,235	0.3%	$7.21	—	COM NEW	053588307
LQDA	LIQUIDIA CORPORATION	16,800	$82	0.0%	$3.99	0.0%	COM NEW	53635D202
—	BIOLINERX LTD	16,667	$34	0.0%	$1.74	—	SPONSORED ADS	09071M205