Opaleye Management Inc. Quant / Systematic

CIK: 0001595855 · Show all filings

Period: Q3 2022 (← Previous) (Next →)

Filing Date: Nov 14, 2022

Total Value ($000): $242,132 (100.0% shares, 0.0% debt)

Holdings (42)

HROW HARROW HEALTH INC 16.7%

Value ($000) $40,360 Shares 3,343,817 Est. Cost $5.30 Unrealized +53.0%

OCUL OCULAR THERAPEUTIX INC 11.1%

Value ($000) $26,830 Shares 6,465,000 Est. Cost $5.00 Unrealized +0.8%

RYTM RHYTHM PHARMACEUTICALS INC 8.2%

Value ($000) $19,845 Shares 810,000 Est. Cost $12.73 Unrealized +46.1%

TELA TELA BIO INC 7.2%

Value ($000) $17,351 Shares 2,036,551 Est. Cost $9.45 Unrealized -12.3%

CRNX CRINETICS PHARMACEUTICALS INC 5.4%

Value ($000) $13,184 Shares 671,300 Est. Cost $21.12 Unrealized -3.4%

CYTK CYTOKINETICS INC 5.3%

Value ($000) $12,742 Shares 263,000 Est. Cost $18.45 Unrealized +160.9%

KROS KEROS THERAPEUTICS INC 5.0%

Value ($000) $12,087 Shares 321,300 Est. Cost $49.36 Unrealized -29.8%

TARA PROTARA THERAPEUTICS INC 3.3%

Value ($000) $7,993 Shares 2,708,067 Est. Cost $29.10 Unrealized -88.4%

CDXS CODEXIS INC 2.9%

Value ($000) $6,999 Shares 1,155,000 Est. Cost $3.62 Unrealized +121.9%

— TRACON PHARMACEUTICALS INC 2.9%

Value ($000) $6,997 Shares 4,190,000 Est. Cost $4.80 Unrealized —

— CUTERA INC 2.8%

Value ($000) $6,735 Shares 147,700 Est. Cost $37.50 Unrealized —

EWTX EDGEWISE THERAPEUTICS INC 2.6%

Value ($000) $6,248 Shares 635,000 Est. Cost $10.83 Unrealized -6.7%

— MERSANA THERAPEUTICS INC 2.5%

Value ($000) $6,086 Shares 900,300 Est. Cost $4.19 Unrealized —

LRMR LARIMAR THERAPEUTICS INC 2.2%

Value ($000) $5,318 Shares 1,661,784 Est. Cost $7.31 Unrealized -65.7%

ETON ETON PHARMACEUTICALS INC 2.2%

Value ($000) $5,294 Shares 2,521,000 Est. Cost $6.13 Unrealized -59.3%

— INHIBRX INC 2.2%

Value ($000) $5,254 Shares 292,700 Est. Cost $11.35 Unrealized —

— MERUS N.V. 2.1%

Value ($000) $5,072 Shares 253,200 Est. Cost $28.57 Unrealized —

PCVX VAXCYTE INC 1.9%

Value ($000) $4,560 Shares 190,000 Est. Cost $38.73 Unrealized -34.5%

XOMA XOMA CORP DEL 1.8%

Value ($000) $4,442 Shares 248,000 Est. Cost $10.28 Unrealized +100.5%

URGN UROGEN PHARMA LTD 1.4%

Value ($000) $3,307 Shares 397,500 Est. Cost $7.43 Unrealized +11.4%

LQDA LIQUIDIA CORPORATION 1.3%

Value ($000) $3,065 Shares 563,500 Est. Cost $5.49 Unrealized +2.3%

FDMT 4D MOLECULAR THERAPEUTICS INC 1.2%

Value ($000) $2,820 Shares 350,700 Est. Cost $20.97 Unrealized -56.8%

STXS STEREOTAXIS INC 1.2%

Value ($000) $2,802 Shares 1,556,800 Est. Cost $2.93 Unrealized -27.0%

— FORTRESS BIOTECH INC 1.1%

Value ($000) $2,579 Shares 2,999,000 Est. Cost $2.69 Unrealized —

PRQR PROQR THERAPEUTICS NV 1.0%

Value ($000) $2,318 Shares 3,115,000 Est. Cost $3.64 Unrealized -78.0%

— GRAPHITE BIO INC 0.8%

Value ($000) $1,830 Shares 577,250 Est. Cost $3.88 Unrealized —

— THESEUS PHARMACEUTICALS INC 0.5%

Value ($000) $1,280 Shares 220,650 Est. Cost $5.76 Unrealized —

— IMPEL PHARMACEUTICALS INC 0.5%

Value ($000) $1,243 Shares 255,250 Est. Cost $7.39 Unrealized —

— ASTRIA THERAPEUTICS INC 0.5%

Value ($000) $1,207 Shares 133,500 Est. Cost $9.04 Unrealized —

MODD MODULAR MEDICAL INC 0.5%

Value ($000) $1,135 Shares 275,422 Est. Cost $3.92 Unrealized +15.9%

— ALLAKOS INC 0.4%

Value ($000) $939 Shares 153,500 Est. Cost $6.12 Unrealized —

— CHIMERIX INC 0.3%

Value ($000) $704 Shares 365,000 Est. Cost $4.26 Unrealized —

DERM JOURNEY MEDICINE CORP 0.3%

Value ($000) $638 Shares 259,293 Est. Cost $4.19 Unrealized -18.8%

— MORPHOSYS AG 0.3%

Value ($000) $609 Shares 121,015 Est. Cost $5.03 Unrealized —

EDAP EDAP TMS SA 0.2%

Value ($000) $588 Shares 71,300 Est. Cost $8.25 Unrealized —

NPCE NEUROPACE INC 0.2%

Value ($000) $436 Shares 116,324 Est. Cost $6.20 Unrealized -22.3%

— LUMOS PHARMA INC 0.2%

Value ($000) $412 Shares 46,576 Est. Cost $8.32 Unrealized —

— NEOLEUKIN THERAPEUTICS INC 0.2%

Value ($000) $368 Shares 575,000 Est. Cost $5.58 Unrealized —

— OPTINOSE INC 0.1%

Value ($000) $333 Shares 90,970 Est. Cost $3.66 Unrealized —

MGTX MEIRAGTX HLDGS PLC 0.0%

Value ($000) $84 Shares 10,000 Est. Cost $8.82 Unrealized 0.0%

IDYA IDEAYA BIOSCIENCES INC 0.0%

Value ($000) $22 Shares 1,500 Est. Cost $12.99 Unrealized 0.0%

— BIOLINERX LTD 0.0%

Value ($000) $16 Shares 16,667 Est. Cost $1.74 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
HROW	HARROW HEALTH INC	3,343,817	$40,360	16.7%	$5.30	+53.0%	COM	415858109
OCUL	OCULAR THERAPEUTIX INC	6,465,000	$26,830	11.1%	$5.00	+0.8%	COM	67576A100
RYTM	RHYTHM PHARMACEUTICALS INC	810,000	$19,845	8.2%	$12.73	+46.1%	COM	76243J105
TELA	TELA BIO INC	2,036,551	$17,351	7.2%	$9.45	-12.3%	COM	872381108
CRNX	CRINETICS PHARMACEUTICALS INC	671,300	$13,184	5.4%	$21.12	-3.4%	COM	22663K107
CYTK	CYTOKINETICS INC	263,000	$12,742	5.3%	$18.45	+160.9%	COM NEW	23282W605
KROS	KEROS THERAPEUTICS INC	321,300	$12,087	5.0%	$49.36	-29.8%	COM	492327101
TARA	PROTARA THERAPEUTICS INC	2,708,067	$7,993	3.3%	$29.10	-88.4%	COM STK	74365U107
CDXS	CODEXIS INC	1,155,000	$6,999	2.9%	$3.62	+121.9%	COM	192005106
—	TRACON PHARMACEUTICALS INC	4,190,000	$6,997	2.9%	$4.80	—	COM NEW	89237H209
—	CUTERA INC	147,700	$6,735	2.8%	$37.50	—	COM	232109108
EWTX	EDGEWISE THERAPEUTICS INC	635,000	$6,248	2.6%	$10.83	-6.7%	COM	28036F105
—	MERSANA THERAPEUTICS INC	900,300	$6,086	2.5%	$4.19	—	COM	59045L106
LRMR	LARIMAR THERAPEUTICS INC	1,661,784	$5,318	2.2%	$7.31	-65.7%	COM	517125100
ETON	ETON PHARMACEUTICALS INC	2,521,000	$5,294	2.2%	$6.13	-59.3%	COM	29772L108
—	INHIBRX INC	292,700	$5,254	2.2%	$11.35	—	COM	45720L107
—	MERUS N.V.	253,200	$5,072	2.1%	$28.57	—	COM	N5749R100
PCVX	VAXCYTE INC	190,000	$4,560	1.9%	$38.73	-34.5%	COM	92243G108
XOMA	XOMA CORP DEL	248,000	$4,442	1.8%	$10.28	+100.5%	COM NEW	98419J206
URGN	UROGEN PHARMA LTD	397,500	$3,307	1.4%	$7.43	+11.4%	COM	M96088105
LQDA	LIQUIDIA CORPORATION	563,500	$3,065	1.3%	$5.49	+2.3%	COM NEW	53635D202
FDMT	4D MOLECULAR THERAPEUTICS INC	350,700	$2,820	1.2%	$20.97	-56.8%	COM	35104E100
STXS	STEREOTAXIS INC	1,556,800	$2,802	1.2%	$2.93	-27.0%	COM NEW	85916J409
—	FORTRESS BIOTECH INC	2,999,000	$2,579	1.1%	$2.69	—	COM	34960Q109
PRQR	PROQR THERAPEUTICS NV	3,115,000	$2,318	1.0%	$3.64	-78.0%	SHS EURO	N71542109
—	GRAPHITE BIO INC	577,250	$1,830	0.8%	$3.88	—	COM	38870X104
—	THESEUS PHARMACEUTICALS INC	220,650	$1,280	0.5%	$5.76	—	COM	88369M101
—	IMPEL PHARMACEUTICALS INC	255,250	$1,243	0.5%	$7.39	—	COM	45258K109
—	ASTRIA THERAPEUTICS INC	133,500	$1,207	0.5%	$9.04	—	COM	04635X102
MODD	MODULAR MEDICAL INC	275,422	$1,135	0.5%	$3.92	+15.9%	COM NEW	60785L207
—	ALLAKOS INC	153,500	$939	0.4%	$6.12	—	COM	01671P100
—	CHIMERIX INC	365,000	$704	0.3%	$4.26	—	COM	16934W106
DERM	JOURNEY MEDICINE CORP	259,293	$638	0.3%	$4.19	-18.8%	COM	48115J109
—	MORPHOSYS AG	121,015	$609	0.3%	$5.03	—	SPONSORED ADS	617760202
EDAP	EDAP TMS SA	71,300	$588	0.2%	$8.25	—	SPONSORED ADR	268311107
NPCE	NEUROPACE INC	116,324	$436	0.2%	$6.20	-22.3%	COM	641288105
—	LUMOS PHARMA INC	46,576	$412	0.2%	$8.32	—	COM	55028X109
—	NEOLEUKIN THERAPEUTICS INC	575,000	$368	0.2%	$5.58	—	COM	64049K104
—	OPTINOSE INC	90,970	$333	0.1%	$3.66	—	COM	68404V100
MGTX	MEIRAGTX HLDGS PLC	10,000	$84	0.0%	$8.82	0.0%	COM	G59665102
IDYA	IDEAYA BIOSCIENCES INC	1,500	$22	0.0%	$12.99	0.0%	COM	45166A102
—	BIOLINERX LTD	16,667	$16	0.0%	$1.74	—	SPONSORED ADS	09071M205