Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q2 2020 (← Previous) (Next →)

Filing Date: Aug 14, 2020

Total Value: $1.665B (100.0% shares, 0.0% debt)

Holdings (41)

— IMMUNOMEDICS INC 11.0%

Value $184M Shares 5,182,983 Est. Cost $13.38 Unrealized —

STAA STAAR SURGICAL CO 10.4%

Value $174M Shares 2,821,154 Est. Cost $13.06 Unrealized +212.8%

BMRN BIOMARIN PHARMACEUTICAL INC 10.4%

Value $173M Shares 1,405,950 Est. Cost $80.19 Unrealized +23.9%

INSM INSMED INC 9.9%

Value $165M Shares 6,002,289 Est. Cost $17.16 Unrealized +38.1%

— ABIOMED INC 7.1%

Value $119M Shares 492,333 Est. Cost $37.80 Unrealized —

FOLD AMICUS THERAPEUTICS INC 6.6%

Value $111M Shares 7,334,714 Est. Cost $7.59 Unrealized +60.5%

UTHR UNITED THERAPEUTICS CORP 5.6%

Value $92.73M Shares 766,406 Est. Cost $88.73 Unrealized +26.8%

— EPIZYME INC 5.3%

Value $88.55M Shares 5,513,676 Est. Cost $15.12 Unrealized —

— KARYOPHARM THERAPEUTICS INC 4.8%

Value $79.92M Shares 4,219,452 Est. Cost $17.42 Unrealized —

ACAD ACADIA PHARMACEUTICALS INC 4.6%

Value $75.85M Shares 1,564,900 Est. Cost $27.34 Unrealized +75.6%

— AIMMUNE THERAPEUTICS INC 3.3%

Value $55.45M Shares 3,318,212 Est. Cost $22.84 Unrealized —

— ALEXION PHARMACEUTICALS INC 3.0%

Value $49.91M Shares 444,629 Est. Cost $121.54 Unrealized —

— MOMENTA PHARMACEUTICALS INC 3.0%

Value $49.22M Shares 1,479,524 Est. Cost $14.06 Unrealized —

VNDA VANDA PHARMACEUTICALS INC 2.8%

Value $47.09M Shares 4,116,548 Est. Cost $11.21 Unrealized +1.0%

— REVANCE THERAPEUTICS INC 2.5%

Value $41.62M Shares 1,704,372 Est. Cost $21.02 Unrealized —

— CLOVIS ONCOLOGY INC 1.8%

Value $29.44M Shares 4,361,411 Est. Cost $48.59 Unrealized —

— SAGE THERAPEUTICS INC 1.4%

Value $23.92M Shares 575,200 Est. Cost $48.62 Unrealized —

— AMAG PHARMACEUTICALS INC 1.4%

Value $22.64M Shares 2,959,587 Est. Cost $29.07 Unrealized —

ALGN ALIGN TECHNOLOGY INC 1.1%

Value $18.53M Shares 67,505 Est. Cost $114.31 Unrealized +97.0%

PBYI PUMA BIOTECHNOLOGY INC 0.8%

Value $14.02M Shares 1,343,897 Est. Cost $28.26 Unrealized -63.4%

— DICERNA PHARMACEUTICALS INC 0.5%

Value $8.428M Shares 331,813 Est. Cost $5.39 Unrealized —

PRTA PROTHENA CORP PLC 0.5%

Value $8.065M Shares 771,065 Est. Cost $32.98 Unrealized -66.3%

— RIGEL PHARMACEUTICALS INC 0.4%

Value $6.483M Shares 3,542,551 Est. Cost $3.40 Unrealized —

KLDO KALEIDO BIOSCIENCES INC 0.4%

Value $5.843M Shares 786,400 Est. Cost $13.76 Unrealized -51.3%

CYTK CYTOKINETICS INC 0.2%

Value $2.915M Shares 123,686 Est. Cost $6.71 Unrealized +179.3%

— ZOGENIX INC 0.2%

Value $2.812M Shares 104,100 Est. Cost $23.14 Unrealized —

GOSS GOSSAMER BIO INC 0.2%

Value $2.655M Shares 204,214 Est. Cost $12.58 Unrealized 0.0%

— ATHENEX INC 0.2%

Value $2.548M Shares 185,200 Est. Cost $13.76 Unrealized —

SNDX SYNDAX PHARMACEUTICALS INC 0.1%

Value $1.893M Shares 127,700 Est. Cost $12.20 Unrealized +24.8%

— APREA THERAPEUTICS INC 0.1%

Value $1.832M Shares 47,234 Est. Cost $38.79 Unrealized —

— MAGENTA THERAPEUTICS INC 0.1%

Value $1.461M Shares 194,600 Est. Cost $7.51 Unrealized —

— ALIMERA SCIENCES INC 0.1%

Value $1.266M Shares 200,919 Est. Cost $6.30 Unrealized —

— KEZAR LIFE SCIENCES INC 0.1%

Value $1.062M Shares 205,086 Est. Cost $5.18 Unrealized —

— INTRA-CELLULAR THERAPIES INC 0.1%

Value $960K Shares 37,400 Est. Cost $34.30 Unrealized —

— RETROPHIN INC 0.1%

Value $959K Shares 47,000 Est. Cost $14.60 Unrealized —

URGN UROGEN PHARMA LTD 0.0%

Value $640K Shares 24,500 Est. Cost $27.01 Unrealized -9.5%

— MARINUS PHARMACEUTICALS INC 0.0%

Value $318K Shares 125,321 Est. Cost $4.17 Unrealized —

— SUNESIS PHARMACEUTICALS INC 0.0%

Value $306K Shares 1,162,473 Est. Cost $4.37 Unrealized —

ALDX ALDEYRA THERAPEUTICS INC 0.0%

Value $306K Shares 73,500 Est. Cost $7.53 Unrealized -51.5%

— IDERA PHARMACEUTICALS INC 0.0%

Value $138K Shares 77,044 Est. Cost $8.90 Unrealized —

— MINERVA NEUROSCIENCES INC 0.0%

Value $131K Shares 36,319 Est. Cost $5.62 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
—	IMMUNOMEDICS INC	5,182,983	$184M	11.0%	$13.38	—	COM	452907108
STAA	STAAR SURGICAL CO	2,821,154	$174M	10.4%	$13.06	+212.8%	COM	852312305
BMRN	BIOMARIN PHARMACEUTICAL INC	1,405,950	$173M	10.4%	$80.19	+23.9%	COM	09061G101
INSM	INSMED INC	6,002,289	$165M	9.9%	$17.16	+38.1%	COM	457669307
—	ABIOMED INC	492,333	$119M	7.1%	$37.80	—	COM	003654100
FOLD	AMICUS THERAPEUTICS INC	7,334,714	$111M	6.6%	$7.59	+60.5%	COM	03152W109
UTHR	UNITED THERAPEUTICS CORP	766,406	$92.73M	5.6%	$88.73	+26.8%	COM	91307C102
—	EPIZYME INC	5,513,676	$88.55M	5.3%	$15.12	—	COM	29428V104
—	KARYOPHARM THERAPEUTICS INC	4,219,452	$79.92M	4.8%	$17.42	—	COM	48576U106
ACAD	ACADIA PHARMACEUTICALS INC	1,564,900	$75.85M	4.6%	$27.34	+75.6%	COM	004225108
—	AIMMUNE THERAPEUTICS INC	3,318,212	$55.45M	3.3%	$22.84	—	COM	00900T107
—	ALEXION PHARMACEUTICALS INC	444,629	$49.91M	3.0%	$121.54	—	COM	015351109
—	MOMENTA PHARMACEUTICALS INC	1,479,524	$49.22M	3.0%	$14.06	—	COM	60877T100
VNDA	VANDA PHARMACEUTICALS INC	4,116,548	$47.09M	2.8%	$11.21	+1.0%	COM	921659108
—	REVANCE THERAPEUTICS INC	1,704,372	$41.62M	2.5%	$21.02	—	COM	761330109
—	CLOVIS ONCOLOGY INC	4,361,411	$29.44M	1.8%	$48.59	—	COM	189464100
—	SAGE THERAPEUTICS INC	575,200	$23.92M	1.4%	$48.62	—	COM	78667J108
—	AMAG PHARMACEUTICALS INC	2,959,587	$22.64M	1.4%	$29.07	—	COM	00163U106
ALGN	ALIGN TECHNOLOGY INC	67,505	$18.53M	1.1%	$114.31	+97.0%	COM	016255101
PBYI	PUMA BIOTECHNOLOGY INC	1,343,897	$14.02M	0.8%	$28.26	-63.4%	COM	74587V107
—	DICERNA PHARMACEUTICALS INC	331,813	$8.428M	0.5%	$5.39	—	COM	253031108
PRTA	PROTHENA CORP PLC	771,065	$8.065M	0.5%	$32.98	-66.3%	COM	G72800108
—	RIGEL PHARMACEUTICALS INC	3,542,551	$6.483M	0.4%	$3.40	—	COM	766559603
KLDO	KALEIDO BIOSCIENCES INC	786,400	$5.843M	0.4%	$13.76	-51.3%	COM	483347100
CYTK	CYTOKINETICS INC	123,686	$2.915M	0.2%	$6.71	+179.3%	COM	23282W605
—	ZOGENIX INC	104,100	$2.812M	0.2%	$23.14	—	COM	98978L204
GOSS	GOSSAMER BIO INC	204,214	$2.655M	0.2%	$12.58	0.0%	COM	38341P102
—	ATHENEX INC	185,200	$2.548M	0.2%	$13.76	—	COM	04685N103
SNDX	SYNDAX PHARMACEUTICALS INC	127,700	$1.893M	0.1%	$12.20	+24.8%	COM	87164F105
—	APREA THERAPEUTICS INC	47,234	$1.832M	0.1%	$38.79	—	COM	03836J102
—	MAGENTA THERAPEUTICS INC	194,600	$1.461M	0.1%	$7.51	—	COM	55910K108
—	ALIMERA SCIENCES INC	200,919	$1.266M	0.1%	$6.30	—	COM	016259202
—	KEZAR LIFE SCIENCES INC	205,086	$1.062M	0.1%	$5.18	—	COM	49372L100
—	INTRA-CELLULAR THERAPIES INC	37,400	$960K	0.1%	$34.30	—	COM	46116X101
—	RETROPHIN INC	47,000	$959K	0.1%	$14.60	—	COM	761299106
URGN	UROGEN PHARMA LTD	24,500	$640K	0.0%	$27.01	-9.5%	COM	M96088105
—	MARINUS PHARMACEUTICALS INC	125,321	$318K	0.0%	$4.17	—	COM	56854Q101
—	SUNESIS PHARMACEUTICALS INC	1,162,473	$306K	0.0%	$4.37	—	COM	867328700
ALDX	ALDEYRA THERAPEUTICS INC	73,500	$306K	0.0%	$7.53	-51.5%	COM	01438T106
—	IDERA PHARMACEUTICALS INC	77,044	$138K	0.0%	$8.90	—	COM	45168K405
—	MINERVA NEUROSCIENCES INC	36,319	$131K	0.0%	$5.62	—	COM	603380106