Palo Alto Investors LP Long-Term Concentrated

Location: Palo Alto, CA

CIK: 0001306923 · Show all filings

Period: Q2 2020 (← Previous) (Next →)

Filing Date: Aug 14, 2020

Total Value: $1.665B (100.0% shares, 0.0% debt)

Holdings (41)

— IMMUNOMEDICS INC 11.0%

Value $184M Shares 5,182,983 Share Price $35.44 Est. Cost/Share $13.38 Unrealized @ Report Date —

STAA STAAR SURGICAL CO 10.4%

Value $174M Shares 2,821,154 Share Price $61.54 * Est. Cost/Share $13.06 Unrealized @ Report Date +212.8%

BMRN BIOMARIN PHARMACEUTICAL INC 10.4%

Value $173M Shares 1,405,950 Share Price $123.34 * Est. Cost/Share $80.19 Unrealized @ Report Date +23.9%

INSM INSMED INC 9.9%

Value $165M Shares 6,002,289 Share Price $27.54 * Est. Cost/Share $17.16 Unrealized @ Report Date +38.1%

— ABIOMED INC 7.1%

Value $119M Shares 492,333 Share Price $241.56 Est. Cost/Share $37.80 Unrealized @ Report Date —

FOLD AMICUS THERAPEUTICS INC 6.6%

Value $111M Shares 7,334,714 Share Price $15.08 * Est. Cost/Share $7.59 Unrealized @ Report Date +60.5%

UTHR UNITED THERAPEUTICS CORP 5.6%

Value $92.73M Shares 766,406 Share Price $121.00 * Est. Cost/Share $88.73 Unrealized @ Report Date +26.8%

— EPIZYME INC 5.3%

Value $88.55M Shares 5,513,676 Share Price $16.06 Est. Cost/Share $15.12 Unrealized @ Report Date —

— KARYOPHARM THERAPEUTICS INC 4.8%

Value $79.92M Shares 4,219,452 Share Price $18.94 Est. Cost/Share $17.42 Unrealized @ Report Date —

ACAD ACADIA PHARMACEUTICALS INC 4.6%

Value $75.85M Shares 1,564,900 Share Price $48.47 Est. Cost/Share $27.34 Unrealized @ Report Date +75.6%

— AIMMUNE THERAPEUTICS INC 3.3%

Value $55.45M Shares 3,318,212 Share Price $16.71 Est. Cost/Share $22.84 Unrealized @ Report Date —

— ALEXION PHARMACEUTICALS INC 3.0%

Value $49.91M Shares 444,629 Share Price $112.24 Est. Cost/Share $121.54 Unrealized @ Report Date —

— MOMENTA PHARMACEUTICALS INC 3.0%

Value $49.22M Shares 1,479,524 Share Price $33.27 Est. Cost/Share $14.06 Unrealized @ Report Date —

VNDA VANDA PHARMACEUTICALS INC 2.8%

Value $47.09M Shares 4,116,548 Share Price $11.44 Est. Cost/Share $11.21 Unrealized @ Report Date +1.0%

— REVANCE THERAPEUTICS INC 2.5%

Value $41.62M Shares 1,704,372 Share Price $24.42 Est. Cost/Share $21.02 Unrealized @ Report Date —

— CLOVIS ONCOLOGY INC 1.8%

Value $29.44M Shares 4,361,411 Share Price $6.75 Est. Cost/Share $48.59 Unrealized @ Report Date —

— SAGE THERAPEUTICS INC 1.4%

Value $23.92M Shares 575,200 Share Price $41.58 Est. Cost/Share $48.62 Unrealized @ Report Date —

— AMAG PHARMACEUTICALS INC 1.4%

Value $22.64M Shares 2,959,587 Share Price $7.65 Est. Cost/Share $29.07 Unrealized @ Report Date —

ALGN ALIGN TECHNOLOGY INC 1.1%

Value $18.53M Shares 67,505 Share Price $274.44 * Est. Cost/Share $114.31 Unrealized @ Report Date +97.0%

PBYI PUMA BIOTECHNOLOGY INC 0.8%

Value $14.02M Shares 1,343,897 Share Price $10.43 Est. Cost/Share $28.26 Unrealized @ Report Date -63.4%

— DICERNA PHARMACEUTICALS INC 0.5%

Value $8.428M Shares 331,813 Share Price $25.40 Est. Cost/Share $5.39 Unrealized @ Report Date —

PRTA PROTHENA CORP PLC 0.5%

Value $8.065M Shares 771,065 Share Price $10.46 * Est. Cost/Share $32.98 Unrealized @ Report Date -66.3%

— RIGEL PHARMACEUTICALS INC 0.4%

Value $6.483M Shares 3,542,551 Share Price $1.83 Est. Cost/Share $3.40 Unrealized @ Report Date —

KLDO KALEIDO BIOSCIENCES INC 0.4%

Value $5.843M Shares 786,400 Share Price $7.43 * Est. Cost/Share $13.76 Unrealized @ Report Date -51.3%

CYTK CYTOKINETICS INC 0.2%

Value $2.915M Shares 123,686 Share Price $23.57 * Est. Cost/Share $6.71 Unrealized @ Report Date +179.3%

— ZOGENIX INC 0.2%

Value $2.812M Shares 104,100 Share Price $27.01 Est. Cost/Share $23.14 Unrealized @ Report Date —

GOSS GOSSAMER BIO INC 0.2%

Value $2.655M Shares 204,214 Share Price $13.00 * Est. Cost/Share $12.58 Unrealized @ Report Date 0.0%

— ATHENEX INC 0.2%

Value $2.548M Shares 185,200 Share Price $13.76 Est. Cost/Share $13.76 Unrealized @ Report Date —

SNDX SYNDAX PHARMACEUTICALS INC 0.1%

Value $1.893M Shares 127,700 Share Price $14.82 * Est. Cost/Share $12.20 Unrealized @ Report Date +24.8%

— APREA THERAPEUTICS INC 0.1%

Value $1.832M Shares 47,234 Share Price $38.79 Est. Cost/Share $38.79 Unrealized @ Report Date —

— MAGENTA THERAPEUTICS INC 0.1%

Value $1.461M Shares 194,600 Share Price $7.51 Est. Cost/Share $7.51 Unrealized @ Report Date —

— ALIMERA SCIENCES INC 0.1%

Value $1.266M Shares 200,919 Share Price $6.30 Est. Cost/Share $6.30 Unrealized @ Report Date —

— KEZAR LIFE SCIENCES INC 0.1%

Value $1.062M Shares 205,086 Share Price $5.18 Est. Cost/Share $5.18 Unrealized @ Report Date —

— INTRA-CELLULAR THERAPIES INC 0.1%

Value $960K Shares 37,400 Share Price $25.67 Est. Cost/Share $34.30 Unrealized @ Report Date —

— RETROPHIN INC 0.1%

Value $959K Shares 47,000 Share Price $20.40 Est. Cost/Share $14.60 Unrealized @ Report Date —

URGN UROGEN PHARMA LTD 0.0%

Value $640K Shares 24,500 Share Price $26.12 * Est. Cost/Share $27.01 Unrealized @ Report Date -9.5%

— MARINUS PHARMACEUTICALS INC 0.0%

Value $318K Shares 125,321 Share Price $2.54 Est. Cost/Share $4.17 Unrealized @ Report Date —

— SUNESIS PHARMACEUTICALS INC 0.0%

Value $306K Shares 1,162,473 Share Price $0.26 Est. Cost/Share $4.37 Unrealized @ Report Date —

ALDX ALDEYRA THERAPEUTICS INC 0.0%

Value $306K Shares 73,500 Share Price $4.16 * Est. Cost/Share $7.53 Unrealized @ Report Date -51.5%

— IDERA PHARMACEUTICALS INC 0.0%

Value $138K Shares 77,044 Share Price $1.79 Est. Cost/Share $8.90 Unrealized @ Report Date —

— MINERVA NEUROSCIENCES INC 0.0%

Value $131K Shares 36,319 Share Price $3.61 Est. Cost/Share $5.62 Unrealized @ Report Date —

Ticker	Issuer	Shares	Value	%	Share Price	Est. Cost/Share	Unrealized @ Report Date	Class	CUSIP
—	IMMUNOMEDICS INC	5,182,983	$184M	11.0%	$35.44	$13.38	—	COM	452907108
STAA	STAAR SURGICAL CO	2,821,154	$174M	10.4%	$61.54 *	$13.06	+212.8%	COM	852312305
BMRN	BIOMARIN PHARMACEUTICAL INC	1,405,950	$173M	10.4%	$123.34 *	$80.19	+23.9%	COM	09061G101
INSM	INSMED INC	6,002,289	$165M	9.9%	$27.54 *	$17.16	+38.1%	COM	457669307
—	ABIOMED INC	492,333	$119M	7.1%	$241.56	$37.80	—	COM	003654100
FOLD	AMICUS THERAPEUTICS INC	7,334,714	$111M	6.6%	$15.08 *	$7.59	+60.5%	COM	03152W109
UTHR	UNITED THERAPEUTICS CORP	766,406	$92.73M	5.6%	$121.00 *	$88.73	+26.8%	COM	91307C102
—	EPIZYME INC	5,513,676	$88.55M	5.3%	$16.06	$15.12	—	COM	29428V104
—	KARYOPHARM THERAPEUTICS INC	4,219,452	$79.92M	4.8%	$18.94	$17.42	—	COM	48576U106
ACAD	ACADIA PHARMACEUTICALS INC	1,564,900	$75.85M	4.6%	$48.47	$27.34	+75.6%	COM	004225108
—	AIMMUNE THERAPEUTICS INC	3,318,212	$55.45M	3.3%	$16.71	$22.84	—	COM	00900T107
—	ALEXION PHARMACEUTICALS INC	444,629	$49.91M	3.0%	$112.24	$121.54	—	COM	015351109
—	MOMENTA PHARMACEUTICALS INC	1,479,524	$49.22M	3.0%	$33.27	$14.06	—	COM	60877T100
VNDA	VANDA PHARMACEUTICALS INC	4,116,548	$47.09M	2.8%	$11.44	$11.21	+1.0%	COM	921659108
—	REVANCE THERAPEUTICS INC	1,704,372	$41.62M	2.5%	$24.42	$21.02	—	COM	761330109
—	CLOVIS ONCOLOGY INC	4,361,411	$29.44M	1.8%	$6.75	$48.59	—	COM	189464100
—	SAGE THERAPEUTICS INC	575,200	$23.92M	1.4%	$41.58	$48.62	—	COM	78667J108
—	AMAG PHARMACEUTICALS INC	2,959,587	$22.64M	1.4%	$7.65	$29.07	—	COM	00163U106
ALGN	ALIGN TECHNOLOGY INC	67,505	$18.53M	1.1%	$274.44 *	$114.31	+97.0%	COM	016255101
PBYI	PUMA BIOTECHNOLOGY INC	1,343,897	$14.02M	0.8%	$10.43	$28.26	-63.4%	COM	74587V107
—	DICERNA PHARMACEUTICALS INC	331,813	$8.428M	0.5%	$25.40	$5.39	—	COM	253031108
PRTA	PROTHENA CORP PLC	771,065	$8.065M	0.5%	$10.46 *	$32.98	-66.3%	COM	G72800108
—	RIGEL PHARMACEUTICALS INC	3,542,551	$6.483M	0.4%	$1.83	$3.40	—	COM	766559603
KLDO	KALEIDO BIOSCIENCES INC	786,400	$5.843M	0.4%	$7.43 *	$13.76	-51.3%	COM	483347100
CYTK	CYTOKINETICS INC	123,686	$2.915M	0.2%	$23.57 *	$6.71	+179.3%	COM	23282W605
—	ZOGENIX INC	104,100	$2.812M	0.2%	$27.01	$23.14	—	COM	98978L204
GOSS	GOSSAMER BIO INC	204,214	$2.655M	0.2%	$13.00 *	$12.58	0.0%	COM	38341P102
—	ATHENEX INC	185,200	$2.548M	0.2%	$13.76	$13.76	—	COM	04685N103
SNDX	SYNDAX PHARMACEUTICALS INC	127,700	$1.893M	0.1%	$14.82 *	$12.20	+24.8%	COM	87164F105
—	APREA THERAPEUTICS INC	47,234	$1.832M	0.1%	$38.79	$38.79	—	COM	03836J102
—	MAGENTA THERAPEUTICS INC	194,600	$1.461M	0.1%	$7.51	$7.51	—	COM	55910K108
—	ALIMERA SCIENCES INC	200,919	$1.266M	0.1%	$6.30	$6.30	—	COM	016259202
—	KEZAR LIFE SCIENCES INC	205,086	$1.062M	0.1%	$5.18	$5.18	—	COM	49372L100
—	INTRA-CELLULAR THERAPIES INC	37,400	$960K	0.1%	$25.67	$34.30	—	COM	46116X101
—	RETROPHIN INC	47,000	$959K	0.1%	$20.40	$14.60	—	COM	761299106
URGN	UROGEN PHARMA LTD	24,500	$640K	0.0%	$26.12 *	$27.01	-9.5%	COM	M96088105
—	MARINUS PHARMACEUTICALS INC	125,321	$318K	0.0%	$2.54	$4.17	—	COM	56854Q101
—	SUNESIS PHARMACEUTICALS INC	1,162,473	$306K	0.0%	$0.26	$4.37	—	COM	867328700
ALDX	ALDEYRA THERAPEUTICS INC	73,500	$306K	0.0%	$4.16 *	$7.53	-51.5%	COM	01438T106
—	IDERA PHARMACEUTICALS INC	77,044	$138K	0.0%	$1.79	$8.90	—	COM	45168K405
—	MINERVA NEUROSCIENCES INC	36,319	$131K	0.0%	$3.61	$5.62	—	COM	603380106