5AM Venture Management, LLC Long-Term Concentrated

CIK: 0001799883 · Show all filings

Period: Q3 2025 (← Previous) (Next →)

Filing Date: Nov 14, 2025

Total Value ($000): $273,045 (100.0% shares, 0.0% debt)

Holdings (25)

SKYE SKYE BIOSCIENCE INC 13.9%

Value ($000) $38,049 Shares 9,681,763 Est. Cost $11.84 Unrealized -68.1%

TRDA ENTRADA THERAPEUTICS INC 9.0%

Value ($000) $24,687 Shares 4,256,379 Est. Cost $17.12 Unrealized —

PHVS PHARVARIS N V 7.3%

Value ($000) $19,900 Shares 797,600 Est. Cost $19.05 Unrealized +16.4%

CAMP CAMP4 THERAPEUTICS CORP 6.4%

Value ($000) $17,607 Shares 5,869,091 Est. Cost $5.03 Unrealized -63.2%

CNTA CENTESSA PHARMACEUTICALS PLC 6.0%

Value ($000) $16,513 Shares 680,945 Est. Cost $11.45 Unrealized —

VRDN VIRIDIAN THERAPEUTICS INC 5.8%

Value ($000) $15,896 Shares 736,595 Est. Cost $17.93 Unrealized +0.6%

ELVN ENLIVEN THERAPEUTICS INC 5.8%

Value ($000) $15,813 Shares 772,477 Est. Cost $20.34 Unrealized -0.9%

EYPT EYEPOINT PHARMACEUTICALS INC 5.5%

Value ($000) $14,952 Shares 1,050,000 Est. Cost $9.03 Unrealized +27.5%

DNTH DIANTHUS THERAPEUTICS INC 5.3%

Value ($000) $14,365 Shares 365,053 Est. Cost $12.62 Unrealized +102.6%

TYRA TYRA BIOSCIENCES INC 4.8%

Value ($000) $13,141 Shares 939,298 Est. Cost $15.18 Unrealized -24.9%

CLDX CELLDEX THERAPEUTICS INC NEW 4.7%

Value ($000) $12,864 Shares 497,270 Est. Cost $32.09 Unrealized -27.8%

ERAS ERASCA INC 4.3%

Value ($000) $11,784 Shares 5,405,404 Est. Cost $2.16 Unrealized -26.3%

PRAX PRAXIS PRECISION MEDICINES I 3.3%

Value ($000) $9,010 Shares 170,000 Est. Cost $44.86 Unrealized +8.1%

GHRS GH RESEARCH PLC 3.0%

Value ($000) $8,189 Shares 572,665 Est. Cost $10.15 Unrealized +37.8%

TECX TECTONIC THERAPEUTIC INC 2.9%

Value ($000) $8,028 Shares 511,660 Est. Cost $15.77 Unrealized +30.9%

BHVN BIOHAVEN LTD 2.6%

Value ($000) $7,189 Shares 478,972 Est. Cost $33.89 Unrealized -57.0%

ARTV ARTIVA BIOTHERAPEUTICS INC 2.5%

Value ($000) $6,754 Shares 2,353,304 Est. Cost $11.59 Unrealized -76.9%

SRZN SURROZEN INC 1.5%

Value ($000) $3,994 Shares 310,000 Est. Cost $11.62 Unrealized -9.8%

TARA PROTARA THERAPEUTICS INC 1.3%

Value ($000) $3,480 Shares 800,000 Est. Cost $3.23 Unrealized +0.2%

ALEC ALECTOR INC 1.1%

Value ($000) $2,948 Shares 995,841 Est. Cost $3.76 Unrealized -41.5%

SLN SILENCE THERAPEUTICS PLC 0.9%

Value ($000) $2,471 Shares 476,200 Est. Cost $21.60 Unrealized —

— ADVERUM BIOTECHNOLOGIES INC 0.9%

Value ($000) $2,454 Shares 541,666 Est. Cost $14.14 Unrealized —

— RALLYBIO CORP 0.7%

Value ($000) $1,812 Shares 3,630,724 Est. Cost $17.58 Unrealized —

ZNTL ZENTALIS PHARMACEUTICALS INC 0.3%

Value ($000) $740 Shares 490,000 Est. Cost $23.99 Unrealized -93.8%

— MERSANA THERAPEUTICS INC 0.1%

Value ($000) $405 Shares 52,200 Est. Cost $7.76 Unrealized —

Ticker	Issuer	Shares	Value ($000)	%	Est. Cost	Unrealized	Class	CUSIP
SKYE	SKYE BIOSCIENCE INC	9,681,763	$38,049	13.9%	$11.84	-68.1%	COM NEW	83086J200
TRDA	ENTRADA THERAPEUTICS INC	4,256,379	$24,687	9.0%	$17.12	—	COM	29384C108
PHVS	PHARVARIS N V	797,600	$19,900	7.3%	$19.05	+16.4%	COM	N69605108
CAMP	CAMP4 THERAPEUTICS CORP	5,869,091	$17,607	6.4%	$5.03	-63.2%	COM	13463J101
CNTA	CENTESSA PHARMACEUTICALS PLC	680,945	$16,513	6.0%	$11.45	—	SPONSORED ADS	152309100
VRDN	VIRIDIAN THERAPEUTICS INC	736,595	$15,896	5.8%	$17.93	+0.6%	COM	92790C104
ELVN	ENLIVEN THERAPEUTICS INC	772,477	$15,813	5.8%	$20.34	-0.9%	COM	29337E102
EYPT	EYEPOINT PHARMACEUTICALS INC	1,050,000	$14,952	5.5%	$9.03	+27.5%	COM NEW	30233G209
DNTH	DIANTHUS THERAPEUTICS INC	365,053	$14,365	5.3%	$12.62	+102.6%	COM	252828108
TYRA	TYRA BIOSCIENCES INC	939,298	$13,141	4.8%	$15.18	-24.9%	COM	90240B106
CLDX	CELLDEX THERAPEUTICS INC NEW	497,270	$12,864	4.7%	$32.09	-27.8%	COM NEW	15117B202
ERAS	ERASCA INC	5,405,404	$11,784	4.3%	$2.16	-26.3%	COM	29479A108
PRAX	PRAXIS PRECISION MEDICINES I	170,000	$9,010	3.3%	$44.86	+8.1%	COM NEW	74006W207
GHRS	GH RESEARCH PLC	572,665	$8,189	3.0%	$10.15	+37.8%	ORDINARY SHARES	G3855L106
TECX	TECTONIC THERAPEUTIC INC	511,660	$8,028	2.9%	$15.77	+30.9%	COM	878972108
BHVN	BIOHAVEN LTD	478,972	$7,189	2.6%	$33.89	-57.0%	COM	G1110E107
ARTV	ARTIVA BIOTHERAPEUTICS INC	2,353,304	$6,754	2.5%	$11.59	-76.9%	COM	04317A107
SRZN	SURROZEN INC	310,000	$3,994	1.5%	$11.62	-9.8%	COM NEW	86889P208
TARA	PROTARA THERAPEUTICS INC	800,000	$3,480	1.3%	$3.23	+0.2%	COM STK	74365U107
ALEC	ALECTOR INC	995,841	$2,948	1.1%	$3.76	-41.5%	COM	014442107
SLN	SILENCE THERAPEUTICS PLC	476,200	$2,471	0.9%	$21.60	—	ADS	82686Q101
—	ADVERUM BIOTECHNOLOGIES INC	541,666	$2,454	0.9%	$14.14	—	COM NEW	00773U207
—	RALLYBIO CORP	3,630,724	$1,812	0.7%	$17.58	—	COM	75120L100
ZNTL	ZENTALIS PHARMACEUTICALS INC	490,000	$740	0.3%	$23.99	-93.8%	COM	98943L107
—	MERSANA THERAPEUTICS INC	52,200	$405	0.1%	$7.76	—	COM	59045L205