5AM Venture Management, LLC Long-Term Concentrated

Location: San Francisco, CA

CIK: 0001799883 · Show all filings

Period: Q3 2025 (← Previous) (Next →)

Filing Date: Nov 14, 2025

Total Value: $273M (100.0% shares, 0.0% debt)

Holdings (25)

SKYE SKYE BIOSCIENCE INC 13.9%

Value $38.05M Shares 9,681,763 Est. Cost $11.84 Unrealized -68.1%

TRDA ENTRADA THERAPEUTICS INC 9.0%

Value $24.69M Shares 4,256,379 Est. Cost $17.12 Unrealized —

PHVS PHARVARIS N V 7.3%

Value $19.9M Shares 797,600 Est. Cost $19.05 Unrealized +16.4%

CAMP CAMP4 THERAPEUTICS CORP 6.4%

Value $17.61M Shares 5,869,091 Est. Cost $5.03 Unrealized -63.2%

CNTA CENTESSA PHARMACEUTICALS PLC 6.0%

Value $16.51M Shares 680,945 Est. Cost $11.45 Unrealized —

VRDN VIRIDIAN THERAPEUTICS INC 5.8%

Value $15.9M Shares 736,595 Est. Cost $17.93 Unrealized +0.6%

ELVN ENLIVEN THERAPEUTICS INC 5.8%

Value $15.81M Shares 772,477 Est. Cost $20.34 Unrealized -0.9%

EYPT EYEPOINT PHARMACEUTICALS INC 5.5%

Value $14.95M Shares 1,050,000 Est. Cost $9.03 Unrealized +27.5%

DNTH DIANTHUS THERAPEUTICS INC 5.3%

Value $14.36M Shares 365,053 Est. Cost $12.62 Unrealized +102.6%

TYRA TYRA BIOSCIENCES INC 4.8%

Value $13.14M Shares 939,298 Est. Cost $15.18 Unrealized -24.9%

CLDX CELLDEX THERAPEUTICS INC NEW 4.7%

Value $12.86M Shares 497,270 Est. Cost $32.09 Unrealized -27.8%

ERAS ERASCA INC 4.3%

Value $11.78M Shares 5,405,404 Est. Cost $2.16 Unrealized -26.3%

PRAX PRAXIS PRECISION MEDICINES I 3.3%

Value $9.01M Shares 170,000 Est. Cost $44.86 Unrealized +8.1%

GHRS GH RESEARCH PLC 3.0%

Value $8.189M Shares 572,665 Est. Cost $10.15 Unrealized +37.8%

TECX TECTONIC THERAPEUTIC INC 2.9%

Value $8.028M Shares 511,660 Est. Cost $15.77 Unrealized +30.9%

BHVN BIOHAVEN LTD 2.6%

Value $7.189M Shares 478,972 Est. Cost $33.89 Unrealized -57.0%

ARTV ARTIVA BIOTHERAPEUTICS INC 2.5%

Value $6.754M Shares 2,353,304 Est. Cost $11.59 Unrealized -76.9%

SRZN SURROZEN INC 1.5%

Value $3.994M Shares 310,000 Est. Cost $11.62 Unrealized -9.8%

TARA PROTARA THERAPEUTICS INC 1.3%

Value $3.48M Shares 800,000 Est. Cost $3.23 Unrealized +0.2%

ALEC ALECTOR INC 1.1%

Value $2.948M Shares 995,841 Est. Cost $3.76 Unrealized -41.5%

SLN SILENCE THERAPEUTICS PLC 0.9%

Value $2.471M Shares 476,200 Est. Cost $21.60 Unrealized —

— ADVERUM BIOTECHNOLOGIES INC 0.9%

Value $2.454M Shares 541,666 Est. Cost $14.14 Unrealized —

— RALLYBIO CORP 0.7%

Value $1.812M Shares 3,630,724 Est. Cost $17.58 Unrealized —

ZNTL ZENTALIS PHARMACEUTICALS INC 0.3%

Value $740K Shares 490,000 Est. Cost $23.99 Unrealized -93.8%

— MERSANA THERAPEUTICS INC 0.1%

Value $405K Shares 52,200 Est. Cost $7.76 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
SKYE	SKYE BIOSCIENCE INC	9,681,763	$38.05M	13.9%	$11.84	-68.1%	COM NEW	83086J200
TRDA	ENTRADA THERAPEUTICS INC	4,256,379	$24.69M	9.0%	$17.12	—	COM	29384C108
PHVS	PHARVARIS N V	797,600	$19.9M	7.3%	$19.05	+16.4%	COM	N69605108
CAMP	CAMP4 THERAPEUTICS CORP	5,869,091	$17.61M	6.4%	$5.03	-63.2%	COM	13463J101
CNTA	CENTESSA PHARMACEUTICALS PLC	680,945	$16.51M	6.0%	$11.45	—	SPONSORED ADS	152309100
VRDN	VIRIDIAN THERAPEUTICS INC	736,595	$15.9M	5.8%	$17.93	+0.6%	COM	92790C104
ELVN	ENLIVEN THERAPEUTICS INC	772,477	$15.81M	5.8%	$20.34	-0.9%	COM	29337E102
EYPT	EYEPOINT PHARMACEUTICALS INC	1,050,000	$14.95M	5.5%	$9.03	+27.5%	COM NEW	30233G209
DNTH	DIANTHUS THERAPEUTICS INC	365,053	$14.36M	5.3%	$12.62	+102.6%	COM	252828108
TYRA	TYRA BIOSCIENCES INC	939,298	$13.14M	4.8%	$15.18	-24.9%	COM	90240B106
CLDX	CELLDEX THERAPEUTICS INC NEW	497,270	$12.86M	4.7%	$32.09	-27.8%	COM NEW	15117B202
ERAS	ERASCA INC	5,405,404	$11.78M	4.3%	$2.16	-26.3%	COM	29479A108
PRAX	PRAXIS PRECISION MEDICINES I	170,000	$9.01M	3.3%	$44.86	+8.1%	COM NEW	74006W207
GHRS	GH RESEARCH PLC	572,665	$8.189M	3.0%	$10.15	+37.8%	ORDINARY SHARES	G3855L106
TECX	TECTONIC THERAPEUTIC INC	511,660	$8.028M	2.9%	$15.77	+30.9%	COM	878972108
BHVN	BIOHAVEN LTD	478,972	$7.189M	2.6%	$33.89	-57.0%	COM	G1110E107
ARTV	ARTIVA BIOTHERAPEUTICS INC	2,353,304	$6.754M	2.5%	$11.59	-76.9%	COM	04317A107
SRZN	SURROZEN INC	310,000	$3.994M	1.5%	$11.62	-9.8%	COM NEW	86889P208
TARA	PROTARA THERAPEUTICS INC	800,000	$3.48M	1.3%	$3.23	+0.2%	COM STK	74365U107
ALEC	ALECTOR INC	995,841	$2.948M	1.1%	$3.76	-41.5%	COM	014442107
SLN	SILENCE THERAPEUTICS PLC	476,200	$2.471M	0.9%	$21.60	—	ADS	82686Q101
—	ADVERUM BIOTECHNOLOGIES INC	541,666	$2.454M	0.9%	$14.14	—	COM NEW	00773U207
—	RALLYBIO CORP	3,630,724	$1.812M	0.7%	$17.58	—	COM	75120L100
ZNTL	ZENTALIS PHARMACEUTICALS INC	490,000	$740K	0.3%	$23.99	-93.8%	COM	98943L107
—	MERSANA THERAPEUTICS INC	52,200	$405K	0.1%	$7.76	—	COM	59045L205