Paradigm Biocapital Advisors LP Quant / Systematic

Location: New York, NY

CIK: 0001855655 · Show all filings

Period: Q2 2024 (← Previous) (Next →)

Filing Date: Aug 14, 2024

Total Value: $2.613B (100.0% shares, 0.0% debt)

Holdings (35)

NUVL NUVALENT INC 13.3%

Value $347M Shares 4,571,678 Est. Cost $56.04 Unrealized +26.9%

ARGX ARGENX SE 8.9%

Value $231M Shares 538,139 Est. Cost $406.28 Unrealized —

ACLX ARCELLX INC 8.1%

Value $212M Shares 3,848,095 Est. Cost $34.61 Unrealized +57.0%

RVMD REVOLUTION MEDICINES INC 7.8%

Value $204M Shares 5,259,089 Est. Cost $33.09 Unrealized +13.0%

SRPT SAREPTA THERAPEUTICS INC 5.7%

Value $150M Shares 947,574 Est. Cost $122.50 Unrealized +4.9%

IRON DISC MEDICINE INC 4.7%

Value $122M Shares 2,704,718 Est. Cost $48.64 Unrealized -30.1%

— MERUS N V 4.6%

Value $120M Shares 2,019,814 Est. Cost $59.17 Unrealized —

CRNX CRINETICS PHARMACEUTICALS IN 4.3%

Value $113M Shares 2,513,302 Est. Cost $25.24 Unrealized +83.0%

— CEREVEL THERAPEUTICS HLDNG I 3.6%

Value $95.29M Shares 2,330,508 Est. Cost $24.52 Unrealized —

KURA KURA ONCOLOGY INC 3.6%

Value $93.47M Shares 4,539,381 Est. Cost $17.57 Unrealized +17.0%

ASND ASCENDIS PHARMA A/S 3.5%

Value $90.6M Shares 664,307 Est. Cost $134.34 Unrealized —

OLMA OLEMA PHARMACEUTICALS INC 3.3%

Value $85.52M Shares 7,903,600 Est. Cost $7.68 Unrealized +41.2%

XENE XENON PHARMACEUTICALS INC 3.0%

Value $79.67M Shares 2,043,280 Est. Cost $38.31 Unrealized +4.3%

TARS TARSUS PHARMACEUTICALS INC 2.5%

Value $66.19M Shares 2,435,416 Est. Cost $24.85 Unrealized +35.3%

JANX JANUX THERAPEUTICS INC 2.5%

Value $65.53M Shares 1,564,452 Est. Cost $46.95 Unrealized 0.0%

ARVN ARVINAS INC 2.5%

Value $64.9M Shares 2,438,149 Est. Cost $36.46 Unrealized -12.6%

LEGN LEGEND BIOTECH CORP 2.0%

Value $53.29M Shares 1,203,308 Est. Cost $50.82 Unrealized —

PCVX VAXCYTE INC 1.8%

Value $47.36M Shares 627,202 Est. Cost $69.25 Unrealized -1.7%

— Y-MABS THERAPEUTICS INC 1.8%

Value $46.76M Shares 3,870,594 Est. Cost $14.49 Unrealized —

EWTX EDGEWISE THERAPEUTICS INC 1.6%

Value $41.88M Shares 2,325,449 Est. Cost $15.89 Unrealized +9.7%

IMTX IMMATICS N.V 1.5%

Value $39.76M Shares 3,421,965 Est. Cost $10.19 Unrealized +10.6%

VRDN VIRIDIAN THERAPEUTICS INC 1.4%

Value $37.68M Shares 2,896,349 Est. Cost $19.51 Unrealized -29.1%

IMVT IMMUNOVANT INC 1.4%

Value $35.98M Shares 1,362,827 Est. Cost $33.16 Unrealized -14.2%

COGT COGENT BIOSCIENCES INC 1.2%

Value $30.55M Shares 3,624,342 Est. Cost $7.58 Unrealized 0.0%

BBIO BRIDGEBIO PHARMA INC 1.1%

Value $27.6M Shares 1,089,492 Est. Cost $27.34 Unrealized 0.0%

CGEM CULLINAN THERAPEUTICS INC 1.0%

Value $26.91M Shares 1,542,805 Est. Cost $16.19 Unrealized +31.5%

ERAS ERASCA INC 0.7%

Value $17.11M Shares 7,250,000 Est. Cost $2.16 Unrealized 0.0%

CMPS COMPASS PATHWAYS PLC 0.5%

Value $14.11M Shares 2,335,926 Est. Cost $7.96 Unrealized —

APGE APOGEE THERAPEUTICS INC 0.5%

Value $12.99M Shares 330,000 Est. Cost $43.66 Unrealized +11.2%

— VERONA PHARMA PLC 0.4%

Value $10.43M Shares 721,087 Est. Cost $14.46 Unrealized —

ALXO ALX ONCOLOGY HLDGS INC 0.4%

Value $9.501M Shares 1,575,605 Est. Cost $12.30 Unrealized 0.0%

CATX PERSPECTIVE THERAPEUTICS INC 0.4%

Value $9.169M Shares 919,692 Est. Cost $14.46 Unrealized 0.0%

— VOR BIOPHARMA INC 0.2%

Value $6.457M Shares 6,457,293 Est. Cost $6.84 Unrealized —

ACRV ACRIVON THERAPEUTICS INC 0.1%

Value $3.826M Shares 659,724 Est. Cost $8.05 Unrealized 0.0%

TCRX TSCAN THERAPEUTICS INC 0.1%

Value $2.07M Shares 353,886 Est. Cost $7.88 Unrealized 0.0%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
NUVL	NUVALENT INC	4,571,678	$347M	13.3%	$56.04	+26.9%	COM	670703107
ARGX	ARGENX SE	538,139	$231M	8.9%	$406.28	—	SPONSORED ADR	04016X101
ACLX	ARCELLX INC	3,848,095	$212M	8.1%	$34.61	+57.0%	COMMON STOCK	03940C100
RVMD	REVOLUTION MEDICINES INC	5,259,089	$204M	7.8%	$33.09	+13.0%	COM	76155X100
SRPT	SAREPTA THERAPEUTICS INC	947,574	$150M	5.7%	$122.50	+4.9%	COM	803607100
IRON	DISC MEDICINE INC	2,704,718	$122M	4.7%	$48.64	-30.1%	COM	254604101
—	MERUS N V	2,019,814	$120M	4.6%	$59.17	—	COM	N5749R100
CRNX	CRINETICS PHARMACEUTICALS IN	2,513,302	$113M	4.3%	$25.24	+83.0%	COM	22663K107
—	CEREVEL THERAPEUTICS HLDNG I	2,330,508	$95.29M	3.6%	$24.52	—	COM	15678U128
KURA	KURA ONCOLOGY INC	4,539,381	$93.47M	3.6%	$17.57	+17.0%	COM	50127T109
ASND	ASCENDIS PHARMA A/S	664,307	$90.6M	3.5%	$134.34	—	SPONSORED ADR	04351P101
OLMA	OLEMA PHARMACEUTICALS INC	7,903,600	$85.52M	3.3%	$7.68	+41.2%	COM	68062P106
XENE	XENON PHARMACEUTICALS INC	2,043,280	$79.67M	3.0%	$38.31	+4.3%	COM	98420N105
TARS	TARSUS PHARMACEUTICALS INC	2,435,416	$66.19M	2.5%	$24.85	+35.3%	COM	87650L103
JANX	JANUX THERAPEUTICS INC	1,564,452	$65.53M	2.5%	$46.95	0.0%	COM	47103J105
ARVN	ARVINAS INC	2,438,149	$64.9M	2.5%	$36.46	-12.6%	COM	04335A105
LEGN	LEGEND BIOTECH CORP	1,203,308	$53.29M	2.0%	$50.82	—	SPONSORED ADS	52490G102
PCVX	VAXCYTE INC	627,202	$47.36M	1.8%	$69.25	-1.7%	COM	92243G108
—	Y-MABS THERAPEUTICS INC	3,870,594	$46.76M	1.8%	$14.49	—	COM	984241109
EWTX	EDGEWISE THERAPEUTICS INC	2,325,449	$41.88M	1.6%	$15.89	+9.7%	COM	28036F105
IMTX	IMMATICS N.V	3,421,965	$39.76M	1.5%	$10.19	+10.6%	SHS	N44445109
VRDN	VIRIDIAN THERAPEUTICS INC	2,896,349	$37.68M	1.4%	$19.51	-29.1%	COM	92790C104
IMVT	IMMUNOVANT INC	1,362,827	$35.98M	1.4%	$33.16	-14.2%	COM	45258J102
COGT	COGENT BIOSCIENCES INC	3,624,342	$30.55M	1.2%	$7.58	0.0%	COM	19240Q201
BBIO	BRIDGEBIO PHARMA INC	1,089,492	$27.6M	1.1%	$27.34	0.0%	COM	10806X102
CGEM	CULLINAN THERAPEUTICS INC	1,542,805	$26.91M	1.0%	$16.19	+31.5%	COM	230031106
ERAS	ERASCA INC	7,250,000	$17.11M	0.7%	$2.16	0.0%	COM	29479A108
CMPS	COMPASS PATHWAYS PLC	2,335,926	$14.11M	0.5%	$7.96	—	SPONSORED ADS	20451W101
APGE	APOGEE THERAPEUTICS INC	330,000	$12.99M	0.5%	$43.66	+11.2%	COM	03770N101
—	VERONA PHARMA PLC	721,087	$10.43M	0.4%	$14.46	—	SPONSORED ADS	925050106
ALXO	ALX ONCOLOGY HLDGS INC	1,575,605	$9.501M	0.4%	$12.30	0.0%	COM	00166B105
CATX	PERSPECTIVE THERAPEUTICS INC	919,692	$9.169M	0.4%	$14.46	0.0%	COM NEW	46489V302
—	VOR BIOPHARMA INC	6,457,293	$6.457M	0.2%	$6.84	—	COM	929033108
ACRV	ACRIVON THERAPEUTICS INC	659,724	$3.826M	0.1%	$8.05	0.0%	COMMON STOCK	004890109
TCRX	TSCAN THERAPEUTICS INC	353,886	$2.07M	0.1%	$7.88	0.0%	COM	89854M101