Paradigm Biocapital Advisors LP Quant / Systematic

Location: New York, NY

CIK: 0001855655 · Show all filings

Period: Q3 2024 (← Previous) (Next →)

Filing Date: Nov 14, 2024

Total Value: $2.956B (100.0% shares, 0.0% debt)

Holdings (33)

NUVL NUVALENT INC 17.3%

Value $512M Shares 5,000,000 Est. Cost $58.34 Unrealized +42.2%

ACLX ARCELLX INC 11.3%

Value $334M Shares 4,000,000 Est. Cost $35.83 Unrealized +85.9%

ARGX ARGENX SE 8.8%

Value $260M Shares 480,374 Est. Cost $406.28 Unrealized —

RVMD REVOLUTION MEDICINES INC 8.2%

Value $241M Shares 5,314,089 Est. Cost $33.20 Unrealized +31.2%

CRNX CRINETICS PHARMACEUTICALS IN 4.4%

Value $129M Shares 2,516,686 Est. Cost $25.24 Unrealized +104.3%

— MERUS N V 4.1%

Value $123M Shares 2,454,917 Est. Cost $57.54 Unrealized —

JANX JANUX THERAPEUTICS INC 3.7%

Value $109M Shares 2,400,574 Est. Cost $45.75 Unrealized -4.9%

KURA KURA ONCOLOGY INC 2.9%

Value $84.63M Shares 4,331,321 Est. Cost $17.57 Unrealized +15.3%

TARS TARSUS PHARMACEUTICALS INC 2.7%

Value $80.27M Shares 2,440,445 Est. Cost $24.85 Unrealized +13.1%

EWTX EDGEWISE THERAPEUTICS INC 2.5%

Value $74.44M Shares 2,789,172 Est. Cost $16.56 Unrealized +20.1%

IRON DISC MEDICINE INC 2.5%

Value $73.6M Shares 1,497,720 Est. Cost $48.64 Unrealized -3.5%

PCVX VAXCYTE INC 2.4%

Value $71.73M Shares 627,732 Est. Cost $69.25 Unrealized +30.1%

ACLX ARCELLX INC 2.3%

Value $66.81M Shares 800,000 Est. Cost $35.83 Unrealized +85.9%

VRDN VIRIDIAN THERAPEUTICS INC 2.2%

Value $65.88M Shares 2,895,689 Est. Cost $19.51 Unrealized -16.2%

OLMA OLEMA PHARMACEUTICALS INC 2.2%

Value $65.71M Shares 5,503,600 Est. Cost $7.68 Unrealized +66.4%

ARVN ARVINAS INC 1.9%

Value $57.63M Shares 2,339,961 Est. Cost $36.46 Unrealized -28.4%

— Y-MABS THERAPEUTICS INC 1.8%

Value $53.74M Shares 4,086,346 Est. Cost $14.42 Unrealized —

COGT COGENT BIOSCIENCES INC 1.7%

Value $49.79M Shares 4,609,762 Est. Cost $8.04 Unrealized +21.0%

VERA VERA THERAPEUTICS INC 1.6%

Value $48.48M Shares 1,096,851 Est. Cost $37.95 Unrealized 0.0%

MLTX MOONLAKE IMMUNOTHERAPEUTICS 1.6%

Value $46.97M Shares 931,480 Est. Cost $46.86 Unrealized 0.0%

ONC BEIGENE LTD 1.5%

Value $44.98M Shares 200,336 Est. Cost $224.51 Unrealized —

IMTX IMMATICS N.V 1.5%

Value $44.55M Shares 3,904,862 Est. Cost $10.40 Unrealized +13.9%

APGE APOGEE THERAPEUTICS INC 1.4%

Value $41.22M Shares 701,817 Est. Cost $45.91 Unrealized +4.4%

IMVT IMMUNOVANT INC 1.3%

Value $38.85M Shares 1,362,827 Est. Cost $33.16 Unrealized -11.1%

CGEM CULLINAN THERAPEUTICS INC 1.3%

Value $38.85M Shares 2,321,013 Est. Cost $16.71 Unrealized +6.2%

SYRE SPYRE THERAPEUTICS INC 1.3%

Value $37.28M Shares 1,267,581 Est. Cost $27.85 Unrealized 0.0%

PLRX PLIANT THERAPEUTICS INC 1.2%

Value $34.8M Shares 3,104,486 Est. Cost $12.51 Unrealized 0.0%

PCVX VAXCYTE INC 1.1%

Value $31.63M Shares 276,800 Est. Cost $69.25 Unrealized +30.1%

KROS KEROS THERAPEUTICS INC 1.0%

Value $30.49M Shares 525,037 Est. Cost $49.39 Unrealized 0.0%

ERAS ERASCA INC 1.0%

Value $29.12M Shares 10,668,141 Est. Cost $2.37 Unrealized +18.9%

ORKA ORUKA THERAPEUTICS INC 0.6%

Value $17.64M Shares 719,660 Est. Cost $34.79 Unrealized 0.0%

CATX PERSPECTIVE THERAPEUTICS INC 0.4%

Value $12.28M Shares 919,692 Est. Cost $14.46 Unrealized -8.0%

CMPS COMPASS PATHWAYS PLC 0.2%

Value $7.308M Shares 1,160,000 Est. Cost $7.96 Unrealized —

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
NUVL	NUVALENT INC	5,000,000	$512M	17.3%	$58.34	+42.2%	COM	670703107
ACLX	ARCELLX INC	4,000,000	$334M	11.3%	$35.83	+85.9%	COMMON STOCK	03940C100
ARGX	ARGENX SE	480,374	$260M	8.8%	$406.28	—	SPONSORED ADR	04016X101
RVMD	REVOLUTION MEDICINES INC	5,314,089	$241M	8.2%	$33.20	+31.2%	COM	76155X100
CRNX	CRINETICS PHARMACEUTICALS IN	2,516,686	$129M	4.4%	$25.24	+104.3%	COM	22663K107
—	MERUS N V	2,454,917	$123M	4.1%	$57.54	—	COM	N5749R100
JANX	JANUX THERAPEUTICS INC	2,400,574	$109M	3.7%	$45.75	-4.9%	COM	47103J105
KURA	KURA ONCOLOGY INC	4,331,321	$84.63M	2.9%	$17.57	+15.3%	COM	50127T109
TARS	TARSUS PHARMACEUTICALS INC	2,440,445	$80.27M	2.7%	$24.85	+13.1%	COM	87650L103
EWTX	EDGEWISE THERAPEUTICS INC	2,789,172	$74.44M	2.5%	$16.56	+20.1%	COM	28036F105
IRON	DISC MEDICINE INC	1,497,720	$73.6M	2.5%	$48.64	-3.5%	COM	254604101
PCVX	VAXCYTE INC	627,732	$71.73M	2.4%	$69.25	+30.1%	COM	92243G108
ACLX	ARCELLX INC	800,000	$66.81M	2.3%	$35.83	+85.9%	Call	03940C100
VRDN	VIRIDIAN THERAPEUTICS INC	2,895,689	$65.88M	2.2%	$19.51	-16.2%	COM	92790C104
OLMA	OLEMA PHARMACEUTICALS INC	5,503,600	$65.71M	2.2%	$7.68	+66.4%	COM	68062P106
ARVN	ARVINAS INC	2,339,961	$57.63M	1.9%	$36.46	-28.4%	COM	04335A105
—	Y-MABS THERAPEUTICS INC	4,086,346	$53.74M	1.8%	$14.42	—	COM	984241109
COGT	COGENT BIOSCIENCES INC	4,609,762	$49.79M	1.7%	$8.04	+21.0%	COM	19240Q201
VERA	VERA THERAPEUTICS INC	1,096,851	$48.48M	1.6%	$37.95	0.0%	CL A	92337R101
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	931,480	$46.97M	1.6%	$46.86	0.0%	CLASS A ORD	61559X104
ONC	BEIGENE LTD	200,336	$44.98M	1.5%	$224.51	—	SPONSORED ADR	07725L102
IMTX	IMMATICS N.V	3,904,862	$44.55M	1.5%	$10.40	+13.9%	SHS	N44445109
APGE	APOGEE THERAPEUTICS INC	701,817	$41.22M	1.4%	$45.91	+4.4%	COM	03770N101
IMVT	IMMUNOVANT INC	1,362,827	$38.85M	1.3%	$33.16	-11.1%	COM	45258J102
CGEM	CULLINAN THERAPEUTICS INC	2,321,013	$38.85M	1.3%	$16.71	+6.2%	COM	230031106
SYRE	SPYRE THERAPEUTICS INC	1,267,581	$37.28M	1.3%	$27.85	0.0%	COM NEW	00773J202
PLRX	PLIANT THERAPEUTICS INC	3,104,486	$34.8M	1.2%	$12.51	0.0%	COM	729139105
PCVX	VAXCYTE INC	276,800	$31.63M	1.1%	$69.25	+30.1%	Call	92243G108
KROS	KEROS THERAPEUTICS INC	525,037	$30.49M	1.0%	$49.39	0.0%	COM	492327101
ERAS	ERASCA INC	10,668,141	$29.12M	1.0%	$2.37	+18.9%	COM	29479A108
ORKA	ORUKA THERAPEUTICS INC	719,660	$17.64M	0.6%	$34.79	0.0%	COM	687604108
CATX	PERSPECTIVE THERAPEUTICS INC	919,692	$12.28M	0.4%	$14.46	-8.0%	COM NEW	46489V302
CMPS	COMPASS PATHWAYS PLC	1,160,000	$7.308M	0.2%	$7.96	—	SPONSORED ADS	20451W101