Paradigm Biocapital Advisors LP Quant / Systematic

Location: New York, NY

CIK: 0001855655 · Show all filings

Period: Q1 2025 (← Previous) (Next →)

Filing Date: May 15, 2025

Total Value: $2.183B (100.0% shares, 0.0% debt)

Holdings (28)

NUVL NUVALENT INC 17.1%

Value $374M Shares 5,269,433 Est. Cost $60.72 Unrealized +28.8%

ACLX ARCELLX INC 13.5%

Value $295M Shares 4,492,032 Est. Cost $40.87 Unrealized +65.8%

RVMD REVOLUTION MEDICINES INC 10.0%

Value $218M Shares 6,178,111 Est. Cost $36.46 Unrealized +11.3%

ONC BEIGENE LTD 8.3%

Value $181M Shares 666,024 Est. Cost $203.25 Unrealized —

— MERUS N V 6.5%

Value $142M Shares 3,369,699 Est. Cost $49.84 Unrealized —

TARS TARSUS PHARMACEUTICALS INC 6.1%

Value $134M Shares 2,610,197 Est. Cost $26.31 Unrealized +87.9%

EWTX EDGEWISE THERAPEUTICS INC 4.4%

Value $96.68M Shares 4,394,556 Est. Cost $22.36 Unrealized +17.3%

JANX JANUX THERAPEUTICS INC 4.1%

Value $89.91M Shares 3,329,909 Est. Cost $48.02 Unrealized -21.5%

CRNX CRINETICS PHARMACEUTICALS IN 3.0%

Value $65.27M Shares 1,946,168 Est. Cost $25.46 Unrealized +46.7%

PCVX VAXCYTE INC 2.9%

Value $64.06M Shares 1,696,481 Est. Cost $85.06 Unrealized -6.0%

IRON DISC MEDICINE INC 2.8%

Value $60.11M Shares 1,210,971 Est. Cost $48.64 Unrealized +14.3%

COGT COGENT BIOSCIENCES INC 2.5%

Value $53.69M Shares 8,963,655 Est. Cost $8.02 Unrealized -2.2%

LENZ LENZ THERAPEUTICS INC 1.8%

Value $38.87M Shares 1,511,932 Est. Cost $27.61 Unrealized -10.8%

APGE APOGEE THERAPEUTICS INC 1.6%

Value $35.93M Shares 961,707 Est. Cost $48.22 Unrealized -19.8%

ARGX ARGENX SE 1.6%

Value $35.32M Shares 59,679 Est. Cost $406.28 Unrealized —

CYTK CYTOKINETICS INC 1.6%

Value $34.51M Shares 858,664 Est. Cost $45.96 Unrealized 0.0%

INSM INSMED INC 1.6%

Value $34.43M Shares 451,359 Est. Cost $76.49 Unrealized 0.0%

SYRE SPYRE THERAPEUTICS INC 1.6%

Value $34.32M Shares 2,127,205 Est. Cost $26.04 Unrealized -20.1%

— METSERA INC 1.5%

Value $32.43M Shares 1,191,462 Est. Cost $27.22 Unrealized —

VRDN VIRIDIAN THERAPEUTICS INC 1.3%

Value $28.24M Shares 2,095,079 Est. Cost $19.19 Unrealized -11.2%

OLMA OLEMA PHARMACEUTICALS INC 1.2%

Value $25.35M Shares 6,741,172 Est. Cost $8.25 Unrealized -39.0%

MLTX MOONLAKE IMMUNOTHERAPEUTICS 1.1%

Value $24.51M Shares 627,423 Est. Cost $48.85 Unrealized -11.8%

ARQT ARCUTIS BIOTHERAPEUTICS INC 1.0%

Value $22.92M Shares 1,465,334 Est. Cost $14.09 Unrealized 0.0%

— Y-MABS THERAPEUTICS INC 0.9%

Value $18.77M Shares 4,236,346 Est. Cost $14.19 Unrealized —

ERAS ERASCA INC 0.7%

Value $14.8M Shares 10,802,354 Est. Cost $2.37 Unrealized -27.6%

EWTX EDGEWISE THERAPEUTICS INC 0.5%

Value $11M Shares 500,000 Est. Cost $22.36 Unrealized +17.3%

OCUL OCULAR THERAPEUTIX INC 0.4%

Value $9.632M Shares 1,314,018 Est. Cost $7.69 Unrealized 0.0%

IMTX IMMATICS N.V 0.4%

Value $8.601M Shares 1,907,108 Est. Cost $9.89 Unrealized -47.3%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
NUVL	NUVALENT INC	5,269,433	$374M	17.1%	$60.72	+28.8%	COM	670703107
ACLX	ARCELLX INC	4,492,032	$295M	13.5%	$40.87	+65.8%	COMMON STOCK	03940C100
RVMD	REVOLUTION MEDICINES INC	6,178,111	$218M	10.0%	$36.46	+11.3%	COM	76155X100
ONC	BEIGENE LTD	666,024	$181M	8.3%	$203.25	—	SPONSORED ADS	07725L102
—	MERUS N V	3,369,699	$142M	6.5%	$49.84	—	COM	N5749R100
TARS	TARSUS PHARMACEUTICALS INC	2,610,197	$134M	6.1%	$26.31	+87.9%	COM	87650L103
EWTX	EDGEWISE THERAPEUTICS INC	4,394,556	$96.68M	4.4%	$22.36	+17.3%	COM	28036F105
JANX	JANUX THERAPEUTICS INC	3,329,909	$89.91M	4.1%	$48.02	-21.5%	COM	47103J105
CRNX	CRINETICS PHARMACEUTICALS IN	1,946,168	$65.27M	3.0%	$25.46	+46.7%	COM	22663K107
PCVX	VAXCYTE INC	1,696,481	$64.06M	2.9%	$85.06	-6.0%	COM	92243G108
IRON	DISC MEDICINE INC	1,210,971	$60.11M	2.8%	$48.64	+14.3%	COM	254604101
COGT	COGENT BIOSCIENCES INC	8,963,655	$53.69M	2.5%	$8.02	-2.2%	COM	19240Q201
LENZ	LENZ THERAPEUTICS INC	1,511,932	$38.87M	1.8%	$27.61	-10.8%	COM	52635N103
APGE	APOGEE THERAPEUTICS INC	961,707	$35.93M	1.6%	$48.22	-19.8%	COM	03770N101
ARGX	ARGENX SE	59,679	$35.32M	1.6%	$406.28	—	SPONSORED ADR	04016X101
CYTK	CYTOKINETICS INC	858,664	$34.51M	1.6%	$45.96	0.0%	COM NEW	23282W605
INSM	INSMED INC	451,359	$34.43M	1.6%	$76.49	0.0%	COM PAR $.01	457669307
SYRE	SPYRE THERAPEUTICS INC	2,127,205	$34.32M	1.6%	$26.04	-20.1%	COM NEW	00773J202
—	METSERA INC	1,191,462	$32.43M	1.5%	$27.22	—	COM	59267L107
VRDN	VIRIDIAN THERAPEUTICS INC	2,095,079	$28.24M	1.3%	$19.19	-11.2%	COM	92790C104
OLMA	OLEMA PHARMACEUTICALS INC	6,741,172	$25.35M	1.2%	$8.25	-39.0%	COM	68062P106
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	627,423	$24.51M	1.1%	$48.85	-11.8%	CLASS A ORD	61559X104
ARQT	ARCUTIS BIOTHERAPEUTICS INC	1,465,334	$22.92M	1.0%	$14.09	0.0%	COM	03969K108
—	Y-MABS THERAPEUTICS INC	4,236,346	$18.77M	0.9%	$14.19	—	COM	984241109
ERAS	ERASCA INC	10,802,354	$14.8M	0.7%	$2.37	-27.6%	COM	29479A108
EWTX	EDGEWISE THERAPEUTICS INC	500,000	$11M	0.5%	$22.36	+17.3%	Call	28036F105
OCUL	OCULAR THERAPEUTIX INC	1,314,018	$9.632M	0.4%	$7.69	0.0%	COM	67576A100
IMTX	IMMATICS N.V	1,907,108	$8.601M	0.4%	$9.89	-47.3%	SHS	N44445109