Paradigm Biocapital Advisors LP Quant / Systematic

Location: New York, NY

CIK: 0001855655 · Show all filings

Period: Q2 2025 (← Previous) (Next →)

Filing Date: Aug 14, 2025

Total Value: $2.342B (100.0% shares, 0.0% debt)

Holdings (28)

NUVL NUVALENT INC 17.2%

Value $402M Shares 5,269,433 Est. Cost $60.72 Unrealized +20.5%

ACLX ARCELLX INC 13.1%

Value $306M Shares 4,649,016 Est. Cost $41.59 Unrealized +49.7%

— MERUS N V 9.6%

Value $225M Shares 4,281,954 Est. Cost $50.43 Unrealized —

RVMD REVOLUTION MEDICINES INC 9.6%

Value $224M Shares 6,093,291 Est. Cost $36.46 Unrealized +5.4%

TARS TARSUS PHARMACEUTICALS INC 5.1%

Value $121M Shares 2,976,099 Est. Cost $28.61 Unrealized +57.3%

PCVX VAXCYTE INC 4.7%

Value $110M Shares 3,372,837 Est. Cost $59.08 Unrealized -44.5%

ONC BEONE MEDICINES LTD 3.6%

Value $84.19M Shares 347,787 Est. Cost $203.25 Unrealized —

EWTX EDGEWISE THERAPEUTICS INC 3.4%

Value $80.53M Shares 6,142,344 Est. Cost $20.10 Unrealized -28.3%

COGT COGENT BIOSCIENCES INC 3.2%

Value $74.33M Shares 10,352,449 Est. Cost $7.69 Unrealized -27.9%

JANX JANUX THERAPEUTICS INC 2.9%

Value $67.46M Shares 2,920,258 Est. Cost $48.02 Unrealized -45.1%

CRNX CRINETICS PHARMACEUTICALS IN 2.9%

Value $67.4M Shares 2,343,553 Est. Cost $26.38 Unrealized +17.1%

IRON DISC MEDICINE INC 2.7%

Value $64.13M Shares 1,210,971 Est. Cost $48.64 Unrealized -3.4%

SRRK SCHOLAR ROCK HLDG CORP 2.4%

Value $56.69M Shares 1,600,554 Est. Cost $31.39 Unrealized 0.0%

LENZ LENZ THERAPEUTICS INC 2.1%

Value $50.33M Shares 1,717,066 Est. Cost $27.56 Unrealized -1.3%

BBIO BRIDGEBIO PHARMA INC 1.8%

Value $41.7M Shares 965,764 Est. Cost $36.37 Unrealized 0.0%

APGE APOGEE THERAPEUTICS INC 1.8%

Value $41.63M Shares 958,630 Est. Cost $48.22 Unrealized -21.1%

MLTX MOONLAKE IMMUNOTHERAPEUTICS 1.8%

Value $41.46M Shares 878,323 Est. Cost $46.53 Unrealized -12.5%

ALKS ALKERMES PLC 1.7%

Value $39.36M Shares 1,375,569 Est. Cost $29.76 Unrealized 0.0%

VRDN VIRIDIAN THERAPEUTICS INC 1.6%

Value $38.33M Shares 2,741,576 Est. Cost $17.86 Unrealized -24.0%

AGIO AGIOS PHARMACEUTICALS INC 1.6%

Value $38M Shares 1,142,511 Est. Cost $30.31 Unrealized 0.0%

OCUL OCULAR THERAPEUTIX INC 1.4%

Value $31.74M Shares 3,420,340 Est. Cost $7.77 Unrealized +0.7%

OLMA OLEMA PHARMACEUTICALS INC 1.2%

Value $28.82M Shares 6,764,172 Est. Cost $8.25 Unrealized -46.0%

SYRE SPYRE THERAPEUTICS INC 1.2%

Value $28M Shares 1,870,445 Est. Cost $26.04 Unrealized -43.2%

— Y-MABS THERAPEUTICS INC 0.8%

Value $19.11M Shares 4,236,346 Est. Cost $14.19 Unrealized —

PHVS PHARVARIS N V 0.8%

Value $18.71M Shares 1,062,911 Est. Cost $16.11 Unrealized 0.0%

IMTX IMMATICS N.V 0.7%

Value $16.92M Shares 3,144,157 Est. Cost $7.95 Unrealized -37.6%

ERAS ERASCA INC 0.6%

Value $15.12M Shares 11,907,182 Est. Cost $2.27 Unrealized -41.1%

CBIO CRESCENT BIOPHARMA INC. 0.4%

Value $10.37M Shares 642,721 Est. Cost $21.15 Unrealized 0.0%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
NUVL	NUVALENT INC	5,269,433	$402M	17.2%	$60.72	+20.5%	COM	670703107
ACLX	ARCELLX INC	4,649,016	$306M	13.1%	$41.59	+49.7%	COMMON STOCK	03940C100
—	MERUS N V	4,281,954	$225M	9.6%	$50.43	—	COM	N5749R100
RVMD	REVOLUTION MEDICINES INC	6,093,291	$224M	9.6%	$36.46	+5.4%	COM	76155X100
TARS	TARSUS PHARMACEUTICALS INC	2,976,099	$121M	5.1%	$28.61	+57.3%	COM	87650L103
PCVX	VAXCYTE INC	3,372,837	$110M	4.7%	$59.08	-44.5%	COM	92243G108
ONC	BEONE MEDICINES LTD	347,787	$84.19M	3.6%	$203.25	—	SPONSORED ADS	07725L102
EWTX	EDGEWISE THERAPEUTICS INC	6,142,344	$80.53M	3.4%	$20.10	-28.3%	COM	28036F105
COGT	COGENT BIOSCIENCES INC	10,352,449	$74.33M	3.2%	$7.69	-27.9%	COM	19240Q201
JANX	JANUX THERAPEUTICS INC	2,920,258	$67.46M	2.9%	$48.02	-45.1%	COM	47103J105
CRNX	CRINETICS PHARMACEUTICALS IN	2,343,553	$67.4M	2.9%	$26.38	+17.1%	COM	22663K107
IRON	DISC MEDICINE INC	1,210,971	$64.13M	2.7%	$48.64	-3.4%	COM	254604101
SRRK	SCHOLAR ROCK HLDG CORP	1,600,554	$56.69M	2.4%	$31.39	0.0%	COM	80706P103
LENZ	LENZ THERAPEUTICS INC	1,717,066	$50.33M	2.1%	$27.56	-1.3%	COM	52635N103
BBIO	BRIDGEBIO PHARMA INC	965,764	$41.7M	1.8%	$36.37	0.0%	COM	10806X102
APGE	APOGEE THERAPEUTICS INC	958,630	$41.63M	1.8%	$48.22	-21.1%	COM	03770N101
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	878,323	$41.46M	1.8%	$46.53	-12.5%	CLASS A ORD	61559X104
ALKS	ALKERMES PLC	1,375,569	$39.36M	1.7%	$29.76	0.0%	SHS	G01767105
VRDN	VIRIDIAN THERAPEUTICS INC	2,741,576	$38.33M	1.6%	$17.86	-24.0%	COM	92790C104
AGIO	AGIOS PHARMACEUTICALS INC	1,142,511	$38M	1.6%	$30.31	0.0%	COM	00847X104
OCUL	OCULAR THERAPEUTIX INC	3,420,340	$31.74M	1.4%	$7.77	+0.7%	COM	67576A100
OLMA	OLEMA PHARMACEUTICALS INC	6,764,172	$28.82M	1.2%	$8.25	-46.0%	COM	68062P106
SYRE	SPYRE THERAPEUTICS INC	1,870,445	$28M	1.2%	$26.04	-43.2%	COM NEW	00773J202
—	Y-MABS THERAPEUTICS INC	4,236,346	$19.11M	0.8%	$14.19	—	COM	984241109
PHVS	PHARVARIS N V	1,062,911	$18.71M	0.8%	$16.11	0.0%	COM	N69605108
IMTX	IMMATICS N.V	3,144,157	$16.92M	0.7%	$7.95	-37.6%	SHS	N44445109
ERAS	ERASCA INC	11,907,182	$15.12M	0.6%	$2.27	-41.1%	COM	29479A108
CBIO	CRESCENT BIOPHARMA INC.	642,721	$10.37M	0.4%	$21.15	0.0%	COM	G2545C104