Paradigm Biocapital Advisors LP Quant / Systematic

Location: New York, NY

CIK: 0001855655 · Show all filings

Period: Q4 2024 (← Previous) (Next →)

Filing Date: Feb 14, 2025

Total Value: $2.874B (100.0% shares, 0.0% debt)

Holdings (28)

NUVL NUVALENT INC 14.6%

Value $420M Shares 5,363,379 Est. Cost $60.72 Unrealized +53.8%

ACLX ARCELLX INC 11.7%

Value $335M Shares 4,371,601 Est. Cost $40.13 Unrealized +115.3%

ARGX ARGENX SE 10.3%

Value $296M Shares 481,305 Est. Cost $406.28 Unrealized —

RVMD REVOLUTION MEDICINES INC 10.0%

Value $287M Shares 6,553,111 Est. Cost $36.46 Unrealized +38.4%

JANX JANUX THERAPEUTICS INC 6.5%

Value $188M Shares 3,515,986 Est. Cost $48.02 Unrealized +10.2%

TARS TARSUS PHARMACEUTICALS INC 4.9%

Value $140M Shares 2,531,896 Est. Cost $25.60 Unrealized +77.4%

EWTX EDGEWISE THERAPEUTICS INC 4.2%

Value $120M Shares 4,493,929 Est. Cost $22.36 Unrealized +42.4%

PCVX VAXCYTE INC 4.1%

Value $116M Shares 1,422,787 Est. Cost $86.04 Unrealized +15.4%

ONC BEIGENE LTD 4.0%

Value $114M Shares 616,024 Est. Cost $197.65 Unrealized —

CRNX CRINETICS PHARMACEUTICALS IN 3.4%

Value $97.7M Shares 1,910,761 Est. Cost $25.24 Unrealized +121.6%

MLTX MOONLAKE IMMUNOTHERAPEUTICS 3.3%

Value $95.97M Shares 1,772,211 Est. Cost $48.85 Unrealized +4.5%

IRON DISC MEDICINE INC 3.3%

Value $94.96M Shares 1,497,720 Est. Cost $48.64 Unrealized +18.9%

— MERUS N V 2.5%

Value $71.06M Shares 1,689,922 Est. Cost $57.54 Unrealized —

VERA VERA THERAPEUTICS INC 2.1%

Value $60.79M Shares 1,437,339 Est. Cost $39.45 Unrealized +12.2%

APGE APOGEE THERAPEUTICS INC 2.0%

Value $58.15M Shares 1,283,766 Est. Cost $48.22 Unrealized +5.8%

OLMA OLEMA PHARMACEUTICALS INC 1.5%

Value $42.59M Shares 7,304,970 Est. Cost $8.25 Unrealized +21.1%

PLRX PLIANT THERAPEUTICS INC 1.5%

Value $42.11M Shares 3,197,050 Est. Cost $12.54 Unrealized +8.8%

IMTX IMMATICS N.V 1.3%

Value $38.5M Shares 5,414,409 Est. Cost $9.89 Unrealized -13.2%

COGT COGENT BIOSCIENCES INC 1.3%

Value $38.36M Shares 4,917,412 Est. Cost $8.16 Unrealized +22.1%

SYRE SPYRE THERAPEUTICS INC 1.2%

Value $35.55M Shares 1,527,205 Est. Cost $28.10 Unrealized +4.4%

VRDN VIRIDIAN THERAPEUTICS INC 1.2%

Value $34.89M Shares 1,820,079 Est. Cost $19.51 Unrealized +11.4%

— Y-MABS THERAPEUTICS INC 1.2%

Value $33.17M Shares 4,236,346 Est. Cost $14.19 Unrealized —

ERAS ERASCA INC 0.9%

Value $26.99M Shares 10,752,354 Est. Cost $2.37 Unrealized +15.7%

TECX TECTONIC THERAPEUTIC INC 0.8%

Value $22.4M Shares 485,105 Est. Cost $42.29 Unrealized 0.0%

LENZ LENZ THERAPEUTICS INC 0.8%

Value $22.24M Shares 770,455 Est. Cost $30.48 Unrealized 0.0%

SRRK SCHOLAR ROCK HLDG CORP 0.6%

Value $17.29M Shares 400,000 Est. Cost $32.56 Unrealized 0.0%

ORKA ORUKA THERAPEUTICS INC 0.6%

Value $15.89M Shares 819,660 Est. Cost $33.52 Unrealized -27.2%

AGIO AGIOS PHARMACEUTICALS INC 0.3%

Value $9.084M Shares 276,439 Est. Cost $46.98 Unrealized 0.0%

Ticker	Issuer	Shares	Value	%	Est. Cost	Unrealized	Class	CUSIP
NUVL	NUVALENT INC	5,363,379	$420M	14.6%	$60.72	+53.8%	COM	670703107
ACLX	ARCELLX INC	4,371,601	$335M	11.7%	$40.13	+115.3%	COMMON STOCK	03940C100
ARGX	ARGENX SE	481,305	$296M	10.3%	$406.28	—	SPONSORED ADR	04016X101
RVMD	REVOLUTION MEDICINES INC	6,553,111	$287M	10.0%	$36.46	+38.4%	COM	76155X100
JANX	JANUX THERAPEUTICS INC	3,515,986	$188M	6.5%	$48.02	+10.2%	COM	47103J105
TARS	TARSUS PHARMACEUTICALS INC	2,531,896	$140M	4.9%	$25.60	+77.4%	COM	87650L103
EWTX	EDGEWISE THERAPEUTICS INC	4,493,929	$120M	4.2%	$22.36	+42.4%	COM	28036F105
PCVX	VAXCYTE INC	1,422,787	$116M	4.1%	$86.04	+15.4%	COM	92243G108
ONC	BEIGENE LTD	616,024	$114M	4.0%	$197.65	—	SPONSORED ADR	07725L102
CRNX	CRINETICS PHARMACEUTICALS IN	1,910,761	$97.7M	3.4%	$25.24	+121.6%	COM	22663K107
MLTX	MOONLAKE IMMUNOTHERAPEUTICS	1,772,211	$95.97M	3.3%	$48.85	+4.5%	CLASS A ORD	61559X104
IRON	DISC MEDICINE INC	1,497,720	$94.96M	3.3%	$48.64	+18.9%	COM	254604101
—	MERUS N V	1,689,922	$71.06M	2.5%	$57.54	—	COM	N5749R100
VERA	VERA THERAPEUTICS INC	1,437,339	$60.79M	2.1%	$39.45	+12.2%	CL A	92337R101
APGE	APOGEE THERAPEUTICS INC	1,283,766	$58.15M	2.0%	$48.22	+5.8%	COM	03770N101
OLMA	OLEMA PHARMACEUTICALS INC	7,304,970	$42.59M	1.5%	$8.25	+21.1%	COM	68062P106
PLRX	PLIANT THERAPEUTICS INC	3,197,050	$42.11M	1.5%	$12.54	+8.8%	COM	729139105
IMTX	IMMATICS N.V	5,414,409	$38.5M	1.3%	$9.89	-13.2%	SHS	N44445109
COGT	COGENT BIOSCIENCES INC	4,917,412	$38.36M	1.3%	$8.16	+22.1%	COM	19240Q201
SYRE	SPYRE THERAPEUTICS INC	1,527,205	$35.55M	1.2%	$28.10	+4.4%	COM NEW	00773J202
VRDN	VIRIDIAN THERAPEUTICS INC	1,820,079	$34.89M	1.2%	$19.51	+11.4%	COM	92790C104
—	Y-MABS THERAPEUTICS INC	4,236,346	$33.17M	1.2%	$14.19	—	COM	984241109
ERAS	ERASCA INC	10,752,354	$26.99M	0.9%	$2.37	+15.7%	COM	29479A108
TECX	TECTONIC THERAPEUTIC INC	485,105	$22.4M	0.8%	$42.29	0.0%	COM	878972108
LENZ	LENZ THERAPEUTICS INC	770,455	$22.24M	0.8%	$30.48	0.0%	COM	52635N103
SRRK	SCHOLAR ROCK HLDG CORP	400,000	$17.29M	0.6%	$32.56	0.0%	COM	80706P103
ORKA	ORUKA THERAPEUTICS INC	819,660	$15.89M	0.6%	$33.52	-27.2%	COM	687604108
AGIO	AGIOS PHARMACEUTICALS INC	276,439	$9.084M	0.3%	$46.98	0.0%	COM	00847X104