| BlackRock, Inc. | 32,524,381 | $463,147 |
| VANGUARD GROUP INC | 29,702,696 | $422,966 |
| HBK INVESTMENTS L P | 15,250,000 | $217,160 |
| STATE STREET CORP | 14,833,314 | $211,226 |
| Pentwater Capital Management LP | 11,500,000 | $163,760 |
| Bellevue Group AG | 10,735,195 | $152,869 |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 10,627,717 | $151,339 |
| GEODE CAPITAL MANAGEMENT, LLC | 7,345,267 | $104,616 |
| PERCEPTIVE ADVISORS LLC | 6,370,851 | $90,721 |
| GOLDMAN SACHS GROUP INC | 6,142,956 | $87,476 |
| UBS Group AG | 5,893,288 | $83,920 |
| MORGAN STANLEY | 5,479,689 | $78,031 |
| Soleus Capital Management, L.P. | 5,207,284 | $74,152 |
| Palo Alto Investors LP | 5,205,767 | $74,130 |
| BALYASNY ASSET MANAGEMENT L.P. | 5,124,427 | $72,972 |
| CITADEL ADVISORS LLC | 5,096,796 | $72,578 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 5,069,590 | $72,191 |
| SOROS FUND MANAGEMENT LLC | 5,000,000 | $71,200 |
| Nuveen, LLC | 4,628,225 | $65,906 |
| Qube Research & Technologies Ltd | 4,434,679 | $63,150 |
| Magnetar Financial LLC | 3,967,915 | $56,503 |
| JPMORGAN CHASE & CO | 3,717,363 | $52,935 |
| RICE HALL JAMES & ASSOCIATES, LLC | 3,509,571 | $49,976 |
| DEUTSCHE BANK AG\ | 3,457,228 | $49,231 |
| BANK OF AMERICA CORP /DE/ | 3,438,241 | $48,961 |
| MILLENNIUM MANAGEMENT LLC | 2,995,089 | $42,650 |
| KRYGER CAPITAL Ltd | 2,994,400 | $42,640 |
| TIG Advisors, LLC | 2,927,424 | $41,687 |
| ALLIANCEBERNSTEIN L.P. | 2,711,443 | $38,611 |
| NORTHERN TRUST CORP | 2,644,213 | $37,654 |
| Blackstone Inc. | 2,574,204 | $36,657 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,561,753 | $36,479 |
| BNP PARIBAS ARBITRAGE, SA | 2,251,710 | $32,064 |
| Point72 Asset Management, L.P. | 2,068,454 | $29,455 |
| Pictet Asset Management Holding SA | 1,994,855 | $28,426 |
| AQR Arbitrage LLC | 1,983,109 | $28,239 |
| Rock Springs Capital Management LP | 1,929,931 | $27,482 |
| Weiss Asset Management LP | 1,892,797 | $26,953 |
| CAPSTONE INVESTMENT ADVISORS, LLC | 1,850,000 | $26,344 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,650,000 | $23,496 |
| CITIGROUP INC | 1,648,547 | $23,475 |
| Sand Grove Capital Management LLP | 1,647,030 | $23,454 |
| GLAZER CAPITAL, LLC | 1,603,788 | $23 |
| D. E. Shaw & Co., Inc. | 1,549,003 | $22,058 |
| Parkman Healthcare Partners LLC | 1,487,283 | $21,179 |
| Allianz Asset Management GmbH | 1,486,996 | $21,175 |
| TWO SIGMA INVESTMENTS, LP | 1,473,341 | $20,980 |
| WELLINGTON MANAGEMENT GROUP LLP | 1,373,867 | $19,564 |
| Stephens Investment Management Group LLC | 1,351,814 | $19,250 |
| Woodline Partners LP | 1,285,200 | $18,301 |
| Invesco Ltd. | 1,259,225 | $17,931 |
| Connor, Clark & Lunn Investment Management Ltd. | 1,218,000 | $17,344 |
| RENAISSANCE TECHNOLOGIES LLC | 1,211,693 | $17,255 |
| NORGES BANK | 1,165,028 | $16,590 |
| LMR Partners LLP | 1,157,200 | $16,479 |
| Prosight Management, LP | 1,150,000 | $16,376 |
| BARCLAYS PLC | 1,134,639 | $16,157 |
| First Trust Capital Management L.P. | 1,088,721 | $15,503 |
| Susquehanna Portfolio Strategies, LLC | 1,075,323 | $15,313 |
| PSquared Asset Management AG | 1,050,000 | $14,952 |
| Trails Edge Capital Partners, LP | 1,043,313 | $14,857 |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AM | 1,000,000 | $14,240 |
| AQR CAPITAL MANAGEMENT LLC | 966,795 | $13,767 |
| FIL Ltd | 957,000 | $13,628 |
| ALPINE ASSOCIATES MANAGEMENT INC. | 949,200 | $13,517 |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 945,628 | $13,466 |
| Alberta Investment Management Corp | 939,200 | $13,374 |
| TUDOR INVESTMENT CORP ET AL | 900,000 | $12,816 |
| Versor Investments LP | 871,234 | $12,406 |
| UBS ASSET MANAGEMENT AMERICAS INC | 857,834 | $12,216 |
| Bank of New York Mellon Corp | 829,904 | $11,818 |
| 683 Capital Management, LLC | 800,000 | $11,392 |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 800,000 | $11,392 |
| Maven Securities LTD | 789,282 | $11,239 |
| Sovereign's Capital Management, LLC | 784,942 | $11,178 |
| ORBIMED ADVISORS LLC | 729,900 | $10,394 |
| JANE STREET GROUP, LLC | 726,797 | $10,350 |
| WATER ISLAND CAPITAL LLC | 706,617 | $10,062 |
| SPHERA FUNDS MANAGEMENT LTD. | 658,377 | $9,375 |
| Verition Fund Management LLC | 649,562 | $9,250 |
| Hudson Bay Capital Management LP | 622,500 | $8,864 |
| PICTON MAHONEY ASSET MANAGEMENT | 615,168 | $8,760 |
| Jump Financial, LLC | 609,941 | $8,686 |
| Athos Capital Ltd | 600,000 | $9 |
| TWO SIGMA ADVISERS, LP | 590,676 | $8,411 |
| PRIMECAP MANAGEMENT CO/CA/ | 589,400 | $8,393 |
| ACADIAN ASSET MANAGEMENT LLC | 576,762 | $8 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 561,133 | $7,991 |
| GABELLI FUNDS LLC | 552,950 | $7,874 |
| Swiss National Bank | 547,000 | $7,789 |
| FIRST TRUST ADVISORS LP | 533,507 | $7,597 |
| METEORA CAPITAL, LLC | 507,951 | $7,233 |
| Rafferty Asset Management, LLC | 493,088 | $7,022 |
| GABELLI & Co INVESTMENT ADVISERS, INC. | 485,950 | $6,920 |
| ABC ARBITRAGE SA | 472,984 | $6,735 |
| PDT Partners, LLC | 449,999 | $6,408 |
| Neo Ivy Capital Management | 420,275 | $5,985 |
| Creative Planning | 402,405 | $5,730 |
| Chicago Capital Management, LLC | 400,000 | $4,284 |
| Man Group plc | 400,000 | $5,696 |
| 226 other institutions | 17,727,818 | $233,396 |