Ticker: APLS CUSIP: 03753U106 Class: Common Stock
Note: Option positions (PUT/CALL) are excluded.
| Institution | Shares | Value ($000) |
|---|---|---|
| RTW INVESTMENTS, LP | 7,666,764 | $192,589 |
| Exome Asset Management LLC | 135,849 | $3,413 |
| APIS CAPITAL ADVISORS, LLC | 192,000 | $4,823 |
| Granite Investment Partners, LLC | 327,094 | $8,217 |
| Coppell Advisory Solutions LLC | 77,390 | $1,953 |
| WINTON GROUP Ltd | 86,653 | $2,177 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 38,521 | $968 |
| Bridgefront Capital, LLC | 11,326 | $285 |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 10,806 | $271 |
| Perbak Capital Partners LLP | 10,217 | $257 |
| DARK FOREST CAPITAL MANAGEMENT LP | 31,091 | $781 |
| Bridgewater Associates, LP | 143,805 | $3,612 |
| FIRST TRUST ADVISORS LP | 495,947 | $12,458 |
| MIRABELLA FINANCIAL SERVICES LLP | 9,078 | $228 |
| TUDOR INVESTMENT CORP ET AL | 215,000 | $5,401 |
| TWO SIGMA ADVISERS, LP | 110,900 | $2,786 |
| ADVENT CAPITAL MANAGEMENT /DE/ | 18,000 | $452 |
| Diversified Trust Co | 18,942 | $476 |
| Maven Securities LTD | 15,000 | $377 |
| Quadrature Capital Ltd | 24,075 | $605 |
| Institution | Prev Shares | Curr Shares | Change |
|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,878,000 | 4,139,426 | +1,261,426 (+43.8%) |
| SPHERA FUNDS MANAGEMENT LTD. | 63,660 | 250,961 | +187,301 (+294.2%) |
| Rhenman & Partners Asset Management AB | 232,250 | 374,450 | +142,200 (+61.2%) |
| Kynam Capital Management, LP | 808,607 | 908,607 | +100,000 (+12.4%) |
| ORBIMED ADVISORS LLC | 2,323,368 | 2,429,868 | +106,500 (+4.6%) |
| Simplify Asset Management Inc. | 106,888 | 538,008 | +431,120 (+403.3%) |
| Polar Capital Holdings Plc | 2,650,230 | 3,706,510 | +1,056,280 (+39.9%) |
| HighVista Strategies LLC | 145,729 | 150,776 | +5,047 (+3.5%) |
| Rock Springs Capital Management LP | 92,000 | 150,500 | +58,500 (+63.6%) |
| Hudson Bay Capital Management LP | 418,500 | 1,179,828 | +761,328 (+181.9%) |
| 683 Capital Management, LLC | 288,000 | 330,000 | +42,000 (+14.6%) |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 620,790 | 951,716 | +330,926 (+53.3%) |
| WELLINGTON MANAGEMENT GROUP LLP | 9,290,960 | 12,721,352 | +3,430,392 (+36.9%) |
| NATIXIS | 52,239 | 257,268 | +205,029 (+392.5%) |
| Virtus Investment Advisers, LLC | 23,073 | 27,086 | +4,013 (+17.4%) |
| MARSHALL WACE, LLP | 396,735 | 990,848 | +594,113 (+149.8%) |
| PROFUND ADVISORS LLC | 34,712 | 61,832 | +27,120 (+78.1%) |
| Point72 Asset Management, L.P. | 217,071 | 597,672 | +380,601 (+175.3%) |
| TWO SIGMA INVESTMENTS, LP | 252,068 | 562,361 | +310,293 (+123.1%) |
| UBS Group AG | 3,429,905 | 4,186,222 | +756,317 (+22.1%) |
| Institution | Prev Shares | Curr Shares | Change |
|---|---|---|---|
| Deep Track Capital, LP | 8,000,382 | 7,750,000 | -250,382 (-3.1%) |
| Ikarian Capital, LLC | 451,902 | 71,747 | -380,155 (-84.1%) |
| ING GROEP NV | 1,174,500 | 139,000 | -1,035,500 (-88.2%) |
| Trexquant Investment LP | 586,939 | 194,592 | -392,347 (-66.8%) |
| Integral Health Asset Management, LLC | 250,000 | 200,000 | -50,000 (-20.0%) |
| Y-Intercept (Hong Kong) Ltd | 163,813 | 31,581 | -132,232 (-80.7%) |
| JENNISON ASSOCIATES LLC | 4,348,055 | 1,504,299 | -2,843,756 (-65.4%) |
| OSSIAM | 555,953 | 431,779 | -124,174 (-22.3%) |
| BOOTHBAY FUND MANAGEMENT, LLC | 179,226 | 21,415 | -157,811 (-88.1%) |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 992,269 | 461,186 | -531,083 (-53.5%) |
| AQR CAPITAL MANAGEMENT LLC | 4,487,354 | 2,276,687 | -2,210,667 (-49.3%) |
| Quarry LP | 16,022 | 5,000 | -11,022 (-68.8%) |
| SRS Capital Advisors, Inc. | 82,067 | 46 | -82,021 (-99.9%) |
| Jefferies Financial Group Inc. | 251,555 | 8,718 | -242,837 (-96.5%) |
| Jump Financial, LLC | 277,648 | 193,876 | -83,772 (-30.2%) |
| IEQ CAPITAL, LLC | 296,784 | 25,500 | -271,284 (-91.4%) |
| BANK OF NOVA SCOTIA | 1,456,225 | 1,070,141 | -386,084 (-26.5%) |
| Edgestream Partners, L.P. | 129,751 | 97,443 | -32,308 (-24.9%) |
| Amundi | 1,493,678 | 30,721 | -1,462,957 (-97.9%) |
| Walleye Capital LLC | 142,158 | 3,955 | -138,203 (-97.2%) |
| Institution | Prev Shares | Prev Value ($000) |
|---|---|---|
| EcoR1 Capital, LLC | 3,447,156 | $78,009 |
| Octagon Capital Advisors LP | 903,500 | $20,446 |
| Scientech Research LLC | 34,182 | $774 |
| READYSTATE ASSET MANAGEMENT LP | 241,977 | $5,476 |
| PharVision Advisers, LLC | 22,291 | $504 |
| Bayforest Capital Ltd | 20,853 | $472 |
| SHERBROOKE PARK ADVISERS LLC | 15,590 | $353 |
| Bayesian Capital Management, LP | 25,500 | $577 |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 75,000 | $1,697 |
| FOX RUN MANAGEMENT, L.L.C. | 27,223 | $616 |
| Campbell & CO Investment Adviser LLC | 53,540 | $1,212 |
| Aquatic Capital Management LLC | 130,828 | $2,961 |
| LECAP ASSET MANAGEMENT LTD | 9,868 | $223 |
| HIGHLAND CAPITAL MANAGEMENT, LLC | 50,133 | $1,135 |
| Aigen Investment Management, LP | 14,181 | $321 |
| Bleakley Financial Group, LLC | 79,305 | $1,795 |
| J. Safra Sarasin Holding AG | 70,500 | $1,595 |
| GSA CAPITAL PARTNERS LLP | 31,446 | $1 |
| Engineers Gate Manager LP | 66,336 | $1,501 |
| Concentric Capital Strategies, LP | 17,979 | $407 |