| Matrix Capital Management Company, LP | 6,922,870 | $37,730 |
| Frazier Life Sciences Management, L.P. | 5,100,000 | $27,795 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,881,125 | $26,602 |
| Long Focus Capital Management, LLC | 4,619,582 | $25,177 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,372,884 | $23,832 |
| BlackRock, Inc. | 3,560,424 | $19,404 |
| Medicxi Ventures Management (Jersey) Ltd | 3,039,892 | $16,567 |
| VANGUARD GROUP INC | 2,936,538 | $16,004 |
| FRANKLIN RESOURCES INC | 2,198,423 | $11,981 |
| Nantahala Capital Management, LLC | 2,117,697 | $11,541 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,255,450 | $6,845 |
| LEVIN CAPITAL STRATEGIES, L.P. | 1,035,586 | $5,644 |
| STATE STREET CORP | 926,534 | $5,050 |
| MILLENNIUM MANAGEMENT LLC | 617,338 | $3,364 |
| ACORN CAPITAL ADVISORS, LLC | 595,744 | $3,247 |
| B Group, Inc. | 572,576 | $3,121 |
| Regency Capital Management Inc.\DE | 538,584 | $2,935 |
| DIMENSIONAL FUND ADVISORS LP | 517,916 | $2,823 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 442,789 | $2 |
| NORTHERN TRUST CORP | 412,809 | $2,250 |
| Decheng Capital LLC | 360,483 | $1,965 |
| MORGAN STANLEY | 218,407 | $1,190 |
| UBS Group AG | 171,639 | $935 |
| BANK OF AMERICA CORP /DE/ | 165,185 | $900 |
| RENAISSANCE TECHNOLOGIES LLC | 145,200 | $791 |
| WELLINGTON MANAGEMENT GROUP LLP | 140,959 | $768 |
| GOLDMAN SACHS GROUP INC | 139,926 | $763 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 135,063 | $736 |
| BNP PARIBAS ARBITRAGE, SA | 114,609 | $625 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 111,865 | $610 |
| Bank of New York Mellon Corp | 107,923 | $588 |
| Resolute Capital Asset Partners LLC | 91,006 | $496 |
| Permanent Capital Management, LP | 75,864 | $413 |
| Nuveen, LLC | 72,334 | $394 |
| BARCLAYS PLC | 69,298 | $378 |
| CITADEL ADVISORS LLC | 68,549 | $374 |
| RHUMBLINE ADVISERS | 65,034 | $354 |
| XTX Topco Ltd | 60,811 | $331 |
| TBH Global Asset Management, LLC | 60,322 | $329 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 59,239 | $325 |
| Point72 Asset Management, L.P. | 54,692 | $298 |
| ExodusPoint Capital Management, LP | 51,419 | $280 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 50,000 | $273 |
| WELLS FARGO & COMPANY/MN | 49,053 | $267 |
| JANE STREET GROUP, LLC | 47,431 | $258 |
| Walleye Capital LLC | 46,371 | $253 |
| Trexquant Investment LP | 42,998 | $234 |
| AMERIPRISE FINANCIAL INC | 42,842 | $233 |
| ALLIANCEBERNSTEIN L.P. | 41,660 | $227 |
| AMERICAN CENTURY COMPANIES INC | 40,744 | $222 |
| TD Asset Management Inc | 40,502 | $221 |
| Quantinno Capital Management LP | 36,381 | $198 |
| Susquehanna Portfolio Strategies, LLC | 36,090 | $197 |
| CITIGROUP INC | 34,891 | $190 |
| HARBOR CAPITAL ADVISORS, INC. | 32,977 | $0 |
| DEUTSCHE BANK AG\ | 30,828 | $168 |
| COMMONWEALTH EQUITY SERVICES, LLC | 30,284 | $165 |
| LETKO, BROSSEAU & ASSOCIATES INC | 28,300 | $154 |
| Invesco Ltd. | 27,282 | $149 |
| EntryPoint Capital, LLC | 26,300 | $143 |
| MetLife Investment Management, LLC | 25,031 | $136 |
| JPMORGAN CHASE & CO | 23,119 | $126 |
| OPAL CAPITAL LLC | 22,034 | $127 |
| INTECH INVESTMENT MANAGEMENT LLC | 20,993 | $114 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20,359 | $111 |
| 49 WEALTH MANAGEMENT, LLC | 18,984 | $103 |
| CANADA PENSION PLAN INVESTMENT BOARD | 18,700 | $102 |
| Ethic Inc. | 17,539 | $96 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 16,276 | $89 |
| MIRABELLA FINANCIAL SERVICES LLP | 14,109 | $77 |
| AQR CAPITAL MANAGEMENT LLC | 13,862 | $76 |
| BROWN ADVISORY INC | 13,400 | $73 |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,104 | $71 |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 11,724 | $60 |
| Police & Firemen's Retirement System of New Jersey | 11,397 | $62 |
| Creative Planning | 11,294 | $62 |
| ProShare Advisors LLC | 10,830 | $59 |
| China Universal Asset Management Co., Ltd. | 10,348 | $56 |
| FMR LLC | 8,138 | $44 |
| Ameritas Investment Partners, Inc. | 4,544 | $25 |
| Legal & General Group Plc | 4,342 | $24 |
| Russell Investments Group, Ltd. | 3,736 | $20 |
| Mirae Asset Global Investments Co., Ltd. | 3,086 | $17 |
| ROYAL BANK OF CANADA | 3,063 | $17 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,704 | $15 |
| SIMPLEX TRADING, LLC | 2,634 | $14 |
| Parallel Advisors, LLC | 2,459 | $13 |
| Tower Research Capital LLC (TRC) | 1,955 | $11 |
| Sterling Capital Management LLC | 1,806 | $10 |
| Smartleaf Asset Management LLC | 1,741 | $10 |
| COMERICA BANK | 1,625 | $9 |
| UBS ASSET MANAGEMENT AMERICAS INC | 1,593 | $9 |
| AMALGAMATED BANK | 1,380 | $0 |
| GF FUND MANAGEMENT CO. LTD. | 1,247 | $7 |
| OSAIC HOLDINGS, INC. | 926 | $5 |
| CWM, LLC | 811 | $0 |
| Versant Capital Management, Inc | 793 | $4 |
| SBI Securities Co., Ltd. | 634 | $3 |
| Optiver Holding B.V. | 584 | $3 |
| IFP Advisors, Inc | 363 | $2 |
| 17 other institutions | 2,165 | $11 |