| FMR LLC | 31,785,605 | $385,877 |
| BlackRock, Inc. | 15,602,394 | $189,413 |
| VANGUARD GROUP INC | 11,575,193 | $140,523 |
| SUMMER ROAD LLC | 11,108,555 | $134,858 |
| Avoro Capital Advisors LLC | 10,777,777 | $130,842 |
| Deep Track Capital, LP | 8,070,414 | $97,975 |
| VR Adviser, LLC | 7,315,547 | $88,811 |
| TCG Crossover Management, LLC | 5,740,231 | $69,686 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,625,050 | $56,148 |
| GEODE CAPITAL MANAGEMENT, LLC | 4,356,547 | $52,896 |
| ALLIANCEBERNSTEIN L.P. | 4,341,951 | $52,711 |
| JANUS HENDERSON GROUP PLC | 4,229,202 | $51,321 |
| STATE STREET CORP | 4,196,330 | $50,943 |
| Logos Global Management LP | 3,500,000 | $42,490 |
| MILLENNIUM MANAGEMENT LLC | 3,207,881 | $38,944 |
| Paradigm Biocapital Advisors LP | 2,935,284 | $35,634 |
| Octagon Capital Advisors LP | 2,623,600 | $31,851 |
| DELTEC ASSET MANAGEMENT LLC | 2,487,934 | $30,204 |
| CITADEL ADVISORS LLC | 2,475,849 | $30,057 |
| Woodline Partners LP | 1,666,136 | $20,227 |
| Opaleye Management Inc. | 1,595,000 | $19,363 |
| GOLDMAN SACHS GROUP INC | 1,547,523 | $18,787 |
| Saturn V Capital Management LP | 1,504,880 | $18,269 |
| NORTHERN TRUST CORP | 1,462,503 | $17,755 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,460,457 | $17,730 |
| MARSHALL WACE, LLP | 1,377,203 | $16,719 |
| UBS Group AG | 1,244,944 | $15,114 |
| D. E. Shaw & Co., Inc. | 1,153,910 | $14,008 |
| Artisan Partners Limited Partnership | 1,063,371 | $12,909 |
| ACUTA CAPITAL PARTNERS, LLC | 1,052,995 | $12,783 |
| JANE STREET GROUP, LLC | 1,034,229 | $12,556 |
| Point72 Asset Management, L.P. | 1,016,248 | $12,337 |
| Invesco Ltd. | 895,687 | $10,874 |
| MORGAN STANLEY | 879,144 | $10,673 |
| BARCLAYS PLC | 857,649 | $10,412 |
| RAYMOND JAMES FINANCIAL INC | 842,187 | $10,224 |
| Candriam S.C.A. | 841,602 | $10,217 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 812,078 | $9,859 |
| RENAISSANCE TECHNOLOGIES LLC | 791,200 | $9,605 |
| Spruce Street Capital LP | 783,999 | $9,518 |
| Qube Research & Technologies Ltd | 769,774 | $9,345 |
| BALYASNY ASSET MANAGEMENT L.P. | 763,559 | $9,270 |
| Cetera Investment Advisers | 722,540 | $8,772 |
| Catalio Capital Management, LP | 714,501 | $8,674 |
| Defilade Capital Management, L.P. | 681,663 | $8,275 |
| Assenagon Asset Management S.A. | 620,814 | $7,537 |
| CITIGROUP INC | 601,917 | $7,307 |
| BANK OF AMERICA CORP /DE/ | 601,360 | $7,301 |
| Knoll Capital Management, LLC | 600,400 | $7,277 |
| Trexquant Investment LP | 592,877 | $7,198 |
| DEUTSCHE BANK AG\ | 590,721 | $7,171 |
| PEREGRINE CAPITAL MANAGEMENT LLC | 571,103 | $6,933 |
| JPMORGAN CHASE & CO | 550,269 | $6,680 |
| Empire Life Investments Inc. | 540,115 | $6,557 |
| STEMPOINT CAPITAL LP | 522,693 | $6,345 |
| Aptus Capital Advisors, LLC | 500,752 | $6,079 |
| Second Line Capital, LLC | 500,746 | $6,079 |
| TUDOR INVESTMENT CORP ET AL | 494,792 | $6,007 |
| Bank of New York Mellon Corp | 490,278 | $5,952 |
| Patient Square Capital LP | 490,000 | $5,949 |
| Nuveen, LLC | 462,807 | $5,618 |
| BNP Paribas Investment Partners S.A. | 445,405 | $5 |
| Squarepoint Ops LLC | 440,437 | $5,347 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 418,080 | $5,075 |
| HRT FINANCIAL LP | 402,963 | $5 |
| Rosalind Advisors, Inc. | 400,000 | $4,856 |
| AMERIPRISE FINANCIAL INC | 395,591 | $4,802 |
| Y-Intercept (Hong Kong) Ltd | 395,335 | $4,799 |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 385,825 | $4,684 |
| TWO SIGMA INVESTMENTS, LP | 380,713 | $4,622 |
| Rock Springs Capital Management LP | 345,820 | $4,198 |
| HighVista Strategies LLC | 344,067 | $4,177 |
| Swiss National Bank | 313,300 | $3,803 |
| PRESCOTT GROUP CAPITAL MANAGEMENT, L.L.C. | 313,000 | $3,800 |
| UBS ASSET MANAGEMENT AMERICAS INC | 307,747 | $3,736 |
| Brevan Howard Capital Management LP | 305,815 | $3,713 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 293,263 | $3,560 |
| FIRST TRUST ADVISORS LP | 268,694 | $3,262 |
| Rhenman & Partners Asset Management AB | 265,000 | $3,217 |
| BNP PARIBAS ARBITRAGE, SA | 255,921 | $3,107 |
| WELLS FARGO & COMPANY/MN | 255,222 | $3,098 |
| RHUMBLINE ADVISERS | 241,321 | $2,930 |
| Walleye Capital LLC | 230,509 | $2,798 |
| AQR CAPITAL MANAGEMENT LLC | 180,723 | $2,194 |
| Jump Financial, LLC | 173,793 | $2,110 |
| Verition Fund Management LLC | 171,606 | $2,083 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 171,524 | $2 |
| SEI INVESTMENTS CO | 169,673 | $2,060 |
| RoundAngle Advisors LLC | 168,854 | $2,050 |
| BEACON INVESTMENT ADVISORS LLC | 165,556 | $2,010 |
| STATE OF WISCONSIN INVESTMENT BOARD | 162,810 | $1,977 |
| Neo Ivy Capital Management | 160,389 | $1,947 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 159,746 | $1,939 |
| Legal & General Group Plc | 157,336 | $1,910 |
| ORBIMED ADVISORS LLC | 157,300 | $1,910 |
| Engineers Gate Manager LP | 154,969 | $1,881 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 150,701 | $1,830 |
| TWO SIGMA ADVISERS, LP | 142,924 | $1,735 |
| Artia Global Partners LP | 141,061 | $1,712 |
| TWINBEECH CAPITAL LP | 140,350 | $1,704 |
| 146 other institutions | 4,065,384 | $42,316 |