| Rubric Capital Management LP | 3,328,653 | $137,307 |
| VANGUARD GROUP INC | 3,112,937 | $128,409 |
| BAKER BROS. ADVISORS LP | 2,826,246 | $116,583 |
| TANG CAPITAL MANAGEMENT LLC | 2,259,889 | $93,220 |
| ACADIAN ASSET MANAGEMENT LLC | 1,713,043 | $71 |
| FMR LLC | 1,642,863 | $67,768 |
| MORGAN STANLEY | 1,360,044 | $56,102 |
| Fairmount Funds Management LLC | 1,319,688 | $54,437 |
| D. E. Shaw & Co., Inc. | 1,241,621 | $51,217 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 1,068,216 | $44,064 |
| BNP PARIBAS ARBITRAGE, SA | 831,777 | $34,311 |
| GOLDMAN SACHS GROUP INC | 829,417 | $34,213 |
| MILLENNIUM MANAGEMENT LLC | 825,285 | $34,043 |
| Point72 Asset Management, L.P. | 797,137 | $32,882 |
| Pictet Asset Management Holding SA | 787,520 | $32,485 |
| Qube Research & Technologies Ltd | 766,291 | $31,610 |
| CITADEL ADVISORS LLC | 742,118 | $30,612 |
| Connor, Clark & Lunn Investment Management Ltd. | 739,326 | $30,497 |
| DIMENSIONAL FUND ADVISORS LP | 683,505 | $28,194 |
| Parkman Healthcare Partners LLC | 665,208 | $27,440 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 632,827 | $26,104 |
| DEUTSCHE BANK AG\ | 630,291 | $26,000 |
| RICE HALL JAMES & ASSOCIATES, LLC | 596,431 | $24,603 |
| Soleus Capital Management, L.P. | 587,000 | $24,214 |
| SG Americas Securities, LLC | 541,396 | $22 |
| TWO SIGMA INVESTMENTS, LP | 530,496 | $21,883 |
| VICTORY CAPITAL MANAGEMENT INC | 512,163 | $21,127 |
| BlackRock, Inc. | 446,603 | $18,422 |
| Spruce Street Capital LP | 434,982 | $17,943 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 425,232 | $17,541 |
| NOMURA HOLDINGS INC | 412,639 | $17,021 |
| abrdn plc | 400,598 | $16,525 |
| AQR CAPITAL MANAGEMENT LLC | 353,062 | $14,564 |
| Logos Global Management LP | 350,000 | $14,438 |
| ArrowMark Colorado Holdings LLC | 333,702 | $13,765 |
| ALLIANCEBERNSTEIN L.P. | 328,274 | $13,541 |
| Granahan Investment Management, LLC | 316,213 | $13,044 |
| BRAIDWELL LP | 313,823 | $12,945 |
| OBERWEIS ASSET MANAGEMENT INC/ | 312,800 | $12,903 |
| Fisher Asset Management, LLC | 267,274 | $11,025 |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 250,975 | $10,353 |
| JANE STREET GROUP, LLC | 242,430 | $10,000 |
| BANK OF AMERICA CORP /DE/ | 229,364 | $9,461 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 228,933 | $9,443 |
| Trexquant Investment LP | 225,128 | $9,287 |
| Hillsdale Investment Management Inc. | 224,074 | $9,243 |
| SEI INVESTMENTS CO | 217,496 | $8,972 |
| PEREGRINE CAPITAL MANAGEMENT LLC | 210,910 | $8,700 |
| TWO SIGMA ADVISERS, LP | 208,300 | $8,592 |
| CASTLEARK MANAGEMENT LLC | 192,192 | $7,928 |
| ORBIMED ADVISORS LLC | 187,199 | $7,722 |
| Rockefeller Capital Management L.P. | 173,438 | $7,154 |
| JANUS HENDERSON GROUP PLC | 153,428 | $6,325 |
| Voleon Capital Management LP | 151,283 | $6,240 |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 148,774 | $6,137 |
| Walleye Capital LLC | 143,293 | $5,911 |
| LAZARD ASSET MANAGEMENT LLC | 140,301 | $5,787 |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 126,409 | $5,214 |
| Linden Thomas Advisory Services, LLC | 114,462 | $4,722 |
| NORDEA INVESTMENT MANAGEMENT AB | 110,682 | $4,539 |
| PDT Partners, LLC | 101,622 | $4,192 |
| EAM Investors, LLC | 96,018 | $3,961 |
| Atika Capital Management LLC | 93,970 | $3,876 |
| GLOBEFLEX CAPITAL L P | 93,396 | $3,853 |
| Jump Financial, LLC | 91,429 | $3,771 |
| Squarepoint Ops LLC | 85,182 | $3,514 |
| Hennion & Walsh Asset Management, Inc. | 79,200 | $3,267 |
| UBS Group AG | 77,916 | $3,214 |
| STATE STREET CORP | 73,002 | $3,011 |
| GSA CAPITAL PARTNERS LLP | 68,994 | $3 |
| Swiss National Bank | 68,600 | $2,830 |
| Schonfeld Strategic Advisors LLC | 63,995 | $2,640 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 63,530 | $2,621 |
| NORTHERN TRUST CORP | 60,297 | $2,487 |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 60,125 | $2,480 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 58,692 | $2,421 |
| WELLS FARGO & COMPANY/MN | 54,393 | $2,244 |
| RAYMOND JAMES FINANCIAL INC | 49,192 | $2,017 |
| SummitTX Capital, L.P. | 48,808 | $2,013 |
| JPMORGAN CHASE & CO | 48,397 | $1,996 |
| IEQ CAPITAL, LLC | 47,841 | $1,973 |
| GEODE CAPITAL MANAGEMENT, LLC | 45,783 | $1,886 |
| Cerity Partners LLC | 43,219 | $1,783 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 42,897 | $1,770 |
| UBS ASSET MANAGEMENT AMERICAS INC | 42,402 | $1,749 |
| Baird Financial Group, Inc. | 42,237 | $1,742 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 40,429 | $1,657 |
| Engineers Gate Manager LP | 39,873 | $1,645 |
| Man Group plc | 39,447 | $1,627 |
| Y-Intercept (Hong Kong) Ltd | 35,889 | $1,480 |
| OpenArc Corporate Advisory, LLC | 33,862 | $1,397 |
| Invesco Ltd. | 32,334 | $1,334 |
| AMERIPRISE FINANCIAL INC | 32,116 | $1,325 |
| Jain Global LLC | 31,806 | $1,312 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 31,498 | $1,299 |
| Artia Global Partners LP | 29,200 | $1,205 |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 28,955 | $1,194 |
| ADAR1 Capital Management, LLC | 28,728 | $1,185 |
| Legal & General Group Plc | 28,566 | $1,178 |
| FOX RUN MANAGEMENT, L.L.C. | 27,804 | $1,147 |
| 119 other institutions | 737,382 | $28,900 |