Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q4 2020 (← Previous) (Next →)
Filing Date: Feb 16, 2021
Total Value: $9.318B (91.6% shares, 8.4% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| — | MIRATI THERAPEUTICS INC | 3,693,516 | $811M | 8.7% | $219.64 | $111.11 | — | COM | 60468T105 |
| FOLD | AMICUS THERAPEUTICS INC | 25,112,048 | $580M | 6.2% | $23.09 * | $6.67 | +206.5% | COM | 03152W109 |
| BBIO | BRIDGEBIO PHARMA INC | 6,706,268 | $477M | 5.1% | $71.11 * | $27.26 | +77.0% | COM | 10806X102 |
| — | RETROPHIN INC | 45,000,000 | $443M | 4.7% | $9.83 | $0.78 | — | NOTE 2.500% 9/1 | 761299AB2 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 9,166,304 | $425M | 4.6% | $46.40 * | $13.07 | +203.8% | COM | 462260100 |
| — | INVITAE CORP | 7,284,466 | $305M | 3.3% | $41.81 | $41.81 | — | COM | 46185L103 |
| — | SPRINGWORKS THERAPEUTICS INC | 4,177,721 | $303M | 3.3% | $72.52 | $30.83 | — | COM | 85205L107 |
| — | GLOBAL BLOOD THERAPEUTICS IN | 5,674,711 | $246M | 2.6% | $43.31 | $32.86 | — | COM | 37890U108 |
| — | HORIZON THERAPEUTICS PUB L | 3,084,042 | $226M | 2.4% | $73.15 | $73.15 | — | SHS | G46188101 |
| — | ZYMEWORKS INC | 4,300,999 | $203M | 2.2% | $47.26 | $28.60 | — | COM | 98985W102 |
| RCKT | ROCKET PHARMACEUTICALS INC | 3,396,867 | $186M | 2.0% | $54.84 * | $23.99 | +52.0% | COM | 77313F106 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 1,899,215 | $182M | 2.0% | $95.85 | $49.72 | +94.3% | COM | 64125C109 |
| — | COLLEGIUM PHARMACEUTICAL INC | 17,500,000 | $173M | 1.9% | $9.90 | $8.98 | — | NOTE 2.625% 2/1 | 19459JAA2 |
| — | NEVRO CORP | 977,565 | $169M | 1.8% | $173.10 | $89.62 | — | COM | 64157F103 |
| — | NEVRO CORP | 9,000,000 | $165M | 1.8% | $18.38 | $13.50 | — | NOTE 2.750% 4/0 | 64157FAC7 |
| — | OUTSET MED INC | 2,847,822 | $162M | 1.7% | $56.84 | $50.00 | — | COM | 690145107 |
| — | VBI VACCINES INC | 55,042,465 | $151M | 1.6% | $2.75 | $1.95 | — | COM NEW | 91822J103 |
| — | ATHENEX INC | 13,532,467 | $150M | 1.6% | $11.06 | $14.52 | — | COM | 04685N103 |
| AVIR | ATEA PHARMACEUTICALS INC | 3,109,224 | $130M | 1.4% | $41.78 * | $32.23 | 0.0% | COM | 04683R106 |
| NVAX | NOVAVAX INC | 1,043,000 | $116M | 1.2% | $111.51 * | $88.78 | +19.7% | COM NEW | 670002401 |
| — | FREQUENCY THERAPEUTICS INC | 3,259,635 | $115M | 1.2% | $35.26 | $16.61 | — | COM | 35803L108 |
| KOD | KODIAK SCIENCES INC | 751,533 | $110M | 1.2% | $146.91 * | $12.82 | +769.5% | COM | 50015M109 |
| — | ATHIRA PHARMA INC | 3,114,805 | $107M | 1.1% | $34.25 | $18.46 | — | COM | 04746L104 |
| MGTX | MEIRAGTX HLDGS PLC | 6,933,277 | $105M | 1.1% | $15.14 * | $14.20 | -0.4% | COM | G59665102 |
| CCCC | C4 THERAPEUTICS INC | 3,158,566 | $105M | 1.1% | $33.13 * | $29.00 | 0.0% | COM STK | 12529R107 |
| RLAY | RELAY THERAPEUTICS INC | 2,329,407 | $96.81M | 1.0% | $41.56 * | $38.13 | +18.6% | COM | 75943R102 |
| TVTX | TRAVERE THERAPEUTICS INC | 3,493,607 | $95.22M | 1.0% | $27.25 * | $23.35 | 0.0% | COM | 89422G107 |
| — | EIDOS THERAPEUTICS INC | 686,922 | $90.39M | 1.0% | $131.58 | $20.90 | — | COM | 28249H104 |
| — | ALBIREO PHARMA INC | 2,360,139 | $88.53M | 1.0% | $37.51 | $25.25 | — | COM | 01345P106 |
| — | QUOTIENT LTD | 16,200,818 | $84.41M | 0.9% | $5.21 | $7.28 | — | SHS | G73268107 |
| — | KRONOS BIO INC | 2,780,097 | $83.04M | 0.9% | $29.87 | $29.87 | — | COM | 50107A104 |
| ARWR | ARROWHEAD PHARMACEUTICALS IN | 1,070,814 | $82.16M | 0.9% | $76.73 * | $63.95 | 0.0% | COM | 04280A100 |
| — | SOLID BIOSCIENCES INC | 10,803,857 | $81.89M | 0.9% | $7.58 | $4.67 | — | COM | 83422E105 |
| CHRS | COHERUS BIOSCIENCES INC | 4,671,836 | $81.2M | 0.9% | $17.38 * | $18.23 | -2.3% | COM | 19249H103 |
| — | CEREVEL THERAPEUTICS HLDNG I | 4,544,062 | $75.34M | 0.8% | $16.58 | $16.58 | — | COM | 15678U128 |
| — | PROVENTION BIO INC | 4,224,389 | $71.56M | 0.8% | $16.94 | $13.33 | — | COM | 74374N102 |
| — | KADMON HLDGS INC | 15,711,334 | $65.2M | 0.7% | $4.15 | $4.45 | — | COM | 48283N106 |
| IMVT | IMMUNOVANT INC | 1,400,000 | $64.67M | 0.7% | $46.19 | $23.28 | +98.6% | COM | 45258J102 |
| — | ONCORUS INC | 1,989,987 | $64.34M | 0.7% | $32.33 | $32.33 | — | COM | 68236R103 |
| — | INARI MED INC | 668,500 | $58.35M | 0.6% | $87.29 | $52.14 | — | COM | 45332Y109 |
| ZNTL | ZENTALIS PHARMACEUTICALS INC | 1,050,003 | $54.54M | 0.6% | $51.94 * | $38.35 | +17.6% | COM | 98943L107 |
| PMVP | PMV PHARMACEUTICALS INC | 885,556 | $54.47M | 0.6% | $61.51 * | $37.57 | +4.4% | COM | 69353Y103 |
| TARS | TARSUS PHARMACEUTICALS INC | 1,296,416 | $53.58M | 0.6% | $41.33 * | $28.48 | 0.0% | COM | 87650L103 |
| ADPT | ADAPTIVE BIOTECHNOLOGIES COR | 904,854 | $53.5M | 0.6% | $59.13 * | $40.48 | +27.4% | COM | 00650F109 |
| CRNX | CRINETICS PHARMACEUTICALS IN | 3,659,381 | $51.63M | 0.6% | $14.11 | $25.99 | -46.4% | COM | 22663K107 |
| UROV | UROVANT SCIENCES LTD | 3,116,831 | $50.27M | 0.5% | $16.13 | $11.13 | — | SHS | G9381B108 |
| CMPS | COMPASS PATHWAYS PLC | 1,047,404 | $49.9M | 0.5% | $47.64 | $34.90 | — | SPONSORED ADS | 20451W101 |
| — | AGILE THERAPEUTICS INC | 15,919,925 | $45.69M | 0.5% | $2.87 | $1.63 | — | COM | 00847L100 |
| — | ARENA PHARMACEUTICALS INC | 575,007 | $44.18M | 0.5% | $76.83 | $51.08 | — | COM NEW | 040047607 |
| — | FORMA THERAPEUTICS HLDGS INC | 1,250,000 | $43.63M | 0.5% | $34.90 | $46.49 | — | SHS | 34633R104 |
| ALDX | ALDEYRA THERAPEUTICS INC | 6,285,458 | $43.12M | 0.5% | $6.86 * | $6.55 | +7.3% | COM | 01438T106 |
| STOK | STOKE THERAPEUTICS INC | 671,978 | $41.62M | 0.4% | $61.93 * | $26.85 | +70.7% | COM | 86150R107 |
| COLL | COLLEGIUM PHARMACEUTICAL INC | 2,058,068 | $41.22M | 0.4% | $20.03 * | $19.57 | -0.2% | COM | 19459J104 |
| — | VERRICA PHARMACEUTICALS INC | 3,410,412 | $39.25M | 0.4% | $11.51 | $19.73 | — | COM | 92511W108 |
| — | SAGE THERAPEUTICS INC | 440,000 | $38.06M | 0.4% | $86.51 | $86.51 | — | COM | 78667J108 |
| — | LYRA THERAPEUTICS INC | 3,222,561 | $36.74M | 0.4% | $11.40 | $11.34 | — | COM | 55234L105 |
| — | VYNE THERAPEUTICS INC | 22,876,410 | $36.15M | 0.4% | $1.58 | $1.66 | — | COM NEW | 92941V100 |
| COGT | COGENT BIOSCIENCES INC | 3,188,750 | $35.81M | 0.4% | $11.23 * | $10.99 | 0.0% | COM | 19240Q201 |
| — | NEPTUNE WELLNESS SOLUTIONS I | 22,214,683 | $34.66M | 0.4% | $1.56 | $3.20 | — | COM | 64079L105 |
| ADMA | ADMA BIOLOGICS INC | 16,584,802 | $32.34M | 0.3% | $1.95 * | $4.00 | -47.4% | COM | 000899104 |
| RNAM | AVIDITY BIOSCIENCES INC | 1,235,818 | $31.54M | 0.3% | $25.52 * | $28.83 | +1.1% | COM | 05370A108 |
| — | RAPT THERAPEUTICS INC | 1,577,481 | $31.16M | 0.3% | $19.75 | $19.75 | — | COM | 75382E109 |
| — | IVERIC BIO INC | 4,482,713 | $30.98M | 0.3% | $6.91 | $6.13 | — | COM | 46583P102 |
| — | SILK RD MED INC | 465,100 | $29.29M | 0.3% | $62.98 | $44.75 | — | COM | 82710M100 |
| ALLO | ALLOGENE THERAPEUTICS INC | 1,143,790 | $28.87M | 0.3% | $25.24 * | $26.57 | +22.7% | COM | 019770106 |
| MGNX | MACROGENICS INC | 1,261,060 | $28.83M | 0.3% | $22.86 | $17.37 | +32.5% | COM | 556099109 |
| XBI | SPDR SER TR | 200,000 | $28.16M | 0.3% | $140.78 | — | — | Put | 78464A870 |
| — | VERU INC | 3,250,000 | $28.11M | 0.3% | $8.65 | $5.03 | — | COM | 92536C103 |
| — | ACCOLADE INC | 626,591 | $27.26M | 0.3% | $43.50 | $41.33 | — | COM | 00437E102 |
| — | CONCERT PHARMACEUTICALS INC | 2,150,641 | $27.18M | 0.3% | $12.64 | $12.16 | — | COM | 206022105 |
| IMTX | IMMATICS N.V | 2,500,000 | $26.98M | 0.3% | $10.79 * | $10.53 | +0.1% | SHS | N44445109 |
| REGN | REGENERON PHARMACEUTICALS | 55,175 | $26.66M | 0.3% | $483.12 * | $525.35 | +2.2% | COM | 75886F107 |
| LUNG | PULMONX CORP | 385,000 | $26.57M | 0.3% | $69.02 * | $48.97 | 0.0% | COM | 745848101 |
| — | FUSION PHARMACEUTICALS INC | 2,235,983 | $26.27M | 0.3% | $11.75 | $16.08 | — | COM | 36118A100 |
| ESTA | ESTABLISHMENT LABS HLDGS INC | 696,633 | $26.22M | 0.3% | $37.64 * | $24.79 | +6.3% | COM | G31249108 |
| ANAB | ANAPTYSBIO INC | 1,195,336 | $25.7M | 0.3% | $21.50 * | $24.28 | 0.0% | COM | 032724106 |
| FDMT | 4D MOLECULAR THERAPEUTICS IN | 600,256 | $24.88M | 0.3% | $41.45 | $41.28 | 0.0% | COM | 35104E100 |
| — | 1LIFE HEALTHCARE INC | 519,844 | $22.69M | 0.2% | $43.65 | $32.21 | — | COM | 68269G107 |
| — | NANOSTRING TECHNOLOGIES INC | 337,800 | $22.59M | 0.2% | $66.88 | $66.88 | — | COM | 63009R109 |
| PCVX | VAXCYTE INC | 850,000 | $22.59M | 0.2% | $26.57 * | $32.16 | +15.6% | COM | 92243G108 |
| GERN | GERON CORP | 13,461,538 | $21.4M | 0.2% | $1.59 * | $1.49 | +21.9% | COM | 374163103 |
| — | THERAPEUTICS ACQUISITION COR | 1,500,000 | $20.88M | 0.2% | $13.92 | $14.38 | — | COM CL A | 88339T103 |
| — | AMYRIS INC | 3,333,332 | $20.58M | 0.2% | $6.17 | $3.08 | — | COM NEW | 03236M200 |
| — | VERONA PHARMA PLC | 2,888,889 | $20.22M | 0.2% | $7.00 | $6.24 | — | SPONSORED ADS | 925050106 |
| WVE | WAVE LIFE SCIENCES LTD | 2,500,000 | $19.68M | 0.2% | $7.87 * | $10.96 | -23.4% | SHS | Y95308105 |
| — | LEAP THERAPEUTICS INC | 8,476,496 | $19.07M | 0.2% | $2.25 | $1.68 | — | COM | 52187K101 |
| VTRS | VIATRIS INC | 1,004,419 | $18.82M | 0.2% | $18.74 * | $13.33 | 0.0% | COM | 92556V106 |
| RGEN | REPLIGEN CORP | 97,500 | $18.68M | 0.2% | $191.63 * | $181.94 | 0.0% | COM | 759916109 |
| SCYX | SCYNEXIS INC | 2,400,000 | $18.36M | 0.2% | $7.65 * | $5.86 | 0.0% | COM NEW | 811292200 |
| HRMY | HARMONY BIOSCIENCES HLDGS IN | 502,622 | $18.17M | 0.2% | $36.15 * | $36.98 | +9.1% | COM | 413197104 |
| NBTX | NANOBIOTIX SA | 1,100,000 | $18.15M | 0.2% | $16.50 | $16.50 | — | SPONSORED ADS | 63009J107 |
| — | DICERNA PHARMACEUTICALS INC | 800,000 | $17.62M | 0.2% | $22.03 | $25.40 | — | COM | 253031108 |
| — | DBV TECHNOLOGIES S A | 6,595,505 | $17.28M | 0.2% | $2.62 | $8.65 | — | SPONSORED ADR | 23306J101 |
| CTMX | CYTOMX THERAPEUTICS INC | 2,577,043 | $16.88M | 0.2% | $6.55 * | $17.25 | -58.6% | COM | 23284F105 |
| — | MORPHIC HLDG INC | 487,000 | $16.34M | 0.2% | $33.55 | $19.82 | — | COM | 61775R105 |
| — | LONGVIEW ACQUISITION CORP | 700,000 | $15.15M | 0.2% | $21.65 | $10.10 | — | UNIT 99/99/9999 | 543195200 |
| TARA | PROTARA THERAPEUTICS INC | 608,544 | $14.73M | 0.2% | $24.21 * | $23.19 | -7.0% | COM STK | 74365U107 |
| — | AMERICAN WELL CORP | 525,000 | $13.3M | 0.1% | $25.33 | $29.06 | — | CL A | 03044L105 |
| PPH | VANECK VECTORS ETF TR | 200,000 | $13.29M | 0.1% | $66.47 | — | — | Put | 92189F692 |
| — | FORTE BIOSCIENCES INC | 350,000 | $12.74M | 0.1% | $36.41 | $36.41 | — | COM | 34962G109 |
| TSHA | TAYSHA GENE THERAPIES INC | 470,440 | $12.48M | 0.1% | $26.54 * | $23.52 | -8.4% | COM SHS | 877619106 |
| — | TCR2 THERAPEUTICS INC | 400,000 | $12.37M | 0.1% | $30.93 | $20.32 | — | COM | 87808K106 |
| HCAT | HEALTH CATALYST INC | 276,084 | $12.02M | 0.1% | $43.53 * | $36.58 | +0.9% | COM | 42225T107 |
| — | BCLS ACQUISITION CORP | 1,000,000 | $11.14M | 0.1% | $11.14 | $11.14 | — | COM CL A | G0904B105 |
| SCPE/U | SC HEALTH CORP | 1,000,000 | $10.99M | 0.1% | $10.99 | $10.35 | — | UNIT 99/99/9999 | G78516302 |
| — | CURIS INC | 1,250,000 | $10.24M | 0.1% | $8.19 | $8.19 | — | COM NEW | 231269200 |
| MRVI | MARAVAI LIFESCIENCES HLDGS I | 350,000 | $9.818M | 0.1% | $28.05 | $27.85 | 0.0% | COM LA A | 56600D107 |
| VRAYQ | VIEWRAY INC | 2,451,748 | $9.366M | 0.1% | $3.82 * | $9.17 | -61.4% | COM | 92672L107 |
| RVMD | REVOLUTION MEDICINES INC | 224,224 | $8.877M | 0.1% | $39.59 | $27.68 | +42.8% | COM | 76155X100 |
| — | POSEIDA THERAPEUTICS INC | 787,745 | $8.642M | 0.1% | $10.97 | $8.87 | — | COM | 73730P108 |
| DYN | DYNE THERAPEUTICS INC | 400,000 | $8.4M | 0.1% | $21.00 * | $21.96 | -9.9% | COM | 26818M108 |
| SHC | SOTERA HEALTH CO | 300,000 | $8.232M | 0.1% | $27.44 * | $26.84 | 0.0% | COM | 83601L102 |
| AQST | AQUESTIVE THERAPEUTICS INC | 1,385,720 | $7.414M | 0.1% | $5.35 * | $4.60 | +30.2% | COM | 03843E104 |
| SNDX | SYNDAX PHARMACEUTICALS INC | 300,000 | $6.672M | 0.1% | $22.24 * | $20.74 | 0.0% | COM | 87164F105 |
| — | VINCERA PHARMA INC | 300,000 | $6.273M | 0.1% | $20.91 | $20.91 | — | COM | 92731L106 |
| — | SIGILON THERAPEUTICS INC | 125,000 | $6.004M | 0.1% | $48.03 | $48.03 | — | COM | 82657L107 |
| — | HEALTH SCIENCES ACQ CORP 2 | 450,000 | $5.765M | 0.1% | $12.81 | $11.00 | — | ORD SHS | G4411D109 |
| — | BCTG ACQUISITION CORP | 500,000 | $5.72M | 0.1% | $11.44 | $10.36 | — | COM | 05492W103 |
| PHR | PHREESIA INC | 100,000 | $5.426M | 0.1% | $54.26 * | $42.91 | 0.0% | COM | 71944F106 |
| — | CONSONANCE HFW ACQUISITION C | 500,000 | $5.235M | 0.1% | $10.47 | $10.47 | — | UNIT 99/99/9999 | G2445M129 |
| — | DEERFIELD HEALTHCARE TECH AC | 300,000 | $4.5M | 0.0% | $15.00 | $10.63 | — | UNIT 07/16/2025 | 244413209 |
| MASS | 908 DEVICES INC | 77,500 | $4.414M | 0.0% | $56.95 * | $58.41 | 0.0% | COM | 65443P102 |
| AVXL | ANAVEX LIFE SCIENCES CORP | 780,007 | $4.212M | 0.0% | $5.40 * | $5.27 | 0.0% | COM NEW | 032797300 |
| PTGX | PROTAGONIST THERAPEUTICS INC | 203,591 | $4.104M | 0.0% | $20.16 * | $21.52 | 0.0% | COM | 74366E102 |
| — | MOTUS GI HLDGS INC | 4,210,542 | $3.906M | 0.0% | $0.93 | $4.01 | — | COM | 62014P108 |
| — | MOLECULAR TEMPLATES INC | 411,818 | $3.867M | 0.0% | $9.39 | $7.26 | — | COM | 608550109 |
| — | BURNING ROCK BIOTECH LTD | 150,000 | $3.465M | 0.0% | $23.10 | $27.01 | — | SPONSORED ADS | 12233L107 |
| GRTX | GALERA THERAPEUTICS INC | 325,000 | $3.325M | 0.0% | $10.23 * | $12.19 | -10.3% | COM | 36338D108 |
| — | LIFESCI ACQUISITION II CORP | 300,000 | $3.201M | 0.0% | $10.67 | $10.67 | — | COM | 53229E103 |
| ADAPY | ADAPTIMMUNE THERAPEUTICS PLC | 400,000 | $2.156M | 0.0% | $5.39 | $10.01 | — | SPONDS ADR | 00653A107 |
| — | EIGER BIOPHARMACEUTICALS INC | 139,890 | $1.719M | 0.0% | $12.29 | $15.33 | — | COM | 28249U105 |
| RACE | FERRARI N V | 6,200 | $1.423M | 0.0% | $229.52 * | $40.37 | +405.4% | COM | N3167Y103 |
| — | SIERRA ONCOLOGY INC | 66,655 | $1.068M | 0.0% | $16.02 | $9.96 | — | COM NEW | 82640U404 |
| — | VINCERA PHARMA INC | 300,000 | $990K | 0.0% | $3.30 | $3.30 | — | *W EXP 12/24/202 | 92731L114 |
| ABCL | ABCELLERA BIOLOGICS INC | 20,000 | $805K | 0.0% | $40.25 * | $45.73 | 0.0% | COM | 00288U106 |
| LEGN | LEGEND BIOTECH CORP | 25,000 | $704K | 0.0% | $28.16 | $42.56 | — | SPONSORED ADS | 52490G102 |
| — | SOCIAL CAPITAL HEDOSOPHIA HLD | 40,000 | $671K | 0.0% | $16.77 | $16.77 | — | SHS CL A | G8251L105 |
| — | DEERFIELD HEALTHCARE TECH AC | 20,000 | $312K | 0.0% | $15.60 | $15.60 | — | COM CL A | 244413100 |
| — | OUTLOOK THERAPEUTICS INC | 420,875 | $93,000 | 0.0% | $0.22 | $0.17 | — | *W EXP 02/18/202 | 69012T115 |