Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q1 2021 (← Previous) (Next →)
Filing Date: Aug 13, 2021
Total Value: $7.908B (89.9% shares, 10.1% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| — | MIRATI THERAPEUTICS INC | 3,474,505 | $595M | 7.5% | $171.30 | $111.11 | — | COM | 60468T105 |
| BBIO | BRIDGEBIO PHARMA INC | 7,756,928 | $478M | 6.0% | $61.60 * | $32.43 | +101.7% | COM | 10806X102 |
| — | RETROPHIN INC | 45,000,000 | $475M | 6.0% | $10.55 | $0.78 | — | NOTE 2.500% 9/1 | 761299AB2 |
| — | SPRINGWORKS THERAPEUTICS INC | 4,849,912 | $357M | 4.5% | $73.57 | $36.75 | — | COM | 85205L107 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 8,651,785 | $274M | 3.5% | $31.66 * | $13.07 | +217.2% | COM | 462260100 |
| FOLD | AMICUS THERAPEUTICS INC | 22,861,329 | $226M | 2.9% | $9.88 * | $6.67 | +132.0% | COM | 03152W109 |
| BIIB | BIOGEN INC | 748,000 | $209M | 2.6% | $279.75 | — | — | Call | 09062X103 |
| — | GLOBAL BLOOD THERAPEUTICS IN | 5,058,642 | $206M | 2.6% | $40.75 | $32.86 | — | COM | 37890U108 |
| — | INVITAE CORP | 5,360,673 | $205M | 2.6% | $38.21 | $41.81 | — | COM | 46185L103 |
| — | COLLEGIUM PHARMACEUTICAL INC | 17,500,000 | $190M | 2.4% | $10.83 | $8.98 | — | NOTE 2.625% 2/1 | 19459JAA2 |
| — | HORIZON THERAPEUTICS PUB L | 2,050,002 | $189M | 2.4% | $92.04 | $73.15 | — | SHS | G46188101 |
| AVIR | ATEA PHARMACEUTICALS INC | 3,109,224 | $185M | 2.3% | $59.40 * | $32.23 | +109.6% | COM | 04683R106 |
| — | VBI VACCINES INC CDA | 55,042,465 | $171M | 2.2% | $3.11 | $1.95 | — | COM NEW | 91822J103 |
| BIIB | BIOGEN INC | 600,000 | $168M | 2.1% | $279.75 | — | — | Put | 09062X103 |
| — | LANDOS BIOPHARMA INC | 14,869,915 | $141M | 1.8% | $9.48 | $9.48 | — | COM | 515069102 |
| — | ZYMEWORKS INC | 4,330,868 | $137M | 1.7% | $31.58 | $28.60 | — | COM | 98985W102 |
| — | NEVRO CORP | 9,000,000 | $135M | 1.7% | $15.04 | $13.50 | — | NOTE 2.750% 4/0 | 64157FAC7 |
| — | OUTSET MED INC | 2,387,535 | $130M | 1.6% | $54.39 | $50.00 | — | COM | 690145107 |
| RCKT | ROCKET PHARMACEUTICALS INC | 2,867,771 | $127M | 1.6% | $44.37 * | $23.99 | +128.9% | COM | 77313F106 |
| CCCC | C4 THERAPEUTICS INC | 3,158,566 | $117M | 1.5% | $36.99 * | $29.00 | +37.2% | COM STK | 12529R107 |
| — | NEVRO CORP | 812,154 | $113M | 1.4% | $139.50 | $89.62 | — | COM | 64157F103 |
| ALDX | ALDEYRA THERAPEUTICS INC | 8,703,879 | $103M | 1.3% | $11.88 * | $7.93 | +45.3% | COM | 01438T106 |
| MGTX | MEIRAGTX HLDGS PLC | 6,933,277 | $93.37M | 1.2% | $13.47 * | $14.20 | +10.0% | COM | G59665102 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 941,832 | $91.59M | 1.2% | $97.25 * | $49.72 | +110.9% | COM | 64125C109 |
| — | ALBIREO PHARMA INC | 2,360,139 | $83.19M | 1.1% | $35.25 | $25.25 | — | COM | 01345P106 |
| TVTX | TRAVERE THERAPEUTICS INC | 3,298,419 | $82.36M | 1.0% | $24.97 * | $23.35 | +18.3% | COM | 89422G107 |
| — | KRONOS BIO INC | 2,780,097 | $79.67M | 1.0% | $28.66 | $29.87 | — | COM | 50107A104 |
| — | SOLID BIOSCIENCES INC | 13,412,552 | $74.17M | 0.9% | $5.53 | $4.84 | — | COM | 83422E105 |
| RLAY | RELAY THERAPEUTICS INC | 2,018,097 | $69.77M | 0.9% | $34.57 * | $38.13 | +13.8% | COM | 75943R102 |
| CHRS | COHERUS BIOSCIENCES INC | 4,697,612 | $68.63M | 0.9% | $14.61 * | $18.23 | -6.9% | COM | 19249H103 |
| MGNX | MACROGENICS INC | 2,148,060 | $68.42M | 0.9% | $31.85 * | $20.23 | +20.1% | COM | 556099109 |
| — | CEREVEL THERAPEUTICS HLDNG I | 4,643,095 | $63.75M | 0.8% | $13.73 | $16.52 | — | COM | 15678U128 |
| — | ATHIRA PHARMA INC | 3,425,916 | $63.04M | 0.8% | $18.40 | $18.45 | — | COM | 04746L104 |
| ESTA | ESTABLISHMENT LABS HLDGS INC | 987,287 | $61.73M | 0.8% | $62.53 * | $34.47 | +67.3% | COM | G31249108 |
| — | KADMON HLDGS INC | 15,711,334 | $61.12M | 0.8% | $3.89 | $4.45 | — | COM | 48283N106 |
| — | INARI MED INC | 565,113 | $60.47M | 0.8% | $107.00 | $52.14 | — | COM | 45332Y109 |
| — | QUOTIENT LTD | 16,200,818 | $59.62M | 0.8% | $3.68 | $7.28 | — | SHS | G73268107 |
| — | MORPHIC HLDG INC | 938,140 | $59.37M | 0.8% | $63.28 | $40.72 | — | COM | 61775R105 |
| — | ATHENEX INC | 13,532,467 | $57.33M | 0.7% | $4.24 | $14.52 | — | COM | 04685N103 |
| — | PROMETHEUS BIOSCIENCES INC | 3,314,032 | $55.35M | 0.7% | $16.70 | $16.70 | — | COM | 74349U108 |
| — | RAPT THERAPEUTICS INC | 2,477,481 | $55M | 0.7% | $22.20 | $20.64 | — | COM | 75382E109 |
| — | VERRICA PHARMACEUTICALS INC | 3,610,412 | $54.7M | 0.7% | $15.15 | $19.48 | — | COM | 92511W108 |
| CRNX | CRINETICS PHARMACEUTICALS IN | 3,659,381 | $51.61M | 0.7% | $14.10 * | $25.99 | -40.4% | COM | 22663K107 |
| — | VERU INC | 4,451,342 | $47.96M | 0.6% | $10.77 | $6.58 | — | COM | 92536C103 |
| EXAS | EXACT SCIENCES CORP | 353,523 | $46.59M | 0.6% | $131.78 * | $136.88 | 0.0% | COM | 30063P105 |
| — | VYNE THERAPEUTICS INC | 6,773,954 | $46.37M | 0.6% | $6.85 | $6.85 | — | COM | 92941V209 |
| KOD | KODIAK SCIENCES INC | 389,008 | $44.11M | 0.6% | $113.39 * | $12.82 | +965.1% | COM | 50015M109 |
| TARS | TARSUS PHARMACEUTICALS INC | 1,296,416 | $41.13M | 0.5% | $31.72 * | $28.48 | +29.8% | COM | 87650L103 |
| — | DBV TECHNOLOGIES S A | 7,695,505 | $41.02M | 0.5% | $5.33 | $8.17 | — | SPONSORED ADR | 23306J101 |
| ALLO | ALLOGENE THERAPEUTICS INC | 1,143,790 | $40.38M | 0.5% | $35.30 * | $26.57 | +27.0% | COM | 019770106 |
| — | ARENA PHARMACEUTICALS INC | 575,007 | $39.9M | 0.5% | $69.39 | $51.08 | — | COM NEW | 040047607 |
| BEAM | BEAM THERAPEUTICS INC | 537,635 | $37.83M | 0.5% | $70.37 * | $95.13 | 0.0% | COM | 07373V105 |
| — | LYRA THERAPEUTICS INC | 3,222,560 | $37.35M | 0.5% | $11.59 | $11.34 | — | COM | 55234L105 |
| ACAD | ACADIA PHARMACEUTICALS INC | 1,410,305 | $36.39M | 0.5% | $25.80 * | $44.02 | 0.0% | COM | 004225108 |
| — | FORMA THERAPEUTICS HOLDINGS | 1,250,000 | $35.02M | 0.4% | $28.02 | $46.49 | — | SHS | 34633R104 |
| — | AGILE THERAPEUTICS INC | 15,919,925 | $33.11M | 0.4% | $2.08 | $1.63 | — | COM | 00847L100 |
| — | PROVENTION BIO INC | 2,852,058 | $29.93M | 0.4% | $10.49 | $13.33 | — | COM | 74374N102 |
| CMPS | COMPASS PATHWAYS PLC | 797,404 | $29.36M | 0.4% | $36.82 | $34.90 | — | SPONSORED ADS | 20451W101 |
| UTHR | UNITED THERAPEUTICS CORP DEL | 175,000 | $29.27M | 0.4% | $167.27 | $166.73 | 0.0% | COM | 91307C102 |
| ADMA | ADMA BIOLOGICS INC | 16,584,802 | $29.19M | 0.4% | $1.76 * | $4.00 | -42.7% | COM | 000899104 |
| NUVB | NUVATION BIO INC | 3,041,004 | $29.04M | 0.4% | $9.55 * | $11.18 | 0.0% | COM CL A | 67080N101 |
| — | IVERIC BIO INC | 4,585,512 | $28.34M | 0.4% | $6.18 | $6.13 | — | COM | 46583P102 |
| IMTX | IMMATICS N.V | 2,500,000 | $28.02M | 0.4% | $11.21 | $10.53 | +7.7% | SHS | N44445109 |
| COGT | COGENT BIOSCIENCES INC | 3,188,750 | $28M | 0.4% | $8.78 * | $10.99 | -12.4% | COM | 19240Q201 |
| — | ONCORUS INC | 1,989,987 | $27.7M | 0.4% | $13.92 | $32.33 | — | COM | 68236R103 |
| ARWR | ARROWHEAD PHARMACEUTICALS IN | 409,341 | $27.14M | 0.3% | $66.31 * | $63.95 | +21.3% | COM | 04280A100 |
| STOK | STOKE THERAPEUTICS INC | 671,978 | $26.1M | 0.3% | $38.84 * | $26.85 | +112.0% | COM | 86150R107 |
| ATEC | ALPHATEC HOLDINGS INC | 1,800,180 | $25.49M | 0.3% | $14.16 * | $15.74 | 0.0% | COM NEW | 02081G201 |
| PMVP | PMV PHARMACEUTICALS INC | 746,557 | $24.55M | 0.3% | $32.89 * | $37.57 | +4.9% | COM | 69353Y103 |
| — | VERONA PHARMA PLC | 2,888,889 | $24.15M | 0.3% | $8.36 | $6.24 | — | SPONSORED ADS | 925050106 |
| RNAM | AVIDITY BIOSCIENCES INC | 1,099,028 | $23.97M | 0.3% | $21.81 * | $28.83 | -15.1% | COM | 05370A108 |
| HCAT | HEALTH CATALYST INC | 506,084 | $23.67M | 0.3% | $46.77 * | $41.97 | +15.4% | COM | 42225T107 |
| — | FORTE BIOSCIENCES INC | 685,000 | $23.48M | 0.3% | $34.27 | $35.36 | — | COM | 34962G109 |
| COLL | COLLEGIUM PHARMACEUTICAL INC | 978,277 | $23.18M | 0.3% | $23.70 | $19.57 | +21.4% | COM | 19459J104 |
| — | FUSION PHARMACEUTICALS INC | 1,950,167 | $20.91M | 0.3% | $10.72 | $16.08 | — | COM | 36118A100 |
| — | DICERNA PHARMACEUTICALS INC | 800,000 | $20.46M | 0.3% | $25.57 | $25.40 | — | COM | 253031108 |
| — | 1LIFE HEALTHCARE INC | 519,844 | $20.32M | 0.3% | $39.08 | $32.21 | — | COM | 68269G107 |
| MREO | MEREO BIOPHARMA GROUP PLC | 6,000,000 | $20.22M | 0.3% | $3.37 | $3.37 | — | ADS | 589492107 |
| — | FREQUENCY THERAPEUTICS INC | 2,113,661 | $20.08M | 0.3% | $9.50 | $16.61 | — | COM | 35803L108 |
| FDMT | 4D MOLECULAR THERAPEUTICS IN | 444,878 | $19.3M | 0.2% | $43.38 * | $41.28 | +7.3% | COM | 35104E100 |
| — | SILK RD MED INC | 340,100 | $17.23M | 0.2% | $50.65 | $44.75 | — | COM | 82710M100 |
| IMCR | IMMUNOCORE HLDGS PLC | 400,000 | $17.03M | 0.2% | $42.57 | $42.57 | — | ADS | 45258D105 |
| PCVX | VAXCYTE INC | 850,000 | $16.79M | 0.2% | $19.75 * | $32.16 | -21.8% | COM | 92243G108 |
| CTMX | CYTOMX THERAPEUTICS INC | 2,153,974 | $16.65M | 0.2% | $7.73 * | $17.25 | -54.1% | COM | 23284F105 |
| — | NEPTUNE WELLNESS SOLUTIONS I | 12,849,706 | $16.55M | 0.2% | $1.29 | $3.20 | — | COM | 64079L105 |
| ACRS | ACLARIS THERAPEUTICS INC | 650,000 | $16.38M | 0.2% | $25.20 * | $19.56 | 0.0% | COM | 00461U105 |
| — | LEAP THERAPEUTICS INC | 8,476,496 | $16.11M | 0.2% | $1.90 | $1.68 | — | COM | 52187K101 |
| — | CM LIFE SCIENCES II INC | 1,250,000 | $16M | 0.2% | $12.80 | $12.80 | — | UNIT 02/25/2028 | 125842203 |
| NBTX | NANOBIOTIX SA | 1,059,800 | $15.94M | 0.2% | $15.04 | $16.50 | — | SPONSORED ADS | 63009J107 |
| — | THERAPEUTICS ACQUISITION COR | 1,500,000 | $15.77M | 0.2% | $10.51 | $14.38 | — | COM CL A | 88339T103 |
| — | ACCOLADE INC | 345,741 | $15.69M | 0.2% | $45.37 | $41.33 | — | COM | 00437E102 |
| HYPR | HEALTHCOR CATALIO ACQU CORP | 1,500,000 | $14.88M | 0.2% | $9.92 | $9.92 | — | CL A SHRS | G44125105 |
| ADPT | ADAPTIVE BIOTECHNOLOGIES COR | 352,804 | $14.2M | 0.2% | $40.26 * | $40.48 | +33.7% | COM | 00650F109 |
| VTRS | VIATRIS INC | 1,004,419 | $14.03M | 0.2% | $13.97 * | $13.33 | -0.1% | COM | 92556V106 |
| — | ACHILLES THERAPEUTICS PLC | 755,375 | $12.5M | 0.2% | $16.55 | $16.55 | — | SPONSORED ADS | 00449L102 |
| — | CONCERT PHARMACEUTICALS INC | 2,150,641 | $10.73M | 0.1% | $4.99 | $12.16 | — | COM | 206022105 |
| — | BCLS ACQUISITION CORP | 1,000,000 | $10.57M | 0.1% | $10.57 | $11.14 | — | COM CL A | G0904B105 |
| CLOV | CLOVER HEALTH INVESTMENTS CO | 1,500,000 | $10.32M | 0.1% | $6.88 * | $11.28 | 0.0% | COM CL A | 18914F103 |
| HRMY | HARMONY BIOSCIENCES HLDGS IN | 311,673 | $10.3M | 0.1% | $33.04 * | $36.98 | -5.2% | COM | 413197104 |
| — | RESEARCH ALLIANCE CORP II | 1,000,000 | $10.25M | 0.1% | $10.25 | $10.25 | — | COM CL A | 760873109 |
| TSHA | TAYSHA GENE THERAPIES INC | 470,440 | $9.548M | 0.1% | $20.30 * | $23.52 | +15.1% | COM SHS | 877619106 |
| XENE | XENON PHARMACEUTICALS INC | 515,042 | $9.219M | 0.1% | $17.90 * | $16.95 | 0.0% | COM | 98420N105 |
| — | POSEIDA THERAPEUTICS INC | 787,745 | $7.523M | 0.1% | $9.55 | $8.87 | — | COM | 73730P108 |
| — | FIBROGEN INC | 200,000 | $6.942M | 0.1% | $34.71 | — | — | Put | 31572Q808 |
| — | TCR2 THERAPEUTICS INC | 313,300 | $6.918M | 0.1% | $22.08 | $20.32 | — | COM | 87808K106 |
| TARA | PROTARA THERAPEUTICS INC | 421,642 | $6.637M | 0.1% | $15.74 * | $23.19 | -20.0% | COM STK | 74365U107 |
| — | DARIOHEALTH CORP | 327,869 | $6.314M | 0.1% | $19.26 | $19.26 | — | COM NEW | 23725P209 |
| — | AMERICAN WELL CORP | 355,000 | $6.166M | 0.1% | $17.37 | $29.06 | — | CL A | 03044L105 |
| SNDX | SYNDAX PHARMACEUTICALS INC | 270,000 | $6.037M | 0.1% | $22.36 | $20.74 | +8.9% | COM | 87164F105 |
| — | VINCERX PHARMA INC | 300,000 | $5.79M | 0.1% | $19.30 | $20.91 | — | COM NEW | 92731L106 |
| — | CATABASIS PHARMACEUTICALS IN | 1,933,551 | $5.588M | 0.1% | $2.89 | $2.89 | — | COM NEW | 14875P206 |
| — | BCTG ACQUISITION CORP | 500,000 | $5.56M | 0.1% | $11.12 | $10.36 | — | COM | 05492W103 |
| PHR | PHREESIA INC | 100,000 | $5.21M | 0.1% | $52.10 * | $42.91 | +46.8% | COM | 71944F106 |
| — | HEALTH SCIENCES ACQ CORP 2 | 450,000 | $5.036M | 0.1% | $11.19 | $11.00 | — | ORD SHS | G4411D109 |
| — | LONGVIEW ACQUISITION CORP II | 500,000 | $5.02M | 0.1% | $10.04 | $10.04 | — | UNIT 99/99/9999 | 54319Q204 |
| — | CONSONANCE HFW ACQUISITION C | 500,000 | $4.88M | 0.1% | $9.76 | $10.47 | — | UNIT 99/99/9999 | G2445M129 |
| — | DEERFIELD HEALTHCARE TECH AC | 300,000 | $3.93M | 0.0% | $13.10 | $10.63 | — | UNIT 07/16/2025 | 244413209 |
| — | THERAPEUTICSMD INC | 2,750,000 | $3.685M | 0.0% | $1.34 | $1.34 | — | COM | 88338N107 |
| — | MERUS N V | 175,000 | $3.655M | 0.0% | $20.89 | $20.89 | — | COM | N5749R100 |
| VRAYQ | VIEWRAY INC | 751,748 | $3.27M | 0.0% | $4.35 * | $9.17 | -47.0% | COM | 92672L107 |
| — | TALIS BIOMEDICAL CORP | 250,000 | $3.212M | 0.0% | $12.85 | $12.85 | — | COM | 87424L108 |
| — | LIFESCI ACQUISITION II CORP | 300,000 | $3.042M | 0.0% | $10.14 | $10.67 | — | COM | 53229E103 |
| — | SIGILON THERAPEUTICS INC | 125,000 | $2.794M | 0.0% | $22.35 | $48.03 | — | COM | 82657L107 |
| RGNX | REGENXBIO INC | 69,283 | $2.363M | 0.0% | $34.11 * | $42.65 | 0.0% | COM | 75901B107 |
| GRTX | GALERA THERAPEUTICS INC | 254,664 | $2.246M | 0.0% | $8.82 * | $12.19 | -10.0% | COM | 36338D108 |
| — | MOTUS GI HLDGS INC | 1,800,542 | $2.07M | 0.0% | $1.15 | $4.01 | — | COM | 62014P108 |
| — | PLX PHARMA INC | 222,180 | $2.006M | 0.0% | $9.03 | $9.03 | — | COM | 72942A107 |
| — | CM LIFE SCIENCES INC | 127,000 | $1.891M | 0.0% | $14.89 | $14.89 | — | COM CL A | 18978W109 |
| BFLYW | BUTTERFLY NETWORK INC | 233,333 | $1.505M | 0.0% | $6.45 | $6.45 | — | *W EXP 05/27/202 | 124155110 |
| RACE | FERRARI N V | 6,200 | $1.298M | 0.0% | $209.35 * | $40.37 | +407.2% | COM | N3167Y103 |
| — | EIGER BIOPHARMACEUTICALS INC | 139,890 | $1.238M | 0.0% | $8.85 | $15.33 | — | COM | 28249U105 |
| — | VINCERX PHARMA INC | 300,000 | $1.212M | 0.0% | $4.04 | $3.30 | — | *W EXP 12/24/202 | 92731L114 |
| — | SIERRA ONCOLOGY INC | 66,655 | $1.148M | 0.0% | $17.22 | $9.96 | — | COM NEW | 82640U404 |
| — | SC HEALTH CORP | 500,000 | $945K | 0.0% | $1.89 | $1.89 | — | *W EXP 99/99/999 | G78516401 |
| PHVS | PHARVARIS N V | 27,000 | $755K | 0.0% | $27.96 * | $31.46 | 0.0% | COM | N69605108 |
| — | CEREVEL THERAPEUTICS HLDNG I | 133,066 | $573K | 0.0% | $4.31 | $4.31 | — | *W EXP 06/09/202 | 15678U102 |
| — | CEL-SCI CORP | 33,700 | $513K | 0.0% | $15.22 | $15.22 | — | COM PAR NEW | 150837607 |
| SANA | SANA BIOTECHNOLOGY INC | 10,000 | $335K | 0.0% | $33.50 * | $32.56 | 0.0% | COM | 799566104 |
| — | DEERFIELD HEALTHCARE TECH AC | 20,000 | $242K | 0.0% | $12.10 | $15.60 | — | COM CL A | 244413100 |