Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q3 2021 (← Previous) (Next →)
Filing Date: Dec 3, 2021
Total Value: $6.884B (88.0% shares, 12.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| — | MIRATI THERAPEUTICS INC | 3,387,745 | $599M | 8.7% | $176.91 | $115.03 | — | COM | 60468T105 |
| — | TRAVERE THERAPEUTICS INC | 45,000,000 | $455M | 6.6% | $10.11 | $0.78 | — | NOTE 2.500% 9/1 | 761299AB2 |
| BBIO | BRIDGEBIO PHARMA INC | 7,756,928 | $364M | 5.3% | $46.87 * | $32.43 | +65.3% | COM | 10806X102 |
| — | SPRINGWORKS THERAPEUTICS INC | 4,849,912 | $308M | 4.5% | $63.44 | $36.75 | — | COM | 85205L107 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 11,489,772 | $283M | 4.1% | $24.66 * | $16.15 | +45.9% | COM | 462260100 |
| FOLD | AMICUS THERAPEUTICS INC | 26,559,443 | $254M | 3.7% | $9.55 * | $7.16 | +42.8% | COM | 03152W109 |
| — | LANDOS BIOPHARMA INC | 14,869,915 | $217M | 3.2% | $14.60 | $9.48 | — | COM | 515069102 |
| — | HORIZON THERAPEUTICS PUB L | 1,956,940 | $214M | 3.1% | $109.54 | $73.15 | — | SHS | G46188101 |
| — | COLLEGIUM PHARMACEUTICAL INC | 17,500,000 | $180M | 2.6% | $10.30 | $8.98 | — | NOTE 2.625% 2/1 | 19459JAA2 |
| — | VBI VACCINES INC CDA | 55,042,465 | $171M | 2.5% | $3.11 | $1.95 | — | COM NEW | 91822J103 |
| — | CEREVEL THERAPEUTICS HLDNG I | 5,086,727 | $150M | 2.2% | $29.50 | $17.65 | — | COM | 15678U128 |
| — | NEVRO CORP | 9,000,000 | $126M | 1.8% | $14.03 | $13.50 | — | NOTE 2.750% 4/0 | 64157FAC7 |
| — | IVERIC BIO INC | 7,471,798 | $121M | 1.8% | $16.24 | $10.04 | — | COM | 46583P102 |
| — | GLOBAL BLOOD THERAPEUTICS IN | 4,407,399 | $112M | 1.6% | $25.48 | $32.43 | — | COM | 37890U108 |
| — | INVITAE CORP | 3,923,741 | $112M | 1.6% | $28.43 | $41.81 | — | COM | 46185L103 |
| — | ZYMEWORKS INC | 3,679,845 | $107M | 1.6% | $29.04 | $28.60 | — | COM | 98985W102 |
| CCCC | C4 THERAPEUTICS INC | 2,258,566 | $101M | 1.5% | $44.68 * | $29.00 | +47.7% | COM STK | 12529R107 |
| — | OUTSET MED INC | 1,990,633 | $98.42M | 1.4% | $49.44 | $50.00 | — | COM | 690145107 |
| MGTX | MEIRAGTX HLDGS PLC | 6,948,277 | $91.58M | 1.3% | $13.18 * | $14.20 | -3.6% | COM | G59665102 |
| — | RAPT THERAPEUTICS INC | 2,907,565 | $90.28M | 1.3% | $31.05 | $22.19 | — | COM | 75382E109 |
| ALDX | ALDEYRA THERAPEUTICS INC | 9,903,879 | $86.96M | 1.3% | $8.78 * | $8.42 | +9.0% | COM | 01438T106 |
| CRNX | CRINETICS PHARMACEUTICALS IN | 3,963,517 | $83.43M | 1.2% | $21.05 | $25.34 | -17.5% | COM | 22663K107 |
| AVIR | ATEA PHARMACEUTICALS INC | 2,259,224 | $79.21M | 1.2% | $35.06 * | $32.23 | -14.0% | COM | 04683R106 |
| — | PROMETHEUS BIOSCIENCES INC | 3,314,032 | $78.58M | 1.1% | $23.71 | $16.70 | — | COM | 74349U108 |
| CHRS | COHERUS BIOSCIENCES INC | 4,779,387 | $76.81M | 1.1% | $16.07 * | $18.17 | -19.3% | COM | 19249H103 |
| — | ALBIREO PHARMA INC | 2,360,139 | $73.64M | 1.1% | $31.20 | $25.25 | — | COM | 01345P106 |
| RCKT | ROCKET PHARMACEUTICALS INC | 2,310,261 | $69.05M | 1.0% | $29.89 * | $23.99 | +51.7% | COM | 77313F106 |
| PRCT | PROCEPT BIOROBOTICS CORP | 1,656,990 | $63.21M | 0.9% | $38.15 | $38.38 | 0.0% | COM | 74276L105 |
| RLAY | RELAY THERAPEUTICS INC | 1,943,097 | $61.27M | 0.9% | $31.53 * | $38.13 | -11.7% | COM | 75943R102 |
| — | ICOSAVAX INC | 1,922,549 | $56.89M | 0.8% | $29.59 | $29.59 | — | COM | 45114M109 |
| NAUT | NAUTILUS BIOTECHNOLOGY INC | 8,911,151 | $54.71M | 0.8% | $6.14 * | $10.83 | -26.4% | COM | 63909J108 |
| — | KRONOS BIO INC | 2,421,142 | $50.75M | 0.7% | $20.96 | $29.87 | — | COM | 50107A104 |
| — | MORPHIC HLDG INC | 887,340 | $50.26M | 0.7% | $56.64 | $40.72 | — | COM | 61775R105 |
| — | COHERUS BIOSCIENCES INC | 4,500,000 | $49.37M | 0.7% | $10.97 | $10.23 | — | NOTE 1.500% 4/1 | 19249HAB9 |
| TVTX | TRAVERE THERAPEUTICS INC | 1,965,555 | $47.66M | 0.7% | $24.25 * | $23.04 | -20.3% | COM | 89422G107 |
| BEAM | BEAM THERAPEUTICS INC | 537,635 | $46.78M | 0.7% | $87.01 * | $95.13 | +5.6% | COM | 07373V105 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 483,007 | $46.33M | 0.7% | $95.91 | $49.72 | +90.0% | COM | 64125C109 |
| — | VERRICA PHARMACEUTICALS INC | 3,610,412 | $45.13M | 0.7% | $12.50 | $19.48 | — | COM | 92511W108 |
| MGNX | MACROGENICS INC | 2,148,060 | $44.98M | 0.7% | $20.94 * | $20.23 | +19.1% | COM | 556099109 |
| KOD | KODIAK SCIENCES INC | 461,248 | $44.27M | 0.6% | $95.98 * | $43.05 | +114.6% | COM | 50015M109 |
| — | ATHENEX INC | 13,532,467 | $40.73M | 0.6% | $3.01 | $14.52 | — | COM | 04685N103 |
| — | VERU INC | 4,451,342 | $37.97M | 0.6% | $8.53 | $6.58 | — | COM | 92536C103 |
| — | RAIN THERAPEUTICS INC | 2,537,019 | $37.95M | 0.6% | $14.96 | $15.54 | — | COM | 75082Q105 |
| — | QUOTIENT LTD | 16,200,818 | $37.91M | 0.6% | $2.34 | $7.28 | — | SHS | G73268107 |
| — | DBV TECHNOLOGIES S A | 7,695,505 | $37.71M | 0.5% | $4.90 | $8.17 | — | SPONSORED ADR | 23306J101 |
| — | INHIBRX INC | 1,121,490 | $37.36M | 0.5% | $33.31 | $28.63 | — | COM | 45720L107 |
| ESTA | ESTABLISHMENT LABS HLDGS INC | 505,541 | $36.19M | 0.5% | $71.58 * | $34.47 | +113.6% | COM | G31249108 |
| — | SINGULAR GENOMICS SYSTEMS IN | 3,073,824 | $34.4M | 0.5% | $11.19 | $27.48 | — | COM | 82933R100 |
| — | LEAP THERAPEUTICS INC | 8,476,496 | $33.99M | 0.5% | $4.01 | $1.68 | — | COM | 52187K101 |
| TMCI | TREACE MED CONCEPTS INC | 1,235,886 | $33.24M | 0.5% | $26.90 * | $31.83 | -13.6% | COM | 89455T109 |
| — | CAREMAX INC | 3,385,000 | $32.7M | 0.5% | $9.66 | $12.84 | — | COM CL A | 14171W103 |
| IMTX | IMMATICS N.V | 2,500,000 | $32.5M | 0.5% | $13.00 * | $10.53 | +20.7% | SHS | N44445109 |
| — | ATHIRA PHARMA INC | 3,425,916 | $32.13M | 0.5% | $9.38 | $18.45 | — | COM | 04746L104 |
| — | SOLID BIOSCIENCES INC | 13,412,552 | $32.06M | 0.5% | $2.39 | $4.84 | — | COM | 83422E105 |
| XENE | XENON PHARMACEUTICALS INC | 2,022,051 | $30.9M | 0.4% | $15.28 * | $17.88 | -2.8% | COM | 98420N105 |
| — | NEVRO CORP | 259,972 | $30.26M | 0.4% | $116.38 | $89.62 | — | COM | 64157F103 |
| NUVB | NUVATION BIO INC | 3,041,004 | $30.23M | 0.4% | $9.94 * | $11.18 | -18.9% | COM CL A | 67080N101 |
| HCAT | HEALTH CATALYST INC | 589,004 | $29.46M | 0.4% | $50.01 * | $43.61 | +25.1% | COM | 42225T107 |
| — | LYRA THERAPEUTICS INC | 3,222,560 | $29.4M | 0.4% | $9.12 | $11.34 | — | COM | 55234L105 |
| TARS | TARSUS PHARMACEUTICALS INC | 1,296,416 | $27.94M | 0.4% | $21.55 * | $28.48 | -13.1% | COM | 87650L103 |
| COGT | COGENT BIOSCIENCES INC | 3,188,750 | $26.82M | 0.4% | $8.41 * | $10.99 | -30.3% | COM | 19240Q201 |
| UTHR | UNITED THERAPEUTICS CORP DEL | 141,700 | $26.16M | 0.4% | $184.58 * | $183.72 | +7.2% | COM | 91307C102 |
| — | SOMALOGIC INC | 2,050,000 | $25.4M | 0.4% | $12.39 | $12.39 | — | CLASS A COM | 83444K105 |
| BCAB | BIOATLA INC | 850,026 | $25.02M | 0.4% | $29.44 * | $43.98 | -11.4% | COM | 09077B104 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 1,423,000 | $23.41M | 0.3% | $16.45 * | $16.03 | -8.5% | COM | 92790C104 |
| RNAM | AVIDITY BIOSCIENCES INC | 885,818 | $21.82M | 0.3% | $24.63 * | $28.83 | -24.6% | COM | 05370A108 |
| CLDX | CELLDEX THERAPEUTICS INC NEW | 393,613 | $21.25M | 0.3% | $53.99 * | $27.45 | +70.9% | COM NEW | 15117B202 |
| APLS | APELLIS PHARMACEUTICALS INC | 615,000 | $20.27M | 0.3% | $32.96 * | $51.60 | +8.9% | COM | 03753U106 |
| — | SEMA4 HOLDINGS CORP | 2,500,000 | $18.98M | 0.3% | $7.59 | $7.59 | — | COM CL A | 81663L101 |
| HRMY | HARMONY BIOSCIENCES HLDGS IN | 491,332 | $18.83M | 0.3% | $38.33 * | $34.43 | -6.5% | COM | 413197104 |
| HLTHQ | CUE HEALTH INC | 1,580,607 | $18.67M | 0.3% | $11.81 | $11.81 | — | COM | 229790100 |
| IMRX | IMMUNEERING CORP | 681,051 | $18.08M | 0.3% | $26.55 | $26.87 | 0.0% | CLASS A COM | 45254E107 |
| NTRA | NATERA INC | 160,000 | $17.83M | 0.3% | $111.44 * | $114.62 | 0.0% | COM | 632307104 |
| TYRA | TYRA BIOSCIENCES INC | 987,500 | $17.37M | 0.3% | $17.59 * | $19.11 | 0.0% | COM | 90240B106 |
| — | ASTRIA THERAPEUTICS INC | 1,959,652 | $17.32M | 0.3% | $8.84 | $8.84 | — | COM | 04635X102 |
| ABSI | ABSCI CORPORATION | 1,476,776 | $17.18M | 0.2% | $11.63 * | $19.41 | 0.0% | COM | 00091E109 |
| NUVL | NUVALENT INC | 750,000 | $16.91M | 0.2% | $22.55 * | $29.01 | 0.0% | COM | 670703107 |
| — | VERONA PHARMA PLC | 2,888,889 | $15.83M | 0.2% | $5.48 | $6.24 | — | SPONSORED ADS | 925050106 |
| — | CHEMOCENTRYX INC | 923,200 | $15.79M | 0.2% | $17.10 | $17.10 | — | Call | 16383L106 |
| — | AGILE THERAPEUTICS INC | 15,919,925 | $15.3M | 0.2% | $0.96 | $1.63 | — | COM | 00847L100 |
| ADMA | ADMA BIOLOGICS INC | 13,262,375 | $14.99M | 0.2% | $1.13 * | $4.00 | -64.9% | COM | 000899104 |
| HYPR | HEALTHCOR CATALIO ACQU CORP | 1,500,000 | $14.85M | 0.2% | $9.90 | $9.92 | — | CL A SHS | G44125105 |
| IMCR | IMMUNOCORE HLDGS PLC | 400,000 | $14.83M | 0.2% | $37.07 | $42.57 | — | ADS | 45258D105 |
| — | GRAPHITE BIO INC | 875,093 | $14.34M | 0.2% | $16.39 | $30.73 | — | COM | 38870X104 |
| ACRS | ACLARIS THERAPEUTICS INC | 781,236 | $14.06M | 0.2% | $18.00 * | $20.30 | -21.0% | COM | 00461U105 |
| BIIB | BIOGEN INC | 48,600 | $13.75M | 0.2% | $282.98 * | $327.75 | 0.0% | COM | 09062X103 |
| VTRS | VIATRIS INC | 1,004,419 | $13.61M | 0.2% | $13.55 * | $13.33 | -12.1% | COM | 92556V106 |
| DAWN | DAY ONE BIOPHARMACEUTICALS I | 556,047 | $13.2M | 0.2% | $23.73 | $20.76 | +15.4% | COM | 23954D109 |
| — | CM LIFE SCIENCES III INC | 1,250,000 | $12.81M | 0.2% | $10.25 | $10.95 | — | UNIT 04/30/2028 | 125841205 |
| — | NANOSTRING TECHNOLOGIES INC | 1,000,000 | $12.8M | 0.2% | $12.80 | $16.19 | — | NOTE 2.625% 3/0 | 63009RAD1 |
| PODD | INSULET CORP | 44,522 | $12.65M | 0.2% | $284.22 | $285.22 | 0.0% | COM | 45784P101 |
| NBTX | NANOBIOTIX SA | 1,059,800 | $12.04M | 0.2% | $11.36 | $16.50 | — | SPONSORED ADS | 63009J107 |
| ADPT | ADAPTIVE BIOTECHNOLOGIES COR | 352,804 | $11.99M | 0.2% | $33.99 * | $40.48 | -10.7% | COM | 00650F109 |
| — | ACCOLADE INC | 279,774 | $11.8M | 0.2% | $42.17 | $41.43 | — | COM | 00437E102 |
| — | ZYMERGEN INC | 883,332 | $11.63M | 0.2% | $13.17 | $40.01 | — | COM | 98985X100 |
| CLOV | CLOVER HEALTH INVESTMENTS CO | 1,500,000 | $11.09M | 0.2% | $7.39 * | $11.28 | -24.2% | COM CL A | 18914F103 |
| — | 1LIFE HEALTHCARE INC | 532,350 | $10.78M | 0.2% | $20.25 | $31.85 | — | COM | 68269G107 |
| KYMR | KYMERA THERAPEUTICS INC | 180,000 | $10.57M | 0.2% | $58.74 | $57.98 | 0.0% | COM | 501575104 |
| — | ONCORUS INC | 1,099,810 | $10.27M | 0.1% | $9.34 | $32.33 | — | COM | 68236R103 |
| FDMT | 4D MOLECULAR THERAPEUTICS IN | 375,256 | $10.12M | 0.1% | $26.97 * | $41.28 | -30.9% | COM | 35104E100 |
| — | SUMMIT HEALTHCRE ACQUISTN CO | 1,000,000 | $10.05M | 0.1% | $10.05 | $10.01 | — | UNIT 06/03/2026 | G8566R128 |
| — | BCLS ACQUISITION CORP | 1,000,000 | $9.96M | 0.1% | $9.96 | $11.14 | — | COM CL A | G0904B105 |
| — | FUSION PHARMACEUTICALS INC | 1,254,607 | $9.936M | 0.1% | $7.92 | $16.08 | — | COM | 36118A100 |
| — | RESEARCH ALLIANCE CORP II | 1,000,000 | $9.85M | 0.1% | $9.85 | $10.25 | — | COM CL A | 760873109 |
| — | POINT BIOPHARMA GLOBAL INC | 1,242,879 | $9.557M | 0.1% | $7.69 | $7.69 | — | COM | 730541109 |
| — | CHEMOCENTRYX INC | 550,000 | $9.405M | 0.1% | $17.10 | $17.10 | — | COM | 16383L106 |
| PMVP | PMV PHARMACEUTICALS INC | 301,714 | $8.991M | 0.1% | $29.80 * | $37.57 | -15.0% | COM | 69353Y103 |
| SGHT | SIGHT SCIENCES INC | 390,000 | $8.853M | 0.1% | $22.70 * | $32.87 | 0.0% | COM | 82657M105 |
| FULC | FULCRUM THERAPEUTICS INC | 294,118 | $8.297M | 0.1% | $28.21 * | $10.11 | +87.4% | COM | 359616109 |
| PRTA | PROTHENA CORP PLC | 100,000 | $7.123M | 0.1% | $71.23 * | $31.20 | +99.1% | SHS | G72800108 |
| — | CONCERT PHARMACEUTICALS INC | 2,150,641 | $7.033M | 0.1% | $3.27 | $12.16 | — | COM | 206022105 |
| RPID | RAPID MICRO BIOSYSTEMS INC | 350,000 | $6.465M | 0.1% | $18.47 * | $20.66 | 0.0% | CLASS A COM | 75340L104 |
| SAVA | CASSAVA SCIENCES INC | 100,000 | $6.208M | 0.1% | $62.08 | — | — | Put | 14817C107 |
| — | NEPTUNE WELLNESS SOLUTIONS I | 10,055,521 | $6.08M | 0.1% | $0.60 | $3.20 | — | COM | 64079L105 |
| — | PROVENTION BIO INC | 948,481 | $6.07M | 0.1% | $6.40 | $13.33 | — | COM | 74374N102 |
| TSHA | TAYSHA GENE THERAPIES INC | 320,440 | $5.967M | 0.1% | $18.62 * | $23.52 | -19.2% | COM SHS | 877619106 |
| — | ACHILLES THERAPEUTICS PLC | 755,375 | $5.884M | 0.1% | $7.79 | $16.55 | — | SPONSORED ADS | 00449L102 |
| — | POSEIDA THERAPEUTICS INC | 787,745 | $5.743M | 0.1% | $7.29 | $8.87 | — | COM | 73730P108 |
| ATEC | ALPHATEC HLDGS INC | 430,900 | $5.252M | 0.1% | $12.19 * | $15.74 | -11.4% | COM NEW | 02081G201 |
| — | DA32 LIFE SCNCE TEC ACQSTN C | 500,000 | $4.915M | 0.1% | $9.83 | $9.83 | — | CLASS A COM | 23312M106 |
| — | CODEX DNA INC | 425,000 | $4.73M | 0.1% | $11.13 | $22.00 | — | COM | 192003101 |
| — | DARIOHEALTH CORP | 327,869 | $4.475M | 0.1% | $13.65 | $19.26 | — | COM NEW | 23725P209 |
| — | HEALTH SCIENCES ACQ CORP 2 | 450,000 | $4.451M | 0.1% | $9.89 | $11.00 | — | ORD SHS | G4411D109 |
| RGNX | REGENXBIO INC | 89,283 | $3.743M | 0.1% | $41.92 * | $41.11 | -12.5% | COM | 75901B107 |
| — | SURROZEN INC | 500,000 | $3.54M | 0.1% | $7.08 | $7.08 | — | COM | 86889P109 |
| — | VYNE THERAPEUTICS INC | 2,330,471 | $3.239M | 0.0% | $1.39 | $6.85 | — | COM | 92941V209 |
| — | LIFESCI ACQUISITION II CORP | 300,000 | $2.94M | 0.0% | $9.80 | $10.67 | — | COM | 53229E103 |
| TARA | PROTARA THERAPEUTICS INC | 421,641 | $2.918M | 0.0% | $6.92 * | $23.19 | -66.4% | COM STK | 74365U107 |
| AXSM | AXSOME THERAPEUTICS INC | 80,420 | $2.651M | 0.0% | $32.96 * | $60.01 | -35.1% | COM | 05464T104 |
| — | IMAGO BIOSCIENCES INC | 125,000 | $2.504M | 0.0% | $20.03 | $20.03 | — | COM | 45250K107 |
| — | FREQUENCY THERAPEUTICS INC | 222,222 | $1.569M | 0.0% | $7.06 | $16.61 | — | COM | 35803L108 |
| RACE | FERRARI N V | 6,200 | $1.297M | 0.0% | $209.19 * | $40.37 | +431.8% | COM | N3167Y103 |
| — | MOTUS GI HLDGS INC | 1,800,542 | $1.242M | 0.0% | $0.69 | $4.01 | — | COM | 62014P108 |
| — | ROCKLEY PHOTONICS HOLDINGS L | 500,000 | $1.195M | 0.0% | $2.39 | $2.39 | — | *W EXP 08/11/202 | G7614L117 |
| — | EIGER BIOPHARMACEUTICALS INC | 139,890 | $934K | 0.0% | $6.68 | $15.33 | — | COM | 28249U105 |
| BFLYW | BUTTERFLY NETWORK INC | 233,333 | $642K | 0.0% | $2.75 | $6.45 | — | *W EXP 02/12/202 | 124155110 |
| PHVS | PHARVARIS N V | 27,000 | $479K | 0.0% | $17.74 * | $31.46 | -45.6% | COM | N69605108 |
| — | SOMALOGIC INC | 110,000 | $380K | 0.0% | $3.45 | $3.45 | — | *W EXP 03/01/202 | 83444K113 |
| SRZNW | SURROZEN INC | 166,666 | $190K | 0.0% | $1.14 | $1.14 | — | *W EXP 08/01/203 | 86889P117 |
| — | CAREMAX INC | 60,000 | $170K | 0.0% | $2.83 | $4.72 | — | *W EXP 06/08/202 | 14171W111 |