Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q4 2021 (← Previous) (Next →)
Filing Date: May 4, 2022
Total Value: $6.489B
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| — | TRAVERE THERAPEUTICS INC | 45,000,000 | $485M | 7.5% | $0.78 | — | — | 761299AB2 |
| — | MIRATI THERAPEUTICS INC | 3,283,783 | $482M | 7.4% | $115.03 | — | — | 60468T105 |
| LIANY | LIANBIO | 56,319,960 | $347M | 5.3% | $6.16 | — | — | 53000N108 |
| FOLD | AMICUS THERAPEUTICS INC | 26,559,443 | $307M | 4.7% | $7.16 | +55.6% | — | 03152W109 |
| — | SPRINGWORKS THERAPEUTICS INC | 4,849,912 | $301M | 4.6% | $36.75 | — | — | 85205L107 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 10,127,941 | $193M | 3.0% | $16.15 | +36.3% | — | 462260100 |
| — | HORIZON THERAPEUTICS PUB L | 1,738,140 | $187M | 2.9% | $73.15 | — | — | G46188101 |
| — | COLLEGIUM PHARMACEUTICAL INC | 17,500,000 | $169M | 2.6% | $8.98 | — | — | 19459JAA2 |
| MGTX | MEIRAGTX HLDGS PLC | 6,948,277 | $165M | 2.5% | $14.20 | +34.8% | — | G59665102 |
| — | CEREVEL THERAPEUTICS HLDNG I | 5,086,727 | $165M | 2.5% | $17.65 | — | — | 15678U128 |
| CRNX | CRINETICS PHARMACEUTICALS IN | 5,163,517 | $147M | 2.3% | $25.18 | -2.1% | — | 22663K107 |
| — | PROMETHEUS BIOSCIENCES INC | 3,172,785 | $125M | 1.9% | $16.70 | — | — | 74349U108 |
| — | VBI VACCINES INC CDA | 52,335,002 | $122M | 1.9% | $1.95 | — | — | 91822J103 |
| BBIO | BRIDGEBIO PHARMA INC | 7,128,755 | $119M | 1.8% | $32.43 | +30.5% | — | 10806X102 |
| — | IVERIC BIO INC | 6,480,000 | $108M | 1.7% | $10.04 | — | — | 46583P102 |
| — | RAPT THERAPEUTICS INC | 2,927,565 | $108M | 1.7% | $22.19 | — | — | 75382E109 |
| BMRN | BIOMARIN PHARMACEUTICAL INC | 1,180,000 | $104M | 1.6% | $82.51 | 0.0% | — | 09061G101 |
| — | NEVRO CORP | 9,000,000 | $102M | 1.6% | $13.50 | — | — | 64157FAC7 |
| — | GLOBAL BLOOD THERAPEUTICS IN | 3,449,915 | $101M | 1.6% | $32.43 | — | — | 37890U108 |
| CHRS | COHERUS BIOSCIENCES INC | 5,407,798 | $86.31M | 1.3% | $18.09 | -3.3% | — | 19249H103 |
| — | OUTSET MED INC | 1,863,397 | $85.88M | 1.3% | $50.00 | — | — | 690145107 |
| XENE | XENON PHARMACEUTICALS INC | 2,411,447 | $75.33M | 1.2% | $19.81 | +50.8% | — | 98420N105 |
| — | LANDOS BIOPHARMA INC | 14,869,915 | $71.38M | 1.1% | $9.48 | — | — | 515069102 |
| CCCC | C4 THERAPEUTICS INC | 2,208,913 | $71.13M | 1.1% | $29.00 | +36.4% | — | 12529R107 |
| APLS | APELLIS PHARMACEUTICALS INC | 1,451,700 | $68.64M | 1.1% | $44.55 | -11.6% | — | 03753U106 |
| — | BELLUS HEALTH INC NEW | 7,645,234 | $61.54M | 0.9% | $8.05 | — | — | 07987C204 |
| — | ZYMEWORKS INC | 3,679,845 | $60.31M | 0.9% | $28.60 | — | — | 98985W102 |
| RLAY | RELAY THERAPEUTICS INC | 1,943,097 | $59.67M | 0.9% | $38.13 | -17.1% | — | 75943R102 |
| — | INHIBRX INC | 1,343,490 | $58.67M | 0.9% | $31.11 | — | — | 45720L107 |
| TVTX | TRAVERE THERAPEUTICS INC | 1,845,555 | $57.29M | 0.9% | $23.04 | +22.2% | — | 89422G107 |
| — | ALBIREO PHARMA INC | 2,360,139 | $54.97M | 0.8% | $25.25 | — | — | 01345P106 |
| — | CHEMOCENTRYX INC | 1,415,446 | $51.54M | 0.8% | $28.91 | — | — | 16383L106 |
| — | COHERUS BIOSCIENCES INC | 4,500,000 | $51.49M | 0.8% | $10.23 | — | — | 19249HAB9 |
| NAUT | NAUTILUS BIOTECHNOLOGY INC | 9,111,151 | $47.2M | 0.7% | $10.71 | -50.0% | — | 63909J108 |
| — | ARENA PHARMACEUTICALS INC | 500,000 | $46.47M | 0.7% | $92.94 | — | — | 040047607 |
| — | ATHIRA PHARMA INC | 3,425,916 | $44.64M | 0.7% | $18.45 | — | — | 04746L104 |
| KOD | KODIAK SCIENCES INC | 520,152 | $44.1M | 0.7% | $49.70 | +104.7% | — | 50015M109 |
| — | ICOSAVAX INC | 1,906,548 | $43.62M | 0.7% | $29.59 | — | — | 45114M109 |
| RCKT | ROCKET PHARMACEUTICALS INC | 1,959,125 | $42.77M | 0.7% | $23.99 | +13.7% | — | 77313F106 |
| — | QUOTIENT LTD | 16,200,818 | $41.96M | 0.6% | $7.28 | — | — | G73268107 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 483,007 | $41.14M | 0.6% | $49.72 | +85.0% | — | 64125C109 |
| — | MORPHIC HLDG INC | 836,521 | $39.63M | 0.6% | $40.72 | — | — | 61775R105 |
| ALDX | ALDEYRA THERAPEUTICS INC | 9,903,879 | $39.62M | 0.6% | $8.42 | -9.5% | — | 01438T106 |
| — | SINGULAR GENOMICS SYSTEMS IN | 3,333,824 | $38.54M | 0.6% | $26.24 | — | — | 82933R100 |
| — | ISOPLEXIS CORP | 4,095,498 | $37.64M | 0.6% | $9.19 | — | — | 465005106 |
| ACAD | ACADIA PHARMACEUTICALS INC | 1,584,052 | $36.97M | 0.6% | $20.11 | 0.0% | — | 004225108 |
| ZNTL | ZENTALIS PHARMACEUTICALS INC | 430,544 | $36.19M | 0.6% | $77.38 | 0.0% | — | 98943L107 |
| IMTX | IMMATICS N.V | 2,500,000 | $33.6M | 0.5% | $10.53 | +18.7% | — | N44445109 |
| PRCT | PROCEPT BIOROBOTICS CORP | 1,328,285 | $33.22M | 0.5% | $38.38 | -3.6% | — | 74276L105 |
| — | VERRICA PHARMACEUTICALS INC | 3,610,412 | $33.07M | 0.5% | $19.48 | — | — | 92511W108 |
| — | KRONOS BIO INC | 2,421,142 | $32.9M | 0.5% | $29.87 | — | — | 50107A104 |
| — | RAIN THERAPEUTICS INC | 2,483,619 | $31.99M | 0.5% | $15.54 | — | — | 75082Q105 |
| TARS | TARSUS PHARMACEUTICALS INC | 1,296,416 | $29.17M | 0.4% | $28.48 | -8.7% | — | 87650L103 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 1,423,053 | $28.13M | 0.4% | $16.03 | +16.2% | — | 92790C104 |
| — | LEAP THERAPEUTICS INC | 8,476,496 | $27.46M | 0.4% | $1.68 | — | — | 52187K101 |
| ESTA | ESTABLISHMENT LABS HLDGS INC | 405,541 | $27.41M | 0.4% | $34.47 | +102.7% | — | G31249108 |
| COGT | COGENT BIOSCIENCES INC | 3,188,750 | $27.36M | 0.4% | $10.99 | -20.9% | — | 19240Q201 |
| — | CAREMAX INC | 3,549,525 | $27.26M | 0.4% | $12.60 | — | — | 14171W103 |
| MGNX | MACROGENICS INC | 1,665,243 | $26.73M | 0.4% | $20.23 | -6.9% | — | 556099109 |
| — | VERU INC | 4,451,342 | $26.22M | 0.4% | $6.58 | — | — | 92536C103 |
| NUVB | NUVATION BIO INC | 2,920,823 | $24.83M | 0.4% | $11.18 | -17.8% | — | 67080N101 |
| LUNG | PULMONX CORP | 762,304 | $24.45M | 0.4% | $36.52 | 0.0% | — | 745848101 |
| — | INVITAE CORP | 1,584,585 | $24.2M | 0.4% | $41.81 | — | — | 46185L103 |
| — | SOLID BIOSCIENCES INC | 13,412,552 | $23.47M | 0.4% | $4.84 | — | — | 83422E105 |
| PYXS | PYXIS ONCOLOGY INC | 1,944,114 | $21.33M | 0.3% | $11.45 | 0.0% | — | 747324101 |
| HLTHQ | CUE HEALTH INC | 1,580,607 | $21.2M | 0.3% | $11.81 | — | — | 229790100 |
| UTHR | UNITED THERAPEUTICS CORP DEL | 94,064 | $20.32M | 0.3% | $183.72 | +6.9% | — | 91307C102 |
| — | VERONA PHARMA PLC | 2,867,510 | $19.27M | 0.3% | $6.24 | — | — | 925050106 |
| — | SCIENCE 37 HOLDINGS INC | 1,500,000 | $18.7M | 0.3% | $12.47 | — | — | 808644108 |
| — | ATHENEX INC | 13,532,467 | $18.4M | 0.3% | $14.52 | — | — | 04685N103 |
| TMCI | TREACE MED CONCEPTS INC | 980,186 | $18.27M | 0.3% | $31.83 | -35.2% | — | 89455T109 |
| HCAT | HEALTH CATALYST INC | 454,004 | $17.99M | 0.3% | $43.61 | +4.5% | — | 42225T107 |
| — | DICE THERAPEUTICS INC | 704,885 | $17.84M | 0.3% | $25.31 | — | — | 23345J104 |
| — | SOMALOGIC INC | 1,500,000 | $17.46M | 0.3% | $12.39 | — | — | 83444K105 |
| ADMA | ADMA BIOLOGICS INC | 11,933,387 | $16.83M | 0.3% | $4.00 | -67.1% | — | 000899104 |
| NUVL | NUVALENT INC | 750,000 | $14.28M | 0.2% | $29.01 | -23.2% | — | 670703107 |
| — | LYRA THERAPEUTICS INC | 3,222,560 | $14.05M | 0.2% | $11.34 | — | — | 55234L105 |
| VTRS | VIATRIS INC | 1,004,419 | $13.59M | 0.2% | $13.33 | -16.6% | — | 92556V106 |
| SAVA | CASSAVA SCIENCES INC | 300,000 | $13.11M | 0.2% | — | — | PUT | 14817C107 |
| BCAB | BIOATLA INC | 661,200 | $12.98M | 0.2% | $43.98 | -41.8% | — | 09077B104 |
| IMCR | IMMUNOCORE HLDGS PLC | 360,000 | $12.33M | 0.2% | $42.57 | — | — | 45258D105 |
| — | NANOSTRING TECHNOLOGIES INC | 1,000,000 | $11.98M | 0.2% | $16.19 | — | — | 63009RAD1 |
| BIIB | BIOGEN INC | 48,600 | $11.66M | 0.2% | $327.75 | -21.5% | — | 09062X103 |
| ABSI | ABSCI CORPORATION | 1,411,776 | $11.58M | 0.2% | $19.41 | -41.3% | — | 00091E109 |
| ACRS | ACLARIS THERAPEUTICS INC | 781,236 | $11.36M | 0.2% | $20.30 | -25.4% | — | 00461U105 |
| — | SEMA4 HOLDINGS CORP | 2,500,000 | $11.15M | 0.2% | $7.59 | — | — | 81663L101 |
| — | MERUS N V | 350,000 | $11.13M | 0.2% | $31.80 | — | — | N5749R100 |
| IMRX | IMMUNEERING CORP | 681,051 | $11.01M | 0.2% | $26.87 | -9.4% | — | 45254E107 |
| HYPR | HYPERFINE INC | 1,500,000 | $10.88M | 0.2% | $9.78 | 0.0% | — | 44916K106 |
| — | GRAPHITE BIO INC | 850,093 | $10.57M | 0.2% | $30.73 | — | — | 38870X104 |
| — | AGILE THERAPEUTICS INC | 21,294,485 | $10.39M | 0.2% | $1.34 | — | — | 00847L100 |
| HRMY | HARMONY BIOSCIENCES HLDGS IN | 239,258 | $10.2M | 0.2% | $34.43 | +15.8% | — | 413197104 |
| — | SUMMIT HEALTHCRE ACQUISTN CO | 1,000,000 | $9.95M | 0.2% | $10.01 | — | — | G8566R128 |
| ADPT | ADAPTIVE BIOTECHNOLOGIES COR | 352,804 | $9.9M | 0.2% | $40.48 | -24.3% | — | 00650F109 |
| KYMR | KYMERA THERAPEUTICS INC | 155,000 | $9.841M | 0.2% | $57.98 | +0.5% | — | 501575104 |
| — | BCLS ACQUISITION CORP | 1,000,000 | $9.8M | 0.2% | $11.14 | — | — | G0904B105 |
| — | RESEARCH ALLIANCE CORP II | 1,000,000 | $9.77M | 0.2% | $10.25 | — | — | 760873109 |
| TYRA | TYRA BIOSCIENCES INC | 673,352 | $9.474M | 0.1% | $19.11 | +3.9% | — | 90240B106 |
| DAWN | DAY ONE BIOPHARMACEUTICALS I | 556,047 | $9.369M | 0.1% | $20.76 | -1.0% | — | 23954D109 |
| — | 1LIFE HEALTHCARE INC | 532,350 | $9.353M | 0.1% | $31.85 | — | — | 68269G107 |
| CLDX | CELLDEX THERAPEUTICS INC NEW | 229,807 | $8.88M | 0.1% | $27.45 | +58.8% | — | 15117B202 |
| LEGN | LEGEND BIOTECH CORP | 189,100 | $8.814M | 0.1% | $46.61 | — | — | 52490G102 |
| NBTX | NANOBIOTIX SA | 1,059,800 | $8.584M | 0.1% | $16.50 | — | — | 63009J107 |
| — | EQRX INC | 1,250,000 | $8.525M | 0.1% | $6.82 | — | — | 26886C107 |
| MDGL | MADRIGAL PHARMACEUTICALS INC | 86,400 | $7.322M | 0.1% | $82.16 | 0.0% | — | 558868105 |
| — | ASTRIA THERAPEUTICS INC | 1,272,200 | $6.857M | 0.1% | $8.84 | — | — | 04635X102 |
| SGHT | SIGHT SCIENCES INC | 390,000 | $6.852M | 0.1% | $32.87 | -33.3% | — | 82657M105 |
| — | CONCERT PHARMACEUTICALS INC | 2,150,641 | $6.774M | 0.1% | $12.16 | — | — | 206022105 |
| — | POINT BIOPHARMA GLOBAL INC | 1,193,995 | $6.686M | 0.1% | $7.69 | — | — | 730541109 |
| AORT | CRYOLIFE INC | 326,318 | $6.641M | 0.1% | $20.17 | 0.0% | — | 228903100 |
| — | ACCOLADE INC | 228,774 | $6.03M | 0.1% | $41.43 | — | — | 00437E102 |
| — | ZYMERGEN INC | 883,332 | $5.909M | 0.1% | $40.01 | — | — | 98985X100 |
| — | PEAR THERAPEUTICS INC | 926,232 | $5.742M | 0.1% | $6.20 | — | — | 704723105 |
| CLOV | CLOVER HEALTH INVESTMENTS CO | 1,500,000 | $5.58M | 0.1% | $11.28 | -45.7% | — | 18914F103 |
| — | PROVENTION BIO INC | 948,481 | $5.33M | 0.1% | $13.33 | — | — | 74374N102 |
| — | ONCORUS INC | 999,812 | $5.269M | 0.1% | $32.33 | — | — | 68236R103 |
| FULC | FULCRUM THERAPEUTICS INC | 294,118 | $5.203M | 0.1% | $10.11 | +95.9% | — | 359616109 |
| — | ENVVENO MEDICAL CORPORATION | 781,615 | $5.15M | 0.1% | $6.59 | — | — | 29415J106 |
| — | FUSION PHARMACEUTICALS INC | 1,227,017 | $5.117M | 0.1% | $16.08 | — | — | 36118A100 |
| PRTA | PROTHENA CORP PLC | 100,000 | $4.94M | 0.1% | $31.20 | +77.7% | — | G72800108 |
| — | DA32 LIFE SCNCE TEC ACQSTN C | 500,000 | $4.905M | 0.1% | $9.83 | — | — | 23312M106 |
| — | CODEX DNA INC | 425,000 | $4.59M | 0.1% | $22.00 | — | — | 192003101 |
| — | HEALTH SCIENCES ACQ CORP 2 | 450,000 | $4.536M | 0.1% | $11.00 | — | — | G4411D109 |
| — | DARIOHEALTH CORP | 327,869 | $4.252M | 0.1% | $19.26 | — | — | 23725P209 |
| — | NEPTUNE WELLNESS SOLUTIONS I | 10,055,521 | $4.123M | 0.1% | $3.20 | — | — | 64079L105 |
| RPID | RAPID MICRO BIOSYSTEMS INC | 385,693 | $4.104M | 0.1% | $20.19 | -22.7% | — | 75340L104 |
| — | SONENDO INC | 668,505 | $3.851M | 0.1% | $5.76 | — | — | 835431107 |
| — | ACHILLES THERAPEUTICS PLC | 755,375 | $3.784M | 0.1% | $16.55 | — | — | 00449L102 |
| AXSM | AXSOME THERAPEUTICS INC | 80,420 | $3.038M | 0.0% | $60.01 | -38.7% | — | 05464T104 |
| PMVP | PMV PHARMACEUTICALS INC | 125,000 | $2.888M | 0.0% | $37.57 | -35.7% | — | 69353Y103 |
| TARA | PROTARA THERAPEUTICS INC | 421,641 | $2.846M | 0.0% | $23.19 | -70.3% | — | 74365U107 |
| — | SURROZEN INC | 413,446 | $2.663M | 0.0% | $7.08 | — | — | 86889P109 |
| — | VYNE THERAPEUTICS INC | 2,178,022 | $2.222M | 0.0% | $6.85 | — | — | 92941V209 |
| — | DECIPHERA PHARMACEUTICALS IN | 200,000 | $1.954M | 0.0% | — | — | CALL | 24344T101 |
| — | NEVRO CORP | 22,946 | $1.86M | 0.0% | $89.62 | — | — | 64157F103 |
| RACE | FERRARI N V | 6,200 | $1.605M | 0.0% | $40.37 | +510.4% | — | N3167Y103 |
| — | ITEOS THERAPEUTICS INC | 20,000 | $931K | 0.0% | $46.55 | — | — | 46565G104 |
| — | MOTUS GI HLDGS INC | 1,800,542 | $841K | 0.0% | $4.01 | — | — | 62014P108 |
| — | EIGER BIOPHARMACEUTICALS INC | 139,890 | $726K | 0.0% | $15.33 | — | — | 28249U105 |
| — | ROCKLEY PHOTONICS HOLDINGS L | 500,000 | $605K | 0.0% | $2.39 | — | — | G7614L117 |
| — | MINERVA SURGICAL INC | 87,768 | $451K | 0.0% | $5.14 | — | — | 60343F106 |
| PHVS | PHARVARIS N V | 27,000 | $389K | 0.0% | $31.46 | -50.3% | — | N69605108 |
| — | SOMALOGIC INC | 110,000 | $367K | 0.0% | $3.45 | — | — | 83444K113 |
| BFLYW | BUTTERFLY NETWORK INC | 233,333 | $296K | 0.0% | $6.45 | — | — | 124155110 |
| — | EQRX INC | 250,000 | $266K | 0.0% | $1.06 | — | — | 26886C115 |
| SRZNW | SURROZEN INC | 166,666 | $192K | 0.0% | $1.14 | — | — | 86889P117 |
| — | CAREMAX INC | 60,000 | $84,000 | 0.0% | $4.72 | — | — | 14171W111 |