Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q3 2022 (← Previous) (Next →)
Filing Date: Nov 14, 2022
Total Value: $3.446B (98.6% shares, 1.4% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| FOLD | AMICUS THERAPEUTICS INC | 27,372,917 | $286M | 8.3% | $10.44 * | $7.31 | +52.4% | COM | 03152W109 |
| — | MIRATI THERAPEUTICS INC | 2,784,796 | $194M | 5.6% | $69.84 | $106.91 | — | COM | 60468T105 |
| — | CEREVEL THERAPEUTICS HLDNG I | 6,511,727 | $184M | 5.3% | $28.26 | $19.97 | — | COM | 15678U128 |
| — | GLOBAL BLOOD THERAPEUTICS IN | 2,322,247 | $158M | 4.6% | $68.10 | $32.68 | — | COM | 37890U108 |
| AMLX | AMYLYX PHARMACEUTICALS INC | 5,472,033 | $154M | 4.5% | $28.15 * | $19.34 | +29.0% | COM | 03237H101 |
| LIANY | LIANBIO | 57,558,451 | $115M | 3.3% | $2.00 | $6.09 | — | SPONSORED ADS | 53000N108 |
| — | CINCOR PHARMA INC | 3,306,649 | $109M | 3.1% | $32.82 | $22.10 | — | COM | 17240Y109 |
| — | BELLUS HEALTH INC NEW | 10,247,073 | $108M | 3.1% | $10.56 | $9.17 | — | COM NEW | 07987C204 |
| CRNX | CRINETICS PHARMACEUTICALS IN | 5,321,032 | $105M | 3.0% | $19.64 * | $25.03 | -18.5% | COM | 22663K107 |
| — | SPRINGWORKS THERAPEUTICS INC | 3,470,563 | $99.02M | 2.9% | $28.53 | $36.75 | — | COM | 85205L107 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 10,248,624 | $98.18M | 2.8% | $9.58 * | $16.03 | -28.1% | COM | 462260100 |
| RLMD | RELMADA THERAPEUTICS INC | 2,383,478 | $88.24M | 2.6% | $37.02 * | $27.35 | +1.3% | COM | 75955J402 |
| — | PROMETHEUS BIOSCIENCES INC | 1,468,512 | $86.66M | 2.5% | $59.01 | $16.70 | — | COM | 74349U108 |
| XENE | XENON PHARMACEUTICALS INC | 2,122,535 | $76.62M | 2.2% | $36.10 | $19.81 | +81.5% | COM | 98420N105 |
| ALDX | ALDEYRA THERAPEUTICS INC | 11,350,085 | $60.61M | 1.8% | $5.34 * | $8.11 | -26.1% | COM | 01438T106 |
| MGTX | MEIRAGTX HLDGS PLC | 6,963,277 | $58.56M | 1.7% | $8.41 * | $14.20 | -37.9% | COM | G59665102 |
| — | INHIBRX INC | 2,887,860 | $51.84M | 1.5% | $17.95 | $24.43 | — | COM | 45720L107 |
| — | VERONA PHARMA PLC | 5,047,264 | $51.58M | 1.5% | $10.22 | $7.88 | — | SPONSORED ADS | 925050106 |
| COGT | COGENT BIOSCIENCES INC | 3,207,441 | $47.85M | 1.4% | $14.92 * | $11.09 | +23.6% | COM | 19240Q201 |
| ACLX | ARCELLX INC | 2,465,405 | $46.28M | 1.3% | $18.77 | $16.25 | +17.8% | COMMON STOCK | 03940C100 |
| — | TRAVERE THERAPEUTICS INC | 45,000,000 | $45.98M | 1.3% | $1.02 | $10.54 | — | NOTE 2.250% 3/0 | 89422GAA5 |
| — | LYRA THERAPEUTICS INC | 9,146,730 | $45.83M | 1.3% | $5.01 | $7.65 | — | COM | 55234L105 |
| — | ALBIREO PHARMA INC | 2,360,139 | $45.69M | 1.3% | $19.36 | $25.25 | — | COM | 01345P106 |
| — | VERU INC | 3,893,000 | $44.85M | 1.3% | $11.52 | $7.08 | — | COM | 92536C103 |
| RLAY | RELAY THERAPEUTICS INC | 1,943,097 | $43.47M | 1.3% | $22.37 | $38.13 | -42.5% | COM | 75943R102 |
| — | SEAGEN INC | 316,544 | $43.31M | 1.3% | $136.83 | $165.22 | — | COM | 81181C104 |
| — | RAPT THERAPEUTICS INC | 1,713,134 | $41.22M | 1.2% | $24.06 | $22.19 | — | COM | 75382E109 |
| — | VBI VACCINES INC CDA | 52,335,002 | $37.16M | 1.1% | $0.71 | $1.95 | — | COM NEW | 91822J103 |
| TMCI | TREACE MED CONCEPTS INC | 1,601,979 | $35.36M | 1.0% | $22.07 * | $26.68 | -27.5% | COM | 89455T109 |
| NUVL | NUVALENT INC | 1,655,007 | $32.17M | 0.9% | $19.44 * | $20.73 | -19.3% | COM | 670703107 |
| ESTA | ESTABLISHMENT LABS HLDGS INC | 578,253 | $31.58M | 0.9% | $54.61 * | $43.69 | +36.8% | COM | G31249108 |
| BMRN | BIOMARIN PHARMACEUTICAL INC | 336,481 | $28.52M | 0.8% | $84.77 * | $84.00 | +6.0% | COM | 09061G101 |
| SRPT | SAREPTA THERAPEUTICS INC | 253,000 | $27.97M | 0.8% | $110.54 * | $100.79 | 0.0% | COM | 803607100 |
| EW | EDWARDS LIFESCIENCES CORP | 330,000 | $27.27M | 0.8% | $82.63 * | $96.22 | 0.0% | COM | 28176E108 |
| — | ZYMEWORKS INC | 4,400,099 | $27.06M | 0.8% | $6.15 | $20.84 | — | COM | 98985W102 |
| ADMA | ADMA BIOLOGICS INC | 10,933,387 | $26.57M | 0.8% | $2.43 | $4.00 | -40.0% | COM | 000899104 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 1,220,575 | $25.03M | 0.7% | $20.51 * | $16.43 | +9.4% | COM | 92790C104 |
| APLS | APELLIS PHARMACEUTICALS INC | 366,400 | $25.02M | 0.7% | $68.30 * | $46.34 | +27.7% | COM | 03753U106 |
| IMTX | IMMATICS N.V | 2,500,000 | $25M | 0.7% | $10.00 * | $10.53 | +2.4% | SHS | N44445109 |
| — | CAREMAX INC | 3,394,939 | $24.07M | 0.7% | $7.09 | $11.96 | — | COM CL A | 14171W103 |
| TARS | TARSUS PHARMACEUTICALS INC | 1,296,416 | $22.19M | 0.6% | $17.12 * | $28.48 | -44.2% | COM | 87650L103 |
| — | REVANCE THERAPEUTICS INC | 808,671 | $21.83M | 0.6% | $27.00 | $18.64 | — | COM | 761330109 |
| MDGL | MADRIGAL PHARMACEUTICALS INC | 331,023 | $21.51M | 0.6% | $64.99 * | $81.18 | -14.4% | COM | 558868105 |
| NAUT | NAUTILUS BIOTECHNOLOGY INC | 9,111,151 | $19.32M | 0.6% | $2.12 * | $10.71 | -76.5% | COM | 63909J108 |
| CTKB | CYTEK BIOSCIENCES INC | 1,289,534 | $18.98M | 0.6% | $14.72 * | $12.99 | 0.0% | COM | 23285D109 |
| — | OUTSET MED INC | 1,168,630 | $18.62M | 0.5% | $15.93 | $45.00 | — | COM | 690145107 |
| — | IVERIC BIO INC | 1,034,169 | $18.55M | 0.5% | $17.94 | $10.04 | — | COM | 46583P102 |
| HRMY | HARMONY BIOSCIENCES HLDGS IN | 411,804 | $18.24M | 0.5% | $44.29 * | $45.02 | +8.3% | COM | 413197104 |
| RCUS | ARCUS BIOSCIENCES INC | 666,477 | $17.43M | 0.5% | $26.16 | $26.45 | 0.0% | COM | 03969F109 |
| BBIO | BRIDGEBIO PHARMA INC | 1,697,033 | $16.87M | 0.5% | $9.94 * | $32.43 | -68.0% | COM | 10806X102 |
| AORT | ARTIVION INC | 1,204,229 | $16.67M | 0.5% | $13.84 * | $19.72 | +2.1% | COM | 228903100 |
| CHRS | COHERUS BIOSCIENCES INC | 1,667,123 | $16.02M | 0.5% | $9.61 * | $18.09 | -44.1% | COM | 19249H103 |
| — | VERRICA PHARMACEUTICALS INC | 5,038,983 | $14.71M | 0.4% | $2.92 | $14.50 | — | COM | 92511W108 |
| — | AKERO THERAPEUTICS INC | 430,000 | $14.64M | 0.4% | $34.05 | $34.05 | — | COM | 00973Y108 |
| — | CONCERT PHARMACEUTICALS INC | 2,150,641 | $14.41M | 0.4% | $6.70 | $12.16 | — | COM | 206022105 |
| — | ATHIRA PHARMA INC | 4,797,278 | $14.25M | 0.4% | $2.97 | $14.05 | — | COM | 04746L104 |
| PRTA | PROTHENA CORP PLC | 230,000 | $13.95M | 0.4% | $60.63 * | $31.61 | 0.0% | SHS | G72800108 |
| — | DICE THERAPEUTICS INC | 687,424 | $13.94M | 0.4% | $20.28 | $22.00 | — | COM | 23345J104 |
| — | HILLEVAX INC | 764,907 | $13.07M | 0.4% | $17.09 | $10.93 | — | COM | 43157M102 |
| — | RAIN THERAPEUTICS INC | 2,483,619 | $12.12M | 0.4% | $4.88 | $15.54 | — | COM | 75082Q105 |
| — | ASTRIA THERAPEUTICS INC | 1,281,197 | $11.58M | 0.3% | $9.04 | $8.84 | — | COM | 04635X102 |
| AXGN | AXOGEN INC | 949,626 | $11.32M | 0.3% | $11.92 * | $10.00 | 0.0% | COM | 05463X106 |
| PRCT | PROCEPT BIOROBOTICS CORP | 263,720 | $10.93M | 0.3% | $41.46 * | $36.84 | +8.3% | COM | 74276L105 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 100,050 | $10.63M | 0.3% | $106.21 * | $49.72 | +104.1% | COM | 64125C109 |
| — | MORPHIC HLDG INC | 363,197 | $10.28M | 0.3% | $28.30 | $40.72 | — | COM | 61775R105 |
| — | CHEMOCENTRYX INC | 192,680 | $9.954M | 0.3% | $51.66 | $28.35 | — | COM | 16383L106 |
| — | LANDOS BIOPHARMA INC | 14,869,915 | $9.665M | 0.3% | $0.65 | $9.48 | — | COM | 515069102 |
| LRMR | LARIMAR THERAPEUTICS INC | 2,860,000 | $9.152M | 0.3% | $3.20 * | $2.51 | 0.0% | COM | 517125100 |
| — | SINGULAR GENOMICS SYSTEMS IN | 3,536,274 | $8.841M | 0.3% | $2.50 | $24.49 | — | COM | 82933R100 |
| RCKT | ROCKET PHARMACEUTICALS INC | 500,000 | $7.98M | 0.2% | $15.96 * | $23.99 | -35.0% | COM | 77313F106 |
| — | KRONOS BIO INC | 2,156,151 | $7.223M | 0.2% | $3.35 | $29.87 | — | COM | 50107A104 |
| — | ISOPLEXIS CORP | 4,095,498 | $7.044M | 0.2% | $1.72 | $9.19 | — | COM | 465005106 |
| — | NEVRO CORP | 150,000 | $6.99M | 0.2% | $46.60 | $46.60 | — | COM | 64157F103 |
| CCCC | C4 THERAPEUTICS INC | 766,231 | $6.72M | 0.2% | $8.77 * | $29.00 | -64.2% | COM STK | 12529R107 |
| — | LEAP THERAPEUTICS INC | 7,472,148 | $6.575M | 0.2% | $0.88 | $1.68 | — | COM | 52187K101 |
| — | SOLID BIOSCIENCES INC | 13,412,552 | $6.258M | 0.2% | $0.47 | $4.84 | — | COM | 83422E105 |
| RVMD | REVOLUTION MEDICINES INC | 310,500 | $6.123M | 0.2% | $19.72 * | $21.98 | 0.0% | COM | 76155X100 |
| ACRS | ACLARIS THERAPEUTICS INC | 341,239 | $5.371M | 0.2% | $15.74 | $20.30 | -22.4% | COM | 00461U105 |
| NTRA | NATERA INC | 120,000 | $5.258M | 0.2% | $43.82 * | $47.60 | 0.0% | COM | 632307104 |
| — | TRICIDA INC | 500,000 | $5.24M | 0.2% | $10.48 | — | — | Put | 89610F101 |
| — | INARI MED INC | 70,000 | $5.085M | 0.1% | $72.64 | $72.64 | — | COM | 45332Y109 |
| — | ENVVENO MEDICAL CORPORATION | 781,615 | $4.909M | 0.1% | $6.28 | $6.59 | — | COM | 29415J106 |
| — | SEMA4 HOLDINGS CORP | 5,000,000 | $4.39M | 0.1% | $0.88 | $4.42 | — | COM CL A | 81663L101 |
| — | SOMALOGIC INC | 1,500,000 | $4.35M | 0.1% | $2.90 | $12.39 | — | CLASS A COM | 83444K105 |
| TYRA | TYRA BIOSCIENCES INC | 494,403 | $4.346M | 0.1% | $8.79 * | $19.11 | -52.1% | COM | 90240B106 |
| — | CTI BIOPHARMA CORP | 735,165 | $4.279M | 0.1% | $5.82 | $5.82 | — | COM | 12648L601 |
| — | ATHENEX INC | 15,532,467 | $4.178M | 0.1% | $0.27 | $12.69 | — | COM | 04685N103 |
| ABOS | ACUMEN PHARMACEUTICALS INC | 400,000 | $4.012M | 0.1% | $10.03 * | $5.44 | +5.4% | COM | 00509G209 |
| — | POINT BIOPHARMA GLOBAL INC | 500,000 | $3.865M | 0.1% | $7.73 | $7.69 | — | COM | 730541109 |
| HCAT | HEALTH CATALYST INC | 389,962 | $3.783M | 0.1% | $9.70 * | $42.38 | -68.8% | COM | 42225T107 |
| NBTX | NANOBIOTIX | 1,059,800 | $3.752M | 0.1% | $3.54 | $16.50 | — | SPONSORED ADS | 63009J107 |
| — | COHERUS BIOSCIENCES INC | 4,500,000 | $3.592M | 0.1% | $0.80 | $10.23 | — | NOTE 1.500% 4/1 | 19249HAB9 |
| — | Y-MABS THERAPEUTICS INC | 212,018 | $3.057M | 0.1% | $14.42 | $15.13 | — | COM | 984241109 |
| PYXS | PYXIS ONCOLOGY INC | 1,528,812 | $3.012M | 0.1% | $1.97 * | $11.45 | -77.2% | COMMON STOCK | 747324101 |
| ABSI | ABSCI CORPORATION | 894,346 | $2.799M | 0.1% | $3.13 * | $19.41 | -81.1% | COM | 00091E109 |
| — | POSEIDA THERAPEUTICS INC | 750,000 | $2.648M | 0.1% | $3.53 | $3.53 | — | COM | 73730P108 |
| CLOV | CLOVER HEALTH INVESTMENTS CO | 1,500,000 | $2.55M | 0.1% | $1.70 * | $11.28 | -76.8% | COM CL A | 18914F103 |
| — | REATA PHARMACEUTICALS INC | 100,000 | $2.513M | 0.1% | $25.13 | $25.13 | — | CL A | 75615P103 |
| — | QUOTIENT LTD | 16,200,818 | $2.43M | 0.1% | $0.15 | $7.28 | — | SHS | G73268107 |
| — | SCIENCE 37 HOLDINGS INC | 1,500,000 | $2.415M | 0.1% | $1.61 | $12.47 | — | COM | 808644108 |
| FULC | FULCRUM THERAPEUTICS INC | 294,118 | $2.379M | 0.1% | $8.09 * | $10.11 | -29.2% | COM | 359616109 |
| TVTX | TRAVERE THERAPEUTICS INC | 90,748 | $2.236M | 0.1% | $24.64 * | $23.04 | +12.1% | COM | 89422G107 |
| — | PEAR THERAPEUTICS INC | 900,548 | $1.837M | 0.1% | $2.04 | $6.20 | — | COM | 704723105 |
| — | DARIOHEALTH CORP | 327,869 | $1.518M | 0.0% | $4.63 | $19.26 | — | COM NEW | 23725P209 |
| TARA | PROTARA THERAPEUTICS INC | 290,051 | $859K | 0.0% | $2.96 * | $23.19 | -85.4% | COM STK | 74365U107 |
| HYPR | HYPERFINE INC | 927,388 | $751K | 0.0% | $0.81 * | $9.78 | -85.6% | COM CL A | 44916K106 |
| — | SONENDO INC | 612,204 | $655K | 0.0% | $1.07 | $5.76 | — | COM | 835431107 |
| — | PROVENTION BIO INC | 110,728 | $498K | 0.0% | $4.50 | $13.33 | — | COM | 74374N102 |
| — | ICOSAVAX INC | 93,591 | $296K | 0.0% | $3.16 | $29.59 | — | COM | 45114M109 |
| — | MOTUS GI HLDGS INC | 90,027 | $221K | 0.0% | $2.45 | $2.45 | — | COM NEW | 62014P405 |
| — | EQRX INC | 250,000 | $205K | 0.0% | $0.82 | $1.06 | — | *W EXP 12/17/202 | 26886C115 |
| — | AGILE THERAPEUTICS INC | 532,361 | $158K | 0.0% | $0.30 | $1.16 | — | COM NEW | 00847L209 |
| — | CAREMAX INC | 60,000 | $113K | 0.0% | $1.88 | $4.72 | — | *W EXP 06/08/202 | 14171W111 |
| — | NEPTUNE WELLNESS SOLUTIONS I | 57,142 | $87,000 | 0.0% | $1.52 | $1.42 | — | COM NEW | 64079L204 |
| SRZNW | SURROZEN INC | 166,666 | $31,000 | 0.0% | $0.19 | $1.14 | — | *W EXP 08/01/203 | 86889P117 |
| — | SURROZEN INC | 6,017 | $12,000 | 0.0% | $1.99 | $7.08 | — | COM | 86889P109 |