Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q4 2022 (← Previous) (Next →)
Filing Date: Feb 14, 2023
Total Value: $3.561B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Est. Cost | Unrealized | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|
| FOLD | AMICUS THERAPEUTICS INC | 27,642,917 | $338M | 9.5% | $7.31 | +54.0% | COM | 03152W109 |
| AMLX | AMYLYX PHARMACEUTICALS INC | 6,088,333 | $225M | 6.3% | $20.97 | +69.2% | COM | 03237H101 |
| MDGL | MADRIGAL PHARMACEUTICALS INC | 731,932 | $212M | 6.0% | $90.28 | +8.3% | COM | 558868105 |
| — | CEREVEL THERAPEUTICS HLDNG I | 6,511,727 | $205M | 5.8% | $19.97 | — | COM | 15678U128 |
| — | PROMETHEUS BIOSCIENCES INC | 1,212,694 | $133M | 3.7% | $16.70 | — | COM | 74349U108 |
| — | VERONA PHARMA PLC | 4,880,719 | $128M | 3.6% | $7.88 | — | SPONSORED ADS | 925050106 |
| — | HORIZON THERAPEUTICS PUB L | 960,000 | $109M | 3.1% | $113.80 | — | SHS | G46188101 |
| — | MIRATI THERAPEUTICS INC | 2,191,425 | $99.29M | 2.8% | $106.91 | — | COM | 60468T105 |
| LIANY | LIANBIO | 57,558,451 | $94.4M | 2.7% | $6.09 | — | SPONSORED ADS | 53000N108 |
| MDGL | MADRIGAL PHARMACEUTICALS INC | 300,000 | $87.08M | 2.4% | $90.28 | +8.3% | Put | 558868105 |
| SRPT | SAREPTA THERAPEUTICS INC | 649,250 | $84.13M | 2.4% | $110.00 | +5.3% | COM | 803607100 |
| — | INHIBRX INC | 3,313,783 | $81.65M | 2.3% | $24.45 | — | COM | 45720L107 |
| ACLX | ARCELLX INC | 2,598,305 | $80.5M | 2.3% | $16.59 | +38.3% | COMMON STOCK | 03940C100 |
| ALDX | ALDEYRA THERAPEUTICS INC | 11,350,085 | $79M | 2.2% | $8.11 | -29.5% | COM | 01438T106 |
| XENE | XENON PHARMACEUTICALS INC | 1,921,273 | $75.76M | 2.1% | $19.81 | +83.8% | COM | 98420N105 |
| CRNX | CRINETICS PHARMACEUTICALS IN | 4,039,276 | $73.92M | 2.1% | $25.03 | -29.6% | COM | 22663K107 |
| — | BELLUS HEALTH INC NEW | 8,891,027 | $73.08M | 2.1% | $9.17 | — | COM NEW | 07987C204 |
| — | SPRINGWORKS THERAPEUTICS INC | 2,617,691 | $68.09M | 1.9% | $36.75 | — | COM | 85205L107 |
| NUVL | NUVALENT INC | 2,255,007 | $67.15M | 1.9% | $22.63 | +23.2% | COM | 670703107 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 9,971,780 | $63.72M | 1.8% | $16.03 | -51.3% | COM | 462260100 |
| PCVX | VAXCYTE INC | 1,170,000 | $56.1M | 1.6% | $39.24 | 0.0% | COM | 92243G108 |
| BMRN | BIOMARIN PHARMACEUTICAL INC | 506,481 | $52.42M | 1.5% | $87.32 | +7.5% | COM | 09061G101 |
| ADMA | ADMA BIOLOGICS INC | 11,900,255 | $46.17M | 1.3% | $3.92 | -21.4% | COM | 000899104 |
| MGTX | MEIRAGTX HLDGS PLC | 6,963,277 | $45.38M | 1.3% | $14.20 | -51.7% | COM | G59665102 |
| TMCI | TREACE MEDICAL CONCEPTS INC | 1,946,403 | $44.75M | 1.3% | $26.03 | -11.6% | COM | 89455T109 |
| — | VERU INC | 7,858,011 | $41.49M | 1.2% | $6.17 | — | COM | 92536C103 |
| — | ALBIREO PHARMA INC | 1,757,160 | $37.97M | 1.1% | $25.25 | — | COM | 01345P106 |
| COGT | COGENT BIOSCIENCES INC | 3,207,441 | $37.08M | 1.0% | $11.09 | +11.8% | COM | 19240Q201 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 1,220,575 | $35.65M | 1.0% | $16.43 | +40.2% | COM | 92790C104 |
| — | RAPT THERAPEUTICS INC | 1,798,955 | $35.62M | 1.0% | $22.07 | — | COM | 75382E109 |
| ZYME | ZYMEWORKS DEL INC | 4,511,275 | $35.46M | 1.0% | $7.03 | 0.0% | COM | 98985Y108 |
| ACRV | ACRIVON THERAPEUTICS INC | 3,007,858 | $34.65M | 1.0% | $12.69 | 0.0% | COMMON STOCK | 004890109 |
| ESTA | ESTABLISHMENT LABS HLDGS INC | 497,857 | $32.68M | 0.9% | $43.69 | +38.3% | COM | G31249108 |
| — | ASTRIA THERAPEUTICS INC | 2,189,462 | $32.6M | 0.9% | $11.35 | — | COM | 04635X102 |
| — | CINCOR PHARMA INC | 2,576,325 | $31.66M | 0.9% | $22.10 | — | COM | 17240Y109 |
| IMTX | IMMATICS N.V | 3,491,500 | $30.41M | 0.9% | $10.48 | -1.3% | SHS | N44445109 |
| RLAY | RELAY THERAPEUTICS INC | 1,943,097 | $29.03M | 0.8% | $38.13 | -49.8% | COM | 75943R102 |
| — | LYRA THERAPEUTICS INC | 9,146,730 | $28.72M | 0.8% | $7.65 | — | COM | 55234L105 |
| — | OUTSET MED INC | 1,089,427 | $28.13M | 0.8% | $45.00 | — | COM | 690145107 |
| HRMY | HARMONY BIOSCIENCES HLDGS IN | 411,804 | $22.69M | 0.6% | $45.02 | +22.1% | COM | 413197104 |
| RCKT | ROCKET PHARMACEUTICALS INC | 1,078,204 | $21.1M | 0.6% | $21.00 | -12.3% | COM | 77313F106 |
| — | VBI VACCINES INC CDA | 52,335,002 | $20.41M | 0.6% | $1.95 | — | COM NEW | 91822J103 |
| — | RAIN ONCOLOGY INC | 2,483,619 | $19.87M | 0.6% | $15.54 | — | COM | 75082Q105 |
| — | AKERO THERAPEUTICS INC | 350,525 | $19.21M | 0.5% | $34.05 | — | COM | 00973Y108 |
| TARS | TARSUS PHARMACEUTICALS INC | 1,296,416 | $19.01M | 0.5% | $28.48 | -41.9% | COM | 87650L103 |
| SLDB | SOLID BIOSCIENCES INC | 3,495,933 | $18.81M | 0.5% | $6.55 | 0.0% | COM NEW | 83422E204 |
| NAUT | NAUTILUS BIOTECHNOLOGY INC | 9,111,151 | $16.4M | 0.5% | $10.71 | -82.0% | COM | 63909J108 |
| ROIV | ROIVANT SCIENCES LTD | 1,981,570 | $15.83M | 0.4% | $5.56 | 0.0% | SHS | G76279101 |
| — | ATHIRA PHARMA INC | 4,797,278 | $15.21M | 0.4% | $14.05 | — | COM | 04746L104 |
| PRTA | PROTHENA CORP PLC | 237,646 | $14.32M | 0.4% | $32.48 | +80.3% | SHS | G72800108 |
| — | VERRICA PHARMACEUTICALS INC | 5,038,983 | $13.86M | 0.4% | $14.50 | — | COM | 92511W108 |
| AXGN | AXOGEN INC | 1,388,126 | $13.85M | 0.4% | $10.35 | +7.3% | COM | 05463X106 |
| — | REVANCE THERAPEUTICS INC | 729,097 | $13.46M | 0.4% | $18.64 | — | COM | 761330109 |
| CTKB | CYTEK BIOSCIENCES INC | 1,289,534 | $13.17M | 0.4% | $12.99 | +3.5% | COM | 23285D109 |
| AORT | ARTIVION INC | 1,085,860 | $13.16M | 0.4% | $19.72 | -39.1% | COM | 228903100 |
| BBIO | BRIDGEBIO PHARMA INC | 1,697,033 | $12.93M | 0.4% | $32.43 | -70.5% | COM | 10806X102 |
| — | IVERIC BIO INC | 587,400 | $12.58M | 0.4% | $10.04 | — | COM | 46583P102 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 100,050 | $11.95M | 0.3% | $49.72 | +135.6% | COM | 64125C109 |
| LRMR | LARIMAR THERAPEUTICS INC | 2,860,000 | $11.81M | 0.3% | $2.51 | +36.2% | COM | 517125100 |
| — | CAREMAX INC | 3,129,195 | $11.42M | 0.3% | $11.96 | — | COM CL A | 14171W103 |
| ISRG | INTUITIVE SURGICAL INC | 40,000 | $10.61M | 0.3% | $243.83 | 0.0% | COM NEW | 46120E602 |
| — | MORPHIC HLDG INC | 363,197 | $9.716M | 0.3% | $40.72 | — | COM | 61775R105 |
| — | DICE THERAPEUTICS INC | 293,362 | $9.153M | 0.3% | $22.00 | — | COM | 23345J104 |
| — | LANDOS BIOPHARMA INC | 14,869,915 | $7.435M | 0.2% | $9.48 | — | COM | 515069102 |
| — | SCPHARMACEUTICALS INC | 952,380 | $6.829M | 0.2% | $7.17 | — | COM | 810648105 |
| — | HILLEVAX INC | 406,024 | $6.793M | 0.2% | $10.93 | — | COM | 43157M102 |
| — | SINGULAR GENOMICS SYSTEMS IN | 3,282,275 | $6.597M | 0.2% | $24.49 | — | COM | 82933R100 |
| — | ISOPLEXIS CORP | 4,095,498 | $6.348M | 0.2% | $9.19 | — | COM | 465005106 |
| PEN | PENUMBRA INC | 25,400 | $5.65M | 0.2% | $195.51 | 0.0% | COM | 70975L107 |
| ACRS | ACLARIS THERAPEUTICS INC | 341,239 | $5.375M | 0.2% | $20.30 | -20.8% | COM | 00461U105 |
| NTRA | NATERA INC | 130,000 | $5.222M | 0.1% | $47.11 | -12.5% | COM | 632307104 |
| — | CYMABAY THERAPEUTICS INC | 708,993 | $4.445M | 0.1% | $6.27 | — | COM | 23257D103 |
| SAVA | CASSAVA SCIENCES INC | 150,000 | $4.431M | 0.1% | — | — | Put | 14817C107 |
| — | ENVVENO MEDICAL CORPORATION | 781,615 | $3.986M | 0.1% | $6.59 | — | COM | 29415J106 |
| NBTX | NANOBIOTIX | 1,059,800 | $3.889M | 0.1% | $16.50 | — | SPONSORED ADS | 63009J107 |
| — | SOMALOGIC INC | 1,500,000 | $3.765M | 0.1% | $12.39 | — | CLASS A COM | 83444K105 |
| TYRA | TYRA BIOSCIENCES INC | 494,403 | $3.757M | 0.1% | $19.11 | -63.0% | COM | 90240B106 |
| — | POINT BIOPHARMA GLOBAL INC | 500,000 | $3.645M | 0.1% | $7.69 | — | COM | 730541109 |
| — | LEAP THERAPEUTICS INC | 6,726,496 | $3.027M | 0.1% | $1.68 | — | COM | 52187K101 |
| CABA | CABALETTA BIO INC | 317,454 | $2.936M | 0.1% | $3.64 | 0.0% | COM | 12674W109 |
| — | KRONOS BIO INC | 1,752,745 | $2.839M | 0.1% | $29.87 | — | COM | 50107A104 |
| PRCT | PROCEPT BIOROBOTICS CORP | 64,537 | $2.681M | 0.1% | $36.84 | +16.6% | COM | 74276L105 |
| IMVT | IMMUNOVANT INC | 150,000 | $2.663M | 0.1% | $12.59 | 0.0% | COM | 45258J102 |
| — | ATHENEX INC | 15,532,467 | $2.291M | 0.1% | $12.69 | — | COM | 04685N103 |
| PRVA | PRIVIA HEALTH GROUP INC | 90,000 | $2.044M | 0.1% | $27.84 | 0.0% | COM | 74276R102 |
| TVTX | TRAVERE THERAPEUTICS INC | 90,748 | $1.908M | 0.1% | $23.04 | -8.0% | COM | 89422G107 |
| ABOS | ACUMEN PHARMACEUTICALS INC | 347,450 | $1.876M | 0.1% | $5.44 | +23.5% | COM | 00509G209 |
| — | DARIOHEALTH CORP | 327,869 | $1.403M | 0.0% | $19.26 | — | COM NEW | 23725P209 |
| CLOV | CLOVER HEALTH INVESTMENTS CO | 1,500,000 | $1.394M | 0.0% | $11.28 | -88.2% | COM CL A | 18914F103 |
| — | NEVRO CORP | 30,000 | $1.188M | 0.0% | $46.60 | — | COM | 64157F103 |
| — | PEAR THERAPEUTICS INC | 900,548 | $1.063M | 0.0% | $6.20 | — | CLASS A COM | 704723105 |
| TARA | PROTARA THERAPEUTICS INC | 290,051 | $777K | 0.0% | $23.19 | -86.4% | COM STK | 74365U107 |
| — | MOTUS GI HLDGS INC | 90,027 | $75,623 | 0.0% | $2.45 | — | COM NEW | 62014P405 |
| — | EQRX INC | 250,000 | $67,050 | 0.0% | $1.06 | — | *W EXP 12/17/202 | 26886C115 |
| — | CAREMAX INC | 60,000 | $31,308 | 0.0% | $4.72 | — | *W EXP 06/08/202 | 14171W111 |
| SRZNW | SURROZEN INC | 166,666 | $9,183 | 0.0% | $1.14 | — | *W EXP 08/01/203 | 86889P117 |