Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q1 2023 (← Previous) (Next →)
Filing Date: May 16, 2023
Total Value: $3.387B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| FOLD | AMICUS THERAPEUTICS INC | 27,662,917 | $307M | 9.1% | $11.09 * | $7.31 | +68.6% | COM | 03152W109 |
| — | REATA PHARMACEUTICALS INC | 2,169,276 | $197M | 5.8% | $90.92 | $90.92 | — | CL A | 75615P103 |
| AMLX | AMYLYX PHARMACEUTICALS INC | 6,034,644 | $177M | 5.2% | $29.34 * | $20.97 | +65.6% | COM | 03237H101 |
| — | CEREVEL THERAPEUTICS HLDNG I | 6,511,727 | $159M | 4.7% | $24.39 | $19.97 | — | COM | 15678U128 |
| MDGL | MADRIGAL PHARMACEUTICALS INC | 650,562 | $158M | 4.7% | $242.26 * | $90.28 | +201.8% | COM | 558868105 |
| — | PROMETHEUS BIOSCIENCES INC | 1,272,694 | $137M | 4.0% | $107.32 | $20.97 | — | COM | 74349U108 |
| ACLX | ARCELLX INC | 3,841,739 | $118M | 3.5% | $30.81 | $21.04 | +44.2% | COMMON STOCK | 03940C100 |
| LIANY | LIANBIO | 57,558,451 | $113M | 3.3% | $1.96 | $6.09 | — | SPONSORED ADS | 53000N108 |
| ALDX | ALDEYRA THERAPEUTICS INC | 11,350,085 | $113M | 3.3% | $9.93 * | $8.11 | -12.9% | COM | 01438T106 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 15,339,735 | $93.73M | 2.8% | $6.11 * | $12.84 | -46.3% | COM | 462260100 |
| — | INHIBRX INC | 3,615,383 | $68.22M | 2.0% | $18.87 | $23.99 | — | COM | 45720L107 |
| XENE | XENON PHARMACEUTICALS INC | 1,832,174 | $65.57M | 1.9% | $35.79 * | $19.81 | +86.4% | COM | 98420N105 |
| BMRN | BIOMARIN PHARMACEUTICAL INC | 673,060 | $65.45M | 1.9% | $97.24 * | $91.36 | +13.5% | COM | 09061G101 |
| TMCI | TREACE MED CONCEPTS INC | 2,442,250 | $61.52M | 1.8% | $25.19 * | $25.52 | -8.0% | COM | 89455T109 |
| NUVL | NUVALENT INC | 2,300,048 | $60.01M | 1.8% | $26.09 * | $22.77 | +29.9% | COM | 670703107 |
| — | MIRATI THERAPEUTICS INC | 1,574,134 | $58.53M | 1.7% | $37.18 | $106.91 | — | COM | 60468T105 |
| CRNX | CRINETICS PHARMACEUTICALS IN | 3,554,887 | $57.09M | 1.7% | $16.06 * | $25.03 | -26.1% | COM | 22663K107 |
| — | VERONA PHARMA PLC | 2,733,790 | $54.89M | 1.6% | $20.08 | $7.88 | — | SPONSORED ADS | 925050106 |
| — | SPRINGWORKS THERAPEUTICS INC | 2,079,352 | $53.52M | 1.6% | $25.74 | $36.75 | — | COM | 85205L107 |
| OBIO | ORCHESTRA BIOMED HLDGS INC | 2,278,226 | $44.58M | 1.3% | $19.57 * | $11.58 | 0.0% | COM | 68572M106 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 1,736,386 | $44.17M | 1.3% | $25.44 * | $21.07 | +52.1% | COM | 92790C104 |
| PCVX | VAXCYTE INC | 1,170,000 | $43.85M | 1.3% | $37.48 * | $39.24 | +8.1% | COM | 92243G108 |
| — | RAPT THERAPEUTICS INC | 2,291,608 | $42.05M | 1.2% | $18.35 | $21.27 | — | COM | 75382E109 |
| SNY | SANOFI | 768,101 | $41.8M | 1.2% | $54.42 | $54.42 | — | SPONSORED ADR | 80105N105 |
| ADMA | ADMA BIOLOGICS INC | 11,900,255 | $39.39M | 1.2% | $3.31 * | $3.92 | -11.9% | COM | 000899104 |
| NTRA | NATERA INC | 707,214 | $39.26M | 1.2% | $55.52 * | $47.83 | +0.3% | COM | 632307104 |
| ACRV | ACRIVON THERAPEUTICS INC | 3,007,858 | $38.17M | 1.1% | $12.69 * | $12.69 | +32.3% | COMMON STOCK | 004890109 |
| APLS | APELLIS PHARMACEUTICALS INC | 555,344 | $36.63M | 1.1% | $65.96 * | $57.70 | 0.0% | COM | 03753U106 |
| MGTX | MEIRAGTX HLDGS PLC | 6,963,277 | $35.98M | 1.1% | $5.17 * | $14.20 | -51.2% | COM | G59665102 |
| SRPT | SAREPTA THERAPEUTICS INC | 260,858 | $35.95M | 1.1% | $137.83 * | $110.00 | +17.9% | COM | 803607100 |
| — | BELLUS HEALTH INC NEW | 4,952,538 | $35.66M | 1.1% | $7.20 | $9.17 | — | COM NEW | 07987C204 |
| — | CYMABAY THERAPEUTICS INC | 3,903,255 | $34.04M | 1.0% | $8.72 | $8.27 | — | COM | 23257D103 |
| — | VERRICA PHARMACEUTICALS INC | 5,038,983 | $32.75M | 1.0% | $6.50 | $14.50 | — | COM | 92511W108 |
| RLAY | RELAY THERAPEUTICS INC | 1,943,097 | $32M | 0.9% | $16.47 * | $38.13 | -53.0% | COM | 75943R102 |
| ESTA | ESTABLISHMENT LABS HLDGS INC | 467,857 | $31.69M | 0.9% | $67.74 | $43.69 | +56.9% | COM | G31249108 |
| BBIO | BRIDGEBIO PHARMA INC | 1,907,033 | $31.62M | 0.9% | $16.58 * | $30.14 | -61.3% | COM | 10806X102 |
| ZYME | ZYMEWORKS INC | 3,378,498 | $30.54M | 0.9% | $9.04 * | $7.03 | +24.1% | COM | 98985Y108 |
| — | ASTRIA THERAPEUTICS INC | 2,189,462 | $29.12M | 0.9% | $13.30 | $11.35 | — | COM | 04635X102 |
| NAUT | NAUTILUS BIOTECHNOLOGY INC | 9,111,151 | $25.24M | 0.7% | $2.77 * | $10.71 | -80.4% | COM | 63909J108 |
| COGT | COGENT BIOSCIENCES INC | 2,282,324 | $24.63M | 0.7% | $10.79 * | $11.09 | +15.4% | COM | 19240Q201 |
| IMTX | IMMATICS N.V | 3,491,500 | $24.09M | 0.7% | $6.90 * | $10.48 | -21.9% | SHS | N44445109 |
| PTGX | PROTAGONIST THERAPEUTICS INC | 965,152 | $22.2M | 0.7% | $23.00 * | $16.79 | 0.0% | COM | 74366E102 |
| — | OUTSET MED INC | 1,089,427 | $20.05M | 0.6% | $18.40 | $45.00 | — | COM | 690145107 |
| IMVT | IMMUNOVANT INC | 1,291,858 | $20.04M | 0.6% | $15.51 * | $16.80 | +3.3% | COM | 45258J102 |
| — | AKERO THERAPEUTICS INC | 523,525 | $20.03M | 0.6% | $38.26 | $35.44 | — | COM | 00973Y108 |
| ROIV | ROIVANT SCIENCES LTD | 2,692,136 | $19.87M | 0.6% | $7.38 * | $6.27 | +31.4% | SHS | G76279101 |
| — | LYRA THERAPEUTICS INC | 9,146,730 | $18.38M | 0.5% | $2.01 | $7.65 | — | COM | 55234L105 |
| SLDB | SOLID BIOSCIENCES INC | 3,495,933 | $16.57M | 0.5% | $4.74 * | $6.55 | -8.3% | COM NEW | 83422E204 |
| TARS | TARSUS PHARMACEUTICALS INC | 1,296,416 | $16.3M | 0.5% | $12.57 * | $28.48 | -48.7% | COM | 87650L103 |
| TERN | TERNS PHARMACEUTICALS INC | 1,350,000 | $15.98M | 0.5% | $11.84 * | $9.56 | 0.0% | COM | 880881107 |
| — | VBI VACCINES INC CDA | 52,335,002 | $15.86M | 0.5% | $0.30 | $1.95 | — | COM NEW | 91822J103 |
| RCKT | ROCKET PHARMACEUTICALS INC | 867,732 | $14.86M | 0.4% | $17.13 * | $21.00 | -6.8% | COM | 77313F106 |
| VKTX | VIKING THERAPEUTICS INC | 871,747 | $14.51M | 0.4% | $16.65 * | $10.33 | 0.0% | COM | 92686J106 |
| MIRM | MIRUM PHARMACEUTICALS INC | 601,566 | $14.45M | 0.4% | $24.02 * | $22.79 | 0.0% | COM | 604749101 |
| — | RAIN ONCOLOGY INC | 1,648,215 | $14.41M | 0.4% | $8.74 | $15.54 | — | COM | 75082Q105 |
| AORT | ARTIVION INC | 1,085,860 | $14.22M | 0.4% | $13.10 * | $19.72 | -35.2% | COM | 228903100 |
| AXGN | AXOGEN INC | 1,409,791 | $13.32M | 0.4% | $9.45 * | $10.33 | -11.5% | COM | 05463X106 |
| ISRG | INTUITIVE SURGICAL INC | 50,000 | $12.77M | 0.4% | $255.47 * | $244.33 | +0.8% | COM NEW | 46120E602 |
| — | IVERIC BIO INC | 500,000 | $12.16M | 0.4% | $24.33 | $10.04 | — | COM | 46583P102 |
| — | ATHIRA PHARMA INC | 4,797,278 | $11.99M | 0.4% | $2.50 | $14.05 | — | COM | 04746L104 |
| CTKB | CYTEK BIOSCIENCES INC | 1,289,534 | $11.85M | 0.3% | $9.19 * | $12.99 | -17.2% | COM | 23285D109 |
| PRTA | PROTHENA CORP PLC | 237,646 | $11.52M | 0.3% | $48.47 * | $32.48 | +62.6% | SHS | G72800108 |
| TCMD | TACTILE SYS TECHNOLOGY INC | 639,877 | $10.51M | 0.3% | $16.42 * | $13.93 | 0.0% | COM | 87357P100 |
| — | FUSION PHARMACEUTICALS INC | 2,759,936 | $10.4M | 0.3% | $3.77 | $3.77 | — | COM | 36118A100 |
| LRMR | LARIMAR THERAPEUTICS INC | 2,280,709 | $10.33M | 0.3% | $4.53 * | $2.51 | +108.6% | COM | 517125100 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 100,050 | $10.13M | 0.3% | $101.22 * | $49.72 | +109.3% | COM | 64125C109 |
| BMEA | BIOMEA FUSION INC | 325,000 | $10.08M | 0.3% | $31.01 * | $12.43 | 0.0% | COM | 09077A106 |
| — | MORPHIC HLDG INC | 256,737 | $9.664M | 0.3% | $37.64 | $40.72 | — | COM | 61775R105 |
| — | CAREMAX INC | 3,576,040 | $9.548M | 0.3% | $2.67 | $10.80 | — | COM CL A | 14171W103 |
| TYRA | TYRA BIOSCIENCES INC | 494,403 | $7.945M | 0.2% | $16.07 * | $19.11 | -37.8% | COM | 90240B106 |
| XBI | SPDR SER TR | 100,000 | $7.621M | 0.2% | $76.21 | — | — | Put | 78464A870 |
| — | BELLEROPHON THERAPEUTICS INC | 930,000 | $7.338M | 0.2% | $7.89 | $7.89 | — | COM NEW | 078771300 |
| — | HILLEVAX INC | 406,024 | $6.712M | 0.2% | $16.53 | $10.93 | — | COM | 43157M102 |
| CABA | CABALETTA BIO INC | 724,777 | $5.994M | 0.2% | $8.27 * | $6.85 | +36.5% | COM | 12674W109 |
| — | AVADEL PHARMACEUTICALS PLC | 590,000 | $5.404M | 0.2% | $9.16 | $9.16 | — | SPONSORED ADR | 05337M104 |
| — | VERU INC | 4,298,212 | $4.986M | 0.1% | $1.16 | $6.17 | — | COM | 92536C103 |
| — | LANDOS BIOPHARMA INC | 14,869,915 | $4.431M | 0.1% | $0.30 | $9.48 | — | COM | 515069102 |
| — | SINGULAR GENOMICS SYSTEMS IN | 3,282,275 | $3.972M | 0.1% | $1.21 | $24.49 | — | COM | 82933R100 |
| — | X4 PHARMACEUTICALS INC | 4,545,454 | $3.955M | 0.1% | $0.87 | $0.87 | — | COM | 98420X103 |
| — | SOMALOGIC INC | 1,500,000 | $3.825M | 0.1% | $2.55 | $12.39 | — | CLASS A COM | 83444K105 |
| NBTX | NANOBIOTIX | 1,059,800 | $3.736M | 0.1% | $3.52 | $16.50 | — | SPONSORED ADS | 63009J107 |
| — | ENVVENO MEDICAL CORPORATION | 781,615 | $3.658M | 0.1% | $4.68 | $6.59 | — | COM | 29415J106 |
| VIR | VIR BIOTECHNOLOGY INC | 142,194 | $3.309M | 0.1% | $23.27 * | $25.58 | 0.0% | COM | 92764N102 |
| HRMY | HARMONY BIOSCIENCES HLDGS IN | 100,000 | $3.265M | 0.1% | $32.65 * | $45.02 | +1.2% | COM | 413197104 |
| ADCT | ADC THERAPEUTICS SA | 1,495,805 | $2.917M | 0.1% | $1.95 * | $3.69 | 0.0% | SHS | H0036K147 |
| — | PHENOMEX INC | 2,506,442 | $2.907M | 0.1% | $1.16 | $1.16 | — | COM | 084310101 |
| — | KRONOS BIO INC | 1,752,745 | $2.558M | 0.1% | $1.46 | $29.87 | — | COM | 50107A104 |
| — | LEAP THERAPEUTICS INC | 6,726,496 | $2.287M | 0.1% | $0.34 | $1.68 | — | COM | 52187K101 |
| TVTX | TRAVERE THERAPEUTICS INC | 90,748 | $2.041M | 0.1% | $22.49 * | $23.04 | -7.8% | COM | 89422G107 |
| QTRX | QUANTERIX CORP | 130,000 | $1.465M | 0.0% | $11.27 * | $12.78 | 0.0% | COM | 74766Q101 |
| — | DARIOHEALTH CORP | 313,869 | $1.293M | 0.0% | $4.12 | $19.26 | — | COM NEW | 23725P209 |
| CLOV | CLOVER HEALTH INVESTMENTS CO | 1,500,000 | $1.268M | 0.0% | $0.85 * | $11.28 | -90.3% | COM CL A | 18914F103 |
| — | ATHENEX INC | 776,623 | $1.033M | 0.0% | $1.33 | $1.33 | — | COM NEW | 04685N202 |
| TARA | PROTARA THERAPEUTICS INC | 290,051 | $908K | 0.0% | $3.13 * | $23.19 | -85.7% | COM STK | 74365U107 |
| — | PEAR THERAPEUTICS INC | 900,548 | $230K | 0.0% | $0.25 | $6.20 | — | COM | 704723105 |
| — | MOTUS GI HLDGS INC | 90,027 | $87,641 | 0.0% | $0.97 | $2.45 | — | COM NEW | 62014P405 |
| — | EQRX INC | 250,000 | $43,125 | 0.0% | $0.17 | $1.06 | — | *W EXP 12/17/202 | 26886C115 |
| — | CAREMAX INC | 60,000 | $28,908 | 0.0% | $0.48 | $4.72 | — | *W EXP 06/08/202 | 14171W111 |
| SRZNW | SURROZEN INC | 166,666 | $16,667 | 0.0% | $0.10 | $1.14 | — | *W EXP 08/01/203 | 86889P117 |