Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q1 2024 (← Previous) (Next →)
Filing Date: Aug 6, 2024
Total Value: $5.715B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| — | CEREVEL THERAPEUTICS HLDNG I | 10,794,876 | $456M | 8.0% | $42.27 | $25.62 | — | COM | 15678U128 |
| FOLD | AMICUS THERAPEUTICS INC | 28,057,456 | $331M | 5.8% | $11.78 * | $7.36 | +73.7% | COM | 03152W109 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 19,272,991 | $286M | 5.0% | $14.82 * | $12.38 | -6.0% | COM | 462260100 |
| ACLX | ARCELLX INC | 3,933,556 | $274M | 4.8% | $69.55 * | $24.76 | +156.1% | COMMON STOCK | 03940C100 |
| NUVL | NUVALENT INC | 2,783,454 | $209M | 3.7% | $75.09 * | $30.85 | +158.0% | COM | 670703107 |
| — | INHIBRX INC | 4,256,104 | $149M | 2.6% | $34.96 | $23.15 | — | COM | 45720L107 |
| — | FUSION PHARMACEUTICALS INC | 6,825,395 | $146M | 2.5% | $21.32 | $14.25 | — | COM | 36118A100 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 3,268,579 | $142M | 2.5% | $43.33 | $34.65 | +26.3% | COM | 76243J105 |
| APGE | APOGEE THERAPEUTICS INC | 2,060,395 | $137M | 2.4% | $66.45 * | $24.47 | +78.4% | COM | 03770N101 |
| PCVX | VAXCYTE INC | 1,932,759 | $132M | 2.3% | $68.31 | $53.61 | +29.2% | COM | 92243G108 |
| SLNO | SOLENO THERAPEUTICS INC | 3,074,542 | $132M | 2.3% | $42.80 * | $4.79 | +843.5% | COM | 834203309 |
| MDT | MEDTRONIC PLC | 1,429,563 | $125M | 2.2% | $87.15 * | $77.49 | +4.1% | SHS | G5960L103 |
| MDGL | MADRIGAL PHARMACEUTICALS INC | 429,953 | $115M | 2.0% | $267.04 * | $189.75 | +24.2% | COM | 558868105 |
| — | SPRINGWORKS THERAPEUTICS INC | 2,262,462 | $111M | 1.9% | $49.22 | $38.38 | — | COM | 85205L107 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 804,409 | $111M | 1.9% | $137.92 | $120.49 | +13.3% | COM | 64125C109 |
| SYRE | SPYRE THERAPEUTICS INC | 2,556,679 | $96.97M | 1.7% | $37.93 * | $13.76 | +110.6% | COM NEW | 00773J202 |
| IMVT | IMMUNOVANT INC | 2,963,212 | $95.74M | 1.7% | $32.31 * | $23.03 | +58.4% | COM | 45258J102 |
| BHVN | BIOHAVEN LTD | 1,725,047 | $94.34M | 1.7% | $54.69 * | $25.94 | +90.9% | COM | G1110E107 |
| SLDB | SOLID BIOSCIENCES INC | 6,906,646 | $92M | 1.6% | $13.32 * | $7.94 | +17.9% | COM NEW | 83422E204 |
| — | ASTRIA THERAPEUTICS INC | 6,485,420 | $91.25M | 1.6% | $14.07 | $11.36 | — | COM | 04635X102 |
| AXSM | AXSOME THERAPEUTICS INC | 1,105,341 | $88.21M | 1.5% | $79.80 * | $71.10 | +18.1% | COM | 05464T104 |
| VKTX | VIKING THERAPEUTICS INC | 994,098 | $81.52M | 1.4% | $82.00 * | $44.50 | 0.0% | COM | 92686J106 |
| EOLS | EVOLUS INC | 5,753,798 | $80.55M | 1.4% | $14.00 * | $10.21 | +27.3% | COM | 30052C107 |
| — | LYRA THERAPEUTICS INC | 12,757,562 | $79.35M | 1.4% | $6.22 | $6.65 | — | COM | 55234L105 |
| — | CARGO THERAPEUTICS INC | 3,448,004 | $76.96M | 1.3% | $22.32 | $23.15 | — | COM | 14179K101 |
| — | INTRA-CELLULAR THERAPIES INC | 1,055,355 | $73.03M | 1.3% | $69.20 | $69.45 | — | COM | 46116X101 |
| NTRA | NATERA INC | 757,225 | $69.26M | 1.2% | $91.46 * | $49.41 | +52.2% | COM | 632307104 |
| CRNX | CRINETICS PHARMACEUTICALS IN | 1,476,203 | $69.1M | 1.2% | $46.81 * | $27.14 | +44.2% | COM | 22663K107 |
| MGTX | MEIRAGTX HLDGS PLC | 11,331,103 | $68.72M | 1.2% | $6.07 * | $11.20 | -43.6% | COM | G59665102 |
| SRPT | SAREPTA THERAPEUTICS INC | 525,683 | $68.05M | 1.2% | $129.46 * | $105.14 | +16.5% | COM | 803607100 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 3,657,099 | $64.04M | 1.1% | $17.51 * | $19.17 | +1.1% | COM | 92790C104 |
| — | VERONA PHARMA PLC | 3,761,576 | $60.52M | 1.1% | $16.09 | $12.90 | — | SPONSORED ADS | 925050106 |
| IRON | DISC MEDICINE INC | 939,866 | $58.52M | 1.0% | $62.26 * | $39.61 | +63.7% | COM | 254604101 |
| CGON | CG ONCOLOGY INC | 1,304,105 | $57.25M | 1.0% | $43.90 * | $40.84 | 0.0% | COM | 156944100 |
| AORT | ARTIVION INC | 2,668,978 | $56.48M | 1.0% | $21.16 * | $19.00 | -2.0% | COM | 228903100 |
| — | APPLIED THERAPEUTICS INC | 8,005,000 | $54.43M | 1.0% | $6.80 | $5.04 | — | COM | 03828A101 |
| ARVN | ARVINAS INC | 1,236,603 | $51.05M | 0.9% | $41.28 * | $37.87 | +15.4% | COM | 04335A105 |
| CELC | CELCUITY INC | 2,362,279 | $51.03M | 0.9% | $21.60 * | $13.53 | +18.0% | COM | 15102K100 |
| PRAX | PRAXIS PRECISION MEDICINES I | 821,589 | $50.13M | 0.9% | $61.02 * | $44.86 | 0.0% | COM NEW | 74006W207 |
| RCKT | ROCKET PHARMACEUTICALS INC | 1,801,068 | $48.52M | 0.8% | $26.94 * | $20.82 | +36.4% | COM | 77313F106 |
| IMTX | IMMATICS N.V | 4,582,409 | $48.16M | 0.8% | $10.51 * | $10.76 | +8.4% | SHS | N44445109 |
| TARS | TARSUS PHARMACEUTICALS INC | 1,296,416 | $47.12M | 0.8% | $36.35 * | $28.48 | +3.2% | COM | 87650L103 |
| BBIO | BRIDGEBIO PHARMA INC | 1,412,033 | $43.66M | 0.8% | $30.92 * | $30.14 | +12.8% | COM | 10806X102 |
| ADMA | ADMA BIOLOGICS INC | 6,433,369 | $42.46M | 0.7% | $6.60 * | $3.92 | +39.4% | COM | 000899104 |
| EWTX | EDGEWISE THERAPEUTICS INC | 2,319,646 | $42.31M | 0.7% | $18.24 * | $13.77 | +15.4% | COM | 28036F105 |
| — | VERRICA PHARMACEUTICALS INC | 7,099,182 | $42.03M | 0.7% | $5.92 | $12.42 | — | COM | 92511W108 |
| ISRG | INTUITIVE SURGICAL INC | 101,800 | $40.63M | 0.7% | $399.09 * | $334.77 | +12.9% | COM NEW | 46120E602 |
| XENE | XENON PHARMACEUTICALS INC | 892,208 | $38.41M | 0.7% | $43.05 * | $26.63 | +72.8% | COM | 98420N105 |
| NAUT | NAUTILUS BIOTECHNOLOGY INC | 12,594,211 | $37.03M | 0.6% | $2.94 * | $8.54 | -66.8% | COM | 63909J108 |
| — | AKERO THERAPEUTICS INC | 1,387,471 | $35.05M | 0.6% | $25.26 | $38.09 | — | COM | 00973Y108 |
| CNTA | CENTESSA PHARMACEUTICALS PLC | 3,083,307 | $34.84M | 0.6% | $11.30 | $11.30 | — | SPONSORED ADS | 152309100 |
| — | LANDOS BIOPHARMA INC | 1,486,991 | $31.94M | 0.6% | $21.48 | $4.21 | — | COM NEW | 515069201 |
| OCUL | OCULAR THERAPEUTIX INC | 3,324,468 | $30.25M | 0.5% | $9.10 * | $7.10 | 0.0% | COM | 67576A100 |
| TMCI | TREACE MED CONCEPTS INC | 2,304,954 | $30.08M | 0.5% | $13.05 * | $19.94 | -33.1% | COM | 89455T109 |
| CABA | CABALETTA BIO INC | 1,716,660 | $29.29M | 0.5% | $17.06 * | $12.38 | +73.3% | COM | 12674W109 |
| PTGX | PROTAGONIST THERAPEUTICS INC | 994,323 | $28.77M | 0.5% | $28.93 * | $24.28 | +12.0% | COM | 74366E102 |
| IRTC | IRHYTHM TECHNOLOGIES INC | 245,205 | $28.44M | 0.5% | $116.00 * | $112.42 | 0.0% | COM | 450056106 |
| ALDX | ALDEYRA THERAPEUTICS INC | 8,593,586 | $28.1M | 0.5% | $3.27 | $8.11 | -59.5% | COM | 01438T106 |
| AUTL | AUTOLUS THERAPEUTICS PLC | 4,330,745 | $27.63M | 0.5% | $6.38 | $6.41 | — | SPON ADS | 05280R100 |
| ACRV | ACRIVON THERAPEUTICS INC | 3,007,858 | $21.51M | 0.4% | $7.15 * | $12.69 | -63.4% | COMMON STOCK | 004890109 |
| PEPG | PEPGEN INC | 1,410,438 | $20.73M | 0.4% | $14.70 * | $11.81 | 0.0% | COM | 713317105 |
| RVMD | REVOLUTION MEDICINES INC | 618,885 | $19.95M | 0.3% | $32.23 * | $29.66 | -0.1% | COM | 76155X100 |
| ABBV | ABBVIE INC | 106,500 | $19.39M | 0.3% | $182.10 * | $135.72 | +19.4% | COM | 00287Y109 |
| IRON | DISC MEDICINE INC | 300,000 | $18.68M | 0.3% | $62.26 * | $39.61 | +63.7% | Put | 254604101 |
| MLTX | MOONLAKE IMMUNOTHERAPEUTICS | 339,012 | $17.03M | 0.3% | $50.23 * | $53.59 | +1.2% | CLASS A ORD | 61559X104 |
| ENGN | ENGENE HOLDINGS INC | 998,888 | $16.93M | 0.3% | $16.95 * | $12.24 | 0.0% | COM | 29286M105 |
| LIVN | LIVANOVA PLC | 299,000 | $16.73M | 0.3% | $55.94 * | $51.96 | 0.0% | SHS | G5509L101 |
| — | ATHIRA PHARMA INC | 5,402,964 | $14.8M | 0.3% | $2.74 | $12.75 | — | COM | 04746L104 |
| TCMD | TACTILE SYS TECHNOLOGY INC | 903,085 | $14.68M | 0.3% | $16.25 * | $14.84 | +1.9% | COM | 87357P100 |
| OBIO | ORCHESTRA BIOMED HLDGS INC | 2,545,881 | $13.42M | 0.2% | $5.27 * | $10.64 | -36.3% | COM | 68572M106 |
| AXGN | AXOGEN INC | 1,553,929 | $12.54M | 0.2% | $8.07 * | $9.65 | -7.2% | COM | 05463X106 |
| EYPT | EYEPOINT PHARMACEUTICALS INC | 589,646 | $12.19M | 0.2% | $20.67 * | $11.18 | +121.5% | COM NEW | 30233G209 |
| ZYME | ZYMEWORKS INC | 1,074,807 | $11.31M | 0.2% | $10.52 * | $7.03 | +58.0% | COM | 98985Y108 |
| — | RAPT THERAPEUTICS INC | 1,223,472 | $10.99M | 0.2% | $8.98 | $21.64 | — | COM | 75382E109 |
| TYRA | TYRA BIOSCIENCES INC | 669,159 | $10.97M | 0.2% | $16.40 | $17.86 | -8.2% | COM | 90240B106 |
| PRCT | PROCEPT BIOROBOTICS CORP | 210,659 | $10.41M | 0.2% | $49.42 * | $47.60 | 0.0% | COM | 74276L105 |
| — | MORPHIC HLDG INC | 288,221 | $10.15M | 0.2% | $35.20 | $33.95 | — | COM | 61775R105 |
| SPRY | ARS PHARMACEUTICALS INC | 867,319 | $8.864M | 0.2% | $10.22 * | $7.46 | 0.0% | COM | 82835W108 |
| ARQT | ARCUTIS BIOTHERAPEUTICS INC | 750,000 | $7.433M | 0.1% | $9.91 * | $7.46 | 0.0% | COM | 03969K108 |
| AVBP | ARRIVENT BIOPHARMA INC | 415,000 | $7.412M | 0.1% | $17.86 * | $20.17 | 0.0% | COM | 04272N102 |
| DTIL | PRECISION BIOSCIENCES INC | 480,483 | $6.515M | 0.1% | $13.56 * | $12.24 | 0.0% | COM NEW | 74019P207 |
| COGT | COGENT BIOSCIENCES INC | 883,333 | $5.936M | 0.1% | $6.72 * | $11.14 | -44.5% | COM | 19240Q201 |
| KALV | KALVISTA PHARMACEUTICALS INC | 500,000 | $5.93M | 0.1% | $11.86 * | $13.33 | 0.0% | COM | 483497103 |
| IBRX | IMMUNITYBIO INC | 1,052,887 | $5.654M | 0.1% | $5.37 * | $4.53 | 0.0% | COM | 45256X103 |
| MGNX | MACROGENICS INC | 378,327 | $5.569M | 0.1% | $14.72 * | $6.91 | +118.6% | COM | 556099109 |
| BBOT | HELIX ACQUISITION CORP II | 500,000 | $5.2M | 0.1% | $10.40 | $10.35 | 0.0% | CL A ORD SHS | G4444H101 |
| — | X4 PHARMACEUTICALS INC | 3,545,454 | $4.928M | 0.1% | $1.39 | $0.87 | — | COM | 98420X103 |
| AMLX | AMYLYX PHARMACEUTICALS INC | 1,679,125 | $4.769M | 0.1% | $2.84 * | $20.97 | -37.6% | Call | 03237H101 |
| XBI | SPDR SER TR | 50,000 | $4.745M | 0.1% | $94.89 | — | — | Put | 78464A870 |
| ESTA | ESTABLISHMENT LABS HLDGS INC | 82,299 | $4.189M | 0.1% | $50.90 * | $43.69 | -8.1% | COM | G31249108 |
| NAMS | NEWAMSTERDAM PHARMA COMPANY | 175,000 | $4.139M | 0.1% | $23.65 * | $20.30 | 0.0% | ORDINARY SHARES | N62509109 |
| ABSI | ABSCI CORPORATION | 700,000 | $3.976M | 0.1% | $5.68 * | $4.51 | 0.0% | COM | 00091E109 |
| — | VERU INC | 5,584,699 | $3.91M | 0.1% | $0.70 | $0.81 | — | COM | 92536C103 |
| KYTX | KYVERNA THERAPEUTICS INC | 150,000 | $3.726M | 0.1% | $24.84 * | $27.84 | 0.0% | COM | 501976104 |
| TRIB | TRINITY BIOTECH PLC | 1,800,000 | $3.672M | 0.1% | $2.04 | $2.04 | — | SPONS ADR NEW | 896438504 |
| NBTX | NANOBIOTIX | 555,066 | $3.608M | 0.1% | $6.50 | $16.50 | — | SPONSORED ADS | 63009J107 |
| — | APPLIED THERAPEUTICS INC | 500,000 | $3.4M | 0.1% | $6.80 | $5.04 | — | Call | 03828A101 |
| — | ENVVENO MEDICAL CORPORATION | 623,315 | $3.391M | 0.1% | $5.44 | $6.59 | — | COM | 29415J106 |
| NVAX | NOVAVAX INC | 700,000 | $3.346M | 0.1% | $4.78 | — | — | Put | 670002401 |
| IMVT | IMMUNOVANT INC | 100,000 | $3.231M | 0.1% | $32.31 * | $23.03 | +58.4% | Call | 45258J102 |
| — | REVANCE THERAPEUTICS INC | 600,000 | $2.952M | 0.1% | $4.92 | $4.92 | — | COM | 761330109 |
| AGIO | AGIOS PHARMACEUTICALS INC | 100,000 | $2.924M | 0.1% | $29.24 | — | — | Call | 00847X104 |
| — | FORTE BIOSCIENCES INC | 3,265,359 | $2.273M | 0.0% | $0.70 | $0.66 | — | COM | 34962G109 |
| — | SINGULAR GENOMICS SYSTEMS IN | 2,126,893 | $1.094M | 0.0% | $0.51 | $24.49 | — | COM | 82933R100 |
| KURA | KURA ONCOLOGY INC | 48,200 | $1.028M | 0.0% | $21.33 * | $19.44 | 0.0% | COM | 50127T109 |
| AMLX | AMYLYX PHARMACEUTICALS INC | 300,000 | $852K | 0.0% | $2.84 * | $20.97 | -37.6% | COM | 03237H101 |
| — | VBI VACCINES INC CDA | 1,261,710 | $757K | 0.0% | $0.60 | $3.29 | — | COM NEW | 91822J202 |
| SYRS | SYROS PHARMACEUTICALS INC | 116,754 | $625K | 0.0% | $5.35 * | $6.91 | 0.0% | COM NEW | 87184Q206 |
| — | CAREMAX INC | 122,643 | $591K | 0.0% | $4.82 | $4.82 | — | CL A NEW | 14171W202 |
| RVMDW | REVOLUTION MEDICINES INC | 250,000 | $45,625 | 0.0% | $0.18 | $0.33 | — | *W EXP 12/17/202 | 76155X118 |
| SRZNW | SURROZEN INC | 166,666 | $5,033 | 0.0% | $0.03 | $1.14 | — | *W EXP 08/01/203 | 86889P117 |
| — | CAREMAX INC | 60,000 | $1,026 | 0.0% | $0.02 | $4.72 | — | *W EXP 06/08/202 | 14171W111 |