Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q4 2023 (← Previous) (Next →)
Filing Date: Feb 26, 2024
Total Value: $4.48B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| — | CEREVEL THERAPEUTICS HLDNG I | 10,965,193 | $465M | 10.4% | $42.40 | $25.62 | — | COM | 15678U128 |
| FOLD | AMICUS THERAPEUTICS INC | 28,057,456 | $398M | 8.9% | $14.19 * | $7.36 | +54.2% | COM | 03152W109 |
| LIANY | LIANBIO | 57,558,451 | $257M | 5.7% | $4.47 | $6.09 | — | SPONSORED ADS | 53000N108 |
| ACLX | ARCELLX INC | 4,544,809 | $252M | 5.6% | $55.50 * | $24.76 | +82.2% | COMMON STOCK | 03940C100 |
| NUVL | NUVALENT INC | 2,917,991 | $215M | 4.8% | $73.59 * | $30.85 | +100.6% | COM | 670703107 |
| — | INHIBRX INC | 4,256,104 | $162M | 3.6% | $38.00 | $23.15 | — | COM | 45720L107 |
| SLNO | SOLENO THERAPEUTICS INC | 3,074,542 | $124M | 2.8% | $40.25 * | $4.79 | +493.4% | COM | 834203309 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 2,154,110 | $99.02M | 2.2% | $45.97 * | $29.93 | +5.4% | COM | 76243J105 |
| IMVT | IMMUNOVANT INC | 2,328,082 | $98.08M | 2.2% | $42.13 * | $19.36 | +90.1% | COM | 45258J102 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 11,979,415 | $97.39M | 2.2% | $8.13 * | $12.84 | -59.2% | COM | 462260100 |
| — | CYMABAY THERAPEUTICS INC | 4,024,400 | $95.06M | 2.1% | $23.62 | $8.78 | — | COM | 23257D103 |
| AXSM | AXSOME THERAPEUTICS INC | 1,038,019 | $82.62M | 1.8% | $79.59 * | $70.26 | -4.8% | COM | 05464T104 |
| MDT | MEDTRONIC PLC | 976,652 | $80.46M | 1.8% | $82.38 * | $76.03 | -6.0% | SHS | G5960L103 |
| — | CARGO THERAPEUTICS INC | 3,436,600 | $79.56M | 1.8% | $23.15 | $23.15 | — | COM | 14179K101 |
| MGTX | MEIRAGTX HLDGS PLC | 11,331,103 | $79.54M | 1.8% | $7.02 * | $11.20 | -55.9% | COM | G59665102 |
| — | VERONA PHARMA PLC | 3,866,214 | $76.86M | 1.7% | $19.88 | $12.90 | — | SPONSORED ADS | 925050106 |
| BHVN | BIOHAVEN LTD | 1,725,047 | $73.83M | 1.6% | $42.80 * | $25.94 | +19.9% | COM | G1110E107 |
| — | SPRINGWORKS THERAPEUTICS INC | 1,957,246 | $71.44M | 1.6% | $36.50 | $36.69 | — | COM | 85205L107 |
| BBIO | BRIDGEBIO PHARMA INC | 1,748,933 | $70.6M | 1.6% | $40.37 * | $30.14 | -0.4% | COM | 10806X102 |
| PCVX | VAXCYTE INC | 1,088,486 | $68.36M | 1.5% | $62.80 * | $41.49 | +25.2% | COM | 92243G108 |
| — | LYRA THERAPEUTICS INC | 12,757,562 | $66.85M | 1.5% | $5.24 | $6.65 | — | COM | 55234L105 |
| IRON | DISC MEDICINE INC | 1,023,045 | $59.09M | 1.3% | $57.76 * | $39.61 | +29.3% | COM | 254604101 |
| SYRE | SPYRE THERAPEUTICS INC | 2,606,679 | $56.1M | 1.3% | $21.52 * | $13.76 | +0.1% | COM NEW | 00773J202 |
| NTRA | NATERA INC | 850,225 | $53.26M | 1.2% | $62.64 * | $49.41 | +1.1% | COM | 632307104 |
| — | RAPT THERAPEUTICS INC | 2,139,950 | $53.18M | 1.2% | $24.85 | $21.64 | — | COM | 75382E109 |
| — | VERRICA PHARMACEUTICALS INC | 7,099,182 | $51.97M | 1.2% | $7.32 | $12.42 | — | COM | 92511W108 |
| RCKT | ROCKET PHARMACEUTICALS INC | 1,707,398 | $51.17M | 1.1% | $29.97 * | $20.40 | +8.2% | COM | 77313F106 |
| APGE | APOGEE THERAPEUTICS INC | 1,827,901 | $51.07M | 1.1% | $27.94 * | $22.03 | -9.0% | COM | 03770N101 |
| XENE | XENON PHARMACEUTICALS INC | 1,100,748 | $50.7M | 1.1% | $46.06 * | $26.63 | +32.7% | COM | 98420N105 |
| — | RAYZEBIO INC | 744,056 | $46.26M | 1.0% | $62.17 | $22.20 | — | COM | 75525N107 |
| CABA | CABALETTA BIO INC | 2,003,058 | $45.47M | 1.0% | $22.70 * | $12.38 | +35.8% | COM | 12674W109 |
| CRNX | CRINETICS PHARMACEUTICALS IN | 1,255,512 | $44.67M | 1.0% | $35.58 * | $25.03 | +22.5% | COM | 22663K107 |
| SRPT | SAREPTA THERAPEUTICS INC | 451,873 | $43.57M | 1.0% | $96.43 | $102.30 | -6.2% | COM | 803607100 |
| EOLS | EVOLUS INC | 3,963,424 | $41.73M | 0.9% | $10.53 * | $8.95 | -0.1% | COM | 30052C107 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 1,730,212 | $37.68M | 0.8% | $21.78 * | $18.94 | -16.6% | COM | 92790C104 |
| NAUT | NAUTILUS BIOTECHNOLOGY INC | 12,594,211 | $37.66M | 0.8% | $2.99 * | $8.54 | -66.5% | COM | 63909J108 |
| ABBV | ABBVIE INC | 238,000 | $36.88M | 0.8% | $154.97 * | $135.72 | 0.0% | COM | 00287Y109 |
| IMTX | IMMATICS N.V | 3,491,500 | $36.77M | 0.8% | $10.53 * | $10.48 | -12.1% | SHS | N44445109 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 270,794 | $35.68M | 0.8% | $131.76 * | $88.80 | +29.6% | COM | 64125C109 |
| MDGL | MADRIGAL PHARMACEUTICALS INC | 151,151 | $34.97M | 0.8% | $231.38 * | $105.14 | +66.4% | COM | 558868105 |
| — | ASTRIA THERAPEUTICS INC | 4,004,070 | $30.75M | 0.7% | $7.68 | $9.69 | — | COM | 04635X102 |
| ALDX | ALDEYRA THERAPEUTICS INC | 8,593,586 | $30.16M | 0.7% | $3.51 * | $8.11 | -62.0% | COM | 01438T106 |
| ADMA | ADMA BIOLOGICS INC | 6,433,369 | $29.08M | 0.6% | $4.52 * | $3.92 | -5.7% | COM | 000899104 |
| AMLX | AMYLYX PHARMACEUTICALS INC | 1,869,125 | $27.51M | 0.6% | $14.72 * | $20.97 | -26.9% | COM | 03237H101 |
| — | FUSION PHARMACEUTICALS INC | 2,751,395 | $26.44M | 0.6% | $9.61 | $3.77 | — | COM | 36118A100 |
| TARS | TARSUS PHARMACEUTICALS | 1,296,416 | $26.25M | 0.6% | $20.25 * | $28.48 | -41.4% | COM | 87650L103 |
| RVMD | REVOLUTION MEDICINES INC | 818,882 | $23.49M | 0.5% | $28.68 * | $29.66 | -19.0% | COM | 76155X100 |
| — | AKERO THERAPEUTICS INC | 967,775 | $22.6M | 0.5% | $23.35 | $43.66 | — | COM | 00973Y108 |
| OBIO | ORCHESTRA BIOMED HLDGS INC | 2,432,089 | $22.2M | 0.5% | $9.13 * | $10.82 | -36.9% | COM | 68572M106 |
| CELC | CELCUITY INC | 1,481,300 | $21.58M | 0.5% | $14.57 * | $12.08 | 0.0% | COM | 15102K100 |
| SLDB | SOLID BIOSCIENCES INC | 3,495,933 | $21.47M | 0.5% | $6.14 * | $6.55 | -51.2% | COM NEW | 83422E204 |
| ISRG | INTUITIVE SURGICAL INC | 55,000 | $18.55M | 0.4% | $337.36 * | $298.09 | 0.0% | COM NEW | 46120E602 |
| AORT | ARTIVION INC | 931,352 | $16.65M | 0.4% | $17.88 * | $19.72 | -21.2% | COM | 228903100 |
| ASND | ASCENDIS PHARMAA/S | 132,176 | $16.65M | 0.4% | $125.95 | $125.95 | — | SPONSORED ADR | 04351P101 |
| TMCI | TREACE MED CONCEPTS INC | 1,250,405 | $15.94M | 0.4% | $12.75 * | $25.52 | -60.4% | COM | 89455T109 |
| MIRM | MIRUM PHARMACEUTICALS INC | 534,942 | $15.79M | 0.4% | $29.52 * | $23.27 | +30.0% | COM | 604749101 |
| ACRV | ACRIVON THERAPEUTICS INC | 3,007,858 | $14.8M | 0.3% | $4.92 * | $12.69 | -58.4% | COMMON STOCK | 004890109 |
| ARVN | ARVINAS INC | 354,082 | $14.57M | 0.3% | $41.16 * | $23.38 | 0.0% | COM | 04335A105 |
| — | APPLIED THERAPEUTICS INC | 4,080,249 | $13.67M | 0.3% | $3.35 | $3.35 | — | COM | 03828A101 |
| EYPT | EYEPOINT PHARMACEUTICALS INC | 589,646 | $13.63M | 0.3% | $23.11 * | $11.18 | 0.0% | COM NEW | 30233G209 |
| — | ATHIRA PHARMA INC | 5,402,964 | $13.13M | 0.3% | $2.43 | $12.75 | — | COM | 04746L104 |
| AUTL | AUTOLUS THERAPEUTICS PLC | 1,831,167 | $11.79M | 0.3% | $6.44 | $6.44 | — | SPON ADS | 05280R100 |
| ZYME | ZYMEWORKS INC | 1,074,807 | $11.17M | 0.2% | $10.39 * | $7.03 | +13.4% | COM | 98985Y108 |
| TNGX | TANGO THERAPEUTICS INC | 1,111,870 | $11.01M | 0.2% | $9.90 * | $6.10 | +42.4% | COM | 87583X109 |
| TCMD | TACTILE SYS TECHNOLOGY INC | 707,159 | $10.11M | 0.2% | $14.30 * | $14.76 | -14.9% | COM | 87357P100 |
| PTGX | PROTAGONIST THERAPEUTICS INC | 383,260 | $8.788M | 0.2% | $22.93 * | $19.62 | -10.8% | COM | 74366E102 |
| — | INTRA-CELLULAR THERAPIES INC | 108,000 | $7.735M | 0.2% | $71.62 | $71.62 | — | COM | 46116X101 |
| OLMA | OLEMA PHARMACEUTICALS INC | 539,831 | $7.574M | 0.2% | $14.03 * | $13.44 | 0.0% | COM | 68062P106 |
| TERN | TERNS PHARMACEUTICALS INC | 1,075,000 | $6.977M | 0.2% | $6.49 * | $6.35 | -16.7% | COM | 880881107 |
| COGT | COGENT BIOSCIENCES INC | 1,122,958 | $6.603M | 0.1% | $5.88 * | $11.14 | -31.2% | COM | 19240Q201 |
| RGNX | REGENXBIO INC | 342,408 | $6.146M | 0.1% | $17.95 | $17.61 | 0.0% | COM | 75901B107 |
| EWTX | EDGEWISE THERAPEUTICS INC | 555,555 | $6.078M | 0.1% | $10.94 * | $7.02 | 0.0% | COM | 28036F105 |
| MGNX | MACROGENICS INC | 611,932 | $5.887M | 0.1% | $9.62 * | $6.91 | 0.0% | COM | 556099109 |
| AXGN | AXOGEN INC | 808,380 | $5.521M | 0.1% | $6.83 * | $10.29 | -46.0% | COM | 05463X106 |
| — | LANDOS BIOPHARMA INC | 1,486,991 | $5.442M | 0.1% | $3.66 | $4.21 | — | COM NEW | 515069201 |
| TYRA | TYRA BIOSCIENCES INC | 360,000 | $4.986M | 0.1% | $13.85 * | $19.11 | -32.3% | COM | 90240B106 |
| MLTX | MOONLAKE IMMUNOTHERAPEUTICS | 82,398 | $4.976M | 0.1% | $60.39 * | $51.54 | 0.0% | CLASS A ORD | 61559X104 |
| NVAX | NOVAVAX INC | 1,400,000 | $4.755M | 0.1% | $3.40 | — | — | Put | 670002401 |
| NBTX | NANOBIOTIX | 555,066 | $4.041M | 0.1% | $7.28 | $16.50 | — | SPONSORED ADS | 63009J107 |
| — | VERU INC | 5,584,699 | $4.021M | 0.1% | $0.72 | $0.81 | — | COM | 92536C103 |
| TVTX | TRAVERE THERAPEUTICS INC | 400,000 | $3.596M | 0.1% | $8.99 * | $16.14 | -54.9% | COM | 89422G107 |
| — | ENVVENO MEDICAL CORPORATION | 623,315 | $3.204M | 0.1% | $5.14 | $6.59 | — | COM | 29415J106 |
| ACAD | ACADIA PHARMACEUTICALS INC | 101,000 | $3.162M | 0.1% | $31.31 * | $23.88 | 0.0% | COM | 004225108 |
| — | X4 PHARMACEUTICALS INC | 3,545,454 | $2.973M | 0.1% | $0.84 | $0.87 | — | COM | 98420X103 |
| — | FORTE BIOSCIENCES INC | 3,265,359 | $2.683M | 0.1% | $0.82 | $0.66 | — | COM | 34962G109 |
| CYTK | CYTOKINETICS INC | 30,317 | $2.531M | 0.1% | $83.49 * | $36.21 | 0.0% | COM NEW | 23282W605 |
| — | KRONOS BIO INC | 1,752,745 | $2.191M | 0.0% | $1.25 | $29.87 | — | COM | 50107A104 |
| ESTA | ESTABLISHMENT LABS HLDGS INC | 82,299 | $2.131M | 0.0% | $25.89 * | $43.69 | -33.0% | COM | G31249108 |
| — | CAREMAX INC | 3,679,284 | $1.832M | 0.0% | $0.50 | $10.31 | — | COM CL A | 14171W103 |
| — | MORPHIC HLDGS INC | 56,980 | $1.646M | 0.0% | $28.88 | $28.88 | — | COM | 61775R105 |
| XBI | SPDR SER TR | 1,900,000 | $1.282M | 0.0% | $0.67 | — | — | Put | 78464A870 |
| — | AMBRX BIOPHARMA INC | 78,811 | $1.122M | 0.0% | $14.24 | $14.24 | — | COM | 641871108 |
| — | SINGULAR GENOMICS SYSTEMS IN | 2,126,893 | $979K | 0.0% | $0.46 | $24.49 | — | COM | 82933R100 |
| — | VBI VACCINES INC CDA | 1,381,355 | $815K | 0.0% | $0.59 | $3.29 | — | COM NEW | 91822J202 |
| — | APPLIED THERAPEUTICS INC | 500,000 | $500K | 0.0% | $1.00 | $3.35 | — | Call | 03828A101 |
| CYPH | LEAP THERAPEUTICS INC | 44,971 | $186K | 0.0% | $4.14 * | $5.02 | -56.9% | COM NEW | 52187K200 |
| BCAB | BIOATLA INC | 73,000 | $180K | 0.0% | $2.46 * | $1.73 | 0.0% | COM | 09077B104 |
| RVMDW | REVOLUTION MEDICINES INC | 250,000 | $82,500 | 0.0% | $0.33 | $0.33 | — | *W EXP 12/17/202 | 76155X118 |
| EYPT | EYEPOINT PHARMACEUTICALS INC | 750,000 | $37,500 | 0.0% | $0.05 * | $11.18 | 0.0% | Put | 30233G209 |
| SRZNW | SURROZEN INC | 166,666 | $3,333 | 0.0% | $0.02 | $1.14 | — | *W EXP 08/01/203 | 86889P117 |
| — | CAREMAX INC | 60,000 | $450 | 0.0% | $0.01 | $4.72 | — | *W EXP 06/08/202 | 14171W111 |