Location: New York, NY
CIK: 0001224962 · Show all filings
Period: Q3 2024 (← Previous) (Next →)
Filing Date: Nov 14, 2024
Total Value: $4.727B (100.0% shares, 0.0% debt)
| Ticker | Issuer | Shares | Value | % | Share Price | Est. Cost/Share | Unrealized @ Report Date | Class | CUSIP |
|---|---|---|---|---|---|---|---|---|---|
| ACLX | ARCELLX INC | 3,888,669 | $325M | 6.9% | $83.51 * | $24.76 | +169.0% | COMMON STOCK | 03940C100 |
| NUVL | NUVALENT INC | 2,979,235 | $305M | 6.4% | $102.30 * | $38.37 | +116.2% | COM | 670703107 |
| FOLD | AMICUS THERAPEUTICS INC | 28,057,456 | $300M | 6.3% | $10.68 | $7.36 | +47.9% | COM | 03152W109 |
| IOVA | IOVANCE BIOTHERAPEUTICS INC | 26,617,709 | $250M | 5.3% | $9.39 | $11.89 | -20.3% | COM | 462260100 |
| PCVX | VAXCYTE INC | 2,027,608 | $232M | 4.9% | $114.27 * | $56.58 | +59.3% | COM | 92243G108 |
| RYTM | RHYTHM PHARMACEUTICALS INC | 3,560,214 | $187M | 3.9% | $52.39 * | $35.33 | +35.6% | COM | 76243J105 |
| — | VERONA PHARMA PLC | 6,315,933 | $182M | 3.8% | $28.77 | $22.65 | — | SPONSORED ADS | 925050106 |
| SLNO | SOLENO THERAPEUTICS INC | 3,204,976 | $162M | 3.4% | $50.49 * | $6.32 | +657.0% | COM | 834203309 |
| — | INTRA-CELLULAR THERAPIES INC | 1,622,215 | $119M | 2.5% | $73.17 | $69.08 | — | COM | 46116X101 |
| APGE | APOGEE THERAPEUTICS INC | 2,015,007 | $118M | 2.5% | $58.74 * | $24.99 | +91.7% | COM | 03770N101 |
| VKTX | VIKING THERAPEUTICS INC | 1,699,987 | $108M | 2.3% | $63.31 * | $52.65 | +11.4% | COM | 92686J106 |
| CNTA | CENTESSA PHARMACEUTICALS PLC | 6,282,290 | $100M | 2.1% | $15.99 | $12.75 | — | SPONSORED ADS | 152309100 |
| IMTX | IMMATICS N.V | 8,086,159 | $92.26M | 2.0% | $11.41 * | $10.98 | +7.8% | SHS | N44445109 |
| EOLS | EVOLUS INC | 5,356,622 | $86.78M | 1.8% | $16.20 * | $10.21 | +36.9% | COM | 30052C107 |
| SYRE | SPYRE THERAPEUTICS INC | 2,872,547 | $84.48M | 1.8% | $29.41 * | $16.88 | +64.9% | COM NEW | 00773J202 |
| AORT | ARTIVION INC | 2,793,703 | $74.37M | 1.6% | $26.62 * | $19.16 | +35.7% | COM | 228903100 |
| BHVN | BIOHAVEN LTD | 1,485,232 | $74.22M | 1.6% | $49.97 * | $25.94 | +50.0% | COM | G1110E107 |
| — | ASTRIA THERAPEUTICS INC | 6,485,420 | $71.4M | 1.5% | $11.01 | $11.36 | — | COM | 04635X102 |
| AXSM | AXSOME THERAPEUTICS INC | 782,844 | $70.35M | 1.5% | $89.87 * | $77.79 | +12.2% | COM | 05464T104 |
| — | APPLIED THERAPEUTICS INC | 8,005,000 | $68.04M | 1.4% | $8.50 | $5.04 | — | COM | 03828A101 |
| — | CARGO THERAPEUTICS INC | 3,683,004 | $67.95M | 1.4% | $18.45 | $22.72 | — | COM | 14179K101 |
| IMVT | IMMUNOVANT INC | 2,378,762 | $67.82M | 1.4% | $28.51 * | $24.27 | +21.5% | COM | 45258J102 |
| PRAX | PRAXIS PRECISION MEDICINES I | 1,164,035 | $66.98M | 1.4% | $57.54 * | $48.12 | +12.3% | COM NEW | 74006W207 |
| ARGX | ARGENX SE | 118,839 | $64.42M | 1.4% | $542.08 | $527.37 | — | SPONSORED ADR | 04016X101 |
| VRDN | VIRIDIAN THERAPEUTICS INC | 2,812,665 | $63.99M | 1.4% | $22.75 * | $17.99 | -9.1% | COM | 92790C104 |
| EWTX | EDGEWISE THERAPEUTICS INC | 2,330,294 | $62.2M | 1.3% | $26.69 * | $15.01 | +32.5% | COM | 28036F105 |
| PTGX | PROTAGONIST THERAPEUTICS INC | 1,374,563 | $61.86M | 1.3% | $45.00 * | $26.52 | +52.3% | COM | 74366E102 |
| MGTX | MEIRAGTX HLDGS PLC | 12,581,103 | $52.43M | 1.1% | $4.17 * | $10.52 | -58.9% | COM | G59665102 |
| ALDX | ALDEYRA THERAPEUTICS INC | 9,275,851 | $50M | 1.1% | $5.39 * | $7.81 | -39.0% | COM | 01438T106 |
| — | AKERO THERAPEUTICS INC | 1,714,806 | $49.2M | 1.0% | $28.69 | $35.95 | — | COM | 00973Y108 |
| SLDB | SOLID BIOSCIENCES INC | 6,906,646 | $48.14M | 1.0% | $6.97 * | $7.94 | +2.2% | COM NEW | 83422E204 |
| TARS | TARSUS PHARMACEUTICALS INC | 1,296,416 | $42.64M | 0.9% | $32.89 * | $28.48 | -1.3% | COM | 87650L103 |
| XBI | SPDR SER TR | 400,000 | $39.52M | 0.8% | $98.80 | $92.71 | — | Put | 78464A870 |
| ACRV | ACRIVON THERAPEUTICS INC | 5,360,858 | $37.53M | 0.8% | $7.00 * | $10.66 | -26.1% | COMMON STOCK | 004890109 |
| CRNX | CRINETICS PHARMACEUTICALS IN | 724,698 | $37.03M | 0.8% | $51.10 | $27.14 | +90.1% | COM | 22663K107 |
| NAUT | NAUTILUS BIOTECHNOLOGY INC | 12,594,211 | $35.89M | 0.8% | $2.85 * | $8.54 | -69.7% | COM | 63909J108 |
| CELC | CELCUITY INC | 2,362,279 | $35.22M | 0.7% | $14.91 * | $13.53 | +21.8% | COM | 15102K100 |
| PODD | INSULET CORP | 142,269 | $33.11M | 0.7% | $232.75 * | $205.35 | 0.0% | COM | 45784P101 |
| ORKA | ORUKA THERAPEUTICS INC | 1,235,187 | $30.27M | 0.6% | $24.51 * | $34.79 | 0.0% | COM | 687604108 |
| CTNM | CONTINEUM THERAPEUTICS INC | 1,516,668 | $29.03M | 0.6% | $19.14 | $16.10 | +19.1% | CL A | 21217B100 |
| OCUL | OCULAR THERAPEUTIX INC | 3,324,468 | $28.92M | 0.6% | $8.70 * | $7.10 | +16.1% | COM | 67576A100 |
| ISRG | INTUITIVE SURGICAL INC | 58,119 | $28.55M | 0.6% | $491.27 * | $334.77 | +39.1% | COM NEW | 46120E602 |
| NTRA | NATERA INC | 220,000 | $27.93M | 0.6% | $126.95 * | $49.41 | +132.4% | COM | 632307104 |
| CGON | CG ONCOLOGY INC | 733,695 | $27.68M | 0.6% | $37.73 * | $40.84 | -14.2% | COM | 156944100 |
| ZYME | ZYMEWORKS INC | 2,180,020 | $27.36M | 0.6% | $12.55 * | $8.44 | +29.0% | COM | 98985Y108 |
| DYN | DYNE THERAPEUTICS INC | 718,144 | $25.8M | 0.5% | $35.92 * | $39.80 | 0.0% | COM | 26818M108 |
| ADGM | ADAGIO MED HLDGS INC | 9,812,419 | $25.32M | 0.5% | $2.58 * | $4.76 | 0.0% | COM | 00534B100 |
| ARVN | ARVINAS INC | 1,027,749 | $25.31M | 0.5% | $24.63 * | $37.87 | -31.1% | COM | 04335A105 |
| PRCT | PROCEPT BIOROBOTICS CORP | 315,659 | $25.29M | 0.5% | $80.12 * | $55.40 | +28.2% | COM | 74276L105 |
| NBIX | NEUROCRINE BIOSCIENCES INC | 212,228 | $24.45M | 0.5% | $115.22 * | $120.49 | +13.8% | COM | 64125C109 |
| OBIO | ORCHESTRA BIOMED HLDGS INC | 4,592,556 | $23.61M | 0.5% | $5.14 * | $8.81 | -25.9% | COM | 68572M106 |
| TIL | INSTIL BIO INC | 345,545 | $23.26M | 0.5% | $67.32 * | $23.54 | 0.0% | COM NEW | 45783C200 |
| LIVN | LIVANOVA PLC | 429,000 | $22.54M | 0.5% | $52.54 * | $53.60 | -7.5% | SHS | G5509L101 |
| — | SPRINGWORKS THERAPEUTICS INC | 692,263 | $22.18M | 0.5% | $32.04 | $38.38 | — | COM | 85205L107 |
| MDT | MEDTRONIC PLC | 245,332 | $22.09M | 0.5% | $90.03 * | $77.49 | +4.3% | SHS | G5960L103 |
| ADMA | ADMA BIOLOGICS INC | 1,060,200 | $21.19M | 0.4% | $19.99 * | $3.92 | +296.5% | COM | 000899104 |
| XENE | XENON PHARMACEUTICALS INC | 524,930 | $20.67M | 0.4% | $39.37 * | $26.63 | +51.4% | COM | 98420N105 |
| ZBIO | ZENAS BIOPHARMA INC | 1,144,035 | $19.36M | 0.4% | $16.92 * | $17.98 | 0.0% | COM | 98937L105 |
| IRON | DISC MEDICINE INC | 387,017 | $19.02M | 0.4% | $49.14 * | $39.61 | +18.5% | COM | 254604101 |
| RCKT | ROCKET PHARMACEUTICALS INC | 931,851 | $17.21M | 0.4% | $18.47 * | $20.82 | -1.6% | COM | 77313F106 |
| INBX | INHIBRX BIOSCIENCES INC | 1,064,026 | $16.66M | 0.4% | $15.66 * | $15.62 | -10.1% | COM | 45720N103 |
| RAPP | RAPPORT THERAPEUTICS INC | 748,183 | $15.32M | 0.3% | $20.48 * | $23.15 | -7.2% | COM | 75383L102 |
| — | MERUS N V | 300,000 | $14.99M | 0.3% | $49.96 | $59.17 | — | COM | N5749R100 |
| INSM | INSMED INC | 180,000 | $13.14M | 0.3% | $73.00 | $38.78 | +90.3% | COM PAR $.01 | 457669307 |
| ICLR | ICON PLC | 44,353 | $12.74M | 0.3% | $287.31 * | $313.96 | +0.4% | SHS | G4705A100 |
| ARQT | ARCUTIS BIOTHERAPEUTICS INC | 1,358,500 | $12.63M | 0.3% | $9.30 * | $8.28 | +19.1% | COM | 03969K108 |
| PEPG | PEPGEN INC | 1,410,438 | $12.06M | 0.3% | $8.55 * | $11.81 | +0.2% | COM | 713317105 |
| TYRA | TYRA BIOSCIENCES INC | 511,226 | $12.02M | 0.3% | $23.51 * | $17.64 | +19.0% | COM | 90240B106 |
| XNCR | XENCOR INC | 527,671 | $10.61M | 0.2% | $20.11 * | $18.77 | 0.0% | COM | 98401F105 |
| — | VERRICA PHARMACEUTICALS INC | 7,099,182 | $10.29M | 0.2% | $1.45 | $12.42 | — | COM | 92511W108 |
| ROIV | ROIVANT SCIENCES LTD | 847,745 | $9.783M | 0.2% | $11.54 | $11.39 | 0.0% | SHS | G76279101 |
| AVBP | ARRIVENT BIOPHARMA INC | 415,000 | $9.752M | 0.2% | $23.50 * | $20.17 | +12.5% | COM | 04272N102 |
| EXAS | EXACT SCIENCES CORP | 125,000 | $8.515M | 0.2% | $68.12 * | $56.44 | 0.0% | COM | 30063P105 |
| EYPT | EYEPOINT PHARMACEUTICALS INC | 1,037,274 | $8.288M | 0.2% | $7.99 * | $10.40 | -15.5% | COM NEW | 30233G209 |
| ALLO | ALLOGENE THERAPEUTICS INC | 2,725,000 | $7.63M | 0.2% | $2.80 * | $2.95 | -9.6% | COM | 019770106 |
| — | VERONA PHARMA PLC | 250,000 | $7.192M | 0.2% | $28.77 | $22.65 | — | Call | 925050106 |
| — | VERONA PHARMA PLC | 250,000 | $7.192M | 0.2% | $28.77 | $22.65 | — | Put | 925050106 |
| AMLX | AMYLYX PHARMACEUTICALS INC | 2,125,649 | $6.887M | 0.1% | $3.24 * | $2.25 | 0.0% | COM | 03237H101 |
| BCYC | BICYCLE THERAPEUTICS PLC | 255,994 | $5.793M | 0.1% | $22.63 | $20.24 | — | SPONSORED ADS | 088786108 |
| — | VERU INC | 7,283,157 | $5.601M | 0.1% | $0.77 | $0.81 | — | COM | 92536C103 |
| SAVA | CASSAVA SCIENCES INC | 183,000 | $5.386M | 0.1% | $29.43 | — | — | Put | 14817C107 |
| FULC | FULCRUM THERAPEUTICS INC | 1,500,000 | $5.355M | 0.1% | $3.57 | — | — | Call | 359616109 |
| BBOT | HELIX ACQUISITION CORP II | 500,000 | $5.225M | 0.1% | $10.45 | $10.35 | +0.1% | CL A ORD SHS | G4444H101 |
| — | BIODESIX INC | 2,173,880 | $3.87M | 0.1% | $1.78 | $1.53 | — | COM | 09075X108 |
| DTIL | PRECISION BIOSCIENCES INC | 426,293 | $3.82M | 0.1% | $8.96 * | $12.24 | -21.3% | COM NEW | 74019P207 |
| MREO | MEREO BIOPHARMA GROUP PLC | 815,722 | $3.353M | 0.1% | $4.11 | $3.60 | — | SPON ADS | 589492107 |
| — | LYRA THERAPEUTICS INC | 12,757,562 | $3.279M | 0.1% | $0.26 | $6.65 | — | COM | 55234L105 |
| NBTX | NANOBIOTIX | 555,066 | $3.192M | 0.1% | $5.75 | $16.50 | — | SPONSORED ADS | 63009J107 |
| ABSI | ABSCI CORPORATION | 700,000 | $2.674M | 0.1% | $3.82 * | $4.51 | -11.7% | COM | 00091E109 |
| — | ATHIRA PHARMA INC | 5,402,964 | $2.41M | 0.1% | $0.45 | $12.75 | — | COM | 04746L104 |
| — | X4 PHARMACEUTICALS INC | 3,545,454 | $2.373M | 0.1% | $0.67 | $0.87 | — | COM | 98420X103 |
| — | ENVVENO MEDICAL CORPORATION | 694,315 | $2.333M | 0.0% | $3.36 | $6.26 | — | COM | 29415J106 |
| KYMR | KYMERA THERAPEUTICS INC | 46,213 | $2.187M | 0.0% | $47.33 * | $44.16 | 0.0% | COM | 501575104 |
| TRIB | TRINITY BIOTECH PLC | 1,800,000 | $1.98M | 0.0% | $1.10 | $2.04 | — | SPONS ADR NEW | 896438504 |
| PYXS | PYXIS ONCOLOGY INC | 508,462 | $1.866M | 0.0% | $3.67 * | $3.50 | 0.0% | COMMON STOCK | 747324101 |
| IRTC | IRHYTHM TECHNOLOGIES INC | 22,591 | $1.677M | 0.0% | $74.24 * | $112.42 | -29.2% | COM | 450056106 |
| GPCR | STRUCTURE THERAPEUTICS INC | 34,852 | $1.53M | 0.0% | $43.89 | $39.27 | — | SPONSORED ADS | 86366E106 |
| LXEO | LEXEO THERAPEUTICS INC | 139,835 | $1.264M | 0.0% | $9.04 * | $11.93 | 0.0% | COM | 52886X107 |
| NVAX | NOVAVAX INC | 100,000 | $1.263M | 0.0% | $12.63 | — | — | Put | 670002401 |
| FATE | FATE THERAPEUTICS INC | 345,575 | $1.21M | 0.0% | $3.50 * | $4.38 | -11.1% | COM | 31189P102 |
| — | SINGULAR GENOMICS SYSTEMS IN | 50,896 | $798K | 0.0% | $15.67 | $8.45 | — | COM NEW | 82933R308 |
| KYTX | KYVERNA THERAPEUTICS INC | 150,000 | $734K | 0.0% | $4.89 * | $27.84 | -72.3% | COM | 501976104 |
| FBRX | FORTE BIOSCIENCES INC | 95,742 | $535K | 0.0% | $5.59 * | $10.28 | 0.0% | COM NEW | 34962G208 |
| SYRS | SYROS PHARMACEUTICALS INC | 116,754 | $251K | 0.0% | $2.15 * | $6.91 | -48.1% | COM NEW | 87184Q206 |
| — | CAREMAX INC | 100,000 | $170K | 0.0% | $1.70 | $4.82 | — | CL A NEW | 14171W202 |
| RVMDW | REVOLUTION MEDICINES INC | 250,000 | $35,000 | 0.0% | $0.14 | $0.33 | — | *W EXP 12/17/202 | 76155X118 |
| SRZNW | SURROZEN INC | 166,666 | $1,717 | 0.0% | $0.01 | $1.14 | — | *W EXP 08/01/203 | 86889P117 |
| — | CAREMAX INC | 60,000 | $594 | 0.0% | $0.01 | $4.72 | — | *W EXP 06/08/202 | 14171W111 |